CN102872246B - Medicine for treating cervical erosion through HPV (human papillomavirus) positive-to-negative change - Google Patents
Medicine for treating cervical erosion through HPV (human papillomavirus) positive-to-negative change Download PDFInfo
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Abstract
The invention relates to medicine for treating cervical erosion through HPV (human papillomavirus) positive-to-negative change. The medicine comprises the following ingredients in the contents (weight percentage): 30 percent to 40 percent of walnut peel, 10 percent to 15 percent of lithospermum, 5 percent to 10 percent of ramulus mori dust, 5 percent to 10 percent of golden cypress, 7 percent to 10 percent of radix sophorae flavescentis, 7 percent to 10 percent of fructus cnidii, 2 to 5 percent of methylcellulose, 2 to 5 percent of agar and 8 to 12 percent of acacia. The medicine has the advantages that the complete HPV positive-to-negative change can be realized, the cervical erosion is radically treated, simplicity is realized, the implementation is easy, high and low temperature is avoided, and the toxic or side effect on human bodies does not exist.
Description
Technical field
The present invention relates to a kind of HPV(of making human papillomavirus, human papilloma virus) sun turns out cloudy, exempts from the medicine of operative treatment cervical erosion, especially relates to a kind of removing HPV, the medicine of non-invasive therapy cervical erosion in various degree.
Background technology
Scientific research has confirmed HPV(human papillomavirus, human papilloma virus) be the arch-criminal who causes cervical cancer, the whole world has 6.3 hundred million people to infect HPV at present, it may be safety and effective that the HPV vaccine of researching and developing infects for prevention HPV, but it can only play the effect of prevention infection, meaningless to infecting the patient of HPV, and for all infection of the another kind of hypotype of anti-virus in advance of vaccine of any hypotype, test simultaneously still can not provide the expiry date of the acquisition of anti-HPV infection.
Cervical erosion is one of modal disease of gynecological, and with the close relationship that has of cervical cancer, active and effective treatment cervical erosion is to reduce the important measures of cervical cancer pathogenesis.
The method of primary treatment cervical erosion has (1) infrared therapy at present: utilize infrared radiation to irradiate and make tissue coagulation degeneration, incrustation comes off, and makes blood vessel solidify obturation, plays anti-inflammation hemostasia effect, easily recurrence for the treatment of in this way.(2) laser therapy: laser therapy has the feature of easy, quick, good effect, few intercurrent disease, but easily recurrence, and repeatedly laser therapy, easily cause cytometaplasia.(3) micro-wave therapeutic: when microwave electrodes presses local patholoic change and organizes, produce high heat very among a small circle and arrive the object of solidifying in moment, thinking at present that microwave can produce solidifies, the triple effects of heat effect and non-thermal effect.(4) LEEP(profit is general) cutter: be applicable to moderate and severe cervical and rotten to the corn face is darker, Implicates pipe person, small number of patients Follow-up After, in cervical canal, nearly cervix uteri collar extension has petal sample columnar epithelium hypertrophy, and have report to find that postoperative cervical canal is narrow, therefore child-bearing woman will not be cautious use of LEEP cutter treatment cervical erosion.
Summary of the invention
The technical problem to be solved in the present invention is: overcome and only have at present HPV vaccine to prevent and can not treat that HPV infects and existing medicine and physiotherapy are treated the problem of not good enough, the easy recurrence of cervical erosion curative effect, damaged tissue organ, provide a kind of can make completely HPV sun turn out cloudy and effect a radical cure cervical erosion, simple, without high and low temperature, medicine that human body is had no side effect.
In order to solve the problems of the technologies described above, the present invention proposes following technical scheme: a kind of human papillomavirus's of making sun is turned out cloudy and treated the medicine of cervical erosion, and its component by following weight percent meter forms:
The further restriction of technique scheme is: this medicine is comprised of the component of following weight percent meter: Exocarpium Juglandis Immaturus 30%; Radix Arnebiae (Radix Lithospermi) 15%; Ramulus Mori ash 10%; Cortex Phellodendri 10%; Radix Sophorae Flavescentis 10%; Fructus Cnidii 10%; Methylcellulose 5%; Agar 2%; Arabic gum 8%.
The further restriction of technique scheme is: this medicine is comprised of the component of following weight percent meter: Exocarpium Juglandis Immaturus 40%; Radix Arnebiae (Radix Lithospermi) 10%; Ramulus Mori ash 7%; Cortex Phellodendri 5%; Radix Sophorae Flavescentis 9.5%; Fructus Cnidii 9.5%; Methylcellulose 2%; Agar 5%; Arabic gum 12%.
The further restriction of technique scheme is: this medicine is comprised of the component of following weight percent meter: Exocarpium Juglandis Immaturus 39%; Radix Arnebiae (Radix Lithospermi) 14%; Ramulus Mori ash 5%; Cortex Phellodendri 9%; Radix Sophorae Flavescentis 7%; Fructus Cnidii 7%; Methylcellulose 4%; Agar 4%; Arabic gum 11%.
Compared with prior art, the present invention has following beneficial effect: this product can make HPV sun turn out cloudy, and effectively prevents the generation of cervical cancer, and can effect a radical cure cervical erosion, recover cervix uteri form, function, can once kill varicella zoster virus, have pain relieving, antiinflammation.This product externally treating herpes zoster, can remove virus fast, has obvious analgesic effect.
The specific embodiment
Human papillomavirus's sun is turned out cloudy and treat a medicine for cervical erosion, its component by following weight percent meter forms:
The preparation method of said medicine comprises the steps:
Step 1: pulverize, get Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash, Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii according to above-mentioned content, utilize additional mechanical force, the cohesiveness between destruction material molecule is that the piece grain of medicine reduces, and surface area is increased, and is prepared into medicinal powder.
Step 2: leach, the medicinal powder that taking-up step 1 prepares is placed in container with lid and adds 1000ml purified water, and sealing lid is jolting constantly, at room temperature dark place dipping 3-5 days, fully leaches effective ingredient, gets upper strata liquid and filters with cloth.Getting filtrate adds in vaporizer and is concentrated into 900ml by evaporation.
Step 3: emulsifying, the concentrated solution that step 2 is obtained adds methylcellulose, agar, the arabic gum of above-mentioned content, carries out forming gel after emulsifying.
Step 4: fill, to administrator, sealing, obtains by gel fill.
The using method of said medicine is: (1) takes out administrator protecgulum, opens cap; (2) lie on the back, administrator main body slowly sent into vagina depths, as feel uncomfortable or have obstruction, stop advancing, using protecgulum as push rod gently by the disposable injection vagina of medicine; (3) extract gently administrator, keep back floating position 15 minutes.
Medicine of the present invention is sepia gel, take Exocarpium Juglandis Immaturus as monarch drug, with Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash compatibility, there is heat-clearing and toxic substances removing double effects, with Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii three tastes are that ministerial drug is used for the treatment of the skin ulcer toxic swelling of itching, and after bursting, do not hold back, and have more heat clearing away, removing toxic substances, anticorrosion, granulation promoting four effects.
Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash, Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii ginseng have heat clearing away, sterilization, anticorrosion, sterilization, antiviral, antitumaous effect, and merceration does not damage its various sterilization antiviral functions.After mixing, slough virus, antibacterial there are is stronger removing power and can stimulate tissue regeneration, to removing HPV and the good curative effect of radical cure cervical erosion.
< < Compendium of Materia Medica > > is recording blue or green Semen Juglandis and is having analgesic effect.In proved recipe of traditional Chinese medicine, Exocarpium Juglandis Immaturus, Exocarpium Juglandis Immaturum, can be used for treating the diseases such as skin pruritus and pain, and Exocarpium Juglandis Immaturus is steep in wine, and can be used for treating the liver peratodynia, gastralgia, acute and chronic stomachache.The blue or green Semen Juglandis of domestic and international use among the people the 1950's steep in wine agent treatment stomachache, dysmenorrhea, cancer pain etc., to replace the analgesic such as morphine, tinctura opii, received good analgesic effect.In Exocarpium Juglandis Immaturus, contain multiple bioactive ingredients, before its immaturity, contain vitamin C.Employing BSLB(brine shrimp lethelity bioassay) result that the active component that method is extracted Exocarpium Juglandis Immaturus carries out Preliminary screening shows: its ethyl acetate extract all has obvious cytotoxicity, is expected further research and makes new antitumor drug.
The present invention uses traditional Chinese medicine theory, and the Exocarpium Juglandis Immaturus pain relieving of take is antitoxin is monarch drug, adds Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash removing heat from blood, the poison of invigorating blood circulation, purify the blood, controls skin ulcer and itch, and is more accompanied by Cortex Phellodendri, Radix Sophorae Flavescentis, and Fructus Cnidii sterilization antiinflammatory, has embodied the powerful effect of Chinese medicine.These six kinds of compatibility of drugss, between without eighteen incompatible medicaments, nineteen medicaments of mutual restraint phenomenon.More because this medicine compatibility, an implementation medicine for external use 10-15 minute service time, without systemic Absorption effect, so safety, have no side effect.
Medicine of the present invention can effect a radical cure cervical erosion, recovers cervix uteri form, function, selectively removes virus and slough, enhancer cervix uteri regeneration capacity.Herpes zoster is controlled in this product external, condyloma acuminatum, and verruca plana etc., can remove the viruses such as HSV, HPV fast, has obvious analgesic effect.Medicine of the present invention is that the modulation of Purely natural edible plant forms, and human body is had no side effect.
Introduce several concrete Preparation Examples below
Embodiment mono-
| Component | Weight (gram) | Percentage ratio (%) |
| Exocarpium Juglandis Immaturus | 300 | 30% |
| Radix Arnebiae (Radix Lithospermi) | 150 | 15% |
| Ramulus Mori ash | 100 | 10% |
| Cortex Phellodendri | 100 | 10% |
| Radix Sophorae Flavescentis | 100 | 10% |
| Fructus Cnidii | 100 | 10% |
| Methylcellulose | 50 | 5% |
| Agar | 20 | 2% |
| Arabic gum | 80 | 8% |
| Gross weight | 1000 | 100% |
Pulverize: according to the weight of upper table, get Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash, Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, utilize additional mechanical force, the cohesiveness between destruction material molecule is that the piece grain of medicine reduces, and surface area is increased, and is prepared into medicinal powder.
Leach: the medicinal powder that taking-up step 1 prepares is placed in container with lid and adds 1000ml purified water, sealing lid is jolting constantly, at room temperature dark place dipping 3-5 days, effective ingredient is fully leached, get upper strata liquid and filter with cloth, get filtrate and add in vaporizer and be concentrated into 900ml by evaporation.
Emulsifying: the concentrated solution that step 2 is obtained adds methylcellulose, agar, the arabic gum of upper table weight, carries out forming gel after emulsifying.
Fill: to administrator, sealing, obtains by gel fill.
Embodiment bis-
| Component | Weight (gram) | Percentage ratio (%) |
| Exocarpium Juglandis Immaturus | 400 | 40% |
| Radix Arnebiae (Radix Lithospermi) | 100 | 10% |
| Ramulus Mori ash | 70 | 7% |
| Cortex Phellodendri | 50 | 5% |
| Radix Sophorae Flavescentis | 95 | 9.5% |
| Fructus Cnidii | 95 | 9.5% |
| Methylcellulose | 20 | 2% |
| Agar | 50 | 5% |
| Arabic gum | 120 | 12% |
| Gross weight | 1000 | 100% |
Pulverize: according to the weight of upper table, get Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash, Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, utilize additional mechanical force, the cohesiveness between destruction material molecule is that the piece grain of medicine reduces, and surface area is increased, and is prepared into medicinal powder.
Leach: the medicinal powder that taking-up step 1 prepares is placed in container with lid and adds 1000ml purified water, sealing lid is jolting constantly, at room temperature dark place dipping 3-5 days, effective ingredient is fully leached, get upper strata liquid and filter with cloth, get filtrate and add in vaporizer and be concentrated into 900ml by evaporation.
Emulsifying: the concentrated solution that step 2 is obtained adds methylcellulose, agar, the arabic gum of upper table weight, carries out forming gel after emulsifying.
Fill: to administrator, sealing, obtains by gel fill.
Embodiment tri-
| Component | Weight (gram) | Percentage ratio (%) |
| Exocarpium Juglandis Immaturus | 390 | 39% |
| Radix Arnebiae (Radix Lithospermi) | 140 | 14% |
| Ramulus Mori ash | 50 | 5% |
| Cortex Phellodendri | 90 | 9% |
| Radix Sophorae Flavescentis | 70 | 7% |
| Fructus Cnidii | 70 | 7% |
| Methylcellulose | 40 | 4% |
| Agar | 40 | 4% |
| Arabic gum | 110 | 11% |
| Gross weight | 1000 | 100% |
Pulverize: according to the weight of upper table, get Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Ramulus Mori ash, Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, utilize additional mechanical force, the cohesiveness between destruction material molecule is that the piece grain of medicine reduces, and surface area is increased, and is prepared into medicinal powder.
Leach: the medicinal powder that taking-up step 1 prepares is placed in container with lid and adds 1000ml purified water, sealing lid is jolting constantly, at room temperature dark place dipping 3-5 days, effective ingredient is fully leached, get upper strata liquid and filter with cloth, get filtrate and add in vaporizer and be concentrated into 900ml by evaporation.
Emulsifying: the concentrated solution that step 2 is obtained adds methylcellulose, agar, the arabic gum of upper table weight, carries out forming gel after emulsifying.
Fill: to administrator, sealing, obtains by gel fill.
Introduce the treatment situation of the part clinical patient that uses medicine of the present invention below:
1. go into business so-and-so, female, 38 years old, Jiangxi, native place, Shenzhen, address, dysmenorrhea always, menoxenia, the frequent pruritus of vagina, lower abdomen distending pain, urine urgency-frequency.Within 2009, be diagnosed as moderate and severe cervical and infect high-risk HPV virus.She has gone to a lot of hospitals, has used a lot of different therapeutic modalities, but always again and again can not cure completely.Through Drug therapy of the present invention, after half a year, symptom fades away, and hospital again examining report proves: the HPV positive has turned negative cervical erosion, recovers completely, and indices is all normal.
Lee so-and-so, female, 29 years old, Guangdong, native place, Guangzhou, address, consultation time on May 16th, 2010, waist and sacrum pain, hypogastric region falling inflation, leucorrhea is undesired, and people is very wan and sallow, checks that finding is cervical erosion and high-risk HPV viral infection, and further checks the precancerous lesion of confirming as cervical cancer.Through Drug therapy of the present invention, recovery from illness in three months.Follow up a case by regular visits to 2 years without recurrence.
History so-and-so, Sichuan Province, female ，42Sui， native place, Guangzhou, address.On April 5th, 2009 is medical, gynecologial examination result: vaginal wall swelling, cervix uteri can contact the cervix uteri of enlargement apart from the about 3CM of vaginal orifice place, cervix uteri diameter 6.2CM left and right, a large amount of purulent secretions.Cervix uteri is uneven, is graininess, and iodine test is negative, belongs to severe uterine erosion.After Drug therapy two wheat harvesting periods of the present invention, remove examination in hospital, the pleasantly surprised discovery of doctors for many years gynecological is healed, cervical erosion rehabilitation, vagina becomes flexibly, obviously shrinks.
4. Zhu, female, 24 years old, Changsha, native place, address Changsha.To Hunan Province healthcare hospital for women & children, check in June, 2011, HPV DNA detection value is 287.82Pg/ml, and cervix uteri, neck tube histopathology are diagnosed as: the squamous epithelial cancer becoming between the fragmentation of (neck tube) small pieces, meets the tired gland of CIN III level.(10 °) chronic cervicitis, special mess CIN II-III level companion viral infection.(2 ° 12 °) chronic cervicitis, special mess CIN II level companion viral infection.(4 °) chronic cervicitis.Through this patent product, treatment has now transferred CIN I level to.
5, Ao so-and-so, female, 48 years old, Jiangxi, native place, Guangzhou, address, consultation time on May 16th, 2011, the yellow-white leucorrhea more than ten years, dyspareunia, hemorrhage, lower abdomen falling inflation, obesity, facial black speck, be cervical erosion through many hospital diagnosis, fails to respond to any medical treatment.After Drug therapy of the present invention 50 days, look into vagina clean, cervical erosion disappears, cervix uteri smooth surface, cervix uteri prolapsus disappears, and cervix uteri reduced is to 3CM left and right, and vagina contraction is good.Cure and follow up a case by regular visits to after 2 years, have no leucorrhea, have no recurrence.Face melanin speckle also disappears with Chinese medicine for 20 days.
6, Wu so-and-so, female, 32 years old, Beijing, Ren， address, Hebei, native place, consultation time on May 18th, 2009, hemorrhage while often having a large amount of yellow leucorrhea, stench, sexual intercourse, through gynecologial examination, cervix uteri three degree are rotten to the corn.Naturopathy is made in private prosecution once Duo Jia hospital, occurs again sanguinous leukorrhea after having upward swing in one to two month.Through medicine liquid medicine treatment of the present invention recovery from illness in 65 days.After follow up a case by regular visits to 2 years without recurrence.
7, king so-and-so, Sichuan Province, female ，34Sui， native place, Guangzhou, address, consultation time in January, 2010 14， main suit's vagina is bled for a long time, hemorrhage increasing when anemia, sexual intercourse, leucorrhoea grow in quantity, frowziness, the disappearance of colpedema wrinkle arm, mucosal bleeding, vagina elasticity disappear, and many hospitalizes are invalid.Through medicine liquid medicine treatment of the present invention recovery from illness in 68 days, follow up a case by regular visits to 2 years without recurrence.
8, military so-and-so, female, 46 years old, Guangdong Province, native place, Shenzhen, address, consultation time: on January 12nd, 2008, through united family hospital, Shenzhen, check cervical erosion Ⅲ degree, gynecologial examination vulvovaginal redness, mucosal bleeding, the contracting of vagina flaccidity, cervical mucosa necrosis area 3x2CM.Through Drug therapy of the present invention recovery from illness in 58 days.
A large amount of healing statements of facts, medicine of the present invention, for the treatment HPV positive and cervical erosion, has extraordinary curative effect.
This product can make HPV sun turn out cloudy, and effectively prevents the generation of cervical cancer, and can effect a radical cure cervical erosion, recovers cervix uteri form, function, can once kill varicella zoster virus, has pain relieving, antiinflammation.This product externally treating herpes zoster, can remove virus fast, has obvious analgesic effect.
Claims (4)
1. make human papillomavirus's sun turn out cloudy and treat a medicine for cervical erosion, its component by following weight percent meter forms:
2. the human papillomavirus's of making sun according to claim 1 is turned out cloudy and is treated the medicine of cervical erosion, it is characterized in that: this medicine is comprised of the component of following weight percent meter: Exocarpium Juglandis Immaturus 30%; Radix Arnebiae (Radix Lithospermi) 15%; Ramulus Mori ash 10%; Cortex Phellodendri 10%; Radix Sophorae Flavescentis 10%; Fructus Cnidii 10%; Methylcellulose 5%; Agar 2%; Arabic gum 8%.
3. the human papillomavirus's of making sun according to claim 1 is turned out cloudy and is treated the medicine of cervical erosion, it is characterized in that: this medicine is comprised of the component of following weight percent meter: Exocarpium Juglandis Immaturus 40%; Radix Arnebiae (Radix Lithospermi) 10%; Ramulus Mori ash 7%; Cortex Phellodendri 5%; Radix Sophorae Flavescentis 9.5%; Fructus Cnidii 9.5%; Methylcellulose 2%; Agar 5%; Arabic gum 12%.
4. the human papillomavirus's of making sun according to claim 1 is turned out cloudy and is treated the medicine of cervical erosion, it is characterized in that: this medicine is comprised of the component of following weight percent meter: Exocarpium Juglandis Immaturus 39%; Radix Arnebiae (Radix Lithospermi) 14%; Ramulus Mori ash 5%; Cortex Phellodendri 9%; Radix Sophorae Flavescentis 7%; Fructus Cnidii 7%; Methylcellulose 4%; Agar 4%; Arabic gum 11%.
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| CN103800684A (en) * | 2014-03-05 | 2014-05-21 | 林仁耳 | Radical operation for treating cervical human papillomavirus (HPV), cervical intraepithelial neoplasia (CIN) and cervical erosion by synchronous external use of traditional Chinese medicines and Western medicines |
| CN106421673B (en) * | 2016-12-13 | 2020-01-24 | 上海世道健康科技有限公司 | Traditional Chinese medicine composition for treating HPV (human papillomavirus) infection and preparation method thereof |
| CN109157566A (en) * | 2018-09-29 | 2019-01-08 | 南京依美生物科技有限公司 | A kind of gynecological gel preparation of anti-inflammation and sterilization and preparation method thereof |
| CN110693988A (en) * | 2019-11-18 | 2020-01-17 | 南宁市昇立中药研究所 | Traditional Chinese medicine preparation for treating cervical HPV (human papillomavirus) infection and preparation method thereof |
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