CN102888404B - siRNA缀合物及其制备方法 - Google Patents

siRNA缀合物及其制备方法 Download PDF

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CN102888404B
CN102888404B CN201210301551.2A CN201210301551A CN102888404B CN 102888404 B CN102888404 B CN 102888404B CN 201210301551 A CN201210301551 A CN 201210301551A CN 102888404 B CN102888404 B CN 102888404B
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sirna
conjugate
peg
polymer
nanoparticle
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CN102888404A (zh
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韩宝蓝
朴翰浯
申美湜
李三用
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Bioneer Corp
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CN201210301551.2A 2009-05-14 2010-05-13 siRNA缀合物及其制备方法 Active CN102888404B (zh)

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KR1020090042297A KR101224828B1 (ko) 2009-05-14 2009-05-14 ｓｉＲＮＡ 접합체 및 그 제조방법
KR10-2009-0042297 2009-05-14

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CN102888404B true CN102888404B (zh) 2015-06-17

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CN201210301551.2A Active CN102888404B (zh) 2009-05-14 2010-05-13 siRNA缀合物及其制备方法
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US (4) US8779114B2 (enExample)
EP (3) EP2626427A3 (enExample)
JP (3) JP5758381B2 (enExample)
KR (1) KR101224828B1 (enExample)
CN (3) CN103233003B (enExample)
AU (1) AU2010248239B2 (enExample)
BR (1) BRPI1012141B1 (enExample)
CA (2) CA2871888A1 (enExample)
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KR101224828B1 (ko) 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
CA2859127C (en) * 2011-12-15 2017-04-25 Bioneer Corporation Novel oligonucleotide conjugates and use thereof
KR101722948B1 (ko) * 2012-01-05 2017-04-04 (주)바이오니아 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법
ES3034830T3 (en) * 2012-01-05 2025-08-25 Bioneer Corp High-efficiency nanoparticle-type double-helical oligo-rna structure and method for preparing same
KR101629233B1 (ko) * 2012-01-18 2016-06-10 (주)바이오니아 자성나노입자-SAMiRNA 복합체 및 그 제조방법
JP6360482B2 (ja) 2012-09-17 2018-07-18 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ クロマトグラフィー担体及びデバイス
WO2014054927A1 (ko) 2012-10-05 2014-04-10 (주)바이오니아 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물
EP2930180B1 (en) * 2012-12-06 2021-11-10 Kyowa Hakko Bio Co., Ltd. Double-stranded ribonucleic acid for adjuvants
SG11201507571TA (en) * 2013-07-05 2015-10-29 Bioneer Corp Dengue virus-specific sirna, double helix oligo-rna structure comprising sirna, and composition for suppressing proliferation of dengue virus comprising rna structure
JP2016525346A (ja) * 2013-07-05 2016-08-25 バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 呼吸器疾患関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体およびこれを含む呼吸器疾患予防または治療用組成物
US10030243B2 (en) 2013-07-05 2018-07-24 Bioneer Corporation Nanoparticle type oligonucleotide structure having high efficiency and method for preparing same
KR20150006742A (ko) * 2013-07-09 2015-01-19 (주)바이오니아 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
KR20150006743A (ko) * 2013-07-09 2015-01-19 (주)바이오니아 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
EP3128008B1 (en) * 2014-04-04 2024-05-29 Bioneer Corporation Double-stranded oligo rna and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases
US11389783B2 (en) 2014-05-02 2022-07-19 W.R. Grace & Co.-Conn. Functionalized support material and methods of making and using functionalized support material
US9975983B2 (en) 2014-10-15 2018-05-22 University Of Connecticut Bio-reducible self-assembled liquid crystalline block copolymer for drug delivery
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