CN102866112A - Six-freedom-degree micro-fluidic control chip absorption spectrum detection support - Google Patents

Six-freedom-degree micro-fluidic control chip absorption spectrum detection support Download PDF

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Publication number
CN102866112A
CN102866112A CN2012103421696A CN201210342169A CN102866112A CN 102866112 A CN102866112 A CN 102866112A CN 2012103421696 A CN2012103421696 A CN 2012103421696A CN 201210342169 A CN201210342169 A CN 201210342169A CN 102866112 A CN102866112 A CN 102866112A
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China
Prior art keywords
arm
micro
fluidic chip
telescopic
detection
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CN2012103421696A
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Chinese (zh)
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CN102866112B (en
Inventor
张荣标
杨宁
徐佩锋
张磊
张永春
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Jiangsu University
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Jiangsu University
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Abstract

The invention discloses a six-freedom-degree micro-fluidic control chip absorption spectrum detection support which is used for the detecting and testing absorbance of a micro-fluidic chip, and the support is provided with an x-directional detection supporting arm, a y-directional detection supporting arm and a z-directional supporting arm, wherein the x-directional, y-directional and the z-directional supporting arms respectively support a corresponding x-directional detection connecting arm, a y-directional detection connecting arm and a z-directional detection connecting arm, the middle position of the support is fixedly connected with four micro-fluidic chip loading arms, the x-directional detection connecting arm, the y-directional detection connecting arm and the z-directional connecting arm are respectively, correspondently and fixedly connected with every two of x-directional, y-directional and z-directional detection optical-fiber loading arms, the micro-fluidic chip loading arm is a hollow tube internally sleeved with a telescopic connecting arm, and an extension end of the telescopic connecting arm is connected with a micro-fluidic chip loading clamp; each detection optical-fiber loading arm is a hollow tube internally sleeved with a telescopic-type crank arm, the extension end of the telescopic-type crank arm is a hollow tube internally sleeved with a telescopic collimation mirror loading arm, the extension end of the telescopic collimation mirror loading arm is fixedly connected with a collimation mirror connecting bushing, and the collimation mirror connecting bushing is connected a collimation mirror which is connected with an optical fiber; and multi-angle detection can be simultaneously conducted on the micro-fluidic chip, and the universality is good.

Description

A kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection
Technical field
The present invention relates to micro-fluidic chip absorption spectrum Bracket for Inspection, when the micro-fluidic chip absorbance detection is tested, use.
Background technology
Microfluidic chip system is that biological, chemical experiment process micro is tested and the new technology of analyzing to only having on several centimetres the chip.The absorbance determination method is a kind of maturation and reliable analytical approach, and according to statistics, the material that accounts for material total amount 80% all has the response of absorption to ultraviolet or visible light, and the Absorbance detection method has advantages of that can to measure substance classes many, simple in structure.Therefore, the micro-fluidic chip absorbance detection technology that micro-fluidic chip is combined with the absorbance determination method becomes domestic and international study hotspot gradually.In order to realize the absorbance detection experiment of micro-fluidic chip, Chinese scholars all is the absorbance detection support according to designed microfluidic chip structure design specialized at present, and special-purpose absorbance detection support can not be transplanted the absorbance detection for other micro-fluidic chips.Yet, the absorbance detection of micro-fluidic chip can be divided into vertical detection and axially detect, and different chip structure, the detection position also varies, some micro-fluidic chips even the needs that exist simultaneously the multichannel absorbance detection to carry out simultaneously, all will redesign the micro-fluidic chip Bracket for Inspection has expended a large amount of human and material resources and financial resources at every turn, and the simultaneously design of support need to be carried out after the micro-fluidic chip design is finished, and has so just caused the waste of experimental period.
Summary of the invention
The poor defective of Bracket for Inspection versatility has proposed a kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection when the objective of the invention is for present micro-fluidic chip absorbance detection experiment.The optional position that this support can transfer to luminous source optical fiber and detection fiber access point micro-fluidic chip comprises lengthwise position and axial location, has the total space range of adjustment of six degree of freedom, and the detection of micro-fluidic chip absorbance is had preferably versatility.
For achieving the above object, the technical scheme of a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection is: this support has x, y, z to detecting sway brace, be supported with respectively corresponding x, y, z to detecting linking arm, the medium position of support is fixedly connected with four micro-fluidic chips of four jiaos that are respectively applied to clamp micro-fluidic chip and carries the dress arm, x, y, z correspondingly respectively are fixedly connected with each two x, y to detecting on the linking arm, z carries the dress arm to detection fiber, and per two the described detection fiber on the equidirectional are carried the both sides that the dress arm is arranged in micro-fluidic chip; It is the hollow tubular that inner sleeve has telescopic linking arm that described micro-fluidic chip carries the dress arm, and the external part of telescopic linking arm connects micro-fluidic chip and carries clamping; Described x, y, y carry the dress arm to detection fiber and are inner sleeve telescopic hollow tubular of cranking arm is arranged, telescopic external part of cranking arm is the hollow tubular that the telescopic collimating mirror of inner sleeve carries the dress arm, the external part that telescopic collimating mirror carries the dress arm is fixedly connected with the collimating mirror joint sleeve, and the collimating mirror joint sleeve connects the collimating mirror that joins with optical fiber; During detection, collimating mirror is relative with micro-fluidic chip check point entrance and exit and be close to.
The present invention compares with technology with existing method, has following advantage:
1, the present invention can carry out the absorbance detection of multi-angle simultaneously to micro-fluidic chip.Solve traditional absorption spectrum Bracket for Inspection and can not carry out the difficult problem that multi-angle detects to micro-fluidic chip simultaneously.
2, the present invention can adjust arbitrarily the detection position according to the structure of micro-fluidic chip, has solved the poor shortcoming of traditional micro-fluidic chip absorption spectrum Bracket for Inspection versatility.
3, the present invention adopts a kind of portable bridge to take structure, and is simple in structure, simple to operate, easy to use, has stronger portability.
4, measurement scale adjusting mechanism of the present invention adopts a kind of engagement anti-skid structure, and the detection position that fixes can not change because being subjected to extraneous factor, guarantees to detect the precision of data.
5, each several part of the present invention is flexible connection, is convenient to the expansion that optical fiber carries the dress arm, can realize that the multiple spot on the same dimension detects simultaneously.
Description of drawings
Fig. 1 is the one-piece construction schematic diagram of a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection;
Fig. 2 is the structural representation that micro-fluidic chip carries dress arm 4 among Fig. 1;
Fig. 3 is the structural representation that y carries dress arm 9 among Fig. 1 to detection fiber;
Fig. 4 is the structure cut-open view that y carries the collimating mirror 18 on the dress arm 9 among Fig. 3 to detection fiber;
Fig. 5 be among Fig. 1 y to the connection diagram that detects linking arm 3 one ends and integral support 1: Fig. 5 (a) is front elevation, and Fig. 5 (b) is left view;
Fig. 6 is the use view of a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection;
The sequence number of each parts and title in the accompanying drawing: 1. integral support body; 2.y to detecting sway brace; 3.y to detecting linking arm; 4. micro-fluidic chip carries the dress arm; 5.x to detecting linking arm; 6.z to detecting sway brace; 7.z to detecting linking arm; 8.x to detecting sway brace; 9.y carry the dress arm to detection fiber; 10.z carry the dress arm to detection fiber; 11.x carry the dress arm to detection fiber; 12. micro-fluidic chip carries clamping; 13. tension spring; 14. telescopic cranking arm; 15. fixed screw; 16. telescopic collimating mirror carries the dress arm; 17. collimating mirror joint sleeve; 18. collimating mirror; 19. simple lens; 20. collimating mirror outward turning mouth; 21. collimating mirror inward turning mouth; 22.y to the engaging tooth that detects on the sway brace 2; 23. engagement shaft collar; 24. fixed knob; 25. rotary screw; 26.y to the inward turning tooth that detects linking arm 3; 27. light source; 28. spectrometer; 29. computing machine; 30. fixed screw; 31. the telescopic linking arm that micro-fluidic chip carries clamping 12 is installed; 32. micro-fluidic chip; 33. fixed screw; 34,35. optical fiber.
Embodiment
Referring to Fig. 1, be a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection one-piece construction schematic diagram.The one-piece construction of support of the present invention adopts steel frame construction, guarantees the stability of duty.Support 1 is the frame type structure, and the medium position of support 1 is fixed with four micro-fluidic chips and carries dress arm 4, four micro-fluidic chips and carry dress arm 4 and be respectively applied to clamp 32 4 jiaos of micro-fluidic chips.Has x on the support 1 to detecting sway brace 8, y is to detecting sway brace 2 and z to detecting sway brace 6, be respectively applied to support corresponding x to detecting linking arm 5, y to detecting linking arm 3 and z to detecting linking arm 7, and can be fixed and be supported in the optional position, x is to detecting linking arm 5, y to detecting linking arm 3 and z to detecting linking arm 7 at orthogonal space.X correspondingly respectively is fixedly connected with two x and carries dress arm 11, two y to detection fiber and carry dress arm 9 and two z carry dress arm 10 to detection fiber to detection fiber to detecting on the linking arm 7 to detecting linking arm 3 and z to detecting linking arm 5, y.Two x carry dress arm 11, two y to detection fiber and carry dress arm 9 and two z to detection fiber and carry dress arm 10 to detection fiber and be used for loading emission and detection fiber, and the detection fiber on per two equidirectionals is carried the dress arm is arranged on micro-fluidic chip 32 in its direction both sides, can realize the absorption spectrum measurement of micro-fluidic chip 32 on x, y, z any direction.
Referring to Fig. 1 and Fig. 2, Fig. 2 carries the structural representation of dress arm 4 for the micro-fluidic chip of a kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection of invention.Micro-fluidic chip carries dress arm 4 and is hollow tubular among Fig. 2, be set with the telescopic linking arm 31 that carries clamping 12 for the installation micro-fluidic chip in it, telescopic linking arm 31 can carry the axial direction slip of dress arm 4 and be fixed in micro-fluidic chip by the screw 30 that is tightened along micro-fluidic chip and carry on the dress arm 4.Fluidic chip carries on the external part that clamping 12 is fixed in telescopic linking arm 31, and fluidic chip carries clamping 12 inside tension spring 13 is installed, and is used for guaranteeing that fluidic chip carries clamping 12 and possesses certain folder power, and micro-fluidic chip is clamped.
Referring to Fig. 1 and Fig. 3, Fig. 3 is the y of a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection carries structural representation from dress arm 9 to detection fiber.Optical fiber carries dress arm 9 and is hollow tubular, is set with in it telescopicly to crank arm 14, and telescopic cranking arm 14 can move along the axial direction that optical fiber carries dress arm 9 and fix by fixed screw 33.Telescopic 14 the flexibility of cranking arm is 90 °, telescopic 14 the external part of cranking arm is hollow tubular, be set with telescopic collimating mirror in it and carry dress arm 16, telescopic collimating mirror carries dress arm 16 and can move and fix by fixed screw 15 along telescopic 14 the axial direction of cranking arm.The external part that telescopic collimating mirror carries dress arm 16 is installed with collimating mirror joint sleeve 17, and collimating mirror joint sleeve 17 inside have screw thread to be used to install collimating mirror 18.X carries dress arm 11 and z to detection fiber, and to carry the structure that dress arm 10 and y carry dress arm 9 to detection fiber to detection fiber identical.
Referring to Fig. 1, Fig. 3 and Fig. 4, Fig. 4 is the y of a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection carries structure cut-open view from the collimating mirror 18 on the dress arm 9 to detection fiber.Collimating mirror 18 inside are equipped with simple lens 19 and are parallel light emergence for incident light is converged, it is that collimating mirror outward turning mouth 20 is used for collimating mirror is mounted to collimating mirror joint sleeve 17 that the head outside of collimating mirror 18 has screw thread, and it is that collimating mirror inward turning mouth 21 is used for optical fiber is mounted to collimating mirror 18 that the afterbody inboard of collimating mirror 18 has screw thread.
Referring to Fig. 1 and Fig. 5, the y of a kind of six degree of freedom micro-fluidic chip of Fig. 5 the present invention absorption spectrum Bracket for Inspection is to the connection diagram that detects linking arm 3 one ends and integral support 1: be divided into Fig. 5 (a) and Fig. 5 (b), wherein Fig. 5 (a) is its front elevation; Its left view of Fig. 5 (b).As shown in the figure, y is the twin columns structure to detecting sway brace 2, has engagement shaft collar 23 between the twin columns, the twin columns inboard arranges horizontal engaging tooth 22, engaging tooth 22 can form the firm attitude of engagement with the engaging tooth 32 that meshes on the shaft collar 23, engagement shaft collar 23 gaps are set in rotary screw 25 outsides, to such an extent as to the medial aperture of engagement shaft collar 23 does not rotate with rotary screw 25 greater than rotary screw 25 engagement shaft collars 23.One end of rotary screw 25 and y are connected to screw thread 26 formation that detect in the linking arm 3, and the other end of rotary screw 25 is fixed with knob 24, and the external diameter of fixed knob 24 is greater than the internal diameter of engagement shaft collar 23.When fixed knob 24 rotation, can move ahead to detecting linking arm 3 interior rotations at y by driven rotary screw mandrel 25, after rotating to some scale, because the external diameter of fixed knob 24 is greater than the internal diameter of engagement shaft collar 23, therefore fixed knob 24 can compress with y engagement shaft collar 23 to detecting sway brace 2 engagements, thereby prevent that effectively y is loosening to detecting linking arm 3, and then impact detects effect.Y is identical to the connected mode and the said structure that detect linking arm 3 other ends and integral support 1; X is to detecting linking arm 5, z to detecting linking arm 7 with identical with syndeton and the said structure of integral support 1.In addition, the each several part of this support 1 is flexible connection, and same support boom can install many linking arms additional, realizes that the multiple spot on the same dimension detects simultaneously.
Referring to Fig. 6, Fig. 6 is a specific embodiment of a kind of six degree of freedom micro-fluidic chip of the present invention absorption spectrum Bracket for Inspection.Micro-fluidic chip 32 to be detected needs z to detection, then by adjust telescopic linking arm 31 be adjusted to can clip to micro-fluidic chip 32 till.The screw 30 that is tightened is fixed telescopic linking arm 31.Micro-fluidic chip 32 is clipped on micro-fluidic chip carries clamping 12.Adjust z to detecting mouth to be detected that linking arm 7 makes its position and micro-fluidic chip 32 on same straight line, and be fixed.Adjusting z carries dress arm 10 to detection fiber to make its telescopic collimating mirror carry the position of collimating mirror 18 on the dress arm relative with micro-fluidic chip 32 check point entrance and exits and be close to.The collimating mirror 18 that optical fiber carries dress arm 10 upsides joins with optical fiber 34, and collimating mirror 18 and the optical fiber 35 of downside join.Optical fiber 34 is connected with light source 27, and optical fiber 35 then is connected with spectrometer 28, and spectrometer 28 connects computer 29.Open light source 27, spectrometer 28 and computer 29 and just can gather and analyze the absorption spectrum signal of micro-fluidic chip along z to check point.

Claims (5)

1. six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection, this support has x, y, z is to detecting sway brace (8,2,6), be supported with respectively corresponding x, y, z is to detecting linking arm (5,3,7), it is characterized in that: the medium position of support is fixedly connected with four micro-fluidic chips of four jiaos that are respectively applied to clamp micro-fluidic chip (32) and carries dress arm (4), x, y, z is to detecting linking arm (5,3,7) corresponding each two x that are fixedly connected with respectively on, y, z carries dress arm (11 to detection fiber, 9,10), per two the described detection fiber on the equidirectional are carried dress arm (11,9,10) be arranged in the both sides of micro-fluidic chip (32); Described micro-fluidic chip carries the hollow tubular of dress arm (4) telescopic linking arm (31) for inner sleeve has, and the external part of telescopic linking arm (31) connects micro-fluidic chip and carries clamping (12); Described x, y, y carry dress arm (11,9,10) to detection fiber and are the hollow tubular that inner sleeve has telescopic cranking arm (14), the external part of telescopic cranking arm (14) is the hollow tubular that the telescopic collimating mirror of inner sleeve carries dress arm (16), the external part that telescopic collimating mirror carries dress arm (16) is fixedly connected with collimating mirror joint sleeve (17), and collimating mirror joint sleeve (17) connects the collimating mirror (18) that joins with optical fiber; During detection, collimating mirror (18) is relative with micro-fluidic chip (32) check point entrance and exit and be close to.
2. a kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection according to claim 1, it is characterized in that: described detection sway brace is the twin columns structure, has engagement shaft collar (23) between the twin columns, the twin columns inboard is provided with and the engaging tooth (22) that meshes shaft collar (23) engagement, engagement shaft collar (23) concentric gap cover has rotary screw (25), rotary screw (25) one ends connect with corresponding described detection linking arm, rotary screw (25) other end connecting external diameter is greater than the fixed knob (24) of engagement shaft collar (23) internal diameter, and fixed knob (24) can compress engagement shaft collar (23) and the engagement of detection sway brace.
3. a kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection according to claim 1 is characterized in that: collimating mirror (18) inside is provided with simple lens (19), the head outside is provided with the collimating mirror outward turning mouth (20) that connects collimating mirror joint sleeve (17), the collimating mirror inward turning mouth (21) that the afterbody inboard is provided with installing optical fibres.
4. a kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection according to claim 1, it is characterized in that: telescopic collimating mirror carries dress arm (16) and can move along the axial direction of telescopic cranking arm (14) and fix by fixed screw, telescopic cranking arm (14) can be moved and fix by another fixed screw along the axial direction that optical fiber carries dress arm (9), and the flexibility of telescopic cranking arm (14) is 90 °.
5. a kind of six degree of freedom micro-fluidic chip absorption spectrum Bracket for Inspection according to claim 1, it is characterized in that: telescopic linking arm (31) can move and fix by fixed screw along the axial direction that micro-fluidic chip carries dress arm (4), and fluidic chip carries clamping (12) inside and is provided with tension spring (13).
CN201210342169.6A 2012-09-17 2012-09-17 Six-freedom-degree micro-fluidic control chip absorption spectrum detection support Expired - Fee Related CN102866112B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104849222A (en) * 2015-01-23 2015-08-19 江苏大学 Rotary disc-type microfluidic concentration measuring apparatus and method based on luminosity detection
CN105784611A (en) * 2016-03-04 2016-07-20 江苏大学 Multi-unit integration experiment device and method based on micro-fluidic chip luminosity detection

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CN101520415A (en) * 2008-02-29 2009-09-02 中国科学院大连化学物理研究所 Micro-fluidic laser-induced fluorescence detector with functions of automatic positioning and focusing
CN201532188U (en) * 2009-10-17 2010-07-21 山东工商学院 Laser intelligent detecting instrument for microfluidic chip
CN102589422A (en) * 2011-12-16 2012-07-18 哈尔滨工业大学 Orthogonal light path two-dimensional micro-focus collimation and three-dimensional coordinate sensor

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2002061400A1 (en) * 2001-01-31 2002-08-08 Sau Lan Tang Staats Optical detection system for chromatographic and electrokinetic liquid phase separations
CN1556371A (en) * 2004-01-02 2004-12-22 清华大学 Multifunction tridimension displacement laser interference measuring system
CN101520415A (en) * 2008-02-29 2009-09-02 中国科学院大连化学物理研究所 Micro-fluidic laser-induced fluorescence detector with functions of automatic positioning and focusing
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN104849222A (en) * 2015-01-23 2015-08-19 江苏大学 Rotary disc-type microfluidic concentration measuring apparatus and method based on luminosity detection
CN104849222B (en) * 2015-01-23 2018-01-16 江苏大学 The micro-fluidic apparatus for measuring concentration of rotation dish-style and method based on photometric detection
CN105784611A (en) * 2016-03-04 2016-07-20 江苏大学 Multi-unit integration experiment device and method based on micro-fluidic chip luminosity detection
CN105784611B (en) * 2016-03-04 2018-08-10 江苏大学 Multiple-unit integration test apparatus and method based on micro-fluidic chip photometric detection

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