CN102822347A - 高价值化学产品的微生物生产，以及相关的组合物、方法和系统 - Google Patents

高价值化学产品的微生物生产，以及相关的组合物、方法和系统 Download PDF

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CN102822347A
CN102822347A CN2011800164006A CN201180016400A CN102822347A CN 102822347 A CN102822347 A CN 102822347A CN 2011800164006 A CN2011800164006 A CN 2011800164006A CN 201180016400 A CN201180016400 A CN 201180016400A CN 102822347 A CN102822347 A CN 102822347A
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activity
genetic modification
microorganism
genetically modified
coa
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迈克尔·D·林奇
R·T·吉尔
坦尼娅·瓦尼克-利普斯科布
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Board Of Directors Of Colorado State University (body Corporate)
OPX Biotechnologies Inc
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Board Of Directors Of Colorado State University (body Corporate)
OPX Biotechnologies Inc
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CN2011800164006A 2010-01-27 2011-01-27 高价值化学产品的微生物生产，以及相关的组合物、方法和系统 Pending CN102822347A (zh)

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US29884410P 2010-01-27 2010-01-27
US61/298,844 2010-01-27
US32148010P 2010-04-06 2010-04-06
US61/321,480 2010-04-06
PCT/US2011/022790 WO2011094457A1 (en) 2010-01-27 2011-01-27 Microorganism production of high-valve chemical products, and related compositions, methods and systems

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CA (1) CA2788045A1 (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104099307A (zh) * 2014-03-12 2014-10-15 江南大学 一种解除酪氨酸反馈抑制的AroF酶突变体及其应用
CN112725251A (zh) * 2019-10-14 2021-04-30 江南大学 一种生产亚精胺的工程菌
CN112881463A (zh) * 2021-01-19 2021-06-01 西安交通大学 一种容器内液体温度变化可视化处理方法
CN112969782A (zh) * 2018-10-26 2021-06-15 于利奇研究中心有限公司 在棒状细菌中提供丙二酰辅酶a以及通过棒状细菌制备多酚和聚酮的方法
CN114369545A (zh) * 2021-12-24 2022-04-19 河北萌帮水溶肥料股份有限公司 一种具有固化重金属镉功能的台湾嗜铜菌菌株ky575及其应用

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
WO2011038364A1 (en) 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
RU2012132908A (ru) 2010-02-11 2014-03-20 Метаболикс, Инк. Способ получения производных химических соединений
CA2807561C (en) 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways
MX2013005654A (es) 2010-11-22 2013-07-17 Novozymes Inc Composiciones y metodos para la produccion de acido 3-hidroxipropionico.
BR112015002940A2 (pt) 2012-08-10 2018-04-24 Opx Biotechnologies Inc microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos.
JP2015536669A (ja) 2012-11-30 2015-12-24 ノボザイムス，インコーポレイティド 組換え酵母による３−ヒドロキシプロピオン酸の生産
US8846369B2 (en) 2012-12-21 2014-09-30 Algenol Biofuels Inc. Cyanobacterium sp. host cell and vector for production of chemical compounds in cyanobacterial cultures
US9157101B2 (en) 2012-12-21 2015-10-13 Algenol Biotech LLC Cyanobacterium sp. for production of compounds
WO2014151266A1 (en) 2013-03-15 2014-09-25 Dow Global Technologies Llc Thermal salt-splitting of (alkyl)ammonium 3-hydroxypropionate
US20140273132A1 (en) 2013-03-15 2014-09-18 Algenol Biofuels Inc. Process for Inoculating a Bioreactor with Cyanobacteria
US20160009624A1 (en) 2013-03-15 2016-01-14 Dow Global Technologies Llc Thermal salt-splitting of ammonium propionate
JP2016518821A (ja) 2013-03-15 2016-06-30 カーギル・インコーポレイテッド ３−ヒドロキシプロピオン酸の回収
WO2014145343A1 (en) * 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2015031504A1 (en) * 2013-08-27 2015-03-05 The Regents Of The University Of California RECOMBINANT PATHWAY AND ORGANISMS FOR MALONYL-CoA SYNTHESIS
BR112016008087B1 (pt) 2013-10-17 2021-06-01 Dow Global Technologies Llc Desidratação catalisada por bissulfato de amônio de ácidos beta-hidroxi
US10632156B2 (en) 2014-03-28 2020-04-28 Atterx Biotherapeutics, Inc. Preparation of small colony variants of therapeutic bacteria
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
WO2016069155A2 (en) * 2014-09-29 2016-05-06 The Regents Of The University Of California Method for biosynthesis of acetaminophen
AU2015371292A1 (en) 2014-12-23 2017-07-20 Algenol Biotech LLC Methods for increasing the stability of production of compounds in microbial host cells
MX387737B (es) 2015-02-27 2025-03-18 White Dog Labs Inc Método de fermentación mixotrófica para producir acetona, isopropanol, acido butírico y otros bioproductos, y mezclas de los mismos.
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
KR20180084756A (ko) 2015-12-07 2018-07-25 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
KR102636404B1 (ko) * 2016-06-15 2024-02-13 경상국립대학교산학협력단 터펜 알코올 또는 그 유도체의 제조 방법
WO2018005793A1 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
WO2018005655A2 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
US10138489B2 (en) 2016-10-20 2018-11-27 Algenol Biotech LLC Cyanobacterial strains capable of utilizing phosphite
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
EP3612199A4 (en) * 2017-04-17 2021-01-06 Baylor College of Medicine COMMENSAL BACTERIA AS A NEW TREATMENT FOR DRY EYE AND SJÖGREN'S SYNDROME
BR112021011954A2 (pt) * 2018-12-18 2021-10-13 Alderys Leveduras que produzem semi-aldeído malônico
CN112410389B (zh) * 2019-08-23 2023-07-18 中国科学院微生物研究所 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用
CN111675743B (zh) * 2020-06-05 2023-10-27 宁夏泰益欣生物科技股份有限公司 一种从多杀菌素发酵液中提取多杀菌素的方法
WO2022098162A1 (ko) * 2020-11-05 2022-05-12 주식회사 엘지화학 3-하이드록시프로피온산의 생산 방법
CN112795525A (zh) * 2021-03-25 2021-05-14 辽宁大学 一种乙酸钙不动杆菌培养基及其在降解双酚a的中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1556855A (zh) * 2000-11-20 2004-12-22 卡吉尔公司 3-羟基丙酸及其它有机化合物
CN101573451A (zh) * 2006-03-15 2009-11-04 马泰克生物科学公司 利用pufa聚酮化合物合成酶系统在异源的生物体中产生多不饱和脂肪酸的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
CA2322105A1 (en) * 2000-10-23 2002-04-23 Plant Bioscience Limited Antibiotic production (ii)
DK1706457T3 (da) * 2003-12-04 2012-05-21 Novozymes As Fremstilling af 3-hydroxypropionsyre ved anvendelse af beta-alanin/pyruvataminotransferase
US7772444B2 (en) * 2005-05-19 2010-08-10 E. I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
MX340759B (es) * 2006-03-15 2015-03-11 Dsm Ip Assets B V * Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados.
WO2009036095A1 (en) * 2007-09-10 2009-03-19 Joule Biotechnologies, Inc. Engineered light-harvesting organisms
US8518678B2 (en) * 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
CN102015995B (zh) * 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
EP2620501A3 (en) * 2008-05-23 2013-10-02 E. I. du Pont de Nemours and Company DGAT genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
AU2009258344B2 (en) * 2008-06-09 2013-11-07 Lanzatech Nz, Inc. Production of butanediol by anaerobic microbial fermentation
DE102008002309A1 (de) * 2008-06-09 2009-12-10 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
US20110244575A1 (en) * 2008-07-23 2011-10-06 Lipscomb Tanya E W Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp)
EP2326709A4 (en) * 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
CA2807561C (en) * 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1556855A (zh) * 2000-11-20 2004-12-22 卡吉尔公司 3-羟基丙酸及其它有机化合物
CN101573451A (zh) * 2006-03-15 2009-11-04 马泰克生物科学公司 利用pufa聚酮化合物合成酶系统在异源的生物体中产生多不饱和脂肪酸的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
徐晓伟等: "脂肪酸合成酶抑制剂的研究进展", 《国际药学研究杂志》, vol. 36, no. 2, 30 April 2009 (2009-04-30) *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104099307A (zh) * 2014-03-12 2014-10-15 江南大学 一种解除酪氨酸反馈抑制的AroF酶突变体及其应用
CN112969782A (zh) * 2018-10-26 2021-06-15 于利奇研究中心有限公司 在棒状细菌中提供丙二酰辅酶a以及通过棒状细菌制备多酚和聚酮的方法
CN112725251A (zh) * 2019-10-14 2021-04-30 江南大学 一种生产亚精胺的工程菌
CN112725251B (zh) * 2019-10-14 2022-07-22 江南大学 一种生产亚精胺的工程菌
CN112881463A (zh) * 2021-01-19 2021-06-01 西安交通大学 一种容器内液体温度变化可视化处理方法
CN114369545A (zh) * 2021-12-24 2022-04-19 河北萌帮水溶肥料股份有限公司 一种具有固化重金属镉功能的台湾嗜铜菌菌株ky575及其应用
CN114369545B (zh) * 2021-12-24 2024-01-30 河北萌帮水溶肥料股份有限公司 一种具有固化重金属镉功能的台湾嗜铜菌菌株ky575及其应用

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