CN115462963A - Wound surface plaster and preparation method thereof - Google Patents
Wound surface plaster and preparation method thereof Download PDFInfo
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- CN115462963A CN115462963A CN202211268348.XA CN202211268348A CN115462963A CN 115462963 A CN115462963 A CN 115462963A CN 202211268348 A CN202211268348 A CN 202211268348A CN 115462963 A CN115462963 A CN 115462963A
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- woven fabric
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
- A61F13/0206—Adhesive plasters or dressings having a fluid handling member the fluid handling member being absorbent fibrous layer, e.g. woven or nonwoven absorbent pad, island dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00731—Plasters means for wound humidity control with absorbing pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00906—Plasters containing means for transcutaneous or transdermal drugs application
Abstract
The application provides a wound dressing and a preparation method thereof, and relates to the technical field of medical instruments. A wound dressing sequentially comprises: release paper, antibacterial surface layer non-woven fabric, absorptive core layer, PE basement membrane, and bottom layer non-woven fabric. The absorbent core layer is a core body formed by making a core layer from plant fibers, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper by an air-laid technology, and then performing light pressing and net pressing. The wound surface plaster prepared by the application has the functions of absorbing water, locking water, absorbing seepage and bleeding, resisting bacteria and diminishing inflammation, inhibiting inflammatory reaction, removing putrefaction and promoting granulation, cooling and easing pain, and deodorizing with fragrance, can be used for nursing non-chronic wound surfaces, and provides a microenvironment for wound surface healing. Can also be used for nursing and fixing a puncture site of a puncture device (such as a catheter), and has wide application.
Description
Technical Field
The application relates to the technical field of medical wound application, in particular to a wound surface application and a preparation method thereof.
Background
The wound surface application, also known as a band-aid, has the functions of stopping bleeding and protecting wound, and is a surgical medical instrument most commonly used in life of people. The first application is mainly composed of gauze, and the adhesive tape is needed to be attached to the skin around the wound surface when in use.
In 2015, 7 months, the medical apparatus classification rules (No. 15) issued by the State food and drug administration headquarters was performed from 2016, 1/1. Wherein, 14 types and 10 categories of the product are 14 subclasses of wound surface application (II types), and all the products do not simultaneously have the functions of absorbing water and locking water, absorbing seepage and bleeding, resisting bacteria and diminishing inflammation and inhibiting inflammatory reaction, and can not meet the clinical requirements under new conditions.
Disclosure of Invention
The application aims to provide a wound surface dressing, which has the functions of absorbing water, locking water, absorbing seepage, seeping blood, resisting bacteria, diminishing inflammation and inhibiting inflammatory reaction.
Another object of the present application is to provide a preparation method of the wound dressing, which is simple and convenient.
The technical problem to be solved by the application is solved by adopting the following technical scheme.
On the one hand, this application embodiment provides a wound surface is applied ointment or plaster, includes in proper order: release paper, antibacterial surface layer non-woven fabric, absorptive core layer, PE basement membrane, and bottom layer non-woven fabric. The absorptive core layer is a core body which is formed by carrying out light pressing and net pressing on a core layer which is prepared by plant fiber, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper through an air-laid technology; wherein the antibacterial surface layer non-woven fabric is adhered to the release paper; the bottom layer non-woven fabric is adhered to the absorbent core layer through the PE bottom film.
On the other hand, the embodiment of the application provides a preparation method of the wound dressing, which comprises the following steps:
crushing the plant pulp board by a crushing system to obtain plant fibers, mixing the plant fibers with crushed sodium alginate, super absorbent resin material and functional material to obtain a particle composition, wrapping the particle composition by using toilet paper as an upper layer and a lower layer, preparing a core layer by using an air-laid technology, and then forming an absorbent core layer by using light pressure and net pressure;
set up antibiotic top layer non-woven fabrics on the upper strata of absorption core layer, the lower floor sets gradually PE basement membrane and bottom non-woven fabrics, and the compound semi-manufactured goods that forms, after the stain detects at the upper adhesion of antibiotic top layer non-woven fabrics from type paper, the preparation obtains the surface of a wound is applied ointment or plaster.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
the wound surface dressing comprises release paper, antibacterial surface layer non-woven fabric, an absorbable core layer, a PE base membrane and a bottom layer non-woven fabric. The absorbent core layer is formed by making a core layer from plant fiber, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper by an air-laid technology, and then performing light pressing and net pressing. The core body is wrapped with non-woven fabrics up and down, wherein the non-woven fabrics on the surface layer are soaked with the antibacterial material and are adhered with release paper to be adhered with the skin around the wound surface; the inner layer of non-woven fabric is adhered with the PE bottom film and the core layer. The components can not be absorbed by human body, and can be provided aseptically for disposable use.
The wound dressing prepared by the application has the functions of super water absorption, water locking, seepage and blood seepage absorption, antibiosis and inflammation diminishing, inflammatory reaction inhibition, slough removal and granulation promotion, cooling and pain relief, and fragrance deodorization, can be used for nursing non-chronic wounds (such as superficial wounds, postoperative suture wounds, mechanical wounds, small wounds, bruises, cut wounds, puncture positions of puncture instruments, I-degree or superficial II-degree burn wounds, infant navel wounds, laser/photon/tartaric acid skin change/micro-plastic postoperative wounds), and provides a microenvironment for wound healing. Can also be used for nursing and fixing the puncture site of a puncture device (such as a catheter), and has wide application.
Drawings
To more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and those skilled in the art can also obtain other related drawings based on the drawings without inventive efforts.
FIG. 1 is a flow chart of a manufacturing process for an embodiment of the present application;
fig. 2 is a diagram of a finished product of the product in example 1 of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
A wound dressing sequentially comprises: release paper, antibacterial surface layer non-woven fabric, absorptive core layer, PE base membrane, and bottom layer non-woven fabric. The absorptive core layer is a core body which is formed by carrying out light pressing and net pressing on a core layer which is prepared by plant fiber, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper through an air-laid technology; wherein the antibacterial surface layer non-woven fabric is adhered to the release paper; the bottom layer non-woven fabric is adhered to the absorbent core layer through the PE base film.
The wound surface dressing comprises release paper, antibacterial surface layer non-woven fabric, an absorbable core layer, a PE base membrane and a bottom layer non-woven fabric. The absorbent core layer is formed by making a core layer from plant fiber, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper by an air-laid technology, and then performing light pressing and net pressing. The core body is wrapped with non-woven fabrics up and down, wherein the non-woven fabrics on the surface layer are soaked with the antibacterial material and are adhered with release paper to be adhered with the skin around the wound surface; the inner layer of non-woven fabric is adhered with the PE bottom film and the core layer. The components can not be absorbed by human body, and can be provided aseptically for disposable use.
The wound dressing prepared by the application has the functions of super-strong water absorption and water locking, seepage and blood seepage absorption, antibiosis and inflammation diminishing, inflammatory reaction inhibition, slough removal and granulation promotion, cooling and pain relief, and fragrance deodorization, can be used for nursing non-chronic wounds (such as superficial wounds, postoperative suture wounds, mechanical wounds, small wounds, bruises, cut wounds, puncture positions of puncture instruments, I-degree or superficial II-degree burn and scald wounds, infant navel wounds, and laser/photon/tartaric acid skin-changing/micro-plastic postoperative wounds), and provides a microenvironment for wound healing. Can also be used for nursing the puncture site of the puncture device (such as a catheter) and fixing the puncture device. Has wide application.
In some embodiments of the present application, the superabsorbent resin material is sodium polyacrylate.
In some embodiments of the present application, the above plant fiber, sodium alginate and super absorbent resin material are added in a mass ratio of (3-7): (3-7): (88-92).
In some embodiments of the present application, the functional material comprises menthol and borneol.
A preparation method of a wound dressing comprises the following steps:
crushing a plant pulp board by a crushing system to obtain plant fibers, mixing the plant fibers with crushed sodium alginate, a super absorbent resin material and a functional material to obtain a particle composition with a uniformly distributed reticular structure, wrapping the particle composition by using toilet paper as an upper layer and a lower layer, preparing a core layer by using an air-laid technology, and forming an absorbent core layer by using light pressure and net pressure;
set up antibiotic top layer non-woven fabrics on the upper strata of absorption core layer, the lower floor sets gradually PE basement membrane and bottom non-woven fabrics, and the compound semi-manufactured goods that forms, after the stain detects at the upper adhesion of antibiotic top layer non-woven fabrics from type paper, the preparation obtains the surface of a wound and applies ointment or plaster.
In some embodiments of the present application, the length of the plant fiber is between 1.8 and 2.3mm, the length of the sodium alginate fiber is between 3 and 4mm, and the particle size of the super absorbent resin material is 200 to 300 mesh.
In some embodiments of the present application, the above-mentioned functional material has a particle size of 200 to 400 mesh after pulverization, and the amount of the functional material is 0.005 to 0.01g/cm 2 。
In some embodiments of the present application, the above mentioned light pressure is 3.5-5MPa, the temperature is 60-110 ℃, the pressure of the above mentioned net pressure is 4-6MPa, and the temperature is 80-120 ℃.
In some embodiments of the present application, the method for preparing the antibacterial surface layer nonwoven fabric comprises: the non-woven fabric is soaked in the organic silicon Ji Nayan antibacterial agent and then dried in the air.
In some embodiments of the present application, the concentration of the silicone Ji Nayan antibacterial agent is 55-65%, and the soaking time is 10-30min.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A wound dressing is prepared by the following steps of, as shown in figure 1:
crushing the plant pulp board by a crushing system to obtain plant fiber with the length of 3-4mm, mixing the plant fiber with crushed sodium alginate (the fiber length is 3-4 mm), sodium polyacrylate, menthol and borneol (the weight ratio of the plant fiber to the sodium alginate to the sodium polyacrylate is 5 2 ) Then the granular composition is obtained, the toilet paper of the upper layer, the granular composition and the toilet paper of the bottom layer are sequentially added into a die wheel device, a core layer is prepared by an air-laid technology, and then prepressing is carried out by optical pressure (4 MPa, the temperature is 80 ℃), compacting and pressing a flow guide groove are carried out by net pressure (5 MPa, the temperature is 100 ℃), and an absorbent core layer is formed;
and respectively coating non-woven fabrics on the upper surface and the lower surface of the semi-finished product of the absorbent core layer, wherein the upper non-woven fabric is an antibacterial surface layer non-woven fabric, the upper non-woven fabric is dried after being soaked in an organosilicon Ji Nayan antibacterial agent with the concentration of 60% for 10-30min, and the lower non-woven fabric is a bottom non-woven fabric and is adhered to the absorbent core layer through a PE (polyethylene) bottom membrane. And spraying glue and detecting stains, adhering a back adhesive release paper on the surface of the antibacterial surface layer non-woven fabric, cutting according to a specified size, packaging, sterilizing by using ethylene oxide, and analyzing to prepare the wound dressing of the embodiment.
The wound dressing prepared in this example is shown in fig. 2.
Example 2
A wound surface patch is prepared by the following steps:
crushing the plant pulp board by a crushing system to obtain plant fibers with the length of 3-4mm, mixing the plant fibers with crushed sodium alginate (the fiber length is 3-4 mm), sodium polyacrylate, menthol and borneol (the weight ratio of the plant fibers to the sodium alginate to the sodium polyacrylate is 3 2 ) Then the granular composition is obtained, the toilet paper of the upper layer, the granular composition and the toilet paper of the bottom layer are sequentially added into a mould wheel device, a core layer is made by the air-laid technology, then prepressing is carried out by the optical pressing (4 MPa, the temperature is 110 ℃), the net pressing (6 MPa,compacting and extruding the diversion trench at the temperature of 120 ℃ to form an absorbent core layer;
and respectively coating non-woven fabrics on the upper surface and the lower surface of the semi-finished product absorbent core layer, wherein the non-woven fabric on the upper layer is an antibacterial surface layer non-woven fabric, the non-woven fabric on the lower layer is a bottom layer non-woven fabric and is adhered to the absorbent core layer through a PE (polyethylene) base membrane after being soaked in 65% organosilicon Ji Nayan antibacterial agent for 10-30min and then dried. And then glue spraying and stain detection are carried out, gum release paper is pasted on the surface of the antibacterial surface layer non-woven fabric, the non-woven fabric is cut according to the specified size, packaged, sterilized by ethylene oxide and analyzed to prepare the wound surface patch of the embodiment.
Example 3
A wound surface patch is prepared by the following steps:
crushing the plant pulp board by a crushing system to obtain plant fiber with the length of 3-4mm, mixing the plant fiber with crushed sodium alginate (the fiber length is 3-4 mm), sodium polyacrylate, menthol and borneol (the weight ratio of the plant fiber to the sodium alginate to the sodium polyacrylate is 7 2 ) Then, adding the toilet paper, the particle composition and the bottom toilet paper into a die wheel device in sequence, preparing a core layer by an air-laid technology, prepressing by optical pressing (3 MPa, the temperature is 60 ℃), compacting by the net pressing (5 MPa, the temperature is 80 ℃) and extruding out of a diversion trench to form an absorbent core layer;
and respectively coating non-woven fabrics on the upper surface and the lower surface of the semi-finished product absorbent core layer, wherein the non-woven fabric on the upper layer is an antibacterial surface layer non-woven fabric, the non-woven fabric on the lower layer is dried after being soaked in 55% organosilicon Ji Nayan antibacterial agent for 10-30min, and the non-woven fabric on the lower layer is a bottom layer non-woven fabric and is adhered to the absorbent core layer through a PE (polyethylene) basement membrane. And then glue spraying and stain detection are carried out, gum release paper is pasted on the surface of the antibacterial surface layer non-woven fabric, the non-woven fabric is cut according to the specified size, packaged, sterilized by ethylene oxide and analyzed to prepare the wound surface patch of the embodiment.
Example 4
A wound surface patch is prepared by the following steps:
crushing plant pulp board by a crushing systemObtaining the plant fiber with the length of 3-4mm, mixing the plant fiber with the crushed sodium alginate (the fiber length is 3-4 mm), the sodium polyacrylate, the menthol and the borneol (the granularity is 400 meshes) (the weight ratio of the plant fiber to the sodium alginate to the sodium polyacrylate is 4 2 ) Then, adding the toilet paper, the particle composition and the bottom layer toilet paper pulp into a die wheel device in sequence, preparing a core layer by an air-laid technology, prepressing by optical pressure (4 MPa, the temperature is 80 ℃), compacting by the net pressure (4 MPa, the temperature is 90 ℃) and extruding out of a diversion trench to form an absorbent core layer;
and respectively coating non-woven fabrics on the upper surface and the lower surface of the semi-finished product absorbent core layer, wherein the non-woven fabric on the upper layer is an antibacterial surface layer non-woven fabric, the non-woven fabric on the lower layer is a bottom layer non-woven fabric and is adhered to the absorbent core layer through a PE (polyethylene) base membrane after being soaked in an organosilicon Ji Nayan antibacterial agent with the concentration of 60% for 10-30min and then dried. And then glue spraying and stain detection are carried out, gum release paper is pasted on the surface of the antibacterial surface layer non-woven fabric, the non-woven fabric is cut according to the specified size, packaged, sterilized by ethylene oxide and analyzed to prepare the wound surface patch of the embodiment.
Experimental example 1
The wound dressing prepared in example 1 of the present application was compared with a conventional dressing on the market, and the results are shown in table 1.
TABLE 1
As can be seen from table 1, the wound dressing prepared by the present application has better performance than the existing products.
Experimental example 2
The wound dressings prepared in examples 1 to 4 of the present application were tested.
1. The items and criteria are as follows:
1.1, appearance: the surface of the product should be flat, and the back patch, the application pad and the protective layer should not be separated.
1.2, size: the size of the product is required to meet the specification and size requirements of the product.
1.3, pH value: should be in the range of 5.5-8.5.
1.4, water absorption: the water absorption of the wound dressing is more than or equal to 300.0g/10g.
1.5, comfort: the non-woven water-absorbing fiber cloth has the length of more than 110mm, the extensibility of less than or equal to 50N/cm and the permanent deformation of less than or equal to 30 percent.
1.6, surface layer non-woven fabric bacteriostatic effect:
gram-positive bacteria: staphylococcus aureus (ATCC 6538), bacteriostasis rate/(%) is more than or equal to 80
Gram-negative bacteria: escherichia coli (ATCC 29522) with bacteriostasis rate/(%) of not less than 70
Fungi: candida albicans (ATCC 10231), bacteriostasis rate/(%) is more than or equal to 60
1.7, viscosity retention: the holding viscosity of the back paste is not more than 2.5mm.
1.8, back adhesive peel strength: the peel strength of the back paste is not lower than 1N/cm.
1.9, microorganism indexes: the wound surface application should be sterile.
1.10, residual amount of ethylene oxide: the wound surface application is sterilized by ethylene oxide, and the residual quantity of the ethylene oxide is not more than 10 mu g/g.
2. Test method and results
2.1 appearance: the result meets the requirement of 1.1 by observation and verification of normal or corrected eyesight.
2.2 size: the vernier caliper is used for detecting the sizes of products of different models, and the result meets the requirement of 1.2.
2.3pH value: taking 1g of a sample, soaking the sample in 50ml of purified water for 30 minutes, pouring the filtrate into a beaker, placing the beaker into a conical flask, sealing the conical flask by using a rubber stopper, placing the conical flask into a constant-temperature water bath, shaking the conical flask for five times at a constant temperature of 60 +/-2 ℃, swelling the conical flask for 10 minutes, cooling the conical flask to room temperature, and testing the conical flask according to the pH value measurement method of annex PH value in the 2020 edition of pharmacopoeia of the people's republic of China, wherein the measurement result meets the requirement of 1.3.
2.4 Water absorption: the pad was cut off, weighed with a scale of 0.01g and recorded as M 1 Making the dressing layer face downward, laying on water surface at 20 + -2 deg.C, holding a corner with small forceps after 5min, taking out, slightly inclining for 10s, weighing as M 2 The water absorption X (%) was calculated according to the formula.
The measurement results meet the requirement of 1.4.
2.5, comfort: taking 3 samples, and carrying out contact wound auxiliary material test according to YY/T0471.1-2004 part 4: comfort test method 1.2.
(1) The test conditions are as follows: temperature (21 + -2 deg.C), relative humidity (60 + -15%), and state condition for at least 16h.
(2) The nonwoven water-absorbent fiber cloth (including air-permeable adhesive tapes of the same area and bonded together) in the test piece was cut into a test piece (25.0 + -0.5) mm wide.
(3) It is relaxed for at least 300s.
(4) Two parallel marks were made on the test article at a distance of (100. + -.10) mm, and the two distances were equidistant from both ends.
(5) The distance between the two marks is measured to the nearest 0.5mm (L1).
(6) The sample was marked off-clamped in the two jaws of a 180 degree peel strength tester and the sample was elongated by 20% at a tensile speed of (300 + -10) mm/min and the maximum load ML recorded to the nearest 0.1N.
(7) The test piece was held at this stretched position (60. + -.1) s, removed from the chuck and relaxed (300. + -.15) s.
(8) The distance between the two marks on the test article is re-measured to the nearest 0.5mm (L2).
(9) And (3) calculating: extensibility = ML/2.5; permanent set = (L2-L1)/L1 × 100%.
And (4) judging a result: all 3 tablets are qualified according to the standard requirement.
2.6 surface layer non-woven fabrics antibacterial effect: the requirements of 1.6 are met according to the test of an annex D quinine method of FZ/T73023-2006 antibacterial knitwear.
2.7 Hold-tack: the test was carried out according to the method in appendix B2 of YY/T0148-2006, the result of which satisfied the requirement of 1.7.
2.8 Peel Strength: the test is carried out according to the method of the appendix B3 of YY/T0148-2006, and the result meets the requirement of 1.8.
2.9 microbiological indicators: 5 pieces of the sample are taken and tested according to sterile detection method of the pharmacopoeia of the people's republic of China 2020 edition, and the measurement result meets the requirement of 1.9.
2.10 residual amount of ethylene oxide: 5 pieces of samples were taken and evaluated according to GB/T16886.7, part 7 of the biological evaluation of medical instruments: ethylene oxide residual quantity detection method-gas chromatography inspection, the measurement result meets the requirement of 1.10.
In summary, the wound dressing and the preparation method thereof provided by the embodiment of the application have the following advantages:
the wound surface dressing comprises release paper, antibacterial surface layer non-woven fabric, an absorbable core layer, a PE base membrane and a bottom layer non-woven fabric. The absorbent core layer is formed by making a core layer from plant fiber, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper by an air-laid technology, and then performing light pressing and net pressing. The core body is wrapped with non-woven fabrics up and down, wherein the non-woven fabrics on the surface layer are soaked with the antibacterial material and are adhered with release paper to be adhered with the skin around the wound surface; the inner layer of non-woven fabric is adhered with the PE bottom film and the core layer. The components can not be absorbed by human body, and can be provided aseptically for disposable use.
The wound dressing prepared by the application has the functions of super water absorption, water locking, seepage and blood seepage absorption, antibiosis and inflammation diminishing, inflammatory reaction inhibition, slough removal and granulation promotion, cooling and pain relief, and fragrance deodorization, can be used for nursing non-chronic wounds (such as superficial wounds, postoperative suture wounds, mechanical wounds, small wounds, bruises, cut wounds, puncture positions of puncture instruments, I-degree or superficial II-degree burn wounds, infant navel wounds, laser/photon/tartaric acid skin change/micro-plastic postoperative wounds), and provides a microenvironment for wound healing. Can also be used for nursing and fixing the puncture site of a puncture device (such as a catheter), and has wide application.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. A wound surface patch is characterized by sequentially comprising: release paper, antibacterial surface layer non-woven fabric, absorptive core layer, PE base membrane and bottom layer non-woven fabric; the absorbent core layer is a core body formed by making a core layer from plant fibers, sodium alginate, a super absorbent resin material, a functional material and upper and lower layers of toilet paper by an air-laid technology, and then performing light pressing and net pressing; wherein the antibacterial surface layer non-woven fabric is adhered to the release paper; the bottom layer non-woven fabric is adhered to the absorbent core layer through the PE bottom film.
2. A wound dressing according to claim 1, wherein the super absorbent resin material is sodium polyacrylate.
3. A wound dressing according to claim 1, wherein the plant fiber, sodium alginate and super absorbent resin material are added in a mass ratio of (3-7): (3-7): (88-92).
4. A wound dressing according to claim 1, wherein the functional material comprises menthol and borneol.
5. A method of preparing a wound dressing according to any of claims 1 to 4, comprising the steps of:
crushing the plant pulp board by a crushing system to obtain plant fibers, mixing the plant fibers with crushed sodium alginate, super absorbent resin material and functional material to obtain a particle composition, wrapping the particle composition by using toilet paper as an upper layer and a lower layer, preparing a core layer by using an air-laid technology, and then forming an absorbent core layer by using light pressure and net pressure;
set up antibiotic top layer non-woven fabrics on the upper strata of absorption core layer, the lower floor sets gradually PE basement membrane and bottom non-woven fabrics, and the compound semi-manufactured goods that forms, after the stain detects at the upper adhesion of antibiotic top layer non-woven fabrics from type paper, the preparation obtains the surface of a wound is applied ointment or plaster.
6. The method for preparing a wound dressing according to claim 5, wherein the fiber length of the plant fiber is between 1.8 mm and 2.3mm, the fiber length of the sodium alginate is between 3mm and 4mm, and the particle size of the super absorbent resin material is 200-300 meshes.
7. A method for preparing a wound dressing according to claim 5, wherein the particle size of the pulverized functional material is 200-400 mesh, and the amount of the functional material is 0.005-0.01g/cm 2 。
8. A method for preparing a wound dressing according to claim 5, wherein the pressure of said light pressure is 3.5-5MPa, the temperature is 60-110 ℃, the pressure of said mesh pressure is 4-6MPa, and the temperature is 80-120 ℃.
9. A method for preparing a wound dressing according to claim 5, wherein the method for preparing the antibacterial surface non-woven fabric comprises: the non-woven fabric is soaked in the organic silicon Ji Nayan antibacterial agent and then dried in the air.
10. A method for preparing a wound dressing according to claim 9, wherein the concentration of the silicone Ji Nayan antibacterial agent is 55-65%, and the soaking time is 10-30min.
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Citations (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681579A (en) * | 1993-03-22 | 1997-10-28 | E.R. Squibb & Sons, Inc. | Polymeric support wound dressing |
| CN1830409A (en) * | 2005-03-09 | 2006-09-13 | 中国人民解放军军事医学科学院卫生装备研究所 | Emergency wound dressing and its preparation method |
| US20110313383A1 (en) * | 2008-12-23 | 2011-12-22 | Juergen Hofstetter | Wound dressing |
| CN102688520A (en) * | 2012-06-28 | 2012-09-26 | 武汉大学 | Preparation method of composite antibacterial surgical dressing |
| CN103142356A (en) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | Cationic wound repair paste and preparation method thereof |
| WO2014140608A1 (en) * | 2013-03-15 | 2014-09-18 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| CN204169985U (en) * | 2014-09-29 | 2015-02-25 | 广东泰宝医疗科技股份有限公司 | One is compound protects wound dressing |
| CN104665994A (en) * | 2013-12-03 | 2015-06-03 | 杭州可靠护理用品股份有限公司 | Pressing technology for nursing mat |
| CN104783966A (en) * | 2015-03-12 | 2015-07-22 | 浙江好时加卫生用品有限公司 | Method for producing antibacterial sanitary towel |
| CN104783970A (en) * | 2015-03-12 | 2015-07-22 | 浙江好时加卫生用品有限公司 | Manufacturing method of ecological diapers |
| CN204814428U (en) * | 2015-07-30 | 2015-12-02 | 南阳市汇博生物技术有限公司 | Dressing of compound activated carbon fiber wound |
| CN205181865U (en) * | 2015-10-13 | 2016-04-27 | 广东泰宝医疗科技股份有限公司 | Double -deck compound wound dressing that protects |
| CN106377791A (en) * | 2016-09-06 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Bamboo alginate functional dressing and preparation method thereof |
| CN106488758A (en) * | 2014-06-30 | 2017-03-08 | 尤妮佳股份有限公司 | Absorbent commodity |
| CN107432787A (en) * | 2016-05-25 | 2017-12-05 | 天津科技大学 | A kind of biological antibiotic hydroscopic sanitary material and preparation method |
| CN107519522A (en) * | 2017-09-19 | 2017-12-29 | 广州暨南生物医药研究开发基地有限公司 | A kind of paper diaper for infant and preparation method thereof |
| CN109224116A (en) * | 2018-09-01 | 2019-01-18 | 成都市水泷头化工科技有限公司 | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable |
| CN110314042A (en) * | 2018-03-30 | 2019-10-11 | 广东娜菲实业股份有限公司 | A kind of unidirectional high moisture-inhibiting paper diaper and preparation method thereof |
| CN110662517A (en) * | 2017-06-14 | 2020-01-07 | T.J.史密夫及内修有限公司 | Negative pressure wound therapy device |
| CN210020501U (en) * | 2018-11-22 | 2020-02-07 | 河南汇博医疗股份有限公司 | Antibacterial alginate dressing |
| CN111481346A (en) * | 2020-06-10 | 2020-08-04 | 吉林大学 | Silica gel plaster and use method and application thereof |
| CN112587314A (en) * | 2020-12-30 | 2021-04-02 | 英氏控股集团股份有限公司 | Biodegradable sports growth trousers |
| CN113242726A (en) * | 2018-12-21 | 2021-08-10 | 保罗·哈特曼股份公司 | Super absorbent wound dressing with silicone wound contact layer |
| CN113242727A (en) * | 2018-12-21 | 2021-08-10 | 保罗·哈特曼股份公司 | Super absorbent wound dressing with silicone wound contact layer |
| CN214679180U (en) * | 2020-12-10 | 2021-11-12 | 河南以斯帖生物科技有限公司 | Functional dressing with alginate |
| CN114469530A (en) * | 2022-03-10 | 2022-05-13 | 嫒赟（上海）生物科技股份有限公司 | Nano silver antibacterial sanitary towel |
-
2022
- 2022-10-17 CN CN202211268348.XA patent/CN115462963A/en active Pending
Patent Citations (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681579A (en) * | 1993-03-22 | 1997-10-28 | E.R. Squibb & Sons, Inc. | Polymeric support wound dressing |
| CN1830409A (en) * | 2005-03-09 | 2006-09-13 | 中国人民解放军军事医学科学院卫生装备研究所 | Emergency wound dressing and its preparation method |
| US20110313383A1 (en) * | 2008-12-23 | 2011-12-22 | Juergen Hofstetter | Wound dressing |
| CN102688520A (en) * | 2012-06-28 | 2012-09-26 | 武汉大学 | Preparation method of composite antibacterial surgical dressing |
| CN103142356A (en) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | Cationic wound repair paste and preparation method thereof |
| CN105188780A (en) * | 2013-03-15 | 2015-12-23 | 史密夫及内修公开有限公司 | Wound dressing sealant and use thereof |
| WO2014140608A1 (en) * | 2013-03-15 | 2014-09-18 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| CN104665994A (en) * | 2013-12-03 | 2015-06-03 | 杭州可靠护理用品股份有限公司 | Pressing technology for nursing mat |
| CN106488758A (en) * | 2014-06-30 | 2017-03-08 | 尤妮佳股份有限公司 | Absorbent commodity |
| CN204169985U (en) * | 2014-09-29 | 2015-02-25 | 广东泰宝医疗科技股份有限公司 | One is compound protects wound dressing |
| CN104783970A (en) * | 2015-03-12 | 2015-07-22 | 浙江好时加卫生用品有限公司 | Manufacturing method of ecological diapers |
| CN104783966A (en) * | 2015-03-12 | 2015-07-22 | 浙江好时加卫生用品有限公司 | Method for producing antibacterial sanitary towel |
| CN204814428U (en) * | 2015-07-30 | 2015-12-02 | 南阳市汇博生物技术有限公司 | Dressing of compound activated carbon fiber wound |
| CN205181865U (en) * | 2015-10-13 | 2016-04-27 | 广东泰宝医疗科技股份有限公司 | Double -deck compound wound dressing that protects |
| CN107432787A (en) * | 2016-05-25 | 2017-12-05 | 天津科技大学 | A kind of biological antibiotic hydroscopic sanitary material and preparation method |
| CN106377791A (en) * | 2016-09-06 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Bamboo alginate functional dressing and preparation method thereof |
| CN110662517A (en) * | 2017-06-14 | 2020-01-07 | T.J.史密夫及内修有限公司 | Negative pressure wound therapy device |
| CN107519522A (en) * | 2017-09-19 | 2017-12-29 | 广州暨南生物医药研究开发基地有限公司 | A kind of paper diaper for infant and preparation method thereof |
| CN110314042A (en) * | 2018-03-30 | 2019-10-11 | 广东娜菲实业股份有限公司 | A kind of unidirectional high moisture-inhibiting paper diaper and preparation method thereof |
| CN109224116A (en) * | 2018-09-01 | 2019-01-18 | 成都市水泷头化工科技有限公司 | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable |
| CN210020501U (en) * | 2018-11-22 | 2020-02-07 | 河南汇博医疗股份有限公司 | Antibacterial alginate dressing |
| CN113242726A (en) * | 2018-12-21 | 2021-08-10 | 保罗·哈特曼股份公司 | Super absorbent wound dressing with silicone wound contact layer |
| CN113242727A (en) * | 2018-12-21 | 2021-08-10 | 保罗·哈特曼股份公司 | Super absorbent wound dressing with silicone wound contact layer |
| CN111481346A (en) * | 2020-06-10 | 2020-08-04 | 吉林大学 | Silica gel plaster and use method and application thereof |
| CN214679180U (en) * | 2020-12-10 | 2021-11-12 | 河南以斯帖生物科技有限公司 | Functional dressing with alginate |
| CN112587314A (en) * | 2020-12-30 | 2021-04-02 | 英氏控股集团股份有限公司 | Biodegradable sports growth trousers |
| CN114469530A (en) * | 2022-03-10 | 2022-05-13 | 嫒赟（上海）生物科技股份有限公司 | Nano silver antibacterial sanitary towel |
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