CN102836298B - Medicine for tranquilizing and allaying excitement - Google Patents
Medicine for tranquilizing and allaying excitement Download PDFInfo
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- CN102836298B CN102836298B CN201210346232.3A CN201210346232A CN102836298B CN 102836298 B CN102836298 B CN 102836298B CN 201210346232 A CN201210346232 A CN 201210346232A CN 102836298 B CN102836298 B CN 102836298B
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- tranquilizing
- allaying
- excitement
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Abstract
The invention relates to a medicine for tranquilizing and allaying excitement, which belongs to the field of traditional Chinese medicines. The invention aims to provide the medicine for tranquilizing and allaying the excitement, which aims at achieving the effect of sleeping peacefully by adopting the theory of traditional Chinese medicine through tranquilizing, allaying the excitement, nourishing the heart, calming the mind, invigorating qi and producing blood. The medicine for tranquilizing and allaying the excitement comprises the following raw materials for preparing effective components: pearl, dragon's bone, spina date seed, polygala tenuifolia, poria with hostwood, rhizoma acori graminei, angelica, white peony root, astragalus root and mugwort leaf. The medicine for tranquilizing and allaying the excitement is simple to prepare and has low price, a good curative effect, no toxic or side effect, a short treatment time and good social and economic benefits. Various medicines are matched. The medicine for tranquilizing and allaying the excitement aims at the symptoms of difficulty in falling asleep, dreaminess, festless sleep and the like, which are caused because of heart disturbance by liver fire, heart-spleen deficiency, fire excess from yin deficiency, internal disturbance by phlegm heat, timidity due to the insufficiency of qi and the deficiency of the blood of the heart and the like, so as to achieve the effect of sleeping peacefully by tranquilizing, allaying the excitement, nourishing the heart, calming the mind, invigorating qi and producing blood.
Description
Technical field
The invention belongs to the field of Chinese medicines.
Background technology
Along with social high speed development, people's rhythm of life is also more and more faster, the corresponding pressure that human body is caused also sharply rises, some diseases is also corresponding, such as: Primary insomnia, examination stress syndrome, autonomic nervous dysfunction, endocrine disturbance, sleep rhythm obstacle, climacteric syndrome, neurasthenia, depression etc.These diseases are perplexing people always, have a strong impact on normal daily life.
Summary of the invention
The object of the invention is to adopt theory of Chinese medical science, to reach tranquillizing and allaying excitement, the sedate that nourishes heart, the medicine of a kind of tranquillizing and allaying excitement of QI invigorating and blood producing and the effect of sleeping peacefully.
The parts by weight of raw materials that the present invention makes effective ingredient consists of:
Margarita 50～150 Os Draconis 50～150 Semen Ziziphi Spinosaes 150～300
Radix Polygalae 150～300 Poria cum Radix Pini's 150～300 Rhizoma Acori Graminei 150～300
Radix Angelicae Sinensis 150～300 Radix Paeoniae Alba 150～300 Radixs Astragali 150～300
Folium Artemisiae Argyi 150～400.
The plaster that said medicine of the present invention is made, its parts by weight of raw materials of making effective ingredient consists of:
The ointment 35 medical hot melt type pressure sensitive adhesives 64.85 that said medicine is made
Azone 0.05 methyl hydroxybenzoate 0.1.
The present invention is prepared simply, cheap, and good effect, has no side effect, and treatment time is short, social and good in economic efficiency.All medicine compatibilities, the difficulty falling asleep that disturb for disturbing due to liver-fire in the heart, deficiency of both the heart and spleen, hyperactivity of fire caused by deficiency of YIN, expectorant heat, timidness due to deficiency of the heart etc. causes, the cards such as dreaming often and waking easily, to reach tranquillizing and allaying excitement, the sedate that nourishes heart, QI invigorating and blood producing and the effect of sleeping peacefully.
The specific embodiment
The parts by weight of raw materials that the present invention makes effective ingredient consists of:
The parts by weight of raw materials that the present invention makes effective ingredient consists of:
Margarita 50～150 Os Draconis 50～150 Semen Ziziphi Spinosaes 150～300
Radix Polygalae 150～300 Poria cum Radix Pini's 150～300 Rhizoma Acori Graminei 150～300
Radix Angelicae Sinensis 150～300 Radix Paeoniae Alba 150～300 Radixs Astragali 150～300
Folium Artemisiae Argyi 150～400.
Get above-mentioned formula Chinese crude drug, Margarita powder is broken into fine powder, standby; All the other medical materials add 8 times of water gagings and decoct 3 times, and each 1.5 hours, collecting decoction, filtered, filtrate is concentrated into relative density 1.30～1.35(80 ℃) thick paste, add Margarita fine powder, mix, according to list of ingredients ratio, add other substrate, mix homogeneously, is coated with cream, and cutting, obtains.
The plaster that said medicine of the present invention is made, its parts by weight of raw materials of making effective ingredient consists of:
The ointment 35 medical hot melt type pressure sensitive adhesives 64.85 that said medicine is made
Azone 0.05 methyl hydroxybenzoate 0.1.
Embodiment 1:
The parts by weight of raw materials that the present invention makes effective ingredient consists of:
Margarita 50 Os Draconis 50 Semen Ziziphi Spinosaes 150
Radix Polygalae 150 Poria cum Radix Pini's 150 Rhizoma Acori Graminei 150
Radix Angelicae Sinensis 150 Radix Paeoniae Alba 150 Radixs Astragali 150
Folium Artemisiae Argyi 150.
Get above-mentioned formula Chinese crude drug, Margarita powder is broken into fine powder, standby; All the other medical materials add 8 times of water gagings and decoct 3 times, and each 1.5 hours, collecting decoction, filtered, filtrate is concentrated into relative density 1.30～1.35(80 ℃) thick paste, add Margarita fine powder, mix, according to list of ingredients ratio, add other substrate, mix homogeneously, is coated with cream, and cutting, obtains.
Embodiment 2:
The parts by weight of raw materials that the present invention makes effective ingredient consists of:
Margarita 100 Os Draconis 100 Semen Ziziphi Spinosaes 200
Radix Polygalae 200 Poria cum Radix Pini's 200 Rhizoma Acori Graminei 200
Radix Angelicae Sinensis 200 Radix Paeoniae Alba 200 Radixs Astragali 200
Folium Artemisiae Argyi 300.
Preparation method is identical with embodiment 1.
Embodiment 3:
The parts by weight of raw materials that the present invention makes effective ingredient consists of:
Margarita 150 Os Draconis 150 Semen Ziziphi Spinosaes 300
Radix Polygalae 300 Poria cum Radix Pini's 300 Rhizoma Acori Graminei 300
Radix Angelicae Sinensis 300 Radix Paeoniae Alba 300 Radixs Astragali 300
Folium Artemisiae Argyi 400.
Preparation method is identical with embodiment 1.
character of medicinal material
margarita:the arresting convulsion of calming the nerves, heat clearing away YIN nourishing, improving eyesight removing toxic substances.Be used for the palpitation with a distress feeling of palpitating with fear, epilepsy infantile convulsion, conjunctival congestion and swelling pain, pterygium, throat rots, aphtha of the mouth and tongue, ulcer does not close up for a long time.
os Draconis:tranquillization with heavy prescription, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Demented for infantile convulsion, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, and spontaneous sweating, seminal emission stranguria with turbid discharge, tells nosebleed and has blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
semen Ziziphi Spinosae:mind tranquilizing and the heart calming, nourishing the liver, arresting sweating.For restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, the empty spontaneous perspiration of body, night sweat.
radix Polygalae:the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm, detumescence.The insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
radix Angelicae Sinensis:enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
poria cum Radix Pini:the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.The palpitation with fear that is used for having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
rhizoma Acori Graminei:waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, the sharp numbness of dispeling the wind, reducing swelling and alleviating pain.For calentura coma, syncope due to accumulation of phlegm, forgetful, tinnitus, deafness, abdominal distention, fasting dysentery, rheumatic arthralgia, traumatic injury, carbuncle scabies.
radix Angelicae Sinensis:enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
the Radix Paeoniae Alba:nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.For the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
the Radix Astragali:invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
folium Artemisiae Argyi:dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spits blood, epistaxis, metrorrhagia warp is many, gestation hemorrhage; External treatment skin pruritus, decortication.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficiency and coldness.
To take Poria cum Radix Pini, Semen Ziziphi Spinosae be monarch drug to all medicines above, tranquillizing and allaying excitement, and the sedate that nourishes heart is to sleep peacefully; Take Margarita, Os Draconis, Radix Polygalae is ministerial drug, the arresting convulsion of calming the nerves, and principal drug assistance strengthens the effect of sleeping peacefully; Adjuvant drug is Rhizoma Acori Graminei, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Astragali etc., with activating blood circulation and dissipating phlegm, and QI invigorating and blood producing; With Folium Artemisiae Argyi for making medicine, coordinating the actions of various ingredients in a prescription, all medicine compatibilities, the difficulty falling asleep that disturb for disturbing due to liver-fire in the heart, deficiency of both the heart and spleen, hyperactivity of fire caused by deficiency of YIN, expectorant heat, timidness due to deficiency of the heart etc. causes, the cards such as dreaming often and waking easily, to reach tranquillizing and allaying excitement, the sedate that nourishes heart, QI invigorating and blood producing and the effect of sleeping peacefully.
Organoleptic indicator
| Project | Index |
| Outward appearance | Faint yellow mastic, color and luster are homogeneous |
| Abnormal smells from the patient | Special Chinese medicine aromatic odor |
| Impurity | Without the visible exogenous impurity of naked eyes |
Physical and chemical index
| Project | Index |
| Net content, g/100cm 2 | 1.5 |
| Net content minus deviation, %≤ | 9 |
| Hydrargyrum, mg/Kg≤ | 1.0 |
| Plumbous (in Pb), mg/Kg≤ | 40.0 |
| Arsenic (in As), mg/Kg≤ | 10.0 |
| Cadmium (in Cd), mg/Kg≤ | 20.0 |
| Methanol is (with CH 3OH counts), mg/Kg≤ | 2000.0 |
| Formaldehyde (in formaldehyde), mg/Kg≤ | 75.0 |
Microbiological indicator
| Project | Index |
| Total plate count, cfu/g≤ | 20000? |
| Yeast and mold, cfu/g≤ | 500 |
| Excrement colibacillus group | Must not detect |
| Bacillus pyocyaneus | Must not detect |
| Staphylococcus aureus | Must not detect |
| Hemolytic streptococcus | Must not detect |
Be applicable to the crowd of the difficulty falling asleep that causes because of Primary insomnia, examination stress syndrome, autonomic nervous dysfunction, endocrine disturbance, sleep rhythm obstacle, climacteric syndrome, neurasthenia, depression.
Be not suitable for anemia of pregnant woman, women breast-feeding their children, infant, skin injury, the infected, to this product allergy sufferers.
Points for attention: 1. external.Forbid taking orally; 2. if erythema swelling appears in local skin after using, pruritus, should stop using immediately, cleans, and seeks advice from if desired to doctor.
1. skin acute toxicity test
1.1 materials and methods:
1.1.1 tested material: the present invention's subsides of calming the nerves, patch, composite membrane is packed.
1.1.2 animal and feeding environment: select 10 of SPF level Wistar rats, male and female half and half, body weight 180.0g～220.0g.Animal quality certification SCXK～(Ji) 20l1～0004.This laboratory animal environmental facility quality certification: lucky moving established word 10～1005, occupancy permit number: SYXK (Ji) 2010～0011,20 ℃～22 ℃ of laboratory animal room temperatures, relative humidity is 55%～655%.
1.1.3 test method: press the dosage of 5000mg/kg body weight, clip sample, is attached to back part of animal depilation district (scope 30cm
2～40cm
2), with two-layer template, cover, with nonirritant adhesive plaster, seal fixedly 24h, after 24h, remove tested material, observe the poisoning sign of animal, 7 days observation periods, within the 7th day, to weigh once, off-test is put to death animal and is observed general pathology and changes.
1.2 result of the tests: after contamination, poisoning sign does not appear in animal, the observation period animal without death, general pathology anatomical examination no abnormality seen, LD
50all be greater than 5000mg/kg body weight.
Tested material is to rat acute percutaneous toxicity test result
LD
50: buck is greater than 5000mg/kg body weight.
Jenny is greater than 5000mg/kg body weight.
1.3 conclusions: tested material is actual nontoxic to rat skin acute toxicity.
2. skin irritation test repeatedly
2.1 materials and methods:
2.1.1 tested material: the present invention's subsides of calming the nerves, patch, composite membrane is packed.
2.1.2 animal and feeding environment: select 4 of healthy white big ear rabbits, regular grade, animal quality certification SCXK ~ (Ji) 2007 ~ 0004.This laboratory animal environmental facility quality certification: lucky moving established word 10 ~ 1005, occupancy permit number: SYXK (Ji) 2010 ~ 0011,19 ℃ ~ 21 ℃ of this laboratory animal room temperatures, relative humidity is 50% ~ 70%.
2.1.3 test method: before test, 24h cuts back part of animal spinal column diamond wool, each about 3cm * 3cm of scope.During test, clip tested material is directly attached to depilation district, right side, area 2.5cm * 2.5cm, seals fixedly lh with nonirritant adhesive plaster, and depilation district, left side is contrast, every day 1 time, continuous 14 days, from second day, give tested material front cropping at every turn, with distilled water, remove residual tested material afterwards, observed result after a hour.
2.2 result of the tests: remove tested material after the 5th day, have two the tested position of animal skins successively to occur faintly visible erythema, average every day, every animal integral mean value was 0.20.
Tested material is to rabbit irritation test result repeatedly
2.3 conclusions: tested material to rabbit repeatedly skin irritation be nonirritant.
3. Skin allergy test
3.1 materials and methods:
3.1.1 tested material: the present invention's subsides of calming the nerves, patch, composite membrane is packed.
3.1.2 positive thing: 2,4-dinitrochlorobenzene.
3.1.3 animal and feeding environment: select 40 of healthy albino guinea-pigs, regular grade.Animal quality certification SCXK～(Ji) 2007～0004.This laboratory animal environmental facility quality certification: lucky moving established word 10～1005, occupancy permit number: SYXK (Ji) 2010～0011,19 ℃～21 ℃ of laboratory animal room temperatures, relative humidity is 50%～70%.
3.1.4 test method: Induction exposure: clip tested material 2cm * 2cm is attached to depilation district, right side (24h cropping before test, scope 6cm
2), then with two layers of gauze, one deck template, cover, then with nonirritant glue and sealing, fixing 6h, the 7th day, the 14th day, same method repeated once.Excite contact: latter 14 days of art time induction, cut and refute tested material 2cm * 2cm and be attached to depilation district, animal left side (24h cropping before test, scope 6cm
2.), then press same method sealing, fixing 6h.Excite the rear 24h of contact and 48h to observe left side dermoreaction, and score.
3.2 result of the tests: after exciting contact, erythema, edema (seeing attached list) do not appear in 24h, 48h left side skin:
Tested material is to guinea pig skin allergy result of the test (BT method)
3.3 conclusions: tested material is weak sensitization to guinea pig skin allergy result of the test.
Result and judgement (Results of Evaluation)
Chinese mugwort network health tranquillizing and allaying excitement pastes, rat skin acute toxicity test LD
50be greater than 5000mg/kg, according to toxicity grading, belong to actual nontoxic level; To rabbit skin repeatedly irritation test be nonirritant; To the test of guinea pig skin allergy, it is weak sensitization.
plaster of the present invention improves sleep function test:
1. materials and methods
1.1. sample copy is invented the subsides of calming the nerves, and approved product is patch, and composite membrane is packed.Main component is Margarita, Os Draconis, Semen Ziziphi Spinosae, Radix Polygalae, volt god, Rhizoma Acori Graminei, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Astragali, Folium Artemisiae Argyi.
1.2. study subject is selected the often trial volunteer of insomnia.Concrete grammar be according to the problem of listing in Athens insomnia scale (revive at time for falling asleep, night, than expected time early awakening, the length of one's sleep, sleep quality, daytime emotion, daytime body function, daytime is drowsy), experimenter is per week in one month in the past has at least occurred three times, and self assessment result total mark can be included in above at 6 minutes.In experimenter, get rid of the age under-18s or over-65s, gestation or nursing women, to given the test agent allergy sufferers: get rid of the patient who is associated with the diseases such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system; Get rid of and use in a short time article relevant to tested function, have influence on the judgement person to result; Get rid of and not use in accordance with regulations given the test agent, cannot judge that effect or data are not congruent affects effect judgement person.
1.3. using method is affixed on cervical region Anmian point in l hour before sleeping, Yinjiao point under umbilicus, hand Shenmen point, friendship cave, foot Sanming City.Rise morning and take off, select 2 caves at every turn.Use 10 days continuously.
1.4. EXPERIMENTAL DESIGN is according to improving sleep human trial regulation in < < health product function assessment assessment process and method of inspection > > (DB22～T397～2006), before and after adopting, experimenter contrasts two kinds of contrast methods between own control and group, according to the requirement of random-blind method, divide into groups, considering experimenter's degree of having a sleepless night, sex, under the influence factors' such as age prerequisite, by experimenter's time for falling asleep, be divided at random test group and matched group, every group of experimenter is 20 examples, and carry out harmony check.Test group is given and given the test agent, and matched group is not processed.Pairing t～check before and after test group data is tested, relatively adopts t～check in groups to two groups of means.When p<0.05, think that difference has significance.
L.5. detect index
1.5.1. time for falling asleep and the length of one's sleep length (unit: min).
1.5.2. revive night, than expected time early awakening, sleep quality, the scoring of daytime is drowsy four indices;
Athens insomnia scale
Note: " time for falling asleep " arrives the sleeping time after referring to turn off the light; " body function on daytime " refers to muscle power or spirit, as memory, cognitive power and attention etc.
1.6. the juice method of uniting and result criterion adopt SPSSll.5 software to check with l the juice of uniting.Pairing t～check before and after test group data is tested, relatively adopts t～check in groups to two groups of means.If experimenter's time for falling asleep after on probation, the length of one's sleep have two obviously to improve in length and (revive night, than expected time early awakening, sleep quality, daytime is drowsy) total mark binomial index, and difference has significance, can judge and be subject to trial product to there is the sleep function of improvement.
2. result
2.1. the whole experimenters of test situation are all complete has participated in whole experimentation, does not have seceder midway, finds no the untoward reaction such as skin allergy.
2.2. test group and matched group are tested front and back time for falling asleep, the length of one's sleep and observation index integral result
Time for falling asleep, the length of one's sleep and observation index integration before and after test group and matched group test (
± S)
As can be seen here, before test, test group is more balanced with the time for falling asleep before matched group test.
2.3. test group is tested front and back time for falling asleep, the length of one's sleep and observation index integration and pairing t-assay
Time for falling asleep, the length of one's sleep and observation index integration and pairing t-check before and after test group test (
± S)
From table, test group is given with the present invention of 10 days and is calmed the nerves after subsides, and improvement in various degree all appears in indices, by pairing t-check difference, has significance (P0.01).
2.4. test group and the rear time for falling asleep of matched group test, the length of one's sleep and observation index integration and in groups t-assay
Time for falling asleep, the length of one's sleep and observation index integration and t-check in groups after test group and matched group test (
± S)
From table, after test group is given and to be calmed the nerves and paste with the present invention of 10 days, by t-check in groups, compare time for falling asleep with matched group and total mark difference has significance (P<0.01).
Brief summary
Screening 40 examples often insomnia and according to Athens insomnia scale self assessment result total mark at more than 6 minutes trial volunteers, 20 examples on request to the present invention's subsides of calming the nerves, 20 examples are as blank.After test, self compare time for falling asleep and shortened 6.5 min before and after test group, extended 28.5 min the length of one's sleep, total mark declines 2.3; Test group and matched group comparison time for falling asleep have shortened 8.2 min, have extended 19.5 min total marks the length of one's sleep and have declined 2.3.Three indexs all have significance by self pairing t-check (JD<0.01) and time for falling asleep, total mark by t-check comparison (P<0.05) difference in groups; Before and after test, other healthy index of correlation of experimenter does not obviously change.According to the criterion in < < health product function assessment assessment process and method of inspection > > (DB22～T397～2006), judge: the present invention calms the nerves to paste and has the sleep function of improvement.
Claims (2)
1. a medicine for tranquillizing and allaying excitement, is characterized in that: the parts by weight of raw materials of making effective ingredient consists of:
Margarita 50～150 Os Draconis 50～150 Semen Ziziphi Spinosaes 150～300
Radix Polygalae 150～300 Poria cum Radix Pini's 150～300 Rhizoma Acori Graminei 150～300
Radix Angelicae Sinensis 150～300 Radix Paeoniae Alba 150～300 Radixs Astragali 150～300
Folium Artemisiae Argyi 150～400.
2. the plaster that described in claim 1, medicine is made, is characterized in that: the parts by weight of raw materials of making effective ingredient consists of:
The ointment 35 medical hot melt type pressure sensitive adhesives 64.85 that said medicine is made
Azone 0.05 methyl hydroxybenzoate 0.1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210346232.3A CN102836298B (en) | 2012-09-18 | 2012-09-18 | Medicine for tranquilizing and allaying excitement |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210346232.3A CN102836298B (en) | 2012-09-18 | 2012-09-18 | Medicine for tranquilizing and allaying excitement |
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| Publication Number | Publication Date |
|---|---|
| CN102836298A CN102836298A (en) | 2012-12-26 |
| CN102836298B true CN102836298B (en) | 2014-04-09 |
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|---|---|---|---|
| CN201210346232.3A Expired - Fee Related CN102836298B (en) | 2012-09-18 | 2012-09-18 | Medicine for tranquilizing and allaying excitement |
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| CN104770717A (en) * | 2015-04-13 | 2015-07-15 | 吉林省中研药业有限公司 | Healthcare product composition for soothing nerves and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757568A (en) * | 2010-04-19 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating insomnia and preparation method thereof |
| CN101991774A (en) * | 2010-11-23 | 2011-03-30 | 张秀兰 | Medicine for treating insomnia and preparation method thereof |
-
2012
- 2012-09-18 CN CN201210346232.3A patent/CN102836298B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757568A (en) * | 2010-04-19 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating insomnia and preparation method thereof |
| CN101991774A (en) * | 2010-11-23 | 2011-03-30 | 张秀兰 | Medicine for treating insomnia and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 《失眠症的中医治疗近况》;仇化国;《右江民族医学院学报》;20030831;第25卷(第4期);580-582 * |
| 仇化国.《失眠症的中医治疗近况》.《右江民族医学院学报》.2003,第25卷(第4期),580-582. |
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| CN102836298A (en) | 2012-12-26 |
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