CN102854232B - 具有信号调节功能的生物传感器系统 - Google Patents
具有信号调节功能的生物传感器系统 Download PDFInfo
- Publication number
- CN102854232B CN102854232B CN201210281077.1A CN201210281077A CN102854232B CN 102854232 B CN102854232 B CN 102854232B CN 201210281077 A CN201210281077 A CN 201210281077A CN 102854232 B CN102854232 B CN 102854232B
- Authority
- CN
- China
- Prior art keywords
- value
- exponential function
- output signal
- sample
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000006870 function Effects 0.000 title claims abstract description 237
- 230000003750 conditioning effect Effects 0.000 title 1
- 239000012491 analyte Substances 0.000 claims abstract description 179
- 150000001875 compounds Chemical class 0.000 claims abstract description 109
- 239000000126 substance Substances 0.000 claims abstract description 18
- 239000002131 composite material Substances 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 47
- 230000007717 exclusion Effects 0.000 claims description 45
- 238000005259 measurement Methods 0.000 claims description 36
- 238000001514 detection method Methods 0.000 claims description 30
- 230000004044 response Effects 0.000 claims description 26
- 238000012360 testing method Methods 0.000 claims description 25
- 238000004891 communication Methods 0.000 claims description 12
- 238000003556 assay Methods 0.000 claims description 7
- 238000010606 normalization Methods 0.000 claims description 6
- 230000001131 transforming effect Effects 0.000 claims 2
- 238000006479 redox reaction Methods 0.000 abstract description 11
- 239000000523 sample Substances 0.000 description 136
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 60
- 239000008103 glucose Substances 0.000 description 60
- 238000004458 analytical method Methods 0.000 description 52
- 210000004369 blood Anatomy 0.000 description 41
- 239000008280 blood Substances 0.000 description 41
- 238000005534 hematocrit Methods 0.000 description 32
- 239000013060 biological fluid Substances 0.000 description 21
- 230000003287 optical effect Effects 0.000 description 20
- 239000004020 conductor Substances 0.000 description 13
- 238000012937 correction Methods 0.000 description 13
- 238000006722 reduction reaction Methods 0.000 description 12
- 230000009467 reduction Effects 0.000 description 11
- 230000035945 sensitivity Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 230000007613 environmental effect Effects 0.000 description 6
- 230000000717 retained effect Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
- 238000004082 amperometric method Methods 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000002596 correlated effect Effects 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 3
- 238000003869 coulometry Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000004832 voltammetry Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 125000003831 tetrazolyl group Chemical group 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000002977 intracellular fluid Anatomy 0.000 description 1
- 238000012804 iterative process Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12052508P | 2008-12-08 | 2008-12-08 | |
| US61/120,525 | 2008-12-08 | ||
| CN2009801490147A CN102239406A (zh) | 2008-12-08 | 2009-12-08 | 具有信号调节功能的生物传感器系统 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801490147A Division CN102239406A (zh) | 2008-12-08 | 2009-12-08 | 具有信号调节功能的生物传感器系统 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102854232A CN102854232A (zh) | 2013-01-02 |
| CN102854232B true CN102854232B (zh) | 2015-12-02 |
Family
ID=42077436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210281077.1A Active CN102854232B (zh) | 2008-12-08 | 2009-12-08 | 具有信号调节功能的生物传感器系统 |
| CN2009801490147A Pending CN102239406A (zh) | 2008-12-08 | 2009-12-08 | 具有信号调节功能的生物传感器系统 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801490147A Pending CN102239406A (zh) | 2008-12-08 | 2009-12-08 | 具有信号调节功能的生物传感器系统 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8744776B2 (enExample) |
| EP (1) | EP2373984B1 (enExample) |
| JP (2) | JP5738770B2 (enExample) |
| CN (2) | CN102854232B (enExample) |
| BR (1) | BRPI0923342A2 (enExample) |
| CA (1) | CA2743440C (enExample) |
| MX (1) | MX2011005864A (enExample) |
| RU (1) | RU2509304C2 (enExample) |
| WO (1) | WO2010077660A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8529751B2 (en) | 2006-03-31 | 2013-09-10 | Lifescan, Inc. | Systems and methods for discriminating control solution from a physiological sample |
| US8778168B2 (en) | 2007-09-28 | 2014-07-15 | Lifescan, Inc. | Systems and methods of discriminating control solution from a physiological sample |
| US8603768B2 (en) | 2008-01-17 | 2013-12-10 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
| US8551320B2 (en) | 2008-06-09 | 2013-10-08 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
| RU2546862C2 (ru) | 2008-12-08 | 2015-04-10 | БАЙЕР ХЕЛТКЭА ЭлЭлСи | Биосенсорная система и тестовые сенсоры для определения концентрации анализируемого вещества (варианты) |
| US9233788B2 (en) | 2010-01-22 | 2016-01-12 | Bayer Healthcare Llc | Biosensor desiccant system having enhanced measurement performance |
| EP2550530A1 (en) * | 2010-03-22 | 2013-01-30 | Bayer HealthCare LLC | Residual compensation for a biosensor |
| EP2577303B1 (en) | 2010-06-07 | 2022-08-03 | Ascensia Diabetes Care Holdings AG | Underfill management system for a biosensor |
| KR102068949B1 (ko) * | 2010-06-07 | 2020-01-21 | 바이엘 헬쓰케어 엘엘씨 | 2차 출력 신호를 포함하는 기울기-기반 보상 |
| EP2595526A4 (en) * | 2010-07-19 | 2016-07-13 | Cilag Gmbh Int | SYSTEM AND METHOD FOR MEASURING AN ANALYZES IN A SAMPLE |
| JP2012032206A (ja) * | 2010-07-29 | 2012-02-16 | National Institute Of Advanced Industrial & Technology | 電気化学分析装置 |
| TWI565943B (zh) | 2011-07-22 | 2017-01-11 | 拜耳保健公司 | 具有增進測量性能之生物感測器乾燥劑系統 |
| EP3586831A1 (en) | 2011-09-21 | 2020-01-01 | Ascensia Diabetes Care Holdings AG | Analysis compensation including segmented signals |
| US9903830B2 (en) | 2011-12-29 | 2018-02-27 | Lifescan Scotland Limited | Accurate analyte measurements for electrochemical test strip based on sensed physical characteristic(s) of the sample containing the analyte |
| HK1221771A1 (zh) * | 2013-03-14 | 2017-06-09 | 安晟信医疗科技控股公司 | 分析物浓度测定的标准化校准 |
| CN105283765B (zh) * | 2013-03-14 | 2018-01-16 | 安晟信医疗科技控股公司 | 分析物浓度测定的系统误差补偿 |
| US9933441B2 (en) | 2013-03-14 | 2018-04-03 | Ascensia Diabetes Care Holdings Ag | Progressive approximation of sample analyte concentration |
| US9459231B2 (en) | 2013-08-29 | 2016-10-04 | Lifescan Scotland Limited | Method and system to determine erroneous measurement signals during a test measurement sequence |
| US9243276B2 (en) | 2013-08-29 | 2016-01-26 | Lifescan Scotland Limited | Method and system to determine hematocrit-insensitive glucose values in a fluid sample |
| EP3295159B1 (en) | 2015-05-15 | 2021-12-01 | Ascensia Diabetes Care Holdings AG | Improved biosensor system analyte measurement |
| CN109690304A (zh) * | 2016-07-12 | 2019-04-26 | 安晟信医疗科技控股公司 | 通过使用来自两个电极的交替输出信号进行电化学分析的方法 |
| EP3548881A1 (en) | 2016-12-05 | 2019-10-09 | Ascensia Diabetes Care Holdings AG | Risk factor monitoring |
| KR102179203B1 (ko) * | 2018-07-09 | 2020-11-16 | 주식회사 필로시스 | 혈당 센싱 데이터 판별 방법 및 장치 |
| JP7494194B2 (ja) | 2019-02-05 | 2024-06-03 | アセンシア・ディアベティス・ケア・ホールディングス・アーゲー | 連続的分析物感知および自動較正のセンサ動作を精査するための装置および方法 |
| EP3928089B1 (en) | 2019-02-22 | 2025-05-14 | Ascensia Diabetes Care Holdings AG | Method and system for glucose concentration monitoring using harmonic relationships |
| CN109884150B (zh) * | 2019-03-08 | 2021-05-14 | 武汉璟泓科技股份有限公司 | 一种红细胞积压校正方法及存储介质 |
| US11963763B2 (en) | 2019-09-10 | 2024-04-23 | Ascensia Diabetes Care Holdings Ag | Methods and apparatus information gathering, error detection and analyte concentration determination during continuous analyte sensing |
| US20230127806A1 (en) * | 2020-03-27 | 2023-04-27 | Lam Research Corporation | Substrate support temperature probe diagnostics and management |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133985A3 (en) * | 2006-05-08 | 2008-01-10 | Bayer Healthcare Llc | Abnormal output detection system for a biosensor |
| WO2009108239A2 (en) * | 2007-12-10 | 2009-09-03 | Bayer Healthcare Llc | Slope-based compensation |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431004A (en) * | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
| US4750496A (en) | 1987-01-28 | 1988-06-14 | Xienta, Inc. | Method and apparatus for measuring blood glucose concentration |
| US5243516A (en) | 1989-12-15 | 1993-09-07 | Boehringer Mannheim Corporation | Biosensing instrument and method |
| US5508171A (en) | 1989-12-15 | 1996-04-16 | Boehringer Mannheim Corporation | Assay method with enzyme electrode system |
| FR2701117B1 (fr) | 1993-02-04 | 1995-03-10 | Asulab Sa | Système de mesures électrochimiques à capteur multizones, et son application au dosage du glucose. |
| US5366609A (en) | 1993-06-08 | 1994-11-22 | Boehringer Mannheim Corporation | Biosensing meter with pluggable memory key |
| US5762770A (en) * | 1994-02-21 | 1998-06-09 | Boehringer Mannheim Corporation | Electrochemical biosensor test strip |
| IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US6153069A (en) | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
| US5620579A (en) | 1995-05-05 | 1997-04-15 | Bayer Corporation | Apparatus for reduction of bias in amperometric sensors |
| US5723284A (en) | 1996-04-01 | 1998-03-03 | Bayer Corporation | Control solution and method for testing the performance of an electrochemical device for determining the concentration of an analyte in blood |
| AU6157898A (en) | 1997-02-06 | 1998-08-26 | E. Heller & Company | Small volume (in vitro) analyte sensor |
| US6391558B1 (en) | 1997-03-18 | 2002-05-21 | Andcare, Inc. | Electrochemical detection of nucleic acid sequences |
| US5798031A (en) | 1997-05-12 | 1998-08-25 | Bayer Corporation | Electrochemical biosensor |
| US6391645B1 (en) | 1997-05-12 | 2002-05-21 | Bayer Corporation | Method and apparatus for correcting ambient temperature effect in biosensors |
| EP0990151A2 (en) | 1997-06-16 | 2000-04-05 | ELAN CORPORATION, Plc | Methods of calibrating and testing a sensor for (in vivo) measurement of an analyte and devices for use in such methods |
| US7494816B2 (en) * | 1997-12-22 | 2009-02-24 | Roche Diagnostic Operations, Inc. | System and method for determining a temperature during analyte measurement |
| JP3260739B2 (ja) | 1997-12-22 | 2002-02-25 | ロシュ ダイアグノスティックス コーポレーション | 生物学的流体の医学的に有意な成分の濃度を測定する装置および方法 |
| US6233471B1 (en) | 1998-05-13 | 2001-05-15 | Cygnus, Inc. | Signal processing for measurement of physiological analysis |
| AU3849799A (en) * | 1998-05-20 | 1999-12-06 | Arkray, Inc. | Method and apparatus for electrochemical measurement using statistical technique |
| RU2161653C2 (ru) * | 1998-08-24 | 2001-01-10 | ФАРМАКОВСКИЙ Дмитрий Александрович | Способ количественного электрохимического анализа биомолекул |
| US6475372B1 (en) | 2000-02-02 | 2002-11-05 | Lifescan, Inc. | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
| WO2001021827A1 (en) | 1999-09-20 | 2001-03-29 | Roche Diagnostics Corporation | Small volume biosensor for continuous analyte monitoring |
| JP4050434B2 (ja) | 1999-11-29 | 2008-02-20 | 松下電器産業株式会社 | サンプルの弁別方法 |
| WO2002057768A1 (fr) | 2001-01-17 | 2002-07-25 | Arkray, Inc. | Procede d'analyse quantitative et dispositif d'analyse quantitative utilisant un capteur |
| US6802957B2 (en) | 2001-09-28 | 2004-10-12 | Marine Biological Laboratory | Self-referencing enzyme-based microsensor and method of use |
| US6797150B2 (en) | 2001-10-10 | 2004-09-28 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
| AU2003234944A1 (en) | 2002-08-27 | 2004-03-18 | Bayer Healthcare, Llc | Methods of Determining Glucose Concentration in Whole Blood Samples |
| US7132041B2 (en) | 2003-02-11 | 2006-11-07 | Bayer Healthcare Llc | Methods of determining the concentration of an analyte in a fluid test sample |
| EP1467206A1 (en) * | 2003-04-08 | 2004-10-13 | Roche Diagnostics GmbH | Biosensor system |
| US7452457B2 (en) | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
| US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
| ES2709991T3 (es) | 2003-08-21 | 2019-04-22 | Agamatrix Inc | Método y aparato para el análisis de propiedades electroquímicas |
| JP4449431B2 (ja) | 2003-11-19 | 2010-04-14 | パナソニック株式会社 | 基質濃度の測定方法 |
| JP4689601B2 (ja) | 2004-04-19 | 2011-05-25 | パナソニック株式会社 | 血液成分の測定方法、それに用いるバイオセンサおよび測定装置 |
| RU2006144458A (ru) | 2004-05-14 | 2008-06-20 | БАЙЕР ХЕЛТКЭР ЭлЭлСи (US) | Способы осуществления корректировки по гематокриту в анализах глюкозы и устройства для этого |
| AU2005295106B2 (en) | 2004-10-12 | 2012-03-15 | Bayer Healthcare Llc | Concentration determination in a diffusion barrier layer |
| GB0501826D0 (en) | 2005-01-28 | 2005-03-09 | Melys Diagnostics Ltd | Apparatus for measurement of analyte concentration |
| US7517439B2 (en) | 2005-04-15 | 2009-04-14 | Agamatrix, Inc. | Error detection in analyte measurements based on measurement of system resistance |
| US7964089B2 (en) * | 2005-04-15 | 2011-06-21 | Agamatrix, Inc. | Analyte determination method and analyte meter |
| EP3483599A1 (en) | 2005-07-20 | 2019-05-15 | Ascensia Diabetes Care Holdings AG | Methods for measuring the concentration of an analyte in solution and for calibrating the measurement as well as handheld devices therefor |
| CA2616402A1 (en) | 2005-07-26 | 2007-02-01 | Bayer Healthcare Llc | Method and system for checking an electromechanical biosensor |
| CN103048442B (zh) | 2005-09-30 | 2015-04-08 | 拜尔健康护理有限责任公司 | 门控伏特安培法 |
| RU2455925C2 (ru) * | 2006-02-27 | 2012-07-20 | БАЙЕР ХЕЛТКЭА ЭлЭлСи | Определение исследуемого вещества с поправкой на температуру для систем биодатчиков |
| ES2825036T3 (es) | 2006-10-24 | 2021-05-14 | Ascensia Diabetes Care Holdings Ag | Amperometría de decaimiento transitorio |
| US20080248581A1 (en) | 2007-04-06 | 2008-10-09 | Bayer Healthcare Llc | Method for performing correction of blood glucose assay bias using blood hemoglobin concentration |
-
2009
- 2009-12-08 RU RU2011128010/28A patent/RU2509304C2/ru not_active IP Right Cessation
- 2009-12-08 CA CA2743440A patent/CA2743440C/en not_active Expired - Fee Related
- 2009-12-08 BR BRPI0923342A patent/BRPI0923342A2/pt not_active IP Right Cessation
- 2009-12-08 MX MX2011005864A patent/MX2011005864A/es active IP Right Grant
- 2009-12-08 JP JP2011540829A patent/JP5738770B2/ja active Active
- 2009-12-08 CN CN201210281077.1A patent/CN102854232B/zh active Active
- 2009-12-08 WO PCT/US2009/067150 patent/WO2010077660A1/en not_active Ceased
- 2009-12-08 CN CN2009801490147A patent/CN102239406A/zh active Pending
- 2009-12-08 EP EP09775450.1A patent/EP2373984B1/en active Active
-
2011
- 2011-06-06 US US13/153,793 patent/US8744776B2/en active Active
-
2014
- 2014-04-01 US US14/231,874 patent/US10656113B2/en active Active
-
2015
- 2015-04-22 JP JP2015087322A patent/JP6002274B2/ja active Active
-
2020
- 2020-05-08 US US16/870,703 patent/US20200271615A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133985A3 (en) * | 2006-05-08 | 2008-01-10 | Bayer Healthcare Llc | Abnormal output detection system for a biosensor |
| WO2009108239A2 (en) * | 2007-12-10 | 2009-09-03 | Bayer Healthcare Llc | Slope-based compensation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5738770B2 (ja) | 2015-06-24 |
| RU2011128010A (ru) | 2013-01-20 |
| RU2509304C2 (ru) | 2014-03-10 |
| JP2015155919A (ja) | 2015-08-27 |
| JP6002274B2 (ja) | 2016-10-05 |
| HK1179346A1 (zh) | 2013-09-27 |
| US10656113B2 (en) | 2020-05-19 |
| JP2012511160A (ja) | 2012-05-17 |
| CN102239406A (zh) | 2011-11-09 |
| US20110297554A1 (en) | 2011-12-08 |
| CA2743440C (en) | 2017-07-18 |
| CN102854232A (zh) | 2013-01-02 |
| MX2011005864A (es) | 2011-06-20 |
| US20140209460A1 (en) | 2014-07-31 |
| US8744776B2 (en) | 2014-06-03 |
| BRPI0923342A2 (pt) | 2016-01-12 |
| US20200271615A1 (en) | 2020-08-27 |
| EP2373984B1 (en) | 2022-11-30 |
| WO2010077660A1 (en) | 2010-07-08 |
| EP2373984A1 (en) | 2011-10-12 |
| CA2743440A1 (en) | 2010-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20200271615A1 (en) | Biosensor Systems for Determining Analyte Concentration Based On Complex Index Functions | |
| US20200348306A1 (en) | Slope-Based Compensation | |
| US10921278B2 (en) | Slope-based compensation including secondary output signals | |
| CN103003692B (zh) | 用于生物传感器的剩余补偿 | |
| JP2012511160A5 (enExample) | ||
| JP2011506966A5 (enExample) | ||
| HK1179346B (en) | Biosensor system with signal adjustment | |
| HK1194136B (en) | Slope-based compensation | |
| HK1181850B (en) | Slope-based compensation including secondary output signals | |
| HK1154656B (en) | Slope-based compensation | |
| HK1194136A (en) | Slope-based compensation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1179346 Country of ref document: HK |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1179346 Country of ref document: HK |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160926 Address after: Basel Patentee after: BAYER HEALTHCARE LLC Address before: American New York Patentee before: Bayer Corp. |