CN102814294B - Cleaning and drying device for biological chip - Google Patents
Cleaning and drying device for biological chip Download PDFInfo
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- CN102814294B CN102814294B CN201210203852.1A CN201210203852A CN102814294B CN 102814294 B CN102814294 B CN 102814294B CN 201210203852 A CN201210203852 A CN 201210203852A CN 102814294 B CN102814294 B CN 102814294B
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- drying device
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- clearing
- cleaning box
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Abstract
The invention discloses a cleaning and drying device for a biological chip. The cleaning and drying device comprises a cylinder, a clamping jaw and a cleaning box, wherein a first nozzle holder and a second nozzle holder are correspondingly arranged in front and back of the cleaning box; air nozzle holders are correspondingly arranged on the left and right in the cleaning box; the other end of each of shafts ,rotationally connected with the nozzle holders and the air nozzle holders, is in guide connection with a shaft connecting plate on the external end face of the cleaning box through long holes arranged on the cleaning box. According to the cleaning and drying device, the problems that the cleaning cannot be completely carried out, the cleaning pressure and the flow rate cannot be quantified, and the position cannot be adjusted can be solved, and meanwhile, thereby solving the problems that the biological samples arrayed on the surface of a chip are damaged or mutually polluted due to insufficient or excessive cleaning, and cannot be fully dried.
Description
Technical field
The present invention relates to a kind of clearing and drying device, particularly relate to a kind of clearing and drying device of biochip.
Background technology
Hard matrix chip is clamped to cleaning and drying area, circular staight needle pipe fixed position is adopted externally to spray liquid, same employing fixed position firm discharge and pressure externally spray gas, chip is driven by clamping device and moves up and down, and the injection of liquids and gases is only for the obverse and reverse of hard matrix chip.The distance of hydro-peening and air blowing, pressure, flow, angle cannot adjust and control, and cause cleaning deficiency or overclean, and the biological sample of chip surface array is destroyed or mutually pollute, and side cannot dry up, liquid residue chip, has a strong impact on next step technique.
Summary of the invention
The defect that the present invention seeks to exist for prior art provides a kind of clearing and drying device of biochip.
The present invention for achieving the above object, adopts following technical scheme:
A kind of clearing and drying device of biochip, comprise cylinder, jaw, cleaning box, before and after in described cleaning box, correspondence arranges first, second nozzle carrier, in cleaning box, left and right correspondence arranges air nozzle seat, and the elongated hole that the axle other end be rotationally connected with described nozzle carrier, air nozzle seat is provided with by described cleaning box leads with the axle connecting plate of cleaning box outer face and is connected.
Described water spout seat, air nozzle seat and axle connecting plate are provided with the fastening bolt that can abut on the shaft.
Described axle connecting plate and described axle are that nonrotational mode is connected.
Described axle connecting plate be provided with multiple can the hex bolts of left and right adjustment axle connecting plate relative position.
The chip cleaning needle bottom water spout seat of described first jet seat being provided with array pin hole and matching with described pin hole, described cleaning needle internal diameter 0.2 mm, external diameter 0.6mm.
The side of described cleaning box is provided with horizontal pressing plate.
Be provided with tap bottom described cleaning box, described tap is by the effluent discharge of sewer pipe joint.
The nozzle width of described air nozzle seat is slightly larger than Chip-wide.
The die gap of described air nozzle seat is 0.3-0.4mm, width 5-6mm.
The present invention has following beneficial effect: solve punching and do not wash clean, the problem that flushing pressure, flow cannot quantize and position cannot adjust, solve cleaning deficiency or overclean, the biological sample of chip surface array is destroyed or mutually pollute simultaneously, problem that cannot be fully dry; 4 very thin air nozzles, in 4 faces, two positive and negatives facing to hard matrix chip, two two sides facing to hard matrix chip, each nozzle can the three-dimensional adjustment of implementation space (X is to, Y-direction, anglec of rotation *), add chip itself to be moved up and down by mechanisms grip, constitute the comprehensive adjustment of 4 dimensions, realize the comprehensive covering of blowing to chip.
Be provided with fluid injector at the tow sides of chip, front is 7 nozzle needles, and reverse side is 1 nozzle needle.Nozzle needle can realize the adjustment of 3 dimensions equally, adds chip itself and is moved up and down by mechanisms grip, constitutes the comprehensive adjustment of 4 dimensions, realizes the comprehensive cleaning of Liquid inject to chip and covers.
Jet and the fluid injector in front is structurally designed to integral type, and the jet and fluid injector of reverse side is structurally also designed to integral type.
For chip, according to predetermined imagination, first carry out jet cleaning, then dry up; Also can dry up rear continuation cleaning, and then dry up.
Liquid inject scavenging period can control separately, and the time that dries up also can control separately, and the pressure of liquid and flow can regulate separately; The jet time can control separately, and pressure and flow also can regulate separately.
Accompanying drawing explanation
Fig. 1: structure principle chart of the present invention.
The B-B profile of Fig. 2: Fig. 1.
The partial enlarged drawing of Fig. 3: Fig. 2.
The A-A profile of Fig. 4: Fig. 1.
The partial enlarged drawing of Fig. 5: Fig. 4 II.
Fig. 6: general assembly axonometric drawing of the present invention.
Detailed description of the invention
As shown in figures 1 to 6, the present invention is a kind of clearing and drying device of biochip, comprise cylinder 1, jaw 2, cleaning box 4, before and after in described cleaning box 4, correspondence arranges first, second nozzle carrier 5,8, in cleaning box 4, left and right correspondence arranges air nozzle seat 7, with described nozzle carrier 5,8, the elongated hole that is provided with by described cleaning box 4 of axle 6 other end that is rotationally connected of air nozzle seat 7 to be led with the axle connecting plate 13 of cleaning box 4 outer face and is connected.Described water spout seat, air nozzle seat 7 and axle connecting plate 13 are provided with the fastening bolt 16 that can abut on the shaft.Described axle connecting plate 13 is connected for nonrotational mode with described axle 6.Preferably, usually use square hole to coordinate with square shaft to lead.Described axle connecting plate 13 be provided with multiple can the hex bolts 15 of left and right adjustment axle connecting plate 13 relative position.The chip cleaning needle 14 bottom water spout seat of described first jet seat 5 being provided with array pin hole and matching with described pin hole, described cleaning needle internal diameter 0.2 mm, external diameter 0.6mm.The side of described cleaning box 4 is provided with horizontal pressing plate 9.Be provided with tap bottom described cleaning box 4, described tap is by sewer pipe joint 10 effluent discharge.The nozzle width of described air nozzle seat 7 is slightly larger than Chip-wide.The die gap of described air nozzle seat 7 is 0.3-0.4mm, width 5-6mm.
The anterior water spout seat of the first water spout seat 5 arranges array pin hole, and the bottom water spout seat of the first water spout seat 5 arranges 7 chip cleaning needles, and water spout seat 8 is designed to 1 cleaning needle 14, described pin hole internal diameter 0.2 mm external diameter 0.6mm.
The present invention has tow sides water spray altogether, positive and negatively adds two sides, and four sides is jet; Double-edged water spray and jetly to design respectively on same carrier.
Glass matrix biochip 3 one side lattice array bioprotein, surface-closed, after bioprotein chip and seroreaction, need from point cleaning and drying, to carry out next step technique.
Cleaning
Adopt 4+3 array pin hole, the aperture of 0.2---0.6mm, seven, front, reverse side one, front is used for the front of the bioprotein rinsing biochip, and reverse side pin rinses the reverse side of chip.
The width range rinsed covers the width of chip, 4+3 array pin hole stagger up and down all with distribute, with reach all with the object of cleaning.
It is stainless steel that cleaning needle installs carrier, lateral inflow, irrigation pressure and time can regulate, carrier tilt adjustable is installed whole, two dimension adjustable in horizontal plane, chip with handle, when moving up and down manually or automatically, can realize the adjustment on four dimensions in conjunction with above adjustment mode, to reach the effect of fully cleaning.
Dry
After cleaning terminates, adopt Medical purification air blow drying chip.
Stainless steel is adopted to be processed into spray nozzle of atmospheric pressure, nozzle width is slightly larger than Chip-wide, jet gap is 0.3-0.4mm, protrude thin nozzle type to save space, valve can both direction regulate in the plane, and the anglec of rotation is adjustable, and chip is when moving up and down manually or automatically, the position adjustment in 4 dimensions can be realized, comprehensively dry up effect to reach.Chip all arranges air nozzle in 4 faces, and each valve has same adjustable function, and air blowing flow, pressure and time control separately by external equipment.
Blow and dry, efficiently solve chip surface residual moisture, the problem of handle and chip residual moisture.
The double-edged nozzle of chip of the present invention and be jetly designed to integral type, the blowing nozzle of side designs separately.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a clearing and drying device for biochip, comprises cylinder, jaw, cleaning box, it is characterized in that, before and after in described cleaning box, correspondence arranges first, second nozzle carrier, and first, second nozzle carrier described is provided with water spout and air nozzle; In cleaning box, left and right correspondence arranges air nozzle seat, and the elongated hole that the axle other end be rotationally connected with described nozzle carrier, air nozzle seat is provided with by described cleaning box leads with the axle connecting plate of cleaning box outer face and is connected.
2. the clearing and drying device of a kind of biochip according to claim 1, is characterized in that, first, second nozzle carrier described, air nozzle seat and axle connecting plate are provided with the fastening bolt that can abut on the shaft.
3. the clearing and drying device of a kind of biochip according to claim 1, is characterized in that, described axle connecting plate and described axle are that nonrotational mode is connected.
4. the clearing and drying device of a kind of biochip according to claim 1 or 2 or 3, is characterized in that, described axle connecting plate and described axle are that square hole and square shaft are connected.
5., according to the clearing and drying device of a kind of biochip described in claim 4, it is characterized in that, described axle connecting plate be provided with multiple can the hex bolts of left and right adjustment axle connecting plate relative position.
6. the clearing and drying device of a kind of biochip according to claim 1, it is characterized in that, the chip cleaning needle bottom water spout seat of described first jet seat being provided with array pin hole and matching with described pin hole, described cleaning needle internal diameter 0.2 mm, external diameter 0.6mm.
7. the clearing and drying device of a kind of biochip according to claim 1, is characterized in that, the side of described cleaning box is provided with horizontal pressing plate.
8. the clearing and drying device of a kind of biochip according to claim 1, is characterized in that, is provided with tap bottom described cleaning box, and described tap is by the effluent discharge of sewer pipe joint.
9. the clearing and drying device of a kind of biochip according to claim 1, is characterized in that, the nozzle width of described air nozzle seat is slightly larger than Chip-wide.
10. the clearing and drying device of a kind of biochip according to claim 1, is characterized in that, the die gap of described air nozzle seat is 0.3-0.4mm, width 5-6mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210203852.1A CN102814294B (en) | 2012-06-19 | 2012-06-19 | Cleaning and drying device for biological chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210203852.1A CN102814294B (en) | 2012-06-19 | 2012-06-19 | Cleaning and drying device for biological chip |
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| Publication Number | Publication Date |
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| CN102814294A CN102814294A (en) | 2012-12-12 |
| CN102814294B true CN102814294B (en) | 2015-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210203852.1A Active CN102814294B (en) | 2012-06-19 | 2012-06-19 | Cleaning and drying device for biological chip |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013204646B4 (en) * | 2013-03-15 | 2018-04-05 | Leica Biosystems Nussloch Gmbh | Device for processing histological samples |
| CN105344639A (en) * | 2015-11-06 | 2016-02-24 | 江苏三联生物工程有限公司 | Biological chip washing mechanism |
| CN105372437A (en) * | 2015-11-25 | 2016-03-02 | 江苏三联生物工程有限公司 | Biochip detection machine with scrubbing function |
| CN105510608A (en) * | 2015-11-25 | 2016-04-20 | 江苏三联生物工程有限公司 | Automatic biochip reading equipment |
| CN106334685B (en) * | 2016-10-19 | 2018-09-21 | 湖州数康生物科技有限公司 | A kind of biochip automated cleaning system |
| CN108856108A (en) * | 2018-07-03 | 2018-11-23 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
| CN108646039A (en) * | 2018-07-03 | 2018-10-12 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument |
| CN111649559B (en) * | 2020-05-29 | 2022-06-14 | 立讯智造(浙江)有限公司 | Drying equipment and drying method for electronic product |
| CN113020088B (en) * | 2021-05-19 | 2021-08-10 | 捷仪科技(北京)有限公司 | Chip washing device |
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| CN101063078A (en) * | 2007-04-20 | 2007-10-31 | 博奥生物有限公司 | Biological chip hybrid cleaning device |
| CN101196447A (en) * | 2007-12-21 | 2008-06-11 | 博奥生物有限公司 | Washing method and device for biological chip |
| CN101435655A (en) * | 2008-12-19 | 2009-05-20 | 江苏三联生物工程有限公司 | Method and tool for drying hard substrate biological chips |
| CN202238734U (en) * | 2011-08-29 | 2012-05-30 | 江阴康强电子有限公司 | Lead frame rinsing tank |
| CN202779013U (en) * | 2012-06-19 | 2013-03-13 | 江苏三联生物工程有限公司 | Washing and drying device of biochips |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH11307508A (en) * | 1998-04-22 | 1999-11-05 | Rohm Co Ltd | Washing/drying device of semiconductor wafer |
| KR20120034948A (en) * | 2010-10-04 | 2012-04-13 | 삼성전자주식회사 | Apparatus for drying a substrate and method for performing the same using thereof |
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2012
- 2012-06-19 CN CN201210203852.1A patent/CN102814294B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101063078A (en) * | 2007-04-20 | 2007-10-31 | 博奥生物有限公司 | Biological chip hybrid cleaning device |
| CN101196447A (en) * | 2007-12-21 | 2008-06-11 | 博奥生物有限公司 | Washing method and device for biological chip |
| CN101435655A (en) * | 2008-12-19 | 2009-05-20 | 江苏三联生物工程有限公司 | Method and tool for drying hard substrate biological chips |
| CN202238734U (en) * | 2011-08-29 | 2012-05-30 | 江阴康强电子有限公司 | Lead frame rinsing tank |
| CN202779013U (en) * | 2012-06-19 | 2013-03-13 | 江苏三联生物工程有限公司 | Washing and drying device of biochips |
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| CN102814294A (en) | 2012-12-12 |
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Denomination of invention: Cleaning and drying device for biological chip Effective date of registration: 20190726 Granted publication date: 20150218 Pledgee: Agricultural Bank of China Limited by Share Ltd Wuxi science and Technology Branch Pledgor: Jiangsu Sanlian Bioengineering Co., Ltd. Registration number: 2019990000792 |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200810 Granted publication date: 20150218 Pledgee: Agricultural Bank of China Limited by Share Ltd. Wuxi science and Technology Branch Pledgor: SUNLANT BIOLOGICAL ENGINEERING Co.,Ltd. Registration number: 2019990000792 |
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| CP03 | Change of name, title or address | ||
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Address after: No. 35-305, Changjiang South Road, Xinwu District, Wuxi, Jiangsu 214111 Patentee after: Jiangsu Sanlian Bioengineering Co.,Ltd. Address before: 214038 block a, Xingye building, No. 97, Linghu Avenue, New District, Wuxi City, Jiangsu Province Patentee before: SUNLANT BIOLOGICAL ENGINEERING CO.,LTD. |