CN102871953B - Super-absorbent adsorption suppository - Google Patents
Super-absorbent adsorption suppository Download PDFInfo
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- CN102871953B CN102871953B CN 201210382633 CN201210382633A CN102871953B CN 102871953 B CN102871953 B CN 102871953B CN 201210382633 CN201210382633 CN 201210382633 CN 201210382633 A CN201210382633 A CN 201210382633A CN 102871953 B CN102871953 B CN 102871953B
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- high water
- fiber
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- fabric
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Abstract
The invention relates to a super-absorbent adsorption suppository which is roll-formed by a super-absorbent fabric. The outer surface of the super-absorbent fabric is adhered with a chitosan film, fiber or powder; The super-absorbent adsorption suppository is roll formed by super-absorbent fiber interweaved or embedded with a chitosan fabric, wherein the chitosan fiber is interweaved or embedded in the surface of the super-absorbent fabric; the super-absorbent fiber and the chitosan fiber form a uniformly distributed non-woven fabric; the volume ration of the super-absorbent fiber in the super-absorbent fiber interweaved or embedded with a chitosan fabric is 10-90%. The super-absorbent adsorption suppository has good effect for absorbing peculiar smell because the super-absorbent fiber has a water-retaining property and hydrophilic groups. Besides, the chitosan has good biocompatibility and the effects of hemostasis, bacteria resistance and bacteriostasis and heal-promotion, so that the super-absorbent adsorption suppository has positive physical effect and positive influence for vagina diseases of females under a non-antibiotic condition. Trial results show that the adsorption suppository has a significant efficiency for the above diseases over 98%, and maintains the weak acidic environment of a tract, and can keep a self-cleaning function of the vagina.
Description
One, technical field
The present invention relates to a kind of high adsorption suppository, especially gynecological patient extensively can widely used dosage form.
Two, background technology
Various colpitis diseases are painful topics of puzzlement women, and sickness rate is almost accounting for more than 1/3 of female population ratio.As colpitis mycotica, patient shows as leucorrhoea grow in quantity, pudendum, pruritus of vagina, burning sensation, painful urination.Sometimes leucorrhea might not be colpitic outstanding symptom, even the water sample leucorrhea until curdy or ointment sample leucorrhea all can occur.If any complete thin in clear thorough serosity transudate, but wherein often contain white plates; What have is sticky as curdled milk or consider to be worth doing granular.Also two kinds of distinct clinical manifestations can often be arranged.
The disease that also has other antibacterial or nonspecific vaginitis disease.But because medicine is difficult to effectively kill mycete.The interior ecology of good body equally also needs conscientiously to maintain simultaneously, so How to choose high adsorption suppository is the problem that need to conscientiously study.CN101628123 discloses a kind of Woman hemostatic absorption plug, described key is comprised of the skin of bolt core and this bolt core of parcel, described key is rolled and is formed by the active carbon fiber felt fabric, and described skin is the chitin-chitosan non-woven fabrics, on described key, is fixed with lead-out wire.Utilize the biocompatibility that chitin-chitosan is good, hemostasis, antibacterial bacteriostatic, promoting healing effect, but on its availability, practicality and cost, all be worth improving.
Three, summary of the invention
The present invention seeks to, propose a kind of high-hydroscopicity absorption suppository, both utilized biocompatibility, hemostasis, antibacterial bacteriostatic and promoting healing effect that chitosan is good, the absorption suppository of a kind of high-hydroscopicity and adsorptivity is proposed again, simultaneously easy to prepare, with low cost, size etc. are controlled easy control all.
Technical scheme of the present invention is that a kind of high-hydroscopicity absorption suppository, rolled and formed by the high water-absorption fiber fabric, superficies adhesion chitosan film, fiber or the powder of described high water-absorption fiber fabric;
High-hydroscopicity absorption suppository, interweave or embed the chitin fiber fabric by high water-absorption fiber and roll and form, the surface of high water-absorption fiber fabric interweaves or embeds chitin fiber, high water-absorption fiber becomes equally distributed non-woven fabrics with chitin fiber, high water-absorption fiber interweaves or embeds the volume ratio that in the chitin fiber fabric, high water-absorption fiber accounts for (content of dry fabric) for 10-90%.
Further, high water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or the dipping organic acid.Described organic acid is lactic acid, acetic acid, citric acid, tartaric acid, succinic acid or ascorbic acid;
Further, high water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or the dipping antibacterial, and antibacterial is silver, iodine or hexamethylene;
Further, high water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven fabric roll are made one to three layer;
Further, high water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven fabric roll are built in the column in-core;
Further, the column core is foamed materials;
Further, foamed materials is high water suction high molecular material, PU, PS or chitosan foam;
Further, chitosan adopts deacetylation to be greater than the chitosan more than 90%;
High water-absorption fiber fabric of the present invention refers to the fabric that than bafta water-taking efficiency prepared by the material more than high ten times (industry is called for short the SAF fiber), typical in vinal PVA, acrylate-vinyl acetate fiber, the treated high water-absorption fiber of polyacrylonitrile (acrylon), have water-retaining property and hydrophilic group; As Japanese LANSEAL fiber, the fiber hydroxyl absorbs ammonia, absorbs the effective of abnormal flavour.
The invention has the beneficial effects as follows, bacterial vaginosis is extensively to exist, and washing liquid as medicinal as frequent use is cleaned vagina, is easy to like this destroy the acid or alkali environment of vagina, easily infects on the contrary monilial vaginitis.In addition, all may cause diabetes, period of pregnancy the candidiasis amount reproduction bacterial bearing rate of vagina to increase.Mycotic or colpitis mycotica, other antibacterial or nonspecific vaginitis disease are main diseases; As bacterial vaginitis source of disease bacterium is saccharomycetic, and wherein Candida albicans accounts for greatly the 80-90% left and right, usually invades V&V simultaneously, therefore claim vulvovaginal candidiasis.In the Newborn of leucorrhoea grow in quantity, approximately have 10%, approximately have 30% in intravaginal, this bacterium parasitism to be arranged in the anemia of pregnant woman, when the vagina glycogen increases, acidity greatly also can cause colpitis.And the vagina brought after the surgical operation of cervicitis pelvic inflammatory disease and gynecological is unholiness and the hemostasis of physics is also the importance that the present invention applies.The present invention is with physical absorption and acid beneficial microorganism growth environment can be provided, harmful microorganism is suppressed, works very well in practicality, especially in above-mentioned disease.Apparent is that the inflammation of wet rumble type is all fabulous effects.
Because high water-absorption fiber has water-retaining property and hydrophilic group, and absorb the effective of abnormal flavour.Add biocompatibility, hemostasis, antibacterial bacteriostatic and promoting healing effect that chitosan is good, the present invention can give positive physical property effect and positive influences by the vagina to the women under the non-antibiotic condition.In on probation, showing, is (effect that applies of physical action and part antibacterial) more than 98% to the obvious effective rate of above-mentioned disease.As in order to prevent recurrence, the weak acid environment that maintains vagina can keep the self-cleaning function of vagina, the invention provides pH value and be 4 or the better effects if of the dosage form of sourer weak acid formula (Adsorption organic acid granule and).
In a word, the absorption suppository of high-hydroscopicity of the present invention and adsorptivity comprehensively, with the high hygroscopicity fibre preparation, especially rolls preparation with compound non-woven fabrics homogenous material, and preparation technology is simple and convenient, also can roll at the column in-core simultaneously, can save material, with low cost, and various dosage form is all easy to prepare, and sizes etc. are controlled easy control all, adopt daily use chemicals level anti-biotic material, meet the mechanism that OTC or physics apply, the patient is easy to use, the good result of goods especially of the present invention in application.Goods of the present invention some users to colpitis mycotica (medication effect is not good) in process on probation have special effect, when especially the user often has bean curd sample, curdy or ointment sample leucorrhea, utilize goods of the present invention bean curd sample, curdy can be adsorbed to slagging, and suppository is discharged residue, particular significant effect while extracting out.
Four, the specific embodiment
High-hydroscopicity absorption suppository, the superficies of high water-absorption fiber fabric adhere to or adhesion chitosan film, fiber or powder.The preparation of chitosan film, adopt prior art, as glutaraldehyde cross-linking; The high water-absorption fiber fabric can be the cloth that longitude and latitude is made into, and can be also " paper " (evenly spread out rear roll extrusion after spray webbing or carry out roll extrusion according to opening coma).Surface adhesion or adhesion adopt cylinder to press (or acupuncture or cylinder press add acupuncture) chitosan film, fiber or spray, painting powder (roll extrusion again).Or hot blast adhesion.The volume ratio that in the chitin fiber fabric, high water-absorption fiber accounts for (content of dry fabric) is 10-90%.Especially 40-60%.
Another embodiment also comprises: after the high water-absorption fiber rolling, chitosan liquid film forming is flooded in the present invention, (prepared by saturated chitosan glue separately, as powder dissolution in aqueous solutions of organic acids, pH value is controlled at 3-5, adopt the organic acid commonly used such as acetic acid, described organic acid also can be lactic acid, citric acid, tartaric acid, succinic acid, ascorbic acid).
High-hydroscopicity absorption suppository, interweave or embed the chitin fiber fabric by high water-absorption fiber and roll and form, the surface of high water-absorption fiber fabric interweaves simultaneously or the technique of embedding more evenly adds chitin fiber, and high water-absorption fiber and chitin fiber are uniformly distributed and are prepared into non-woven fabrics.
Adopting PVA(or river, Nantong tide fiber company product by the high-hydroscopicity vinal) embedding, high water-absorption fiber and chitin fiber be woven into equally distributed non-woven fabrics jointly, and high water-absorption fiber fabric or high water-absorption fiber and chitin fiber jointly are woven into equally distributed non-woven fabrics and add the acupuncture preparation with roll extrusion or roll extrusion.Two kinds of fiber volume fractions of high water-absorption fiber and chitin fiber can be 20-80% to 80-20%, especially 40-60% to 60-40%.High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven fabric roll are made one to three layer.
High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven fabric roll are prepared into a web-like or column in-core, and inner core can adopt the foamed materials of some strength.The material that the column core is foam polymer,, as PU, PS or chitosan foam.
High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or dipping or spraying organic acid.Described organic acid is lactic acid, acetic acid, citric acid, tartaric acid, succinic acid, ascorbic acid; Roll extrusion again after the solid, powdery organic acid adheres to.Its amount is every goods consumption 0.1 to 0.8 gram.
High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or dipping or spraying antibacterial, and antibacterial is silver salt, iodine or hexamethylene, benzoic acid, sorbate or methyl hydroxybenzoate etc.Its amount is every goods consumption 0.05 to 0.8 gram.
Fiber, thin film, foam state, anti-inflammation hemostasis, reduce wound surface and ooze out and promote tissue regeneration, all with the composite of macromolecular material, soluble while hanging down pH value.
Claims (6)
1. a high-hydroscopicity absorption suppository, is characterized in that being rolled and being formed by the high water-absorption fiber fabric superficies adhesion chitin fiber of described high water-absorption fiber fabric; Chitosan adopts deacetylation to be greater than the chitosan more than 90%; High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or the dipping organic acid; High water-absorption fiber fabric or high water-absorption fiber and chitin fiber surface adhesion or dipping antibacterial, antibacterial is silver, iodine, hexamethylene, benzoic acid, sorbate or methyl hydroxybenzoate; High water-absorption fiber fabric or high water-absorption fiber and chitin fiber are woven into equally distributed non-woven fabrics jointly, and with roll extrusion or acupuncture preparation.
2. a high-hydroscopicity adsorbs suppository, it is characterized in that is interweaved or embedded the chitin fiber fabric by high water-absorption fiber rolls and forms, the surface of high water-absorption fiber fabric interweaves or embeds chitin fiber, high water-absorption fiber becomes equally distributed non-woven fabrics with chitin fiber, high water-absorption fiber interweaves or embeds the volume ratio that in the chitin fiber fabric, high water-absorption fiber accounts for is 10-90%; Chitosan adopts deacetylation to be greater than the chitosan more than 90%; High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or the dipping organic acid; High water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven surface adhere to or the dipping antibacterial, and antibacterial is silver, iodine, hexamethylene, benzoic acid, sorbate or methyl hydroxybenzoate; High water-absorption fiber fabric or high water-absorption fiber and chitin fiber are woven into equally distributed non-woven fabrics jointly, and with roll extrusion or acupuncture preparation.
3. high-hydroscopicity according to claim 1 and 2 absorption suppository, is characterized in that high water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven fabric roll make one to three layer.
4. high-hydroscopicity absorption suppository according to claim 3, is characterized in that high water-absorption fiber fabric or high water-absorption fiber and chitosan nonwoven fabric roll are built in the column in-core; The column core is foamed materials.
5. high-hydroscopicity absorption suppository according to claim 4, is characterized in that foamed materials is high water suction high molecular material, PU, PS or chitosan foamed materials.
6. high-hydroscopicity absorption suppository according to claim 1 and 2, is characterized in that the high water-absorption fiber fabric is vinal PVA, acrylate-vinyl acetate fiber or treated acrylic fiber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210382633 CN102871953B (en) | 2012-10-09 | 2012-10-09 | Super-absorbent adsorption suppository |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210382633 CN102871953B (en) | 2012-10-09 | 2012-10-09 | Super-absorbent adsorption suppository |
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| CN102871953A CN102871953A (en) | 2013-01-16 |
| CN102871953B true CN102871953B (en) | 2013-12-18 |
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| CN 201210382633 Expired - Fee Related CN102871953B (en) | 2012-10-09 | 2012-10-09 | Super-absorbent adsorption suppository |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106178142B (en) * | 2016-08-18 | 2019-06-04 | 赵秀芝 | A kind of woman's absorption plug |
| CN107469128A (en) * | 2017-08-02 | 2017-12-15 | 武汉医佳宝生物材料有限公司 | A kind of antimicrobial form alginates complex function dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101260570A (en) * | 2008-04-29 | 2008-09-10 | 东华大学 | High water absorption polyvinyl alcohol fibre and preparation thereof |
| CN101613512B (en) * | 2009-07-16 | 2011-02-16 | 中国科学院长春应用化学研究所 | Rapid-imbibing foamed material with antibacterial property and preparation method thereof |
| CN101816803B (en) * | 2009-07-21 | 2013-09-25 | 王剑峰 | Disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing |
| CN101927028A (en) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | Preparation method of chitosan/ acetalized poval medical dressing |
| CN102688520A (en) * | 2012-06-28 | 2012-09-26 | 武汉大学 | Preparation method of composite antibacterial surgical dressing |
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Address after: 225400 Taixing medicine high tech Zone, Jiangsu, China, Taizhou Patentee after: Jiang Zhiyin Address before: 321000 Zhejiang city of Jinhua province Xian No. 398 North Street Patentee before: Jiang Zhiyin |
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Granted publication date: 20131218 Termination date: 20191009 |