CN102872250A

CN102872250A - Lotion for treating eczema

Info

Publication number: CN102872250A
Application number: CN2012103391474A
Authority: CN
Inventors: 杨永军; 张宗保
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-14
Filing date: 2012-09-14
Publication date: 2013-01-16
Anticipated expiration: 2032-09-14
Also published as: CN102872250B

Abstract

The invention relates to a medicine for treating skin diseases, in particular to lotion for treating eczema. The lotion comprises the following components in part by weight: 12 to 18 parts of fineleaf schizonepeta herb, 10 to 15 parts of divaricate saposhnikovia root, 8 to 13 parts of garden balsam stem, 6 to 13 parts of sappan wood, 8 to 13 parts of Chinese Cinquefoil Herb, 10 to 15 parts of honeysuckle flower, 6 to 10 parts of safflower, 13 to 19 parts of lightyellow sophora root, 10 to 15 parts of belvedere fruit, 13 to 15 parts of Chinese red pepper, 10 to 15 parts of laver, 8 to 12 parts of Chinese angelica, 6 to 10 parts of garden burnet root, 2 to 6 parts of borneol, 8 to 12 parts of coptis root, 4 to 8 parts of liquoric root, 13 to 15 parts of calcined clam shell, 13 to 19 parts of calcined gypsum, 10 to 15 parts of phellodendron, 3 to 7 parts of natural indigo, 6 to 13 parts of cortex dictamni, 5 to 9 parts of tree peony bark and 6 to 10 parts of plantain seed. The lotion has the advantages that the lotion has the remarkable effect of treating eczema, and is superior to similar comparison medicines; and the clinical cure rate, the obvious effective rate and the total effective rate are 33.33 percent, 27.5 percent and 88.33percent respectively.

Description

A kind of washing liquid for the treatment of eczema

Technical field

The present invention relates to a kind of dermopathic medicine for the treatment of, more specifically a kind of washing liquid for the treatment of eczema.

Background technology

Eczema is a kind of allergic inflammation dermatoses that is caused by multiple internal and external factor.With the pleomorphism skin lesion, symmetrical, be easy to ooze out conscious pruritus, repeatedly outbreak and the chronic Clinical symptoms that turns to.The primary disease men and women, old and young all can suffer from, and take the not anti-person of natural endowment as many.Generally can be divided into acute, subacute, chronic three classes, primary disease is equivalent to the eczema of doctor trained in Western medicine, and traditional Chinese medical science ancient literature generally has different titles according to its site of pathological change, skin lesion characteristics, if contamination all over body, is grown the more person of water, claims acute eczema; Take pimple as main person, claim itching eruption due to wind-heat in blood or chestnut skin ulcer; Send out in the person of ear, claim eczema of ear; Send out in the nipple person, claim cracked nipple; Send out in the hand person, claim lame skin ulcer; Send out in the umbilical part person, claim umbilical sore; Occurring in YIN part of the body capsule person claims scrotal eczema or eczema of scrotum; Send out in extremity bending section person, claim atopic eczema; Send out in baby person, claim infantile eczema or tire disease skin ulcer.Acute eczema onset is very fast, and normal symmetrical the generation can be sent out any one position in health, also can general in whole body, but common to locate around the forehead of face, eyelid, buccal, ear, the lip etc.From the beginning of erubescence, swelling, pruritus, on flushing, swelling or the skin around it, pimple, papulovesicle, vesicle appear then.Skin lesion is trooped or is intensive in blocks, and form is not of uniform size, obscure boundary.Chang Yin scratches and vesicle is broken, form rotten to the corn, stream is grown, incrustation.Conscious pruritus, the lighter is little to itch, and the violent pruritus of severe one is intermittence or paroxysmal outbreak, and exacerbate the night of being everlasting, the impact sleep.The extensive person of skin lesion can have the General Symptomies such as heating, constipation, oliguria with reddish urine; Subacute eczema is many, and redness, the vesicle of acute stage alleviate by acute eczema delay, and stream is grown and reduced, but still has erythema, pimple, desquamation.Conscious pruritus, light or heavy, generally without general malaise; Chronic eczema is many to be shown effect repeatedly by acute, subacute eczema, also but onset is chronic eczema, it shows as pars affecta skin and thickens, rough surface, dermatoglyph is remarkable or lichenification is arranged, and that touches is harder, dark red or puce, often with a small amount of scratch, blood crusts, squama and pigmentation, there are erosion, stream to grow.Conscious acute pruritus, during especially with the product of night, nervous, the pungent fish raw meat wind symptom of food for very.Chap if occur in the palm sole of the foot, the easy of joint portion, cause pain.The course of disease is longer, and several months to the several years is not waited, often the General Symptoms such as, soreness of the loins and weakness of the limbs weak with giddy.Modern medicine is thought, eczema be since widely inherent or extraneous various simple or complicated factor cause, be a kind of allergy dermatopathy, when the cause of disease mostly is allergic diathesis and exists in the sensitization source, can thoroughly send out eczema, cause mental fatigue, anxiety, melancholy.At present, the treatment eczema is main mainly with the Chinese patent medicine orally taken for curing, but this orally taken for curing mode treatment cycle is long, skin ulcer face antibacterial, fungus, virus without tagging effect, easily repeatedly show effect, and medicine for external use are mainly played the sterilizing effect, effect is single, and cure rate is low.

Summary of the invention

For above deficiency, the invention provides the washing liquid of the high treatment eczema of a kind of cure rate.

The present invention is achieved by the following technical solutions:

A kind of washing liquid for the treatment of eczema, this washing liquid is in weight portion, and it comprises following component: Herba Schizonepetae 12-18 part, Radix Saposhnikoviae 10-15 part, Herba speranskiae tuberculatae 8-13 part, Lignum Sappan 6-13 part, Herba Potentillae Chinensis 8-13 part, Flos Lonicerae 10-15 part, Flos Carthami 6-10 part, Radix Sophorae Flavescentis 13-19 part, Fructus Kochiae 10-15 part, Pericarpium Zanthoxyli 13-15 part, Radix Arnebiae (Radix Lithospermi) 10-15 part, Radix Angelicae Sinensis 8-12 part, Radix Sanguisorbae 6-10 part, Borneolum Syntheticum 2-6 part, Rhizoma Coptidis 8-12 part, Radix Glycyrrhizae 4-8 part, calcined CONCHA MERETRICIS SEU CYCLINAE 13-15 part, Gypsum Fibrosum Preparatum 13-19 part, Cortex Phellodendri 10-15 part, Indigo Naturalis 3-7 part, Cortex Dictamni 6-13 part, Cortex Moutan 5-9 part, Semen Plantaginis 6-10 part.

The manufacture method of above-mentioned calcined CONCHA MERETRICIS SEU CYCLINAE is: get clean Concha Meretricis Seu Cyclinae, put on the smokeless stove fire or put in the suitable container, be calcined to crisp or when being popular in, take out, cool, pulverize.List of references is 2010 editions appendix II D of the Pharmacopoeia of the People's Republic of China.

The manufacture method of above-mentioned Gypsum Fibrosum Preparatum is: get clean Gypsum Fibrosum, pound into fritter, put on the smokeless stove fire or put in the suitable container, be calcined to crisp or when being popular in, take out, cool, pulverize.List of references is 2010 editions appendix II D of the Pharmacopoeia of the People's Republic of China.

It comprises following component to above-mentioned washing liquid in weight portion: 15 parts of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 11 parts of Herba speranskiae tuberculataes, Lignum Sappan 9,11 parts of Herba Potentillae Chinensis, 12 parts of Flos Loniceraes, 8 parts on Flos Carthami, 16 parts of Radix Sophorae Flavescentiss, 13 parts of the Fructus Kochiae, 14 parts in Pericarpium Zanthoxyli, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Sanguisorbaes, 4 parts of Borneolum Syntheticums, 10 parts of Rhizoma Coptidis, 6 parts in Radix Glycyrrhizae, 14 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 16 parts of Gypsum Fibrosum Preparatum, 12 parts of Cortex Phellodendris, 5 parts of Indigo Naturaliss, 9 parts of Cortex Dictamni, 7 parts of Cortex Moutans, 8 parts of Semen Plantaginiss.

Above-mentioned a kind of manufacture method for the treatment of the washing liquid of eczema comprises following step:

A. get 2-6 part Borneolum Syntheticum powder and be broken to the 80-100 order, get the Borneolum Syntheticum fine powder;

B. with 12-18 part Herba Schizonepetae, 10-15 part Radix Saposhnikoviae, 10-15 part Flos Lonicerae, 13-15 part Pericarpium Zanthoxyli, 8-12 part Radix Angelicae Sinensis, 8-13 part Herba speranskiae tuberculatae was with steam distillation 1 hour and extract volatile oil, with the distillation after aqueous solution collect with container; All the other components except above-mentioned Borneolum Syntheticum, Herba Schizonepetae, Radix Saposhnikoviae, Flos Lonicerae, Pericarpium Zanthoxyli, Radix Angelicae Sinensis, Herba speranskiae tuberculatae and the medicinal residues behind the above-mentioned distillating extracting oil decoct with water and extract three times, the water boiling and extraction 2 hours that adds for the first time 7 times of except Borneolum Syntheticum all the other component gross masses, adding for the second time except Borneolum Syntheticum 6 times of water gagings of all the other component gross masses decocts and extracted 1.5 hours, add for the third time except Borneolum Syntheticum 3 times of water gagings of all the other component gross masses and decoct and extracted 1 hour, decoct the decocting liquid that extracts with 3 times and merge;

C. add the aqueous solution after the above-mentioned distillation in the decocting liquid after merge, filter, filtrate is concentrated into that relative density is 1.07～1.10 in the time of 60 ℃, lets cool to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stirs evenly, and leaves standstill under 6～9 ℃ 24 hours, filters; Filtrate is concentrated into that relative density is 1.07～1.10 in the time of 60 ℃, and in concentration process Recycled ethanol, add again with concentrated after the isopyknic water dilution of filtrate, stir evenly, left standstill lower 24 hours at 6～9 ℃, filter; Stir filtrate, and add the whole Borneolum Syntheticum fine powders among the step a; Regulate pH value to 5.5～7.0, sterilization namely gets described washing liquid.

A. get 4 parts of Borneolum Syntheticum powder and be broken to 90 orders, get the Borneolum Syntheticum fine powder;

B. with 15 portions of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 12 portions of Flos Loniceraes, 14 portions of Pericarpium Zanthoxylies, 10 parts of Radix Angelicae Sinensis, 11 parts of Herba speranskiae tuberculataes with steam distillation 1 hour and extract volatile oil, the aqueous solution after the distillation is collected with container; All the other components except above-mentioned Borneolum Syntheticum, Herba Schizonepetae, Radix Saposhnikoviae, Flos Lonicerae, Pericarpium Zanthoxyli, Radix Angelicae Sinensis, Herba speranskiae tuberculatae and the medicinal residues behind the above-mentioned distillating extracting oil decoct with water and extract three times, the decocting that adds for the first time 7 times of except Borneolum Syntheticum all the other component gross masses boiled 2 hours, adding for the second time except Borneolum Syntheticum 6 times of water gagings of all the other component gross masses decocts and extracted 1.5 hours, add for the third time except Borneolum Syntheticum 3 times of water gagings of all the other component gross masses and decoct and extracted 1 hour, decoct the decocting liquid that extracts with 3 times and merge;

C. add the aqueous solution after the above-mentioned distillation in the decocting liquid after merge, filter, filtrate is concentrated into that relative density is 1.08 in the time of 60 ℃, lets cool to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stirs evenly, and leaves standstill under 8 ℃ 24 hours, filters; Filtrate is concentrated into that relative density is 1.08 in the time of 60 ℃, and in concentration process Recycled ethanol, add again with concentrated after the isopyknic water dilution of filtrate, stir evenly, left standstill lower 24 hours at 8 ℃, filter; Stir filtrate, and add the whole Borneolum Syntheticum fine powders among the step a; Regulate pH value to 6.0, sterilization namely gets described washing liquid.

The invention has the beneficial effects as follows: washing liquid of the present invention has remarkable therapeutical effect to eczema, and clinical cure rate is 33.33%, obvious effective rate is 27.5%, total effective rate is 88.33%, is better than similar contrast medicine, for eczema obvious therapeutic effect is arranged.

The specific embodiment

The present invention will be further described below in conjunction with specific embodiment, so that those skilled in the art can better understand the present invention, but therefore do not limit the present invention.

A kind of manufacture method for the treatment of the washing liquid of eczema comprises following step:

A. get 2-6 part Borneolum Syntheticum powder and be broken to 90 orders, get the Borneolum Syntheticum fine powder;

Embodiment 1

Get following component in weight portion: 12 parts of Herba Schizonepetae, 10 parts of Radix Saposhnikoviaes, 8 parts of Herba speranskiae tuberculataes, 6 parts of Lignum Sappans, 8 parts of Herba Potentillae Chinensis, 10 parts of Flos Loniceraes, 6 parts on Flos Carthami, 13 parts of Radix Sophorae Flavescentiss, 10 parts of the Fructus Kochiae, 13 parts in Pericarpium Zanthoxyli, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Radix Angelicae Sinensis, 6 parts of Radix Sanguisorbaes, 2 parts of Borneolum Syntheticums, 8 parts of Rhizoma Coptidis, 4 parts in Radix Glycyrrhizae, 13 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 13 parts of Gypsum Fibrosum Preparatum, 10 parts of Cortex Phellodendris, 3 parts of Indigo Naturaliss, 6 parts of Cortex Dictamni, 5 parts of Cortex Moutans, 6 parts of Semen Plantaginiss, and by above-mentioned steps manufacturing washing liquid.

Embodiment 2

Get following component in weight portion: 18 parts of Herba Schizonepetae, 15 parts of Radix Saposhnikoviaes, 13 parts of Herba speranskiae tuberculataes, 13 parts of Lignum Sappans, 13 parts of Herba Potentillae Chinensis, 15 parts of Flos Loniceraes, 10 parts on Flos Carthami, 19 parts of Radix Sophorae Flavescentiss, 15 parts of the Fructus Kochiae, 15 parts in Pericarpium Zanthoxyli, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Radix Angelicae Sinensis, 10 parts of Radix Sanguisorbaes, 6 parts of Borneolum Syntheticums, 12 parts of Rhizoma Coptidis, 8 parts in Radix Glycyrrhizae, 15 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 19 parts of Gypsum Fibrosum Preparatum, 15 parts of Cortex Phellodendris, 7 parts of Indigo Naturaliss, 13 parts of Cortex Dictamni, 9 parts of Cortex Moutans, Semen Plantaginis 10, and by above-mentioned steps manufacturing washing liquid.

Embodiment 3

Get following component in weight portion: 15 parts of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 11 parts of Herba speranskiae tuberculataes, Lignum Sappan 9,11 parts of Herba Potentillae Chinensis, 12 parts of Flos Loniceraes, 8 parts on Flos Carthami, 16 parts of Radix Sophorae Flavescentiss, 13 parts of the Fructus Kochiae, 14 parts in Pericarpium Zanthoxyli, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Sanguisorbaes, 4 parts of Borneolum Syntheticums, 10 parts of Rhizoma Coptidis, 6 parts in Radix Glycyrrhizae, 14 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 16 parts of Gypsum Fibrosum Preparatum, 12 parts of Cortex Phellodendris, 5 parts of Indigo Naturaliss, 9 parts of Cortex Dictamni, 7 parts of Cortex Moutans, 8 parts of Semen Plantaginiss, and by above-mentioned steps manufacturing washing liquid.

Above-mentioned three groups of embodiment are respectively to 16～44 years old age, average 24.94 ± 3.91 years old; The course of disease 1 week～14 year, average 3.3 ± 3.14 years; I degree 32 examples, II degree 26 examples, III degree 8 examples, IV degree 4 examples are carried out clinical treatment, according to the skin lesion curative effect determinate standard

(1) clinical recovery: skin lesion all disappears, and occurs without new rash.Skin lesion extinction rate 〉=95%.

(2) produce effects: the skin lesion major part disappears, and newly plays erythra and is less than 5.95%＞skin lesion extinction rate 〉=70%.

(3) effective: skin lesion partly disappears, and newly plays erythra and is less than 10.70%＞skin lesion extinction rate 〉=50%.

The results are shown in Table 1.

Can find out that according to table 1 proportioning among the embodiment 3 is best proportioning.

Proportioning for embodiment 3 is carried out again 120 routine clinical treatments, 16～44 years old age, average 24.94 ± 3.91 years old; The course of disease 1 week～14 year, average 3.3 ± 3.14 years; I degree 62 examples, II degree 43 examples, III degree 10 examples, IV degree 5 examples.

Select the skin health lotion that 80 examples are carried out clinical treatment, 16～34 years old age, average 22.13 ± 3.93 years old; The course of disease 1 week～14 year, average 3.5 ± 3.22 years; I degree 44 examples, II degree 28 examples, III degree 5 examples, IV degree 3 examples.

Two groups of indices all have comparability (P＞0.05), and two groups all basically identical in sex, age, the course of disease, symptom and sign, has comparability.

Embodiment 4: make washing liquid according to embodiment 3 proportionings, and 62 routine I degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Embodiment 5: make washing liquid according to embodiment 3 proportionings, and 43 routine II degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Embodiment 6: make washing liquid according to embodiment 3 proportionings, and 10 routine III degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Embodiment 7: make washing liquid according to embodiment 3 proportionings, and 5 routine IV degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Reference examples 1: select the skin health lotion that 44 routine I degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Reference examples 2: select the skin health lotion that 28 routine II degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Reference examples 3: select the skin health lotion that 5 routine III degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Reference examples 4: select the skin health lotion that 3 routine IV degree patients are carried out clinical treatment, therapeutic outcome sees Table 2.

Figure 2012103391474100002DEST_PATH_IMAGE002

Clinical observation shows, washing liquid of the present invention has remarkable therapeutical effect to eczema, and clinical cure rate is 33.33%, obvious effective rate is 27.5%, total effective rate is 88.33%, is better than similar contrast medicine, and eczema is had obvious therapeutic effect.

Claims

1. washing liquid for the treatment of eczema, it is characterized in that: this washing liquid is in weight portion, and it comprises following component: Herba Schizonepetae 12-18 part, Radix Saposhnikoviae 10-15 part, Herba speranskiae tuberculatae 8-13 part, Lignum Sappan 6-13 part, Herba Potentillae Chinensis 8-13 part, Flos Lonicerae 10-15 part, Flos Carthami 6-10 part, Radix Sophorae Flavescentis 13-19 part, Fructus Kochiae 10-15 part, Pericarpium Zanthoxyli 13-15 part, Radix Arnebiae (Radix Lithospermi) 10-15 part, Radix Angelicae Sinensis 8-12 part, Radix Sanguisorbae 6-10 part, Borneolum Syntheticum 2-6 part, Rhizoma Coptidis 8-12 part, Radix Glycyrrhizae 4-8 part, calcined CONCHA MERETRICIS SEU CYCLINAE 13-15 part, Gypsum Fibrosum Preparatum 13-19 part, Cortex Phellodendri 10-15 part, Indigo Naturalis 3-7 part, Cortex Dictamni 6-13 part, Cortex Moutan 5-9 part, Semen Plantaginis 6-10 part.

2. a kind of washing liquid for the treatment of eczema according to claim 1, it is characterized in that: this washing liquid is in weight portion, and it comprises following component: 15 parts of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 11 parts of Herba speranskiae tuberculataes, Lignum Sappan 9,11 parts of Herba Potentillae Chinensis, 12 parts of Flos Loniceraes, 8 parts on Flos Carthami, 16 parts of Radix Sophorae Flavescentiss, 13 parts of the Fructus Kochiae, 14 parts in Pericarpium Zanthoxyli, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Sanguisorbaes, 4 parts of Borneolum Syntheticums, 10 parts of Rhizoma Coptidis, 6 parts in Radix Glycyrrhizae, 14 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 16 parts of Gypsum Fibrosum Preparatum, 12 parts of Cortex Phellodendris, 5 parts of Indigo Naturaliss, 9 parts of Cortex Dictamni, 7 parts of Cortex Moutans, 8 parts of Semen Plantaginiss.

3. a kind of manufacture method for the treatment of the washing liquid of eczema according to claim 1 comprises following step:

4. a kind of manufacture method for the treatment of the washing liquid of eczema according to claim 3 comprises following step:

B. with 15 portions of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 12 portions of Flos Loniceraes, 14 portions of Pericarpium Zanthoxylies, 10 parts of Radix Angelicae Sinensis, 11 parts of Herba speranskiae tuberculataes with steam distillation 1 hour and extract volatile oil, the aqueous solution after the distillation is collected with container; All the other components except above-mentioned Borneolum Syntheticum, Herba Schizonepetae, Radix Saposhnikoviae, Flos Lonicerae, Pericarpium Zanthoxyli, Radix Angelicae Sinensis, Herba speranskiae tuberculatae and the medicinal residues behind the above-mentioned distillating extracting oil decoct with water and extract three times, the water boiling and extraction 2 hours that adds for the first time 7 times of except Borneolum Syntheticum all the other component gross masses, adding for the second time except Borneolum Syntheticum 6 times of water gagings of all the other component gross masses decocts and extracted 1.5 hours, add for the third time except Borneolum Syntheticum 3 times of water gagings of all the other component gross masses and decoct and extracted 1 hour, decoct the decocting liquid that extracts with 3 times and merge;