CN101816803B - Disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing - Google Patents
Disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing Download PDFInfo
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- CN101816803B CN101816803B CN 200910041306 CN200910041306A CN101816803B CN 101816803 B CN101816803 B CN 101816803B CN 200910041306 CN200910041306 CN 200910041306 CN 200910041306 A CN200910041306 A CN 200910041306A CN 101816803 B CN101816803 B CN 101816803B
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- chitin
- suppository
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- stanching
- adsorbing
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- 230000035876 healing Effects 0.000 title claims abstract description 21
- 230000001737 promoting effect Effects 0.000 title claims abstract description 16
- 230000006870 function Effects 0.000 title claims abstract description 14
- 239000000829 suppository Substances 0.000 title claims abstract description 14
- 229920001222 biopolymer Polymers 0.000 title claims abstract description 11
- 229920001661 Chitosan Polymers 0.000 claims abstract description 26
- 239000004744 fabric Substances 0.000 claims abstract description 20
- 239000000835 fiber Substances 0.000 claims abstract description 16
- 238000001179 sorption measurement Methods 0.000 claims abstract description 10
- 239000004745 nonwoven fabric Substances 0.000 claims description 16
- 229920002101 Chitin Polymers 0.000 claims description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 5
- 230000006196 deacetylation Effects 0.000 claims description 5
- 238000003381 deacetylation reaction Methods 0.000 claims description 5
- 229910052740 iodine Inorganic materials 0.000 claims description 5
- 239000011630 iodine Substances 0.000 claims description 5
- 241000381602 Vachellia nebrownii Species 0.000 claims description 2
- 238000005098 hot rolling Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 244000052616 bacterial pathogen Species 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract description 5
- 230000028327 secretion Effects 0.000 abstract description 4
- 210000001215 vagina Anatomy 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000002980 postoperative effect Effects 0.000 description 4
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 3
- 206010046914 Vaginal infection Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 2
- 208000037486 Postoperative Hemorrhage Diseases 0.000 description 2
- 208000006374 Uterine Cervicitis Diseases 0.000 description 2
- 201000008100 Vaginitis Diseases 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000004917 carbon fiber Substances 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 206010008323 cervicitis Diseases 0.000 description 2
- 210000003679 cervix uteri Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 210000005000 reproductive tract Anatomy 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010051077 Post procedural haemorrhage Diseases 0.000 description 1
- 206010067268 Post procedural infection Diseases 0.000 description 1
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000037009 Vaginitis bacterial Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000007084 catalytic combustion reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000002003 vulvitis Diseases 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing, which has obvious effect, simple structure and simple implementation. The adsorbing suppository utilizes chitin-chitosan fiber non-woven cloth and activated carbon fiber felt cloth as raw materials, the activated carbon fiber felt cloth is rolled and made into a suppository core, then an external layer of the suppository core is coated with the chitin-chitosan non-woven cloth, and by utilizing the adsorption and drainage functions of the activated carbon fiber and good biocompatibility and functions of stanching and promoting healing of the chitin-chitosan fiber, pathogenic bacteria and unfavorable secretion in a vagina are adsorbed and taken out of the body, thusachieving the aims of curing and preventing diseases.
Description
Technical field
The present invention relates to field of medicaments, relate to a kind of pathogen growth of adsorbing effectively and suppress more specifically, promote the disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing of intravaginal erosion, ulcer wound surface healing.
Background technology
Gynecological inflammation is that the commonly encountered diseases of department of obstetrics and gynecology also is frequently-occurring disease, investigation according to the WHO of World Health Organization (WHO): have Chinese women more than 40% to suffer from various degree gynecological inflammation, married women gynecological prevalence is more up to more than 90%, wherein outbreak repeatedly about half brings endless worry to the woman.The gynecological inflammation infection is many to be caused by antibacterial.Just there is various bacteria in vagina itself, under the normal condition, these antibacterials keep a kind of poised state, can not cause disease, but whole poised state changes, or external certain factor destroyed whole balance as reasons such as puerperal, miscarriage, dilatation and curettage, placement intrauterine devices, and these antibacterials will become pathogenic bacterium and cause infection.Infection can betide down reproductive tract, causes vulvitis, vaginitis and cervicitis; Also can attack reproductive tract is internal genitalia, causes pelvic inflammatory disease and adnexitis.In recent years, and since the improvement of medical condition, the raising of the masses' hygienic knowledge level, and some serious critical gynecological inflammations reduce gradually, but general gynecological inflammation obviously increases.Chronic pelvic inflammatory disease, vaginitis, cervicitis are women's frequently-occurring diseases since extent of disease extensively, easily outbreak repeatedly, have a strong impact on WomanHealth, live and work, often cause infertilely, a few patients also canceration can occur.Often occur in addition bleeding in a large number after gynecological's physics operation (leep, laser, electric ring cutting etc.), wound is difficult to healing, brings very big misery to the patient.In sum, at present also a product useless reach comparatively ideal effect at aspects such as gynecological inflammation and operation back wound healings.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, provide a kind of effect obvious, simple in structure, implement to be simple and easy to into the disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing; The present invention utilizes chitin-chitosan fabric nonwoven cloth and NACF felt fabric to be raw material, make through multiple working procedure, utilize adsorption and drainage effect, the chitin-chitosan fiber excellent biological compatibility of NACF, hemostasis, promoting healing effect, the absorption of intravaginal pathogenic bacterium and bad secretions is taken out of external, thereby reach treatment and prophylactic purpose.
The technical solution adopted in the present invention is: the present invention includes the bolt core of being made by NACF felt fabric warrping and the chitin-chitosan non-woven fabrics skin that is wrapped on the described bolt core, the deacetylation of chitin fiber is 50%-99.9% in the described chitin-chitosan non-woven fabrics, and the iodine sorption value of described NACF felt fabric is 1500-3000mg/g.
The chitin-chitosan fiber content of described chitin-chitosan non-woven fabrics is 1%-100%.
Described chitin-chitosan non-woven fabrics is non-woven fabrics such as hot rolling, hot blast, water thorn or acupuncture.
Be installed with the convenient lead-out wire that takes out on the described disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing.
The invention has the beneficial effects as follows: chitin-chitosan is the unique a kind of cationic natural aminopolysaccharide of being with of nature, specific molecule structure and physicochemical property make chitosan have multiple effects such as antibiotic, promoting healing, the lubricated mucosa of nourishing, thereby make this product possess following performance and the mechanism of action:
1, the adsorption of NACF
Utilize the adsorption of NACF, effectively the absorption of intravaginal pathogenic bacterium is attached on the chitin-chitosan anti-bacterial fibre.
2, anti-microbial property
The distinctive cationic structural characteristics of chitin-chitosan are antibacterial bacteriostatic effectively, and the antibacterial barrier layer is provided.The pathogenic bacterium of carbon fiber adsorption and catalytic combustion (as: pathogenic bacterias such as gram positive bacteria, Candida albicans, staphylococcus aureus), electronegative in the adsorbable bacterial cell of Zhunyang ion positive charge that chitin fiber carries, flocculation takes place, upset the cell normal physiological activity, or transcribing of DNA copied in the blocking-up bacterial body, suppress bacterial reproduction, play good inhibition effect.
3, biocompatibility
The chitin-chitosan fiber has excellent biocompatibility, to human body safety non-toxic, non-stimulated, no sensitization, and effectively promotes the healing of the rotten to the corn wound surface of intravaginal.
In sum: the present invention to the human body safety non-toxic, harmless, non-stimulated, to improve the effect of intravaginal environment clearly effective, easy to use in absorption.The physical characteristic of this material product by material self reaches the effect of auxiliary treatment and Related products such as antibiotic, Chinese medicine easily produce drug resistance and occupancy has incomparable advantage.
The specific embodiment
Embodiment one:
Present embodiment is that the NACF felt fabric warrping that length and width is of a size of (20 ± 5) * (10 ± 5) mm is made the bolt core, again the chitin-chitosan non-woven fabrics of (20 ± 5) * (10 ± 5) mm is wrapped in the skin of NACF felt fabric, be contact human body layer, play the effect that active carbon fiber felt contacts with human body of isolating simultaneously, the iodine sorption value of described NACF felt fabric is 100mg/g, the fiber content of described chitin-chitosan non-woven fabrics is 90%, and the deacetylation of chitin fiber is 50%; The weight of absorption plug finished product is about 0.5g, and an end of finished product is subsidiary lead-out wire also, makes key be positioned over the convenient taking-up of certain hour in the human vagina, can be to suppress in key, and perhaps firmly bolt places two kinds of forms of key afterbody.
Embodiment two:
Present embodiment is that the NACF felt fabric warrping that length and width is of a size of (250 ± 5) * (90 ± 5) mm is made the bolt core, again the chitin-chitosan non-woven fabrics of (250 ± 5) * (90 ± 5) mm is wrapped in the skin of NACF felt fabric, the iodine sorption value of described NACF felt fabric is 1500mg/g, the fiber content of described chitin-chitosan non-woven fabrics is 90%, and the deacetylation of chitin fiber is 80%; The weight of absorption plug finished product is about 15g, and other features are with embodiment one.
Embodiment three:
Present embodiment is that the NACF felt fabric warrping that length and width is of a size of (500 ± 5) * (150 ± 5) mm is made the bolt core, again the chitin-chitosan non-woven fabrics of (500 ± 5) * (150 ± 5) mm is wrapped in the skin of NACF felt fabric, the iodine sorption value of described NACF felt fabric is 3000mg/g, the fiber content of described chitin-chitosan non-woven fabrics is 90%, and the deacetylation of chitin fiber is 99%; The weight of absorption plug finished product is about 30g, and other features are with embodiment one.
The hemostasis, drain, promoting healing that product is mainly used in gynecological physics operation (leep, laser, electric ring cutting etc.) among the above embodiment with and the aspects such as antibacterial, debridement effect of gynecological inflammation.
In the case of functions of stanching and promoting healing, 100% healing 100% that takes a turn for the better after 77%, 8 day is cured in improvement 77% after 4 days according to observations after physics is performed the operation, and the doctor is summarized as follows;
Treatment group: do not have 1 example and go to a doctor because of postoperative hemorrhage, do not have 1 routine postoperative infection.Patient's readme: postoperative secretions is less, and vagina does not have sense of discomfort.Postoperative 1 weekly check: the cervix uteri mucosa does not have obvious hyperemia, as seen is dispersed in new epithelize and covers, and shifts to an earlier date 3-4 days than conventional therapy healing time.
Matched group: the more prescription on individual diagnosis of 4 routine postoperative hemorrhages.Most of patients postoperative secretions is more.Postoperative 1 weekly check: the cervix uteri mucosa is congested in various degree, and 6 routine secondary vaginal infection are arranged.
Aspect the treatment gynecological inflammation, the correlated observation data show, treatment nonspecific vaginitis, 4 days cure rates be 96.3%, 8 day be 100%; Bacterial vaginosis 6 examples are the gravid woman, 66.7%, 8 day cure rate 100% of 4 days cure rates.
Claims (4)
1. disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing, it is characterized in that: it comprises the bolt core of being made by NACF felt fabric warrping and the chitin-chitosan non-woven fabrics skin that is wrapped on the described bolt core, the deacetylation of chitin fiber is 50%-99.9% in the described chitin-chitosan non-woven fabrics, and the iodine sorption value of described NACF felt fabric is 1500-3000mg/g.
2. disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing according to claim 1, it is characterized in that: the chitin-chitosan fiber content of described chitin-chitosan non-woven fabrics is 1%-100%.
3. according to claim 1 or 2 each described disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing, it is characterized in that: described chitin-chitosan non-woven fabrics is hot rolling, hot blast, water thorn or needle punched non-woven fabrics.
4. according to claim 1 or 2 each described disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing, it is characterized in that: be installed with lead-out wire on the described disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910041306 CN101816803B (en) | 2009-07-21 | 2009-07-21 | Disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910041306 CN101816803B (en) | 2009-07-21 | 2009-07-21 | Disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101816803A CN101816803A (en) | 2010-09-01 |
| CN101816803B true CN101816803B (en) | 2013-09-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910041306 Active CN101816803B (en) | 2009-07-21 | 2009-07-21 | Disposable female biopolymer adsorbing suppository with functions of stanching and promoting healing |
Country Status (1)
| Country | Link |
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| CN (1) | CN101816803B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106178090A (en) * | 2016-07-26 | 2016-12-07 | 四川艾医生医疗科技有限公司 | A kind of biological activity gynecological thromboembolism and preparation method thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871953B (en) * | 2012-10-09 | 2013-12-18 | 姜志银 | Super-absorbent adsorption suppository |
| CN103948956A (en) * | 2014-04-01 | 2014-07-30 | 王剑峰 | Medical composite shaping restoration material layer for cavity |
| CN105520957B (en) * | 2015-12-18 | 2018-08-03 | 上海韬鸿化工科技有限公司 | A kind of pharmaceutical composition for treating cervical erosion |
-
2009
- 2009-07-21 CN CN 200910041306 patent/CN101816803B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106178090A (en) * | 2016-07-26 | 2016-12-07 | 四川艾医生医疗科技有限公司 | A kind of biological activity gynecological thromboembolism and preparation method thereof |
| CN106178090B (en) * | 2016-07-26 | 2019-06-18 | 四川艾医生医疗科技有限公司 | A kind of bioactivity gynaecology embolism and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101816803A (en) | 2010-09-01 |
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Effective date of registration: 20200415 Address after: Room 402, 4 / F and 501, 5 / F, building e, emerging industry incubation zone, 39 Yunda West Road, Kunming Economic and Technological Development Zone, Yunnan Province, 650000 Patentee after: YUNNAN SHUYUN TECHNOLOGY Co.,Ltd. Address before: 519015 Guangdong Province, Zhuhai city Xiangzhou District Jiuzhou Road No. 3033 West 24 Building No. 503 Silverstone Graceland Patentee before: Wang Jianfeng |
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