CN108856108A - Full-automatic protein chip immunity analysis instrument chip cleans dry body - Google Patents
Full-automatic protein chip immunity analysis instrument chip cleans dry body Download PDFInfo
- Publication number
- CN108856108A CN108856108A CN201810716222.1A CN201810716222A CN108856108A CN 108856108 A CN108856108 A CN 108856108A CN 201810716222 A CN201810716222 A CN 201810716222A CN 108856108 A CN108856108 A CN 108856108A
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- China
- Prior art keywords
- chip
- waste water
- fermentation vat
- cleaning
- stainless steel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 23
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 23
- 238000004458 analytical method Methods 0.000 title claims abstract description 21
- 230000036039 immunity Effects 0.000 title claims abstract description 19
- 238000004140 cleaning Methods 0.000 claims abstract description 38
- 239000002351 wastewater Substances 0.000 claims abstract description 30
- 238000000855 fermentation Methods 0.000 claims abstract description 24
- 230000004151 fermentation Effects 0.000 claims abstract description 24
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 16
- 239000010935 stainless steel Substances 0.000 claims abstract description 16
- 238000005086 pumping Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims description 12
- 230000002093 peripheral effect Effects 0.000 claims description 11
- 238000002791 soaking Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 3
- 230000005284 excitation Effects 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000005081 chemiluminescent agent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/004—Nozzle assemblies; Air knives; Air distributors; Blow boxes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present invention is full-automatic protein chip immunity analysis instrument chip cleaning dry body, its structure is that middle part sets chip fermentation vat in cleaning box, chip rack is set above chip fermentation vat, chip placement on chip rack, stainless steel needle tubing is set respectively on the pool wall of chip fermentation vat two sides, the external cleaning solution diaphragm pump of stainless steel needle tubing, the liquid outlet of two sides stainless steel needle tubing is oppositely arranged, two sides stainless steel needle tubing upper die rack two sides set jet thrust respectively, jet thrust connects gas-tpe fitting, the external blow-dry device with solenoid valve of gas-tpe fitting, chip impregnates bottom of pond portion and the cleaning box bottom of chip fermentation vat bottom outside is separately connected a waste water connector, the waste water connector that chip impregnates bottom of pond portion connects a diaphragm valve, the external same pumping waste water diaphragm pump of two waste water connectors.Advantages of the present invention:Cleaning efficiency is high, and effect is good.
Description
Technical field
The present invention relates to full-automatic protein chip immunity analysis instrument chips to clean dry body.
Background technique
Protein chip is a kind of protein-function assays technology of high throughput, can be used for protein expression spectrum analysis, studies egg
The interaction of white matter and protein or even the interaction of DNA- protein, RNA- protein, screen pharmaceutically-active albumen
Target spot etc..
Protein chip carries out immunoassay using immunity analysis instrument, and immunity analysis instrument refers specifically to progress chemiluminescent labeling and exempts from
Epidemic disease analyzes the instrument of (also known as chemiluminescence immune assay), is the immunoassay with the direct labelled antigen of chemiluminescent agent or antibody
Method.
The protein chip immunity analysis instrument of the prior art generally comprises two parts, i.e. immune response system and chemiluminescence
Analysis system.Immune response system is used to for luminescent substance (generating excitation state intermediate under reaction solution excitation) being marked directly on
On antigen (chemiluminescence immune assay) or antibody (immunochemiluminometry) or enzyme effect is in luminous substrate.Chemiluminescence
Analysis system is used for the oxidation using catalysis and oxidant of the chemiluminescent substance through catalyst, forms the centre of an excitation state
Body when this excitation state intermediate returns to stable ground state, while launching photon (hM), utilizes luminous signal measuring instrument
Measure quantum yield of luminscence.
Generally each system of the protein chip immunity analysis instrument of the prior art and mechanism are provided separately, and operation needs repeatedly artificial
Operation, low efficiency is time-consuming long, cannot achieve fully automatic operation.
Summary of the invention
Proposed by the present invention is full-automatic protein chip immunity analysis instrument chip cleaning dry body, and purpose is intended to overcome
Deficiencies of the prior art realizes that full-automatic protein chip immunity analysis instrument chip cleans drying automatically.
Technical solution of the invention:Full-automatic protein chip immunity analysis instrument chip cleans dry body, structure
Including cleaning box, chip rack, chip fermentation vat and jet thrust, wherein middle part sets chip fermentation vat, chip leaching in cleaning box
Bubble sets chip rack above pond, chip placement on chip rack, sets stainless pin respectively on the pool wall of chip fermentation vat two sides
Pipe, the external cleaning solution diaphragm pump of stainless steel needle tubing, the liquid outlet of two sides stainless steel needle tubing is oppositely arranged, on the stainless steel needle tubing of two sides
Square chip rack two sides set jet thrust respectively, and jet thrust connects gas-tpe fitting, the external drying with solenoid valve of gas-tpe fitting
Device, chip impregnates bottom of pond portion and the cleaning box bottom of chip fermentation vat bottom outside is separately connected a waste water connector, chip
The waste water connector for impregnating bottom of pond portion connects a diaphragm valve, the external same pumping waste water diaphragm pump of two waste water connectors.
Preferably, the cleaning box bottom sets jet apart from adjusting block, and jet connects two sides jet thrust apart from adjusting block.
The chip drying method of full-automatic protein chip immunity analysis instrument chip cleaning dry body, includes the following steps:
1) cleaning solution diaphragm pump is opened, and takes out waste water diaphragm pump and diaphragm valve is closed, pure water 3s is infused into chip fermentation vat, outside
If chip is placed on chip rack by mechanical arm, 4s is impregnated;
2) cleaning solution diaphragm pump, pumping waste water diaphragm pump and diaphragm valve open simultaneously, and chip continues to impregnate 2s;
3) it takes out waste water diaphragm pump and diaphragm valve is opened, take out waste water 1s;
4) step 1)~step 3) is a circulation, the circulation is carried out in 120s 12 times, soaking and washing chip;
5) chip cleaning finishes, and peripheral hardware mechanical arm picks up chip, moves up and down secondary, and solenoid valve is opened at this time, passes through spray
Gas head carries out drying 30s to chip surface;
6) after drying up, peripheral hardware mechanical arm grab chips, into subsequent work stations.
Advantages of the present invention:Structure is simple and effective, and chip is placed on chip rack from preamble station by peripheral hardware mechanical arm
On, pure water is extracted into chip fermentation vat by cleaning needle tubing and can carry out soaking and washing to chip by cleaning solution diaphragm pump, is cooperated
Take out waste water diaphragm pump can soaking and washing chip 12 times in 120s, cleaning efficiency is high, and effect is good, after chip cleans, peripheral hardware
Chip is picked up and moves up and down and dried up by jet thrust to chip surface by mechanical arm, after drying, peripheral hardware mechanical arm
Grab chips enter subsequent work stations.
Detailed description of the invention
Fig. 1 is the schematic perspective view of full-automatic protein chip immunity analysis instrument chip cleaning dry body of the invention.
Fig. 2 is the side sectional structure signal of full-automatic protein chip immunity analysis instrument chip cleaning dry body of the invention
Figure.
1 in figure it is cleaning box, 2 be chip rack, 3 be chip, 4 be chip fermentation vat, 5 be stainless steel needle tubing, 6 is
Waste water connector, 7 be jet thrust, 8 be gas-tpe fitting, 9 be jet apart from adjusting block.
Specific embodiment
Below with reference to embodiment and specific embodiment, the present invention is described in further detail.
As shown in Figure 1 and Figure 2, full-automatic protein chip immunity analysis instrument chip cleans dry body, and structure includes cleaning
Box 1, chip rack 2, chip fermentation vat 4 and jet thrust 7, wherein middle part sets chip fermentation vat 4 in cleaning box 1, and chip impregnates
Chip rack 2 is set above pond 4, chip placement 3 on chip rack 2 sets stainless steel on 4 two sides pool wall of chip fermentation vat respectively
Needle tubing 5, the external cleaning solution diaphragm pump of stainless steel needle tubing 5, the liquid outlet of two sides stainless steel needle tubing 5 are oppositely arranged, two sides stainless steel
5 upper die rack of needle tubing, 2 two sides set jet thrust 7 respectively, and jet thrust 7 connects gas-tpe fitting 8, and gas-tpe fitting 8 is external to be had
1 bottom of cleaning box of the blow-dry device of solenoid valve, 4 bottom outside of 4 bottom of chip fermentation vat and chip fermentation vat is separately connected one
The waste water connector 6 of a waste water connector 6,4 bottom of chip fermentation vat connects a diaphragm valve, and two waste water connectors 6 are external same
Take out waste water diaphragm pump.
1 bottom of cleaning box sets jet apart from adjusting block 9, and jet connects two sides jet thrust 7 apart from adjusting block 9.It can
Control the relative distance of two sides jet thrust.
According to the above structure, full-automatic protein chip immunity analysis instrument chip drying method, includes the following steps:
1) cleaning solution diaphragm pump is opened, and takes out waste water diaphragm pump and diaphragm valve is closed, pure water 3s is infused into chip fermentation vat 4,
Chip 3 is placed on chip rack 2 by peripheral hardware mechanical arm, impregnates 4s;
2) cleaning solution diaphragm pump, pumping waste water diaphragm pump and diaphragm valve open simultaneously, and chip 3 continues to impregnate 2s;
3) it takes out waste water diaphragm pump and diaphragm valve is opened, take out waste water 1s;
4) step 1)~step 3) is a circulation, the circulation is carried out in 120s 12 times, soaking and washing chip 3;
5) cleaning of chip 3 finishes, and peripheral hardware mechanical arm picks up chip 3, moves up and down 4 times, and solenoid valve is opened at this time, passes through
Jet thrust 7 carries out drying 30s to 3 surface of chip;
6) after drying up, peripheral hardware mechanical arm grab chips 3, into subsequent work stations.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those of ordinary skill in the art
For, without departing from the concept of the premise of the invention, various modifications and improvements can be made, these belong to the present invention
Protection scope.
Claims (3)
1. full-automatic protein chip immunity analysis instrument chip cleans dry body, feature includes cleaning box, chip rack, core
Piece fermentation vat and jet thrust, wherein middle part sets chip fermentation vat in cleaning box, sets chip rack, chip above chip fermentation vat
Chip placement on rack, sets stainless steel needle tubing on the pool wall of chip fermentation vat two sides respectively, the external cleaning solution of stainless steel needle tubing every
The liquid outlet of membrane pump, two sides stainless steel needle tubing is oppositely arranged, and two sides stainless steel needle tubing upper die rack two sides set spray respectively
Gas head, jet thrust connect gas-tpe fitting, the external blow-dry device with solenoid valve of gas-tpe fitting, and chip impregnates bottom of pond portion and chip
The cleaning box bottom of fermentation vat bottom outside is separately connected a waste water connector, and chip impregnates the waste water connector connection one of bottom of pond portion
A diaphragm valve, the external same pumping waste water diaphragm pump of two waste water connectors.
2. full-automatic protein chip immunity analysis instrument chip as described in claim 1 cleans dry body, it is characterized in that described
Cleaning box bottom set jet apart from adjusting block, jet connects two sides jet thrust apart from adjusting block.
3. the chip drying of full-automatic protein chip immunity analysis instrument chip cleaning dry body as claimed in claim 1 or 2
Method, it is characterized in that this approach includes the following steps:
1) cleaning solution diaphragm pump is opened, and takes out waste water diaphragm pump and diaphragm valve is closed, pure water 3s, peripheral hardware machine are infused into chip fermentation vat
Chip is placed on chip rack by tool arm, impregnates 4s;
2) cleaning solution diaphragm pump, pumping waste water diaphragm pump and diaphragm valve open simultaneously, and chip continues to impregnate 2s;
3) it takes out waste water diaphragm pump and diaphragm valve is opened, take out waste water 1s;
4) step 1)~step 3) is a circulation, the circulation is carried out in 120s 12 times, soaking and washing chip;
5) chip cleaning finishes, and peripheral hardware mechanical arm picks up chip, moves up and down secondary, and solenoid valve is opened at this time, passes through jet thrust
Drying 30s is carried out to chip surface;
6) after drying up, peripheral hardware mechanical arm grab chips, into subsequent work stations.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810716222.1A CN108856108A (en) | 2018-07-03 | 2018-07-03 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810716222.1A CN108856108A (en) | 2018-07-03 | 2018-07-03 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
Publications (1)
Publication Number | Publication Date |
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CN108856108A true CN108856108A (en) | 2018-11-23 |
Family
ID=64298492
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CN201810716222.1A Pending CN108856108A (en) | 2018-07-03 | 2018-07-03 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
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Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011021213A (en) * | 2009-07-14 | 2011-02-03 | World Kiko:Kk | Cleaning method, cleaning apparatus and drying apparatus |
CN102814294A (en) * | 2012-06-19 | 2012-12-12 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
CN204842320U (en) * | 2015-08-19 | 2015-12-09 | 深圳市汇北川电子技术有限公司 | Temperature sensor is belt cleaning device for chip |
CN105414089A (en) * | 2015-12-16 | 2016-03-23 | 芜湖普威技研有限公司 | Automobile rear shaft cleaning device |
CN106409717A (en) * | 2015-07-27 | 2017-02-15 | 沈阳芯源微电子设备有限公司 | Wafer metal-stripping and photoresist-stripping cleaning device |
CN206104448U (en) * | 2016-08-19 | 2017-04-19 | 郑州博奥医学检验所有限公司 | Biochip self - cleaning device |
CN206435531U (en) * | 2016-12-30 | 2017-08-25 | 通威太阳能(成都)有限公司 | A kind of repetend ability of swimming solar silicon wafers prerinse equipment |
CN207009409U (en) * | 2017-05-26 | 2018-02-13 | 常州市杰洋精密机械有限公司 | Photovoltaic cleaning equipment spray system |
CN107931219A (en) * | 2017-11-29 | 2018-04-20 | 芜湖戎征达伺服驱动技术有限公司 | Between automatic production line mold clean |
CN207371959U (en) * | 2017-09-11 | 2018-05-18 | 浙江千鹤工艺品有限公司 | A kind of cleaning device for craftwork |
CN108212903A (en) * | 2018-03-23 | 2018-06-29 | 郑州金恒电子技术有限公司 | A kind of automatic cleaning, drying equipment about silicon chip |
CN208482983U (en) * | 2018-07-03 | 2019-02-12 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
-
2018
- 2018-07-03 CN CN201810716222.1A patent/CN108856108A/en active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011021213A (en) * | 2009-07-14 | 2011-02-03 | World Kiko:Kk | Cleaning method, cleaning apparatus and drying apparatus |
CN102814294A (en) * | 2012-06-19 | 2012-12-12 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
CN106409717A (en) * | 2015-07-27 | 2017-02-15 | 沈阳芯源微电子设备有限公司 | Wafer metal-stripping and photoresist-stripping cleaning device |
CN204842320U (en) * | 2015-08-19 | 2015-12-09 | 深圳市汇北川电子技术有限公司 | Temperature sensor is belt cleaning device for chip |
CN105414089A (en) * | 2015-12-16 | 2016-03-23 | 芜湖普威技研有限公司 | Automobile rear shaft cleaning device |
CN206104448U (en) * | 2016-08-19 | 2017-04-19 | 郑州博奥医学检验所有限公司 | Biochip self - cleaning device |
CN206435531U (en) * | 2016-12-30 | 2017-08-25 | 通威太阳能(成都)有限公司 | A kind of repetend ability of swimming solar silicon wafers prerinse equipment |
CN207009409U (en) * | 2017-05-26 | 2018-02-13 | 常州市杰洋精密机械有限公司 | Photovoltaic cleaning equipment spray system |
CN207371959U (en) * | 2017-09-11 | 2018-05-18 | 浙江千鹤工艺品有限公司 | A kind of cleaning device for craftwork |
CN107931219A (en) * | 2017-11-29 | 2018-04-20 | 芜湖戎征达伺服驱动技术有限公司 | Between automatic production line mold clean |
CN108212903A (en) * | 2018-03-23 | 2018-06-29 | 郑州金恒电子技术有限公司 | A kind of automatic cleaning, drying equipment about silicon chip |
CN208482983U (en) * | 2018-07-03 | 2019-02-12 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
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