CN108856108A - Full-automatic protein chip immunity analysis instrument chip cleans dry body - Google Patents

Full-automatic protein chip immunity analysis instrument chip cleans dry body Download PDF

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Publication number
CN108856108A
CN108856108A CN201810716222.1A CN201810716222A CN108856108A CN 108856108 A CN108856108 A CN 108856108A CN 201810716222 A CN201810716222 A CN 201810716222A CN 108856108 A CN108856108 A CN 108856108A
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CN
China
Prior art keywords
chip
waste water
fermentation vat
cleaning
stainless steel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810716222.1A
Other languages
Chinese (zh)
Inventor
马贵兰
徐艳娟
陆冬雷
杜彬
田小慧
戴良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WUXI GUOSHENG BIOLOGICAL ENGINEERING Co Ltd
Original Assignee
WUXI GUOSHENG BIOLOGICAL ENGINEERING Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WUXI GUOSHENG BIOLOGICAL ENGINEERING Co Ltd filed Critical WUXI GUOSHENG BIOLOGICAL ENGINEERING Co Ltd
Priority to CN201810716222.1A priority Critical patent/CN108856108A/en
Publication of CN108856108A publication Critical patent/CN108856108A/en
Pending legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B13/00Accessories or details of general applicability for machines or apparatus for cleaning
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/004Nozzle assemblies; Air knives; Air distributors; Blow boxes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention is full-automatic protein chip immunity analysis instrument chip cleaning dry body, its structure is that middle part sets chip fermentation vat in cleaning box, chip rack is set above chip fermentation vat, chip placement on chip rack, stainless steel needle tubing is set respectively on the pool wall of chip fermentation vat two sides, the external cleaning solution diaphragm pump of stainless steel needle tubing, the liquid outlet of two sides stainless steel needle tubing is oppositely arranged, two sides stainless steel needle tubing upper die rack two sides set jet thrust respectively, jet thrust connects gas-tpe fitting, the external blow-dry device with solenoid valve of gas-tpe fitting, chip impregnates bottom of pond portion and the cleaning box bottom of chip fermentation vat bottom outside is separately connected a waste water connector, the waste water connector that chip impregnates bottom of pond portion connects a diaphragm valve, the external same pumping waste water diaphragm pump of two waste water connectors.Advantages of the present invention:Cleaning efficiency is high, and effect is good.

Description

Full-automatic protein chip immunity analysis instrument chip cleans dry body
Technical field
The present invention relates to full-automatic protein chip immunity analysis instrument chips to clean dry body.
Background technique
Protein chip is a kind of protein-function assays technology of high throughput, can be used for protein expression spectrum analysis, studies egg The interaction of white matter and protein or even the interaction of DNA- protein, RNA- protein, screen pharmaceutically-active albumen Target spot etc..
Protein chip carries out immunoassay using immunity analysis instrument, and immunity analysis instrument refers specifically to progress chemiluminescent labeling and exempts from Epidemic disease analyzes the instrument of (also known as chemiluminescence immune assay), is the immunoassay with the direct labelled antigen of chemiluminescent agent or antibody Method.
The protein chip immunity analysis instrument of the prior art generally comprises two parts, i.e. immune response system and chemiluminescence Analysis system.Immune response system is used to for luminescent substance (generating excitation state intermediate under reaction solution excitation) being marked directly on On antigen (chemiluminescence immune assay) or antibody (immunochemiluminometry) or enzyme effect is in luminous substrate.Chemiluminescence Analysis system is used for the oxidation using catalysis and oxidant of the chemiluminescent substance through catalyst, forms the centre of an excitation state Body when this excitation state intermediate returns to stable ground state, while launching photon (hM), utilizes luminous signal measuring instrument Measure quantum yield of luminscence.
Generally each system of the protein chip immunity analysis instrument of the prior art and mechanism are provided separately, and operation needs repeatedly artificial Operation, low efficiency is time-consuming long, cannot achieve fully automatic operation.
Summary of the invention
Proposed by the present invention is full-automatic protein chip immunity analysis instrument chip cleaning dry body, and purpose is intended to overcome Deficiencies of the prior art realizes that full-automatic protein chip immunity analysis instrument chip cleans drying automatically.
Technical solution of the invention:Full-automatic protein chip immunity analysis instrument chip cleans dry body, structure Including cleaning box, chip rack, chip fermentation vat and jet thrust, wherein middle part sets chip fermentation vat, chip leaching in cleaning box Bubble sets chip rack above pond, chip placement on chip rack, sets stainless pin respectively on the pool wall of chip fermentation vat two sides Pipe, the external cleaning solution diaphragm pump of stainless steel needle tubing, the liquid outlet of two sides stainless steel needle tubing is oppositely arranged, on the stainless steel needle tubing of two sides Square chip rack two sides set jet thrust respectively, and jet thrust connects gas-tpe fitting, the external drying with solenoid valve of gas-tpe fitting Device, chip impregnates bottom of pond portion and the cleaning box bottom of chip fermentation vat bottom outside is separately connected a waste water connector, chip The waste water connector for impregnating bottom of pond portion connects a diaphragm valve, the external same pumping waste water diaphragm pump of two waste water connectors.
Preferably, the cleaning box bottom sets jet apart from adjusting block, and jet connects two sides jet thrust apart from adjusting block.
The chip drying method of full-automatic protein chip immunity analysis instrument chip cleaning dry body, includes the following steps:
1) cleaning solution diaphragm pump is opened, and takes out waste water diaphragm pump and diaphragm valve is closed, pure water 3s is infused into chip fermentation vat, outside If chip is placed on chip rack by mechanical arm, 4s is impregnated;
2) cleaning solution diaphragm pump, pumping waste water diaphragm pump and diaphragm valve open simultaneously, and chip continues to impregnate 2s;
3) it takes out waste water diaphragm pump and diaphragm valve is opened, take out waste water 1s;
4) step 1)~step 3) is a circulation, the circulation is carried out in 120s 12 times, soaking and washing chip;
5) chip cleaning finishes, and peripheral hardware mechanical arm picks up chip, moves up and down secondary, and solenoid valve is opened at this time, passes through spray Gas head carries out drying 30s to chip surface;
6) after drying up, peripheral hardware mechanical arm grab chips, into subsequent work stations.
Advantages of the present invention:Structure is simple and effective, and chip is placed on chip rack from preamble station by peripheral hardware mechanical arm On, pure water is extracted into chip fermentation vat by cleaning needle tubing and can carry out soaking and washing to chip by cleaning solution diaphragm pump, is cooperated Take out waste water diaphragm pump can soaking and washing chip 12 times in 120s, cleaning efficiency is high, and effect is good, after chip cleans, peripheral hardware Chip is picked up and moves up and down and dried up by jet thrust to chip surface by mechanical arm, after drying, peripheral hardware mechanical arm Grab chips enter subsequent work stations.
Detailed description of the invention
Fig. 1 is the schematic perspective view of full-automatic protein chip immunity analysis instrument chip cleaning dry body of the invention.
Fig. 2 is the side sectional structure signal of full-automatic protein chip immunity analysis instrument chip cleaning dry body of the invention Figure.
1 in figure it is cleaning box, 2 be chip rack, 3 be chip, 4 be chip fermentation vat, 5 be stainless steel needle tubing, 6 is Waste water connector, 7 be jet thrust, 8 be gas-tpe fitting, 9 be jet apart from adjusting block.
Specific embodiment
Below with reference to embodiment and specific embodiment, the present invention is described in further detail.
As shown in Figure 1 and Figure 2, full-automatic protein chip immunity analysis instrument chip cleans dry body, and structure includes cleaning Box 1, chip rack 2, chip fermentation vat 4 and jet thrust 7, wherein middle part sets chip fermentation vat 4 in cleaning box 1, and chip impregnates Chip rack 2 is set above pond 4, chip placement 3 on chip rack 2 sets stainless steel on 4 two sides pool wall of chip fermentation vat respectively Needle tubing 5, the external cleaning solution diaphragm pump of stainless steel needle tubing 5, the liquid outlet of two sides stainless steel needle tubing 5 are oppositely arranged, two sides stainless steel 5 upper die rack of needle tubing, 2 two sides set jet thrust 7 respectively, and jet thrust 7 connects gas-tpe fitting 8, and gas-tpe fitting 8 is external to be had 1 bottom of cleaning box of the blow-dry device of solenoid valve, 4 bottom outside of 4 bottom of chip fermentation vat and chip fermentation vat is separately connected one The waste water connector 6 of a waste water connector 6,4 bottom of chip fermentation vat connects a diaphragm valve, and two waste water connectors 6 are external same Take out waste water diaphragm pump.
1 bottom of cleaning box sets jet apart from adjusting block 9, and jet connects two sides jet thrust 7 apart from adjusting block 9.It can Control the relative distance of two sides jet thrust.
According to the above structure, full-automatic protein chip immunity analysis instrument chip drying method, includes the following steps:
1) cleaning solution diaphragm pump is opened, and takes out waste water diaphragm pump and diaphragm valve is closed, pure water 3s is infused into chip fermentation vat 4, Chip 3 is placed on chip rack 2 by peripheral hardware mechanical arm, impregnates 4s;
2) cleaning solution diaphragm pump, pumping waste water diaphragm pump and diaphragm valve open simultaneously, and chip 3 continues to impregnate 2s;
3) it takes out waste water diaphragm pump and diaphragm valve is opened, take out waste water 1s;
4) step 1)~step 3) is a circulation, the circulation is carried out in 120s 12 times, soaking and washing chip 3;
5) cleaning of chip 3 finishes, and peripheral hardware mechanical arm picks up chip 3, moves up and down 4 times, and solenoid valve is opened at this time, passes through Jet thrust 7 carries out drying 30s to 3 surface of chip;
6) after drying up, peripheral hardware mechanical arm grab chips 3, into subsequent work stations.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those of ordinary skill in the art For, without departing from the concept of the premise of the invention, various modifications and improvements can be made, these belong to the present invention Protection scope.

Claims (3)

1. full-automatic protein chip immunity analysis instrument chip cleans dry body, feature includes cleaning box, chip rack, core Piece fermentation vat and jet thrust, wherein middle part sets chip fermentation vat in cleaning box, sets chip rack, chip above chip fermentation vat Chip placement on rack, sets stainless steel needle tubing on the pool wall of chip fermentation vat two sides respectively, the external cleaning solution of stainless steel needle tubing every The liquid outlet of membrane pump, two sides stainless steel needle tubing is oppositely arranged, and two sides stainless steel needle tubing upper die rack two sides set spray respectively Gas head, jet thrust connect gas-tpe fitting, the external blow-dry device with solenoid valve of gas-tpe fitting, and chip impregnates bottom of pond portion and chip The cleaning box bottom of fermentation vat bottom outside is separately connected a waste water connector, and chip impregnates the waste water connector connection one of bottom of pond portion A diaphragm valve, the external same pumping waste water diaphragm pump of two waste water connectors.
2. full-automatic protein chip immunity analysis instrument chip as described in claim 1 cleans dry body, it is characterized in that described Cleaning box bottom set jet apart from adjusting block, jet connects two sides jet thrust apart from adjusting block.
3. the chip drying of full-automatic protein chip immunity analysis instrument chip cleaning dry body as claimed in claim 1 or 2 Method, it is characterized in that this approach includes the following steps:
1) cleaning solution diaphragm pump is opened, and takes out waste water diaphragm pump and diaphragm valve is closed, pure water 3s, peripheral hardware machine are infused into chip fermentation vat Chip is placed on chip rack by tool arm, impregnates 4s;
2) cleaning solution diaphragm pump, pumping waste water diaphragm pump and diaphragm valve open simultaneously, and chip continues to impregnate 2s;
3) it takes out waste water diaphragm pump and diaphragm valve is opened, take out waste water 1s;
4) step 1)~step 3) is a circulation, the circulation is carried out in 120s 12 times, soaking and washing chip;
5) chip cleaning finishes, and peripheral hardware mechanical arm picks up chip, moves up and down secondary, and solenoid valve is opened at this time, passes through jet thrust Drying 30s is carried out to chip surface;
6) after drying up, peripheral hardware mechanical arm grab chips, into subsequent work stations.
CN201810716222.1A 2018-07-03 2018-07-03 Full-automatic protein chip immunity analysis instrument chip cleans dry body Pending CN108856108A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810716222.1A CN108856108A (en) 2018-07-03 2018-07-03 Full-automatic protein chip immunity analysis instrument chip cleans dry body

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810716222.1A CN108856108A (en) 2018-07-03 2018-07-03 Full-automatic protein chip immunity analysis instrument chip cleans dry body

Publications (1)

Publication Number Publication Date
CN108856108A true CN108856108A (en) 2018-11-23

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CN201810716222.1A Pending CN108856108A (en) 2018-07-03 2018-07-03 Full-automatic protein chip immunity analysis instrument chip cleans dry body

Country Status (1)

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CN (1) CN108856108A (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011021213A (en) * 2009-07-14 2011-02-03 World Kiko:Kk Cleaning method, cleaning apparatus and drying apparatus
CN102814294A (en) * 2012-06-19 2012-12-12 江苏三联生物工程有限公司 Cleaning and drying device for biological chip
CN204842320U (en) * 2015-08-19 2015-12-09 深圳市汇北川电子技术有限公司 Temperature sensor is belt cleaning device for chip
CN105414089A (en) * 2015-12-16 2016-03-23 芜湖普威技研有限公司 Automobile rear shaft cleaning device
CN106409717A (en) * 2015-07-27 2017-02-15 沈阳芯源微电子设备有限公司 Wafer metal-stripping and photoresist-stripping cleaning device
CN206104448U (en) * 2016-08-19 2017-04-19 郑州博奥医学检验所有限公司 Biochip self - cleaning device
CN206435531U (en) * 2016-12-30 2017-08-25 通威太阳能(成都)有限公司 A kind of repetend ability of swimming solar silicon wafers prerinse equipment
CN207009409U (en) * 2017-05-26 2018-02-13 常州市杰洋精密机械有限公司 Photovoltaic cleaning equipment spray system
CN107931219A (en) * 2017-11-29 2018-04-20 芜湖戎征达伺服驱动技术有限公司 Between automatic production line mold clean
CN207371959U (en) * 2017-09-11 2018-05-18 浙江千鹤工艺品有限公司 A kind of cleaning device for craftwork
CN108212903A (en) * 2018-03-23 2018-06-29 郑州金恒电子技术有限公司 A kind of automatic cleaning, drying equipment about silicon chip
CN208482983U (en) * 2018-07-03 2019-02-12 无锡国盛生物工程有限公司 Full-automatic protein chip immunity analysis instrument chip cleans dry body

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011021213A (en) * 2009-07-14 2011-02-03 World Kiko:Kk Cleaning method, cleaning apparatus and drying apparatus
CN102814294A (en) * 2012-06-19 2012-12-12 江苏三联生物工程有限公司 Cleaning and drying device for biological chip
CN106409717A (en) * 2015-07-27 2017-02-15 沈阳芯源微电子设备有限公司 Wafer metal-stripping and photoresist-stripping cleaning device
CN204842320U (en) * 2015-08-19 2015-12-09 深圳市汇北川电子技术有限公司 Temperature sensor is belt cleaning device for chip
CN105414089A (en) * 2015-12-16 2016-03-23 芜湖普威技研有限公司 Automobile rear shaft cleaning device
CN206104448U (en) * 2016-08-19 2017-04-19 郑州博奥医学检验所有限公司 Biochip self - cleaning device
CN206435531U (en) * 2016-12-30 2017-08-25 通威太阳能(成都)有限公司 A kind of repetend ability of swimming solar silicon wafers prerinse equipment
CN207009409U (en) * 2017-05-26 2018-02-13 常州市杰洋精密机械有限公司 Photovoltaic cleaning equipment spray system
CN207371959U (en) * 2017-09-11 2018-05-18 浙江千鹤工艺品有限公司 A kind of cleaning device for craftwork
CN107931219A (en) * 2017-11-29 2018-04-20 芜湖戎征达伺服驱动技术有限公司 Between automatic production line mold clean
CN108212903A (en) * 2018-03-23 2018-06-29 郑州金恒电子技术有限公司 A kind of automatic cleaning, drying equipment about silicon chip
CN208482983U (en) * 2018-07-03 2019-02-12 无锡国盛生物工程有限公司 Full-automatic protein chip immunity analysis instrument chip cleans dry body

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