CN102688520A - Preparation method of composite antibacterial surgical dressing - Google Patents
Preparation method of composite antibacterial surgical dressing Download PDFInfo
- Publication number
- CN102688520A CN102688520A CN2012102161437A CN201210216143A CN102688520A CN 102688520 A CN102688520 A CN 102688520A CN 2012102161437 A CN2012102161437 A CN 2012102161437A CN 201210216143 A CN201210216143 A CN 201210216143A CN 102688520 A CN102688520 A CN 102688520A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- nanometer silver
- absorbent material
- film
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to the field of medical materials and discloses a preparation method of a composite antibacterial surgical dressing. The preparation method comprises the following steps of: adding carboxymethyl chitosan into distilled water to prepare a solution; adding in nanometer silver powder to prepare a uniform nanometer silver/chitosan suspension, and placing the uniform nanometer silver/chitosan suspension into a 60-DEG C drying oven for continuous roasting to prepare a nanometer silver/chitosan film; mixing ES (Ethylene-Propylene Side by Side) short fiber and paper pulp, carrying out air forming at the temperature of 130 DEG C, adding in sodium polyacrylate, carrying out air forming again and spraying a structural adhesive, then, sticking non-woven fabrics to two sides and compacting the prepare a polymer absorbent material; and inlaying the nanometer silver/chitosan film on the polymer absorbent material, and then sticking the nanometer silver/chitosan film and the polymer absorbent material on a polyurethane film to prepare the composite antibacterial surgical dressing. The dressing provided by the invention is antibacterial by utilizing nanometer silver, chitosan can promote a wound to heal, and the polymer absorbent material can absorb redundant seepage of the wound, keep the wound wet and promote the wound to heal.
Description
?
Technical field
The present invention relates to nanometer silver/chitosan film and macromolecule water absorbent material and combine and make the method for composite antibiosis surgical dressing, belong to the medical material field.
Technical background
In the age 60 o'clock last century, when professor Winter finds that wound surface is in moist environment, more help wound healing.Clinical dressing commonly used at present can be divided into dryness dressing and moist dressing; Dryness dressing such as gauze, cotton pad etc. have certain water absorption, but are easy to wound surface adhesion, incrustation; Cause wound surface to damage once more during replacing; No antibiotic and the effect that promotes wound healing lose buffer action after dressing is drenched, cause traumatic infection easily.Moist dressing such as hydrogel, chitosan dressing etc., though can keep wound surface moistening, its soaking effect is not good enough, is prone to cause hydrops and brings out infection.There was the scholar to adopt the photo-reduction technology in the past,, made up a kind of chitosan/nanometer silver laminated film at chitosan film surface adsorption silver ion.This kind laminated film only surface adsorption has silver ion, and silver ion content is few, and the bacteriostasis time is short, and silver ion is prone to combine with intravital chloride ion, loses fungistatic effect.Chitosan/nanometer silver laminated film water absorbing properties is poor, is prone to cause the wound surface hydrops and brings out infection.
Summary of the invention
Problem to be solved by this invention is to provide the manufacture method of all good composite antibiosis surgical dressings of a kind of antibiotic and water absorbing properties.
The technical scheme that the present invention taked in turn includes the following steps:
1, the preparation of nanometer silver/chitosan film
Carboxymethyl chitosan is dissolved in distilled water, processes the carboxymethyl chitosan sugar juice of mass concentration 4%, and, stir and process nanometer silver/chitosan suspension to the nanometer silver powder that wherein adds 1-2wt%; Then nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens and toast continuously, be prepared into nanometer silver/chitosan film;
2, macromolecule water absorbent material preparation
ES short fiber and paper pulp are blended under 130 ℃ through air forming; Ratio in article shaped and sodium polyacrylate mass ratio 20 ~ 5:1 is sprayed at the surface with the sodium polyacrylate powder then; Pass through air forming again, after the sprinkling structure glue, paste non-woven fabrics in both sides; Compacting then, the preparation macromolecule water absorbent material;
3, dressing molding
Nanometer silver/chitosan film is embedded in macromolecule water absorbent material, is pasted on polyamine base Ethyl formate thin film then together.
In the such scheme, in the step (1), can nanometer silver/chitosan suspension be put into 60 ℃ of baking ovens and toast 40 hours continuously, be prepared into nanometer silver/chitosan film.
In the such scheme, in the step (2), use 5Kg/m
2Pressure will be pasted the shaping thing compacting of non-woven fabrics, the preparation macromolecule water absorbent material.
Beneficial effect of the present invention is: chitosan film has slow releasing function to nanometer silver, and nano silver antibacterial is effective, has no drug resistance, and can keep the permanent bacteriostasis to wound surface; Chitosan has the effect that promotes wound healing; The macromolecule water absorbent material that contains sodium polyacrylate around the chitosan film can absorb the unnecessary sepage of wound surface.This new pattern compress can keep the moistening environment of wound surface, is beneficial to wound healing, can absorb the unnecessary transudate of wound surface in a large number again, also has effect antibiotic and the promotion wound healing.The antibacterial intensity of material strengthens along with the increase of content of nanometer silver.
The specific embodiment
Embodiment 1
Take by weighing carboxymethyl chitosan 4g and put into special container, add distilled water, put into the chitosan solution that continuous stirring in the agitator was made into mass fraction 4% in 6 hours until 100ml.Chitosan solution is put into the continuous baking of 60 ℃ of baking ovens be prepared into simple chitosan film in 40 hours, be labeled as CS.
Embodiment 2
Take by weighing carboxymethyl chitosan 4g and put into special container, add distilled water, put into the chitosan solution that continuous stirring in the agitator was made into mass fraction 4% in 6 hours until 100ml.Taking by weighing nanometer silver powder 2.0g joins in the chitosan solution; Continue to stir 24 hours, process uniform nanometer silver/chitosan suspension, nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens toasted 40 hours continuously; Be prepared into nanometer silver/chitosan film, be labeled as N ~ CS
1
Embodiment 3
Take by weighing carboxymethyl chitosan 4g and put into special container, add distilled water, put into the chitosan solution that continuous stirring in the agitator was made into mass fraction 4% in 6 hours until 100ml.Taking by weighing nanometer silver powder 1.5g joins in the chitosan solution; Continue to stir 24 hours, process uniform nanometer silver/chitosan suspension, nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens toasted 40 hours continuously; Be prepared into nanometer silver/chitosan film, be labeled as N ~ CS
2
Embodiment 4
Take by weighing carboxymethyl chitosan 4g and put into special container, add distilled water, put into the chitosan solution that continuous stirring in the agitator was made into mass fraction 4% in 6 hours until 100ml.Taking by weighing nanometer silver powder 1.0g joins in the chitosan solution; Continue to stir 24 hours, process uniform nanometer silver/chitosan suspension, nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens toasted 40 hours continuously; Be prepared into nanometer silver/chitosan film, be labeled as N ~ CS
3
The combine dressing anti-microbial property detects: with 4% chitosan film and 2.0%, 1.5%, it is 0.6cm that 1.0% nanometer silver/chitosan film is made conglobate diameter, and thickness is 0.3cm size round die block, uses oxirane disinfection.Get bacillus pyocyaneus, staphylococcus aureus, the escherichia coli bacterial strain is inoculated into solid medium respectively, places 37 ℃ of constant incubators to cultivate 24 hours.Choose single bacterium with inoculating loop and in 2ml normal saline test tube, process bacteria suspension.Get the 100ul bacteria suspension, evenly coat on the culture medium, rotate 60 ° on culture dish at every turn, repeat above operation 4 times, around culture dish, be coated with 3 times more at last, really the fungus preserving liquid coating evenly.The culture dish of coating bacterium liquid was left standstill 5 minutes, make all bacterium liquid all absorbed by agar.Then with the cefotaxime sodium reagent paper, vancomycin reagent paper, ceftazidime reagent paper be respectively as bacillus pyocyaneus group, staphylococcus aureus group, (positive control) of escherichia coli group, disinfectant CS, N ~ CS
1,N ~ CS
2, N ~ CS
3, gauze (negative control) is attached on the MH agar culture dish by sequence number in advance, makes spacing between each sample greater than 20mm, and apart from the culture dish edge greater than 15mm.All culture dishs are inserted in 37 ℃ the CO2 constant incubator and cultivated 24 hours, observe bacterial growth situation around the material module, the size of inhibition zone is with the anti-microbial property of assess sample.
Anti-microbial property: CS is for producing inhibition zone, N ~ CS
1,N ~ CS
2, N ~ CS
3Inhibition zone to bacillus pyocyaneus is (16.3 ± 0.8) mm, (14.1 ± 1.3) mm, (13.1 ± 0.4) mm; The inhibition zone of staphylococcus aureus (18.2 ± 0.9) mm, (16.3 ± 1.5) mm, (13.7 ± 0.6) mm; The inhibition zone of escherichia coli (12.0 ± 0.5) mm, (11.1 ± 0.3) mm, (10.8 ± 1.1) mm.4% simple carboxymethyl chitosan film is not all seen obvious inhibition zone to bacillus pyocyaneus, staphylococcus aureus and escherichia coli, explains that simple chitosan film does not have obvious bacteriostasis to above-mentioned three kinds of antibacterials.Composite nano silver/the chitosan film that adds nanometer silver has obvious antibacterial effect, is accompanied by successively decreasing of contained nanometer silver concentration in the dressing, and fungistatic effect also weakens.
Embodiment 5
Take by weighing carboxymethyl chitosan 3g and put into special container, add distilled water, put into the chitosan solution that continuous stirring in the agitator was made into mass fraction 4% in 6 hours until 60ml.Take by weighing nanometer silver powder 1.5g and join in the chitosan solution, continue to stir 24 hours, process uniform nanometer silver/chitosan suspension, nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens toasted 40 hours continuously, be prepared into nanometer silver/chitosan film.
Embodiment 6
ES short fiber and paper pulp are blended under 130 ℃ through air forming, add sodium polyacrylate in the 20:1 ratio then, pass through air forming again, spray structure glue after, non-woven fabrics is pasted in both sides, be 5Kg/m at pressure
2With its compacting, the preparation macromolecule water absorbent material is labeled as A
1
Embodiment 7
ES short fiber and paper pulp are blended under 130 ℃ through air forming, add sodium polyacrylate in the 10:1 ratio then, pass through air forming again, spray structure glue after, non-woven fabrics is pasted in both sides, be 5Kg/m at pressure
2With its compacting, the preparation macromolecule water absorbent material is labeled as A
2
Embodiment 8
ES short fiber and paper pulp are blended under 130 ℃ through air forming, add sodium polyacrylate in the 5:1 ratio then, pass through air forming again, spray structure glue after, non-woven fabrics is pasted in both sides, be 5Kg/m at pressure
2With its compacting, the preparation macromolecule water absorbent material is labeled as A
3
Water absorbing properties: with the dry macromolecule water absorbent material W that weighs
1, put into then and placed 30 minutes after beaker adds distilled water, then macromolecule water absorbent material is taken out, clean surface moisture with absorbent paper, be weighed as W once more
2Utilize formula (W
2-W
1)/W
1* 100%=water absorption rate.A
1Water absorption rate be 300, A
2Water absorption rate be 600, A
3Water absorption rate be 1200.
Claims (3)
1. the manufacture method of a composite antibiosis surgical dressing is characterized in that comprising the steps:
1) preparation of nanometer silver/chitosan film
Carboxymethyl chitosan is dissolved in distilled water, processes the carboxymethyl chitosan sugar juice of mass concentration 4%, and, stir and process nanometer silver/chitosan suspension to the nanometer silver powder that wherein adds 1-2wt%; Then nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens and toast continuously, be prepared into nanometer silver/chitosan film;
2) macromolecule water absorbent material preparation
ES short fiber and paper pulp are blended under 130 ℃ through air forming; Ratio in shaping thing and sodium polyacrylate mass ratio 20 ~ 5:1 is sprayed at the surface with the sodium polyacrylate powder then; Pass through air forming again, after the sprinkling structure glue, paste non-woven fabrics in both sides; Compacting then, the preparation macromolecule water absorbent material;
3) dressing molding
Nanometer silver/chitosan film is embedded in macromolecule water absorbent material, is pasted on polyamine base Ethyl formate thin film then together.
2. method for preparing according to claim 1 is characterized in that, in the step (1), nanometer silver/chitosan suspension is put into 60 ℃ of baking ovens toasted 40 hours continuously, is prepared into nanometer silver/chitosan film.
3. method for preparing according to claim 1 is characterized in that, in the step (2), uses 5Kg/m
2Pressure will be pasted the shaping thing compacting of non-woven fabrics, the preparation macromolecule water absorbent material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102161437A CN102688520A (en) | 2012-06-28 | 2012-06-28 | Preparation method of composite antibacterial surgical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102161437A CN102688520A (en) | 2012-06-28 | 2012-06-28 | Preparation method of composite antibacterial surgical dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102688520A true CN102688520A (en) | 2012-09-26 |
Family
ID=46854361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102161437A Pending CN102688520A (en) | 2012-06-28 | 2012-06-28 | Preparation method of composite antibacterial surgical dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102688520A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871953A (en) * | 2012-10-09 | 2013-01-16 | 姜志银 | Super-absorbent adsorption suppository |
| CN105147644A (en) * | 2015-09-26 | 2015-12-16 | 谈伟强 | Novel chitosan application and preparing method thereof |
| CN105624920A (en) * | 2016-02-26 | 2016-06-01 | 湖北立天生物工程有限公司 | Highly-antibacterial novel slightly-soluble nonwoven cloth capable of adsorbing heavy metal particles |
| CN108866809A (en) * | 2018-07-13 | 2018-11-23 | 合肥洁诺医疗用品有限公司 | A kind of non-woven fabrics that medical bed is applied alone antifouling property good |
| CN115462963A (en) * | 2022-10-17 | 2022-12-13 | 刘建华 | Wound surface plaster and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86106747A (en) * | 1986-10-06 | 1988-04-20 | 上海申达羽绒制品公司 | Compound hygienic material |
| US20090130186A1 (en) * | 2002-06-14 | 2009-05-21 | Hemcon Medical Technologies, Inc. | Wound dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan and incorporating silver nanoparticles |
| CN101537204A (en) * | 2008-03-18 | 2009-09-23 | 威海威高创新有限公司 | Medical nanometer antibacterial composite dressing and method for preparing same |
| WO2011077096A1 (en) * | 2009-12-24 | 2011-06-30 | Advanced Medical Solutions Limited | Absorbent material comprising carboxymethyl chitosan, chitosan and an antimicrobial agent |
| CN102302398A (en) * | 2011-08-15 | 2012-01-04 | 万绵水 | Wound treatment device |
| CN102512290A (en) * | 2011-12-23 | 2012-06-27 | 大连创达技术交易市场有限公司 | Breathable instant-absorbing health-care diaper for babies |
-
2012
- 2012-06-28 CN CN2012102161437A patent/CN102688520A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86106747A (en) * | 1986-10-06 | 1988-04-20 | 上海申达羽绒制品公司 | Compound hygienic material |
| US20090130186A1 (en) * | 2002-06-14 | 2009-05-21 | Hemcon Medical Technologies, Inc. | Wound dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan and incorporating silver nanoparticles |
| CN101537204A (en) * | 2008-03-18 | 2009-09-23 | 威海威高创新有限公司 | Medical nanometer antibacterial composite dressing and method for preparing same |
| WO2011077096A1 (en) * | 2009-12-24 | 2011-06-30 | Advanced Medical Solutions Limited | Absorbent material comprising carboxymethyl chitosan, chitosan and an antimicrobial agent |
| CN102302398A (en) * | 2011-08-15 | 2012-01-04 | 万绵水 | Wound treatment device |
| CN102512290A (en) * | 2011-12-23 | 2012-06-27 | 大连创达技术交易市场有限公司 | Breathable instant-absorbing health-care diaper for babies |
Non-Patent Citations (4)
| Title |
|---|
| 《Biomacromolecules》 20060325 Ying Wan等 "Biodegradable Polylactide/Chitosan Blend Membranes" 第1362-1372页 全文 第7卷, 第4期 * |
| 《交通医学》 20090430 罗勇华等 ""纳米银/羧甲基壳聚糖"生物敷料的研制、表征及抑菌试验研究" 第141-144页 1-3 第23卷, 第2期 * |
| YING WAN等: ""Biodegradable Polylactide/Chitosan Blend Membranes"", 《BIOMACROMOLECULES》, vol. 7, no. 4, 25 March 2006 (2006-03-25), pages 1362 - 1372 * |
| 罗勇华等: """纳米银/羧甲基壳聚糖"生物敷料的研制、表征及抑菌试验研究"", 《交通医学》, vol. 23, no. 2, 30 April 2009 (2009-04-30), pages 141 - 144 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871953A (en) * | 2012-10-09 | 2013-01-16 | 姜志银 | Super-absorbent adsorption suppository |
| CN105147644A (en) * | 2015-09-26 | 2015-12-16 | 谈伟强 | Novel chitosan application and preparing method thereof |
| CN105624920A (en) * | 2016-02-26 | 2016-06-01 | 湖北立天生物工程有限公司 | Highly-antibacterial novel slightly-soluble nonwoven cloth capable of adsorbing heavy metal particles |
| CN105624920B (en) * | 2016-02-26 | 2018-11-16 | 湖北立天生物工程有限公司 | A kind of high antibacterial, the novel slightly soluble non-woven fabrics for adsorbing heavy metal molecule |
| CN108866809A (en) * | 2018-07-13 | 2018-11-23 | 合肥洁诺医疗用品有限公司 | A kind of non-woven fabrics that medical bed is applied alone antifouling property good |
| CN115462963A (en) * | 2022-10-17 | 2022-12-13 | 刘建华 | Wound surface plaster and preparation method thereof |
| CN115462963B (en) * | 2022-10-17 | 2024-06-18 | 刘建华 | Wound surface application and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103961738B (en) | A kind of chitosan-nanometer silver wound dressing and preparation method thereof | |
| CN102688520A (en) | Preparation method of composite antibacterial surgical dressing | |
| CN103120803B (en) | Preparation method of bacterial cellulose composite chitosan moist antimicrobial dressing | |
| CN101905031B (en) | Method for preparing flamazine/bacterial cellulose composite wound dressing | |
| KR101379249B1 (en) | Antimicrobial sanitary non-weaven fabric, and sanitary products using thereof, and method of producing the same | |
| CN103194856B (en) | The preparation method of the shitosan/silk gum composite nano fiber of antibacterial, wound healing effect | |
| CN104231299A (en) | Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing | |
| CN107296975A (en) | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof | |
| CN109350762A (en) | A kind of medical dressing and preparation method thereof applied to chronic wound | |
| CN103074777A (en) | Silver-loaded alginate fiber and preparation method thereof | |
| CN105126159A (en) | Biomedical polysaccharide colloidal solution and preparation method thereof | |
| CN108066808B (en) | Negative ion sanitary towel and preparation method thereof | |
| CN105147644A (en) | Novel chitosan application and preparing method thereof | |
| CN107854716A (en) | A kind of antibacterial dehumidification type dressing patch and preparation method thereof | |
| CN104784739B (en) | A kind of preparation method for carrying flamazine compound antiseptic dressing | |
| CN108969791B (en) | Composite wound dressing loaded with nano-silver and preparation method thereof | |
| CN206026745U (en) | Anti bacteria dressing of slowly -releasing | |
| CN1706503A (en) | Antibiotic aerogel dressing of hollow acetate fiber and its prepn | |
| CN103394117B (en) | Self-adhesive type composite active carbon fiber dressing and preparation method thereof | |
| CN101019793A (en) | Interactive medical wet dressing and its prepn and application | |
| CN204158771U (en) | A kind of Bacterial cellulose/chitosan composite sponge dressing | |
| CN107185026B (en) | Preparation method of medical konjac glucomannan antibacterial dressing | |
| CN103736146B (en) | Method for preparing silver-loaded non-woven fabric | |
| CN204563043U (en) | A kind of chitosan dressing | |
| CN114288090A (en) | Preparation method of disposable hygienic product with oxygen slow release function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120926 |