CN100434083C - Medicinal use of fugu cod liver oil - Google Patents
Medicinal use of fugu cod liver oil Download PDFInfo
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- CN100434083C CN100434083C CNB2006100169852A CN200610016985A CN100434083C CN 100434083 C CN100434083 C CN 100434083C CN B2006100169852 A CNB2006100169852 A CN B2006100169852A CN 200610016985 A CN200610016985 A CN 200610016985A CN 100434083 C CN100434083 C CN 100434083C
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Abstract
An application of the globefish's liver fat in preparing medicines in the form of exterior-applied liquid, ointment, or suppository for treating pile, cervical erosion, phlebeurysma and beriberi is disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, i.e. the medical usage of Oleum Fugu ocellatus in preparation treatment hemorrhoid, cervical erosion, varicosis, beriberi medicine.
Background technology
In prior art, hemorrhoid, cervical erosion, varicosis and beriberi disease are commonly encountered diseases.It is more to treat this type of sick medicine, and its shortcoming is take effect slow (generally needing more than 15 days), and is not thorough, easily recurrence, and the prescription complexity has side effect to health.The medicine that with the Oleum Fugu ocellatus is raw material does not appear in the newspapers.
Summary of the invention
The objective of the invention is to provide a kind of at above-mentioned deficiency is raw material with the Oleum Fugu ocellatus, the medical usage of the Oleum Fugu ocellatus that treatment hemorrhoid, cervical erosion, varicosis and beriberi are evident in efficacy.
Technical solution of the present invention is: the purposes of Oleum Fugu ocellatus in preparation treatment hemorrhoid, cervical erosion, varicosis or beriberi medicine.Oleum Fugu ocellatus can be a single preparations of ephedrine, and the called after Oleum Fugu ocellatus also can be a compound, called after Oleum Fugu ocellatus pharmaceutical composition.Can be mixed and made into preferred dosage form by pharmaceutical carrier, additive or adjuvant commonly used in above-mentioned medicinal raw material and the pharmacy is liquid preparation for external application, ointment or suppository.
The Oleum Fugu ocellatus pharmaceutical composition of treatment hemorrhoid, cervical erosion, varicosis or beriberi is made by following raw materials by weight percent: Oleum Fugu ocellatus 97.8-99%, Borneolum Syntheticum 0.5-1%, azone 0.3-0.7%, Oleum menthae 0.2-0.5%.
The preferred version of treatment hemorrhoid, cervical erosion, varicosis or beriberi Oleum Fugu ocellatus pharmaceutical composition is: Oleum Fugu ocellatus 98%, Borneolum Syntheticum 1%, azone 0.5%, Oleum menthae 0.5%.
Traditional Therapeutic Method Shi Ma Paralysis neuron reaches analgesic effect to suppress conduction function.And this prescription is the rapid permeability skin histology, and blood capillary makes impaired blood capillary, and organized renewing is normal between flanking cell, makes problem Lock-outs such as pain and pruritus, red aspect giving birth to good effect is arranged at repair cell and promoting healing.Oleum Fugu ocellatus has effects such as the pain of relieving the pain, hemostasis, antiinflammatory, detumescence.The alcohol leaching Borneolum Syntheticum is used for external golden Portugal bacterium, escherichia coli, Hemolytic streptococcus, has bacterio static itching-relieving, detumescence effect.Oleum menthae has antiinflammatory, antipruritic, refrigerant lax blood vessel, local tight muscle is had the effect of loosening.Azone has the transdermal of enhancing and helps the effect of oozing.More than four flavors form this prescription altogether.Show that through clinical experimental study result for many years this product has activating blood and removing stasis, mass dissipating and swelling eliminating, anti-inflammatory analgetic, hemostasis, promoting healing etc. and does usefulness.Golden Portugal bacterium, escherichia coli, Candida albicans, mycoplasma, chlamydia, fungus etc. had inhibition and very strong killing action.
Preparation method: the liver of getting globe fish makes the cytoclasis of fish liver, thereby liver oil is separated under the situation of steaming and decocting heating.Liver oil after the steaming and decocting can separate moisture wherein with sedimentation or centrifuging, both can obtain liver oil.Can directly use, also can add Borneolum Syntheticum after the emulsifying, azone, Oleum menthae is made ointment or suppository etc., presses the Oleum Fugu ocellatus pharmaceutical composition and uses.
Advantage of the present invention is: be that raw material refines the new drug that processes with deep-sea Fugu ocellatus Fish 1,, well-known doctor's check and correction in secular clinical practice, have been obtained, make its determined curative effect, the prescription science, treatment hemorrhoid, cervical erosion, varicosis or beriberi disease are of miraculous efficacy, but quick-acting antalgesic, antiinflammatory, hemostasis, detumescence, particularly critical hemorrhoid patients, use this product promptly to heal in 5-6 days, and need not to take medicine.2, this product is without any side effects, and skin is not had any stimulation, finds no allergy sufferers, and is safe in utilization, and curative effect is rapid, the cure rate height, and the patient is easy to accept.3, through clinical 169 routine hemorrhoid patients are treated, cure rate is 97%, and obvious effective rate 3%, total effective rate are 100%.To 30 routine patients of cervical ruin treatments, cure 29 examples, cure rate 96.7%, produce effects 1 example, total effective rate 100% through clinical., cure 25 examples and account for 83% 30 routine chronic ulcer of the lower limb patient treatments through clinical.Effective 5 examples account for 16.7%; Total effective rate is 100%.Through clinical 39 routine beriberi patient treatments are cured 39 examples, total effective rate is 100%.
Below in conjunction with embodiment the present invention is described in further detail.
The specific embodiment
Embodiment 1
Oleum Fugu ocellatus adopts conventional method, under the situation of effluent filefish Liver Channel steaming and decocting heating, makes the cytoclasis of fish liver, thereby liver oil is separated, and separates moisture, promptly.
Embodiment 2
The Oleum Fugu ocellatus pharmaceutical composition is made by following raw materials by weight percent: Oleum Fugu ocellatus 98%, Borneolum Syntheticum 1%, azone 0.5%, Oleum menthae 0.5%.
Embodiment 3
The Oleum Fugu ocellatus pharmaceutical composition is made by following raw materials by weight percent: Oleum Fugu ocellatus 99%, Borneolum Syntheticum 0.5%, azone 0.3%, Oleum menthae 0.2%.
Embodiment 4
The Oleum Fugu ocellatus pharmaceutical composition is made by following raw materials by weight percent: Oleum Fugu ocellatus 97.8%, Borneolum Syntheticum 1%, azone 0.7%, Oleum menthae 0.5%.
Experimental example 1: Oleum Fugu ocellatus treatment hemorrhoid 169 routine clinical data reports
1, physical data: this organizes male 74 examples in the 169 routine hemorrhoid patients, women 95 examples; 1-2 phase internal hemorrhoid 45 examples, 3 phase mixed hemorrhoids, 51 examples, simple property external hemorrhoid 73 examples; Thrombosis type 14 examples in the external hemorrhoid, inflammatory type 26 examples, varicosis type 12 examples, connective tissue type 14 examples, the course of disease are in 13 examples more than 20 years, patient's 44 examples more than 10 years, patient's 46 examples more than 5 years; Maximum 80 years old, minimum 11 years old.
2, diagnostic criteria:
(1) internal hemorrhoid: 1 phase had blood in stool, color scarlet one class asymptomatic, the anus mirror is looked into: mucosa protuberance on the tooth trace, surplus color is light red.Deviate from outside the anus with swollen thing when 2 phase defecations or increase abdominal pressure, can not reply voluntarily, need to have a rest or manual reduction, have blood in stool rare or nothing, above the anoscopy tooth trace mucosal protrusion is arranged, there is fibrosis on the surface.
(2) external hemorrhoid: the inflammatory type, anal skin damage or infection, the pain increased for red and swollen ulceration.
(3) thrombosis type: swollen thing appears in the up and down same side of anus and interior tooth trace, the local skin edema, and the lump initial stage is still soft, and the pain increased, touches a tender spot obviously.
(4) mixed type: have blood in stool and the swollen thing of podex, rectal tenesmus can be arranged, foreign body or pain can be with merocrine secretion or prurituss, and swollen thing appears in the up and down same orientation of anus and interior tooth trace.
3, criterion of therapeutical effect: (disease of tcm diagnosis criterion of therapeutical effect) according in June, 1994 issue of national Chinese medicine management board drafted.
(1) cure: treatment back transference cure, blood stasis disappears or atrophy fully.
(2) take a turn for the better: doing well,improving, blood stasis dwindle or atrophy incomplete.
(3) invalid: treatment back symptom and sign has no significant change.
4, therapeutic outcome:
Administrated method: Oleum Fugu ocellatus is made cotton sliver suppository.Get cotton sliver and dip in after the Oleum Fugu ocellatus drug solns is smeared crissum in the bottle, cotton sliver is slowly being inserted anal, the cotton sliver afterbody stayed and is exposed at the outer end and gets final product for half centimetre, changed a cotton sliver every 6-8 hour.The 3-6 days course of treatment.
Healing 164 examples, cure rate are 97% in 169 examples.Take a turn for the better 5 examples, be 3%, total effective rate is 100%.
5, model case:
(1), Zhao, the man suffered from mixed hemorrhoid in 46 years old and had blood in stool for many years 2 years, swollen thing is deviate from companion's anus, repeatedly outbreak, prolongedly do not heal, anus inspection rectal wall is deviate from, and penetrates blood, and tooth trace has many pieces of blood stasis in same orientation up and down, there is fibrosis on the surface, and sharp ache is had a blood test: hb80g/L, wbc5.0 * 10
9/ L, platelet 50 * 10
9/ L, bp9/6kpa are diagnosed as the incarceration mixed hemorrhoid.After using milt oil emersion object is sent back in the anus, 1 day pain relief still has and weighs down the sense of expanding, and foreign body is deviate from after an action of the bowels, has not had hemorrhagely, and further consultation is accused and more followed up a case by regular visits to not recurrence in 2 years after 6 days.
(2) Liu Fengqin, woman, 35 years old, patient main suit: suffer from 3 years frequent pain of anus of hemorrhoid.Toposcopy: inspection: anal has two blood stasis, in 3 of calculi positions and 6 anal 1-2cm place ulcer.Diagnosis: mixed hemorrhoids.Dispose: be coated in anal 1.5-3cm place with the Oleum Fugu ocellatus medicine, treat healing in 6 days, checking the hemorrhoid complete obiteration after 3 months.
6, know from experience:
Hemorrhoid are common multiple disease, and Therapeutic Method is a lot, and curative effect differs.The traditional Chinese medical science thinks that primary disease is that the anus blood vessels are retarded by silt, and due to QI and blood is not smooth, with the passing of time becomes silted up and becomes hemorrhoid, the damage venation is had blood in stool, and obstructed mistake is adopted the Oleum Fugu ocellatus treatment rapidly freely and bitterly, easy and simple to handle, safe in utilization, clinical treatment 169 routine patients there is no bad reflection, and cure rate height, relapse rate is low, and the patient is easy to accept, and application value is arranged very much.
Experimental example 2: Oleum Fugu ocellatus treatment vaginitis cervical erosion 30 routine clinical data reports:
1, physical data: this organizes 30 examples, 18～50 years old age, and in the majority with 40 years old left and right sides case, rotten to the corn 19 examples of simple type, rotten to the corn 11 examples of granular pattern; Rotten to the corn 5 examples of nipple type have contact bleeding 16 examples, acute severe cervical erosion, and the surface is rotten to the corn or ooze pus 9 examples.
2, using method: routine disinfection pudendum and vagina, expose cervix uteri, after cleaning vagina, dry (seal is done) cervix uteri and vagina with dry cotton ball, be coated on the cervical erosion face with the ocellated puffer liver ointment then, cover whole rotten to the corn face, thickness is advisable cannot see the cervix uteri color, every day 1 time, 10 days is 1 course of treatment.Suppository: clean external genital, suppository is filled in vagina deep or medication under physician guidance.1 every night, each 1 sooner or later of serious symptom.
3, diagnostic criteria:
(1) cure: cervical erosion disappears, and sepage stops, and contactless property is hemorrhage, and cervix uteri is pale red, smooth surface.
(2) produce effects: the cervical erosion face reduces, and transfers moderate or slight to by severe, transfers the simple type erosion to by nipple type or granular pattern erosion, the cervix uteri color dodge, and swelling is disappeared, and sepage reduces, and contactless property is hemorrhage.
(3) effective: the cervical erosion face does not reduce, but transfers the granular pattern erosion to by the erosion of former nipple type, or transfers the simple type erosion to by former granular pattern erosion, and swelling alleviates, and sepage reduces, accidental contact bleeding.
(4) invalid: rotten to the corn area no change or dwindle less than 1/2.
4, therapeutic outcome: the 3-10 days course of treatment.Cure 29 examples, cure rate 96.7%, produce effects 1 example.Total effective rate accounts for 100%.
5, model case:
The Rhizoma Polygonati pretty young woman, the woman, 34 years old, patient main suit: trichomonal vaginitis, pruritus vulvae is arranged the year before, secretions increase, urgent micturition, frequent micturition, leucorrhea show bubble and with diseases such as stench flavors is gone to the hospital and is checked and be diagnosed as trichomonal vaginitis.Though once used lotion, spray, do not see much variations yet, can only respite.Oleum Fugu ocellatus suppository is used in the back, and symptom had just disappeared in 3 days, continues medication symptom complete obiteration in 6 days, follows up a case by regular visits to healing after 3 months.
Appoint the hero, the woman, 42 years old, patient main suit: leucorrhoea grow in quantity recently, abnormal flavour is arranged, be grumeleuse or bean curd slag specimen, simultaneously with pruritus vulvae, especially increase the weight of night, simultaneously also with symptoms such as urinary tract infection such as frequent micturition, urgent micturition, dysureas.Check to find: pudendum is ground pattern erythema, edema, scratch is arranged, vaginal mucosa edema, erythema, adularescent block.Diagnosis: candidiasis, typical colpitis mycotica.With Oleum Fugu ocellatus suppository treatment 3 days, asymptomatic, the pruritus vulvae problem malaise symptoms complete obiteration for the treatment of 10 days patients was followed up a case by regular visits to and is not had recurrence so far.
6, know from experience: cervical erosion is the nonspecific inflammation that bacterial infection causes, its pathogenic bacterium mostly are staphylococcus, streptococcus, escherichia coli and anaerobe, and general oral antibiotic acts on cervix uteri, is difficult to reach valid density, and easily develops immunity to drugs.Common employing improves vaginal environment and the application specific medicine is treated, and also can reach certain effect.And the present invention is the rapid permeability skin histology, and blood capillary makes impaired blood capillary, and organized renewing is normal between flanking cell, thereby effectively reaches promotion cell regeneration, eliminates the cell and the congestion that come off, the poisonous dirt of residue etc. that remains in uterus and vagina is excreted, eliminate the source of infection.For many years to women's cervical erosion, vaginitis waits gynaecopathia to observe through us, and the result confirms that Oleum Fugu ocellatus has significant curative effect in the treatment gynaecopathia, have application value very much.
Experimental example 3: Oleum Fugu ocellatus treatment varicosis 30 routine clinical disease row data are as follows:
1, physical data: this organizes 30 examples, wherein male 21 examples, women 9 examples.Maximum age person 61 years old, minimal ages person 32 years old.Varicosis merges ulcus cruris 23 examples, simple ulcer 7 examples.The course of disease reaches 16 years most, and is the shortest 30 days.
2, diagnostic criteria:
Healing, effective: wound healing, incrustation come off, there is fresh granulation tissue growth at the wound surface edge.Invalid, wound surface no change or deterioration before and after the medication.
3, using method: this product is a kind of unguentum, and Oleum Fugu ocellatus ointment of the present invention is smeared the thick 3～5mm in affected part, pricks with medicinal bundle, and change dressings once every day.When changing dressings, in time remove slough,, clean out, and tie with medicinal bundle and to get final product with gauze for forming severe ulcer.
4, therapeutic effect among the 30 routine chronic ulcer of the lower limb patients, is cured 25 examples and is accounted for 83%.Effective 5 examples account for 16.7%; Total effective rate is 100%.Followed up a case by regular visits to through 6 to 12 months,, do not have the cicatricial contracture hypertrophy though more there are cicatrix or surrounding skin pigmentation in various degree in the back.
5, model case:
Jiang Zheng, the woman, 42 years old, patient main suit: think that skin of leg is itched, shank swelling, ache, fatigue.Diagnosis: the superficial veins of lower limb inflammation is mixed with the superficial vein thrombosis.Dispose: smear the affected part with Oleum Fugu ocellatus, the fatigue of aching alleviated in 3 days, disappeared with shank swelling in 20 days and cured.Can it be a course of treatment with 30 days continuously according to the state of an illness, to reach satisfied effect.
Li Xin, the woman, 45 years old, the teacher, patient main suit: right leg varicosis companion ulcer 4 years is invalid through western medicine.Check: right leg internal malleolus ulcer, area are 6cm * 8cm * 0.1cm, the wound surface canescence, and granulation is stale, has slough to cover, and the edge is unclear, and skin is kermesinus.Dispose: debridement slough at first, to wipe away driedly behind the reuse normal saline flushing gently, external application Oleum Fugu ocellatus ointment is changed dressings 1 every day, and after 2 weeks, wound surface is 4cm * 5cm, the red work of granulation, dry tack free is through treatment in 30 days, wound healing.
6, know from experience: the pathogeny of chronic ulcer of the lower limb is many by station of a specified duration or because of bearing a heavy burden, impairment caused by overstrain QI and blood or because of wound, and skin multiple factor such as scratch, it is not smooth to cause the lower limb passages through which vital energy circulates stasis of blood to stagnate, failure of skin and muscle to be nourished, continuing then, the corruption of intenseness of heat meat forms.Should advise the patient to put prevention first, minimizing is stood, and raises the trouble limb, suitably increases physical fitness training, avoids risk factor as far as possible, in case recurrence.The speed of wound healing is relevant with the time of changing dressings with the processing of wound surface.Dry, the fresh wound surface time of changing dressings was difficult for diligent; with tamper-proof newborn granulation growth, infective wound surface moves when debridement wants light, notes the epithelial tissue that protection is newborn; external application binder or Elastic bandage elasticity will suit, and chronic ulcer of the lower limb is infected serious wound surface best results.Because this product is that sliver contains ointment, the hemorrhage and pain of wound surface when this has just been avoided changing dressings prevents that incrustation from forming, and does not produce cicatricial contracture and hypertrophy after making more, has shortened healing course of treatment greatly, and it is satisfied to firmly get extensive patients.
Experimental example 4: Oleum Fugu ocellatus treatment beriberi 30 routine clinical disease row data are as follows:
1, physical data: this organizes 39 examples, wherein male 24 examples, women 15 examples.Maximum age person 55 years old, minimal ages person 11 years old.Blister type 23 examples wherein, erosive type 7 examples, keratinization type 9 examples, the course of disease reaches 12 years most, the shortest half a year.
2, diagnostic criteria: cure: there is fresh granulation tissue growth at wound healing, wound surface edge.Invalid: wound surface no change or deterioration before and after the medication.
3, using method: this product is a kind of unguentum, uses the warm water cleaning affected part every day, and Oleum Fugu ocellatus ointment of the present invention is smeared the affected part, once a day, both heals in 7-12 days.
4, therapeutic effect: among the 39 routine beriberi patients, cure 39 examples, account for 100%.Total effective rate is 100%.Followed up a case by regular visits to whole healings through 3 to 12 months.
5, model case:
Sun Yue, man, 50 years old.Patient main suit: foot three, five toes seam toe pain pruritus about before half a year, do not feel any better with a lot of medicines.Inspection: the visible 0.6X0.6cm of the place skin infection of foot three, five toes seam toe about looking into, blister.Diagnosis: fungus, candida albicans infection.Smeared one day with Oleum Fugu ocellatus ointment of the present invention, be clearly better, sensation was not itched, and 7 days wound healings of medication were followed up a case by regular visits to healing through 3 to 2 months.
Hao Yuhua, woman, 35 years old.Patient main suit: sufficient two, three, the five toes seam in a left side is painful itched inspection five days: festering in visible affected part, has a small amount of thin pus to overflow, and the color flat taste is smelly, and once personal " beriberi liquor " treated the commentaries on classics of not getting better.Diagnosis: the concurrent shallow table skin infection of beriberi infection, wound surface 0.5x0.5cm three places were coated with the Oleum Fugu ocellatus ointment one day, pain relief, fester with nothing in the affected part, and wound surface obviously dwindles, 7 days wound healings of medication, further consultation on the three is cured behind the medicine.
6, know from experience:
Beriberi is that the multiple disease of a kind of skin has infectiousness, and main pathogenic bacteria is fungus and candidiasis, often partly has play to itch, the easily bacterial infection of back of scratching, and other drug is cured the symptoms, not the disease, and the present invention has significantly antibacterial and biocidal efficacies aspect the treatment beriberi skin.And curative effect is rapid, is the specific medicament of present clinical treatment beriberi.
Claims (4)
1, the purposes of Oleum Fugu ocellatus in preparation treatment hemorrhoid, cervical erosion, varicosis or beriberi external used medicine.
2,, it is characterized in that described medicine made by following raw materials by weight percent: Oleum Fugu ocellatus 97.8-99%, Borneolum Syntheticum 0.5-1%, azone 0.3-0.7%, Oleum menthae 0.2-0.5% according to the described purposes of claim 1.
3,, it is characterized in that described medicine made by following raw materials by weight percent: Oleum Fugu ocellatus 98%, Borneolum Syntheticum 1%, azone 0.5%, Oleum menthae 0.5% according to the described purposes of claim 2.
4,, it is characterized in that described medicine is liquid preparation for external application, ointment or suppository according to claim 1,2 or 3 described purposes.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100169852A CN100434083C (en) | 2006-06-29 | 2006-06-29 | Medicinal use of fugu cod liver oil |
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| CNB2006100169852A CN100434083C (en) | 2006-06-29 | 2006-06-29 | Medicinal use of fugu cod liver oil |
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| CN100434083C true CN100434083C (en) | 2008-11-19 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066340B (en) * | 2007-05-16 | 2012-06-27 | 苏振芳 | Compound externally applied tetrodotoxin ointment and its prepn |
| CN104352527A (en) * | 2014-10-20 | 2015-02-18 | 中山百鸥医药科技有限公司 | Application of cod liver oil to the treatment of gynaecopathia |
| CN105559060B (en) * | 2015-12-19 | 2018-03-16 | 青岛浩大海洋生物科技股份有限公司 | A kind of beneficial spleen stomach invigorating filefish fish oil health-caring capsule |
| CN110420224A (en) * | 2019-07-25 | 2019-11-08 | 江苏华豚药业有限公司 | The saponified application and preparation method thereof of filefish liver oil |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193516A (en) * | 1997-03-13 | 1998-09-23 | 辽阳鸿宇制药有限公司 | Application of liver oil of globefish in preparation of medicines for drug dependence |
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2006
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193516A (en) * | 1997-03-13 | 1998-09-23 | 辽阳鸿宇制药有限公司 | Application of liver oil of globefish in preparation of medicines for drug dependence |
Non-Patent Citations (2)
| Title |
|---|
| 河豚的化学成分研究. 王小逸等.中国海洋药物，第1999年卷第1期. 1999 |
| 河豚的化学成分研究. 王小逸等.中国海洋药物，第1999年卷第1期. 1999 * |
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