CN102872250B

CN102872250B - Lotion for treating eczema

Info

Publication number: CN102872250B
Application number: CN201210339147.4A
Authority: CN
Inventors: 杨永军; 张宗保
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-14
Filing date: 2012-09-14
Publication date: 2014-03-12
Anticipated expiration: 2032-09-14
Also published as: CN102872250A

Abstract

The invention relates to a medicine for treating skin diseases, in particular to lotion for treating eczema. The lotion comprises the following components in part by weight: 12 to 18 parts of fineleaf schizonepeta herb, 10 to 15 parts of divaricate saposhnikovia root, 8 to 13 parts of garden balsam stem, 6 to 13 parts of sappan wood, 8 to 13 parts of Chinese Cinquefoil Herb, 10 to 15 parts of honeysuckle flower, 6 to 10 parts of safflower, 13 to 19 parts of lightyellow sophora root, 10 to 15 parts of belvedere fruit, 13 to 15 parts of Chinese red pepper, 10 to 15 parts of laver, 8 to 12 parts of Chinese angelica, 6 to 10 parts of garden burnet root, 2 to 6 parts of borneol, 8 to 12 parts of coptis root, 4 to 8 parts of liquoric root, 13 to 15 parts of calcined clam shell, 13 to 19 parts of calcined gypsum, 10 to 15 parts of phellodendron, 3 to 7 parts of natural indigo, 6 to 13 parts of cortex dictamni, 5 to 9 parts of tree peony bark and 6 to 10 parts of plantain seed. The lotion has the advantages that the lotion has the remarkable effect of treating eczema, and is superior to similar comparison medicines; and the clinical cure rate, the obvious effective rate and the total effective rate are 33.33 percent, 27.5 percent and 88.33percent respectively.

Description

A kind of washing liquid for the treatment of eczema

Technical field

The present invention relates to a kind of dermopathic medicine for the treatment of, more specifically a kind of washing liquid for the treatment of eczema.

Background technology

Eczema is a kind of allergic inflammation dermatoses being caused by multiple internal and external factor.With pleomorphism skin lesion, symmetrical, be easy to ooze out conscious pruritus, repeatedly outbreak and the chronic Clinical symptoms that turns to.Primary disease men and women, old and young all can suffer from, and take the not resistance to person of natural endowment as many.Generally can be divided into acute, subacute, chronic three classes, primary disease is equivalent to the eczema of doctor trained in Western medicine, and traditional Chinese medical science ancient literature generally has different titles according to its site of pathological change, skin lesion feature, if contamination, all over body, is grown the more person of water, claims acute eczema; Take pimple as main person, claim itching eruption due to wind-heat in blood or chestnut skin ulcer; The person of Fa Yu ear, claims eczema of ear; Send out in nipple person, claim cracked nipple; Send out in hand person, claim lame skin ulcer; Send out in umbilical part person, claim umbilical sore; Occurring in YIN part of the body capsule person, claims scrotal eczema or eczema of scrotum; Send out in extremity bending section person, claim atopic eczema; Send out in baby person, claim infantile eczema or tire disease skin ulcer.Acute eczema onset is very fast, and normal symmetrical generation, can send out any one position in health, also can general in whole body, but etc. locate common around with facial forehead, eyelid, buccal, ear, lip.From the beginning of erubescence, swelling, pruritus, then, on flushing, swelling or its skin around, there is pimple, papulovesicle, vesicle.Skin lesion is trooped or is intensive in blocks, and form is not of uniform size, obscure boundary.Chang Yin scratches and vesicle is broken, form rotten to the corn, stream is grown, incrustation.Conscious pruritus, the lighter is micro-to itch, and the violent pruritus of severe one is intermittence or paroxysmal outbreak, and exacerbate the night of being everlasting, impact sleep.The extensive person of skin lesion, can have the General Symptomies such as heating, constipation, oliguria with reddish urine; Subacute eczema is many to be delayed by acute eczema, and redness, the vesicle of acute stage alleviate, and stream is grown and reduced, but still has erythema, pimple, desquamation.Conscious pruritus, light or heavy, generally without general malaise; Chronic eczema is many to be shown effect repeatedly by acute, subacute eczema, also can onset be chronic eczema, it shows as pars affecta skin and thickens, rough surface, dermatoglyph is remarkable or have lichenification, and that touches is harder, dark red or puce, often with a small amount of scratch, blood crusts, squama and pigmentation, there are erosion, stream to grow.Conscious acute pruritus, during especially with night, nervous, the product of eating pungent fish raw meat wind symptom for very.If occur in the palm sole of the foot, the easy of joint portion, chap, cause pain.The course of disease is longer, several months to the several years not etc., the normal General Symptoms such as, soreness of the loins and weakness of the limbs weak with giddy.Modern medicine is thought, eczema is to cause due to inherent or extraneous various simple or complicated factor widely, is a kind of allergy dermatopathy, when the cause of disease mostly is allergic diathesis and exists in sensitization source, can thoroughly send out eczema, cause mental fatigue, anxiety, melancholy.At present, treatment eczema is main mainly with Chinese patent medicine orally taken for curing, but this orally taken for curing mode treatment cycle is long, skin ulcer face antibacterial, fungus, virus, without tagging effect, easily repeatedly show effect, and medicine for external use are mainly played sterilizing effect to, effect is single, and cure rate is low.

Summary of the invention

For above deficiency, the invention provides the washing liquid of the treatment eczema that a kind of cure rate is high.

The present invention is achieved by the following technical solutions:

A kind of washing liquid for the treatment of eczema, this washing liquid is in weight portion, it comprises following component: Herba Schizonepetae 12-18 part, Radix Saposhnikoviae 10-15 part, Herba speranskiae tuberculatae 8-13 part, Lignum Sappan 6-13 part, Herba Potentillae Chinensis 8-13 part, Flos Lonicerae 10-15 part, Flos Carthami 6-10 part, Radix Sophorae Flavescentis 13-19 part, Fructus Kochiae 10-15 part, Pericarpium Zanthoxyli 13-15 part, Radix Arnebiae (Radix Lithospermi) 10-15 part, Radix Angelicae Sinensis 8-12 part, Radix Sanguisorbae 6-10 part, Borneolum Syntheticum 2-6 part, Rhizoma Coptidis 8-12 part, Radix Glycyrrhizae 4-8 part, calcined CONCHA MERETRICIS SEU CYCLINAE 13-15 part, Gypsum Fibrosum Preparatum 13-19 part, Cortex Phellodendri 10-15 part, Indigo Naturalis 3-7 part, Cortex Dictamni 6-13 part, Cortex Moutan 5-9 part, Semen Plantaginis 6-10 part.

The manufacture method of above-mentioned calcined CONCHA MERETRICIS SEU CYCLINAE is: get clean Concha Meretricis Seu Cyclinae, put on smokeless stove fire or put in suitable container, be calcined to crisply or while being popular in, take out, cool, pulverize.List of references is 2010 editions appendix II D of < < Pharmacopoeia of People's Republic of China > >.

The manufacture method of above-mentioned Gypsum Fibrosum Preparatum is: get clean Gypsum Fibrosum, pound into fritter, put on smokeless stove fire or put in suitable container, be calcined to crisply or while being popular in, take out, cool, pulverize.List of references is 2010 editions appendix II D of < < Pharmacopoeia of People's Republic of China > >.

In weight portion, it comprises following component to above-mentioned washing liquid: 15 parts of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 11 parts of Herba speranskiae tuberculataes, Lignum Sappan 9,11 parts of Herba Potentillae Chinensis, 12 parts of Flos Loniceraes, 8 parts, Flos Carthami, 16 parts of Radix Sophorae Flavescentiss, 13 parts of the Fructus Kochiae, 14 parts, Pericarpium Zanthoxyli, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Sanguisorbaes, 4 parts of Borneolum Syntheticums, 10 parts of Rhizoma Coptidis, 6 parts, Radix Glycyrrhizae, 14 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 16 parts of Gypsum Fibrosum Preparatum, 12 parts of Cortex Phellodendris, 5 parts of Indigo Naturaliss, 9 parts of Cortex Dictamni, 7 parts of Cortex Moutans, 8 parts of Semen Plantaginiss.

Above-mentioned a kind of manufacture method for the treatment of the washing liquid of eczema comprises following step:

A. get 2-6 part Borneolum Syntheticum powder and be broken to 80-100 order, obtain Borneolum Syntheticum fine powder;

B. by 12-18 part Herba Schizonepetae, 10-15 part Radix Saposhnikoviae, 10-15 part Flos Lonicerae, 13-15 part Pericarpium Zanthoxyli, 8-12 part Radix Angelicae Sinensis, 8-13 part Herba speranskiae tuberculatae was with steam distillation 1 hour and extract volatile oil, by distillation after aqueous solution with container, collect; All the other components except above-mentioned Borneolum Syntheticum, Herba Schizonepetae, Radix Saposhnikoviae, Flos Lonicerae, Pericarpium Zanthoxyli, Radix Angelicae Sinensis, Herba speranskiae tuberculatae and the medicinal residues after above-mentioned distillating extracting oil decoct with water and extract three times, the water boiling and extraction 2 hours that adds for the first time 7 times of except Borneolum Syntheticum all the other component gross masses, add for the second time except Borneolum Syntheticum 6 times of amount water boiling and extraction of all the other component gross masses 1.5 hours, add for the third time except Borneolum Syntheticum 3 times of amount water boiling and extraction of all the other component gross masses 1 hour, by 3 times, decoct the decocting liquid extracting and merge;

C. in the decocting liquid after merging, add the aqueous solution after above-mentioned distillation, filter, it is 1.07～1.10 that filtrate is concentrated into relative density in the time of 60 ℃, lets cool to room temperature, adds ethanol to reaching 60% containing alcohol amount, stirs evenly, and at 6～9 ℃ standing 24 hours, filters; It is 1.07～1.10 that filtrate is concentrated into relative density in the time of 60 ℃, and in concentration process, reclaims ethanol, then add with concentrated after the isopyknic water dilution of filtrate, stir evenly, 6～9 ℃ standing lower 24 hours, filter; Stir filtrate, and add the whole Borneolum Syntheticum fine powders in step a; Regulate pH value to 5.5～7.0, sterilizing, obtains described washing liquid.

A. get 4 parts of Borneolum Syntheticum powder and be broken to 90 orders, obtain Borneolum Syntheticum fine powder;

B. by 15 portions of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 12 portions of Flos Loniceraes, 14 portions of Pericarpium Zanthoxylies, 10 parts of Radix Angelicae Sinensis, 11 parts of Herba speranskiae tuberculataes with steam distillation 1 hour and extract volatile oil, the aqueous solution after distillation is collected with container; All the other components except above-mentioned Borneolum Syntheticum, Herba Schizonepetae, Radix Saposhnikoviae, Flos Lonicerae, Pericarpium Zanthoxyli, Radix Angelicae Sinensis, Herba speranskiae tuberculatae and the medicinal residues after above-mentioned distillating extracting oil decoct with water and extract three times, the decocting that adds for the first time 7 times of except Borneolum Syntheticum all the other component gross masses boils 2 hours, add for the second time except Borneolum Syntheticum 6 times of amount water boiling and extraction of all the other component gross masses 1.5 hours, add for the third time except Borneolum Syntheticum 3 times of amount water boiling and extraction of all the other component gross masses 1 hour, by 3 times, decoct the decocting liquid extracting and merge;

C. in the decocting liquid after merging, add the aqueous solution after above-mentioned distillation, filter, it is 1.08 that filtrate is concentrated into relative density in the time of 60 ℃, lets cool to room temperature, adds ethanol to reaching 60% containing alcohol amount, stirs evenly, and at 8 ℃ standing 24 hours, filters; It is 1.08 that filtrate is concentrated into relative density in the time of 60 ℃, and in concentration process, reclaims ethanol, then add with concentrated after the isopyknic water dilution of filtrate, stir evenly, 8 ℃ standing lower 24 hours, filter; Stir filtrate, and add the whole Borneolum Syntheticum fine powders in step a; Regulate pH value to 6.0, sterilizing, obtains described washing liquid.

The invention has the beneficial effects as follows: washing liquid of the present invention has remarkable therapeutical effect to eczema, clinical cure rate is 33.33%, obvious effective rate is 27.5%, total effective rate is 88.33%, is better than similar contrast medicine, for eczema, has obvious therapeutic effect.

The specific embodiment

Below in conjunction with specific embodiment, the present invention will be further described, so that those skilled in the art can better understand the present invention, but therefore do not limit the present invention.

A kind of manufacture method for the treatment of the washing liquid of eczema comprises following step:

A. get 2-6 part Borneolum Syntheticum powder and be broken to 90 orders, obtain Borneolum Syntheticum fine powder;

Embodiment 1

Get the following component in weight portion: 12 parts of Herba Schizonepetae, 10 parts of Radix Saposhnikoviaes, 8 parts of Herba speranskiae tuberculataes, 6 parts of Lignum Sappans, 8 parts of Herba Potentillae Chinensis, 10 parts of Flos Loniceraes, 6 parts, Flos Carthami, 13 parts of Radix Sophorae Flavescentiss, 10 parts of the Fructus Kochiae, 13 parts, Pericarpium Zanthoxyli, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 8 parts of Radix Angelicae Sinensis, 6 parts of Radix Sanguisorbaes, 2 parts of Borneolum Syntheticums, 8 parts of Rhizoma Coptidis, 4 parts, Radix Glycyrrhizae, 13 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 13 parts of Gypsum Fibrosum Preparatum, 10 parts of Cortex Phellodendris, 3 parts of Indigo Naturaliss, 6 parts of Cortex Dictamni, 5 parts of Cortex Moutans, 6 parts of Semen Plantaginiss, and manufacture washing liquid by above-mentioned steps.

Embodiment 2

Get the following component in weight portion: 18 parts of Herba Schizonepetae, 15 parts of Radix Saposhnikoviaes, 13 parts of Herba speranskiae tuberculataes, 13 parts of Lignum Sappans, 13 parts of Herba Potentillae Chinensis, 15 parts of Flos Loniceraes, 10 parts, Flos Carthami, 19 parts of Radix Sophorae Flavescentiss, 15 parts of the Fructus Kochiae, 15 parts, Pericarpium Zanthoxyli, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Radix Angelicae Sinensis, 10 parts of Radix Sanguisorbaes, 6 parts of Borneolum Syntheticums, 12 parts of Rhizoma Coptidis, 8 parts, Radix Glycyrrhizae, 15 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 19 parts of Gypsum Fibrosum Preparatum, 15 parts of Cortex Phellodendris, 7 parts of Indigo Naturaliss, 13 parts of Cortex Dictamni, 9 parts of Cortex Moutans, Semen Plantaginis 10, and manufacture washing liquid by above-mentioned steps.

Embodiment 3

Get the following component in weight portion: 15 parts of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 11 parts of Herba speranskiae tuberculataes, Lignum Sappan 9,11 parts of Herba Potentillae Chinensis, 12 parts of Flos Loniceraes, 8 parts, Flos Carthami, 16 parts of Radix Sophorae Flavescentiss, 13 parts of the Fructus Kochiae, 14 parts, Pericarpium Zanthoxyli, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Sanguisorbaes, 4 parts of Borneolum Syntheticums, 10 parts of Rhizoma Coptidis, 6 parts, Radix Glycyrrhizae, 14 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 16 parts of Gypsum Fibrosum Preparatum, 12 parts of Cortex Phellodendris, 5 parts of Indigo Naturaliss, 9 parts of Cortex Dictamni, 7 parts of Cortex Moutans, 8 parts of Semen Plantaginiss, and manufacture washing liquid by above-mentioned steps.

Above-mentioned three groups of embodiment are respectively to 16～44 years old age, average 24.94 ± 3.91 years old; The course of disease 1 week～14 years, average 3.3 ± 3.14 years; I degree 32 examples, II degree 26 examples, III degree 8 examples, IV degree 4 examples, carry out clinical treatment, according to skin lesion curative effect determinate standard

(1) clinical recovery: skin lesion all disappears, occurs without new rash.Skin lesion extinction rate >=95%.

(2) effective: skin lesion major part disappears, newly play erythra and be less than 5.95% > skin lesion extinction rate >=70%.

(3) effective: skin lesion partly disappears, and newly plays erythra and is less than 10.70% > skin lesion extinction rate >=50%.

The results are shown in Table 1.

Figure 2012103391474100002DEST_PATH_IMAGE001

According to table 1, can find out that the proportioning in embodiment 3 is best proportioning.

Proportioning for embodiment 3 is carried out again 120 routine clinical treatments, 16～44 years old age, average 24.94 ± 3.91 years old; The course of disease 1 week～14 years, average 3.3 ± 3.14 years; I degree 62 examples, II degree 43 examples, III degree 10 examples, IV degree 5 examples.

Select skin health lotion to carry out clinical treatment to 80 examples, 16～34 years old age, average 22.13 ± 3.93 years old; The course of disease 1 week～14 years, average 3.5 ± 3.22 years; I degree 44 examples, II degree 28 examples, III degree 5 examples, IV degree 3 examples.

Two groups of indices all have comparability (P > 0.05), and two groups all basically identical in sex, age, the course of disease, symptom and sign, has comparability.

Embodiment 4: according to embodiment 3 proportionings, make washing liquid, and 62 routine I degree patients are carried out to clinical treatment, therapeutic outcome is in Table 2.

Embodiment 5: according to embodiment 3 proportionings, make washing liquid, and 43 routine II degree patients are carried out to clinical treatment, therapeutic outcome is in Table 2.

Embodiment 6: according to embodiment 3 proportionings, make washing liquid, and 10 routine III degree patients are carried out to clinical treatment, therapeutic outcome is in Table 2.

Embodiment 7: according to embodiment 3 proportionings, make washing liquid, and 5 routine IV degree patients are carried out to clinical treatment, therapeutic outcome is in Table 2.

Reference examples 1: select skin health lotion to carry out clinical treatment to 44 routine I degree patients, therapeutic outcome is in Table 2.

Reference examples 2: select skin health lotion to carry out clinical treatment to 28 routine II degree patients, therapeutic outcome is in Table 2.

Reference examples 3: select skin health lotion to carry out clinical treatment to 5 routine III degree patients, therapeutic outcome is in Table 2.

Reference examples 4: select skin health lotion to carry out clinical treatment to 3 routine IV degree patients, therapeutic outcome is in Table 2.

Figure 2012103391474100002DEST_PATH_IMAGE002

Clinical observation shows, washing liquid of the present invention has remarkable therapeutical effect to eczema, and clinical cure rate is 33.33%, obvious effective rate is 27.5%, total effective rate is 88.33%, is better than similar contrast medicine, and eczema is had to obvious therapeutic effect.

Claims

1. a washing liquid for the treatment of eczema, it is characterized in that: this washing liquid is in weight portion, by following raw material of Chinese medicine, made: Herba Schizonepetae 12-18 part, Radix Saposhnikoviae 10-15 part, Herba speranskiae tuberculatae 8-13 part, Lignum Sappan 6-13 part, Herba Potentillae Chinensis 8-13 part, Flos Lonicerae 10-15 part, Flos Carthami 6-10 part, Radix Sophorae Flavescentis 13-19 part, Fructus Kochiae 10-15 part, Pericarpium Zanthoxyli 13-15 part, Radix Arnebiae (Radix Lithospermi) 10-15 part, Radix Angelicae Sinensis 8-12 part, Radix Sanguisorbae 6-10 part, Borneolum Syntheticum 2-6 part, Rhizoma Coptidis 8-12 part, Radix Glycyrrhizae 4-8 part, calcined CONCHA MERETRICIS SEU CYCLINAE 13-15 part, Gypsum Fibrosum Preparatum 13-19 part, Cortex Phellodendri 10-15 part, Indigo Naturalis 3-7 part, Cortex Dictamni 6-13 part, Cortex Moutan 5-9 part, Semen Plantaginis 6-10 part.

2. a kind of washing liquid for the treatment of eczema according to claim 1, it is characterized in that: this washing liquid, in weight portion, is made by following raw material of Chinese medicine: 15 parts of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 11 parts of Herba speranskiae tuberculataes, Lignum Sappan 9,11 parts of Herba Potentillae Chinensis, 12 parts of Flos Loniceraes, 8 parts, Flos Carthami, 16 parts of Radix Sophorae Flavescentiss, 13 parts of the Fructus Kochiae, 14 parts, Pericarpium Zanthoxyli, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Sanguisorbaes, 4 parts of Borneolum Syntheticums, 10 parts of Rhizoma Coptidis, 6 parts, Radix Glycyrrhizae, 14 parts of calcined CONCHA MERETRICIS SEU CYCLINAEs, 16 parts of Gypsum Fibrosum Preparatum, 12 parts of Cortex Phellodendris, 5 parts of Indigo Naturaliss, 9 parts of Cortex Dictamni, 7 parts of Cortex Moutans, 8 parts of Semen Plantaginiss.

3. a kind of manufacture method for the treatment of the washing liquid of eczema according to claim 1 comprises following step:

4. a kind of manufacture method for the treatment of the washing liquid of eczema according to claim 3 comprises following step:

B. by 15 portions of Herba Schizonepetae, 13 parts of Radix Saposhnikoviaes, 12 portions of Flos Loniceraes, 14 portions of Pericarpium Zanthoxylies, 10 parts of Radix Angelicae Sinensis, 11 parts of Herba speranskiae tuberculataes with steam distillation 1 hour and extract volatile oil, the aqueous solution after distillation is collected with container; All the other components except above-mentioned Borneolum Syntheticum, Herba Schizonepetae, Radix Saposhnikoviae, Flos Lonicerae, Pericarpium Zanthoxyli, Radix Angelicae Sinensis, Herba speranskiae tuberculatae and the medicinal residues after above-mentioned distillating extracting oil decoct with water and extract three times, the water boiling and extraction 2 hours that adds for the first time 7 times of except Borneolum Syntheticum all the other component gross masses, add for the second time except Borneolum Syntheticum 6 times of amount water boiling and extraction of all the other component gross masses 1.5 hours, add for the third time except Borneolum Syntheticum 3 times of amount water boiling and extraction of all the other component gross masses 1 hour, by 3 times, decoct the decocting liquid extracting and merge;