CN101196447A - Washing method and device for biological chip - Google Patents
Washing method and device for biological chip Download PDFInfo
- Publication number
- CN101196447A CN101196447A CNA2007103039291A CN200710303929A CN101196447A CN 101196447 A CN101196447 A CN 101196447A CN A2007103039291 A CNA2007103039291 A CN A2007103039291A CN 200710303929 A CN200710303929 A CN 200710303929A CN 101196447 A CN101196447 A CN 101196447A
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- bottle
- liquid
- purge chamber
- cleaning
- pipeline
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- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000005406 washing Methods 0.000 title description 13
- 239000007788 liquid Substances 0.000 claims abstract description 140
- 238000004140 cleaning Methods 0.000 claims abstract description 83
- 238000000018 DNA microarray Methods 0.000 claims abstract description 39
- 239000002699 waste material Substances 0.000 claims abstract description 36
- 238000010926 purge Methods 0.000 claims description 57
- 239000002537 cosmetic Substances 0.000 claims description 31
- 239000000126 substance Substances 0.000 claims description 31
- 239000012530 fluid Substances 0.000 claims description 30
- 238000010438 heat treatment Methods 0.000 claims description 10
- 230000008676 import Effects 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 238000009396 hybridization Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- Non-Flushing Toilets (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Abstract
The invention relates to a cleaning method of biochip and device, which comprises the following procedures: firstly, a plurality of fixing grooves fixed with a biochip are arranged in a cleaning chamber; secondly, at least a pipeline to a liquid cleaning bottle and a pipeline to a waste liquid bottle are connected under the cleaning chamber, a liquid pump and a valve are arranged on the pipeline; thirdly, the valve to the waste liquid bottle is closed, the valve to the cleaning liquid is opened, through liquid pump, make the cleaning liquid pump in the cleaning chamber; fourthly, the valve to the cleaning liquid is closed and the valve to the waste liquid bottle is opened. Starts the liquid pump for/backward frequently, and makes the cleaning liquid pump in the cleaning chamber enter into the waste liquid bottle by pump. The invention has simple structure and lower cost, which realizes the automatic cleaning to biochip, avoids the error caused by manual operation, and is easier to realize automatic controlling and integrating.
Description
Technical field
The present invention relates to a kind of cleaning method and device, particularly about a kind of cleaning method and device of biochip.
Background technology
Existing biochip washing methods mainly contains two classes, and a class is to adopt instrument to clean, and an other class is to adopt shaking table vibration washing.
Adopt instrument to clean and mainly contain two kinds: a kind of is special-purpose cleaning instrument, the AdvaWash AW400 microslide of producing as Advalytix company washs instrument, it can clean general wave carrier piece, can clean four chips simultaneously, though it has realized the automatic cleaning of chip, can not satisfy the requirement that some chip must clean under the uniform temperature condition.Another is that the wash mill that adopts hybridization instrument to carry washs, Lucidea SlidePro hybridization instrument as the production of Amersham Biosciences company, can hybridize six chips simultaneously, available its subsidiary clearing and drying device in hybridization back carries out cleaning-drying to chip, but it is full automatic working, be difficult to realize independent operation, also be unfavorable for washing in enormous quantities, and there is dead volume in its chip in cleaning process, is especially occurring the thorough phenomenon of dot matrix cleaning especially easily at the bigger chip of dot matrix scopes such as express spectra.
Adopt shaking table vibration washing, wherein shaking table is divided into common shaking table and shaking bath again.Cleaning fluid can be poured in the plastic casing or in the beaker, chip directly put in the plastic casing or the copper frame of beaker on the washing of vibrating.With respect to washing on the copper frame, the washing of chip in plastic casing is unfavorable for washing in enormous quantities and concentrated centrifuge dripping.When chip washs on the copper frame in beaker, because copper frame levels washing lotion flow velocity difference strengthens, also easily chip is exerted an influence, the amount difference of washing lotion is bigger for the influence of cleaning speed in the beaker in addition, and this just greatly reduces the chip repeatability of cleaning.At the mode of these two kinds of shaking table washings, if need at chip under the situation of two or more cleaning fluids cleanings, its process of changing clothes liquid also needs artificial manual operations, and the artificial manual error of being brought has more reduced the chip repeatability of cleaning.
Summary of the invention
At the problems referred to above, the purpose of this invention is to provide a kind of easy to operately, flushing dose is big, the biochip cleaning method and the device of the full automatic washing that efficient is high.
For achieving the above object, the present invention takes following technical scheme: a kind of cleaning method of biochip, and it may further comprise the steps: (1) is provided with the plurality of fixed groove that is fixed with biochip in a purge chamber; (2) connect at least one pipeline and pipeline that leads to waste liquid bottle that leads to bottle for handling liquid toilet or cosmetic substance in the bottom of described purge chamber, pipeline is provided with liquid pump and valve; (3) close the valve that leads to waste liquid bottle, open and lead to the wherein valve of a cleaning fluid,, cleaning fluid is pumped into described purge chamber by liquid pump; (4) close the valve that leads to cleaning fluid, open the valve that leads to waste liquid bottle, frequent forward and reverse startup liquid pump makes cleaning fluid frequency vibration to set in the purge chamber; (5) after reaching cleaning requirement, the cleaning fluid in the purge chamber is pumped into waste liquid bottle.
The cleaning fluid that more than one are different is connected the import of liquid pump respectively with valve by pipeline.
Described liquid pump is a liquid pump that connects the two-way wriggling of described bottle for handling liquid toilet or cosmetic substance and waste liquid bottle in parallel.
Described liquid pump is that a unidirectional liquid pump that connects described bottle for handling liquid toilet or cosmetic substance is connected the unidirectional liquid pump of waste liquid bottle with one.
A kind of device of realizing above-mentioned biochip cleaning method, it is characterized in that: it comprises one by the purge chamber, in described purge chamber, be provided with the pickup groove that at least one is inserted with some biochips, at least one bottle for handling liquid toilet or cosmetic substance is connected described clean container by a valve respectively with a waste liquid bottle with pipeline, be connected with liquid pump on the described pipeline, a liquid level sensor is set in the described purge chamber at least.
Described liquid pump is one to connect the liquid pump of the two-way wriggling of described purge chamber, and the other end of the liquid pump of described two-way wriggling is by pipeline be connected in parallel described bottle for handling liquid toilet or cosmetic substance and waste liquid bottle.
Described liquid pump is two one-way pumps, and described two one-way pumps connect described purge chamber by a pipeline, and the other end of described two one-way pumps connects described bottle for handling liquid toilet or cosmetic substance and waste liquid bottle by pipeline respectively.
Described bottle for handling liquid toilet or cosmetic substance is two or more that are arranged in parallel, and the valve that connects described bottle for handling liquid toilet or cosmetic substance also is two or more.
The pipeline that enters described purge chamber is provided with heating element, is provided with temperature sensor in described purge chamber.
Both sides in described purge chamber are provided with heating element, are provided with temperature sensor in described clean container.
The present invention is owing to take above technical scheme, and it has the following advantages: 1, the inventive method is because therefore the mode that adopts the cleaning fluid vibration to clean can make whole chip clean homogeneous, no dead volume.2, apparatus of the present invention are provided with the pickup groove that can plug many biochips in the purge chamber, therefore can easily biochip be put into cleaning, and can after cleaning is finished, pickup groove be taken out, be fixed in the hydro-extractor, easily biochip carried out centrifuge dripping.3, the present invention has been arranged in parallel a plurality of bottle for handling liquid toilet or cosmetic substance, puts into different types of cleaning fluid in bottle for handling liquid toilet or cosmetic substance, therefore can pump into different cleaning fluids from the trend purge chamber by the control of valve, finishes different cleaning procedures quickly and easily.4, the present invention is provided with heating arrangement, therefore can heat cleaning fluid as required, has satisfied the cleaning demand, has improved cleaning efficiency.Cleaning procedure of the present invention can be finished automatically through setting in advance, and whole apparatus structure is simple, easy to operate, efficient is higher, and cost is lower, the error of having avoided manual operations to bring, it can be widely used in the robotization of various biochips or other similar products and clean.
Description of drawings
Fig. 1 is a perspective view of the present invention
Fig. 2 is a schematic top plan view of the present invention
Fig. 3 is a purge chamber of the present invention structural representation
Fig. 4 is a purge chamber of the present invention cross-sectional schematic
Fig. 5 is the embodiment of the invention one schematic diagram
Fig. 6 is the embodiment of the invention two schematic diagrams
Embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.
As shown in Figure 1 and Figure 2, the present invention includes purge chamber 1, plurality of pipelines 2, heating element 3, liquid pump 4, four-way connection 5, three valves 6, two bottle for handling liquid toilet or cosmetic substance 7, a waste liquid bottle 8 and a control circuit.Three interfaces in the four-way connection 5 are connected with an end of three valves 6 respectively by pipeline 2, the other end of three valves 6 connects two bottle for handling liquid toilet or cosmetic substance 7 and waste liquid bottle 8 respectively by pipeline 2, four-way connection 5 remaining interfaces are connected with a liquid pump 4 one ends by pipeline 2, the other end of liquid pump 4 is connected with purge chamber 1 by pipeline 2, if cleaning process need be carried out at a certain temperature, can on the pipeline 2 between liquid pump 4 and the purge chamber 1, heating element 3 be set, also can heating element 3 be set 1 both sides, can also all be provided with at several places in the purge chamber.
As shown in Figure 3, Figure 4, in the foregoing description, 1 top, one side articulates a loam cake 9 in the purge chamber, and 1 bottom is provided with purge chamber's inlet attack 10 in the purge chamber, in purge chamber 1, be provided with a liquid level upper limit sensor 11, in purge chamber 1, also be provided with a temperature sensor 12.In purge chamber 1, be provided with the pickup groove 13 that several can take out and put into, on pickup groove 13, can plug fixing biochip 14 to be cleaned.
The quantity of above-mentioned bottle for handling liquid toilet or cosmetic substance 7 can change to some extent according to cleaning needs, and such as having only a bottle for handling liquid toilet or cosmetic substance 7 or two above bottle for handling liquid toilet or cosmetic substance 7, the setting of four-way connection 5, valve 6 also can change according to the quantity of bottle for handling liquid toilet or cosmetic substance 7.
As Fig. 1, shown in Figure 5, in the foregoing description, liquid pump 4 can adopt the liquid pump 4 of the two-way wriggling of a changeable liquid flow direction, liquid pump 4 one ends of two-way wriggling each valve 6 that is connected in parallel (comprises 6a, 6b, 6c ...), liquid pump 4 other ends of two-way wriggling are connected with purge chamber's inlet attack 10, by selecting to open different valves 6, different cleaning fluids can being pumped in the purge chamber 1 biochip 14 is cleaned.Such as: 6a opens with valve, valve 6b, 6c are closed, can the cleaning fluid among the bottle for handling liquid toilet or cosmetic substance 7a be pumped into purge chamber 1 by the liquid pump 4 of two-way wriggling, liquid to be cleaned reaches on the liquid level prescribes a time limit, liquid level sensor 11 will be closed valve 6a by control circuit, open the valve 6c that leads to waste liquid bottle 8, by the frequent positive and negative wriggling of two-way wriggling, make cleaning fluid frequency vibration with the liquid pump 4 forward and reverse variations of two-way wriggling in purge chamber 1, biochip 14 is cleaned; When cleaning was finished, the waste liquid after the liquid pump 4 by two-way wriggling will clean entered waste liquid bottle 8 by valve 6c.Use another kind of cleaning fluid again biochip 14 to be cleaned if desired, with regard to valve-off 6c, Open valve 6b, the liquid pump 4 of cleaning fluid among the needed bottle for handling liquid toilet or cosmetic substance 7b by two-way wriggling pumped into purge chamber 1 continue biochip 14 is cleaned, clean and by valve 6c waste liquid is drained into waste liquid bottle 8 again after finishing.Can take out pickup groove 13 after cleaning finishes and be fixed in the hydro-extractor, so that biochip 14 is carried out centrifuge dripping.
As shown in Figure 6, in the foregoing description, liquid pump also can adopt two unidirectional liquid pumps 4, promptly on purge chamber's inlet attack 10 by pipeline two the unidirectional liquid pumps 4 that are connected in parallel, liquid pump that one of them is unidirectional 4 connects the valve 6c that leads to waste liquid bottle 8, and another unidirectional liquid pump 4 each bottle for handling liquid toilet or cosmetic substance 7 that is connected in parallel (comprises 7a, 7b ...).Present embodiment in use maybe be opened two different unidirectional liquid pump 4a, 4b as required with the district of the foregoing description.Such as: 6a opens with valve, valve 6b, 6c are closed, unidirectional liquid pump 4b closes, and opens unidirectional liquid pump 4a, the cleaning fluid among the bottle for handling liquid toilet or cosmetic substance 7a can be pumped into purge chamber 1, liquid to be cleaned reaches on the liquid level prescribes a time limit, liquid level sensor 11 will be closed valve 6a by control circuit, Open valve 6c, and frequently start two unidirectional liquid pump 4a, 4b by turns, make cleaning fluid 1 medium frequency vibration, biochip 14 is cleaned in the purge chamber; When cleaning is finished, unidirectional liquid pump 4a is closed, only open unidirectional liquid pump 4b, the waste liquid after cleaning is entered waste liquid bottle 8 by valve 6c.
In sum, as can be seen, biochip cleaning method provided by the invention may further comprise the steps:
(1) the plurality of fixed groove 13 that is fixed with biochip 14 is set in a purge chamber 1;
(2) connect at least one pipeline and pipeline that leads to waste liquid bottle 8 that leads to bottle for handling liquid toilet or cosmetic substance 7 in the bottom of described purge chamber 1, pipeline is provided with liquid pump 4 and valve 6;
(3) close the valve 6 that leads to waste liquid bottle 8, open and lead to the wherein valve 6 of a bottle for handling liquid toilet or cosmetic substance 7,, cleaning fluid is pumped into described purge chamber 1 by liquid pump 4;
(4) close the valve that leads to described washer bottle, open the valve 6 that leads to waste liquid bottle 8, frequent forward and reverse startup liquid pump 4 makes cleaning fluid internal vibration in purge chamber 1;
(5) after reaching cleaning requirement, the cleaning fluid in the purge chamber 1 is pumped into waste liquid bottle 8.
Biochip of the present invention uses multiple cleaning fluid to clean if desired, can enter the purge chamber by the cleaning fluid in the different bottle for handling liquid toilet or cosmetic substance 7 of valve 6 controls.
Claims (12)
1. the cleaning method of a biochip, it may further comprise the steps:
(1) the plurality of fixed groove that is fixed with biochip is set in a purge chamber;
(2) connect at least one pipeline and pipeline that leads to waste liquid bottle that leads to bottle for handling liquid toilet or cosmetic substance in the bottom of described purge chamber, pipeline is provided with liquid pump and valve;
(3) close the valve that leads to waste liquid bottle, open and lead to the wherein valve of a cleaning fluid,, cleaning fluid is pumped into described purge chamber by liquid pump;
(4) close the valve that leads to cleaning fluid, open the valve that leads to waste liquid bottle, frequent forward and reverse startup liquid pump makes cleaning fluid frequency vibration to set in the purge chamber;
(5) after reaching cleaning requirement, the cleaning fluid in the purge chamber is pumped into waste liquid bottle.
2. the cleaning method of a kind of biochip as claimed in claim 1, it is characterized in that: the cleaning fluid that more than one are different is connected the import of liquid pump respectively with valve by pipeline.
3. the cleaning method of a kind of biochip as claimed in claim 1 or 2 is characterized in that: described liquid pump is a liquid pump that connects the two-way wriggling of described bottle for handling liquid toilet or cosmetic substance and waste liquid bottle in parallel.
4. the cleaning method of a kind of biochip as claimed in claim 1 or 2 is characterized in that: described liquid pump is that a unidirectional liquid pump that connects described bottle for handling liquid toilet or cosmetic substance is connected the unidirectional liquid pump of waste liquid bottle with one.
5. a realization is as the device of biochip cleaning method as described in the claim 1～4, it is characterized in that: it comprises one by the purge chamber, in described purge chamber, be provided with the pickup groove that at least one is inserted with some biochips, at least one bottle for handling liquid toilet or cosmetic substance is connected described clean container by a valve respectively with a waste liquid bottle with pipeline, be connected with liquid pump on the described pipeline, a liquid level sensor is set in the described purge chamber at least.
6. the cleaning device of a kind of biochip as claimed in claim 5 is characterized in that: described liquid pump is one to connect the liquid pump of the two-way wriggling of described purge chamber, and the other end of the liquid pump of described two-way wriggling is by pipeline be connected in parallel described bottle for handling liquid toilet or cosmetic substance and waste liquid bottle.
7. the cleaning device of a kind of biochip as claimed in claim 5, it is characterized in that: described liquid pump is two one-way pumps, described two one-way pumps connect described purge chamber by a pipeline, and the other end of described two one-way pumps connects described bottle for handling liquid toilet or cosmetic substance and waste liquid bottle by pipeline respectively.
8. as the cleaning device of claim 5 or 6 or 7 described a kind of biochips, it is characterized in that: described bottle for handling liquid toilet or cosmetic substance is two or more that are arranged in parallel, and the valve that connects described bottle for handling liquid toilet or cosmetic substance also is two or more.
9. as the cleaning device of claim 5 or 6 or 7 described a kind of biochips, it is characterized in that: the pipeline that enters described purge chamber is provided with heating element, is provided with temperature sensor in described purge chamber.
10. the cleaning device of a kind of biochip as claimed in claim 8, it is characterized in that: the pipeline that enters described purge chamber is provided with heating element, is provided with temperature sensor in described purge chamber.
11. the cleaning device as claim 5 or 6 or 7 described a kind of biochips is characterized in that: the both sides in described purge chamber are provided with heating element, are provided with temperature sensor in described clean container.
12. the cleaning device of a kind of biochip as claimed in claim 8 is characterized in that: the both sides in described purge chamber are provided with heating element, are provided with temperature sensor in described clean container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103039291A CN101196447B (en) | 2007-12-21 | 2007-12-21 | Washing method and device for biological chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103039291A CN101196447B (en) | 2007-12-21 | 2007-12-21 | Washing method and device for biological chip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101196447A true CN101196447A (en) | 2008-06-11 |
| CN101196447B CN101196447B (en) | 2010-09-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007103039291A Active CN101196447B (en) | 2007-12-21 | 2007-12-21 | Washing method and device for biological chip |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102794279A (en) * | 2011-05-26 | 2012-11-28 | 合肥安弗朋德生物技术有限公司 | Full-automatic cleaning instrument for swing type biological experiment |
| CN102814294A (en) * | 2012-06-19 | 2012-12-12 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
| CN103954782A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
| CN103955236A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Fluid control system of medical testing equipment |
| CN104492742A (en) * | 2015-01-06 | 2015-04-08 | 北京九州泰康生物科技有限责任公司 | Biochip cleaning device |
| CN105344639A (en) * | 2015-11-06 | 2016-02-24 | 江苏三联生物工程有限公司 | Biological chip washing mechanism |
| CN107355628A (en) * | 2017-09-01 | 2017-11-17 | 苏州出入境检验检疫局检验检疫综合技术中心 | The pretreating device that water distribution pipeline detects in a kind of drinking water related product |
| CN107583918A (en) * | 2017-08-25 | 2018-01-16 | 博奥生物集团有限公司 | A kind of semi-automated biological device for cleaning chip |
| CN107630226A (en) * | 2017-02-25 | 2018-01-26 | 威海出入境检验检疫局检验检疫技术中心 | Hermetically sealed micro-wave digestion pipe acid cleaning unit |
| CN110734851A (en) * | 2018-07-19 | 2020-01-31 | 深圳华大生命科学研究院 | Liquid changing device and gene sequencer |
| CN110734963A (en) * | 2019-09-28 | 2020-01-31 | 北京安博迪恩生物科技有限公司 | method for detecting 21-trisomy syndrome chromosome karyotype based on efficient chip washing and drying instrument |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100612879B1 (en) * | 2004-12-06 | 2006-08-14 | 삼성전자주식회사 | Hybridization device using the control of pump and valves in closed system |
| CN101063078B (en) * | 2007-04-20 | 2010-06-09 | 博奥生物有限公司 | Biological chip hybrid cleaning device |
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2007
- 2007-12-21 CN CN2007103039291A patent/CN101196447B/en active Active
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102794279A (en) * | 2011-05-26 | 2012-11-28 | 合肥安弗朋德生物技术有限公司 | Full-automatic cleaning instrument for swing type biological experiment |
| CN102814294B (en) * | 2012-06-19 | 2015-02-18 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
| CN102814294A (en) * | 2012-06-19 | 2012-12-12 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
| CN103955236B (en) * | 2014-04-11 | 2017-01-25 | 珠海迪尔生物工程有限公司 | Fluid control system of medical testing equipment |
| CN103955236A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Fluid control system of medical testing equipment |
| CN103954782B (en) * | 2014-04-11 | 2015-05-20 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
| CN103954782A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
| CN104492742A (en) * | 2015-01-06 | 2015-04-08 | 北京九州泰康生物科技有限责任公司 | Biochip cleaning device |
| CN105344639A (en) * | 2015-11-06 | 2016-02-24 | 江苏三联生物工程有限公司 | Biological chip washing mechanism |
| CN107630226A (en) * | 2017-02-25 | 2018-01-26 | 威海出入境检验检疫局检验检疫技术中心 | Hermetically sealed micro-wave digestion pipe acid cleaning unit |
| CN107583918A (en) * | 2017-08-25 | 2018-01-16 | 博奥生物集团有限公司 | A kind of semi-automated biological device for cleaning chip |
| CN107583918B (en) * | 2017-08-25 | 2019-08-20 | 博奥生物集团有限公司 | A kind of semi-automated biological device for cleaning chip |
| CN107355628A (en) * | 2017-09-01 | 2017-11-17 | 苏州出入境检验检疫局检验检疫综合技术中心 | The pretreating device that water distribution pipeline detects in a kind of drinking water related product |
| CN107355628B (en) * | 2017-09-01 | 2023-01-03 | 苏州出入境检验检疫局检验检疫综合技术中心 | Pretreatment device for detection of water conveying and distributing pipe in wading product |
| CN110734851A (en) * | 2018-07-19 | 2020-01-31 | 深圳华大生命科学研究院 | Liquid changing device and gene sequencer |
| CN110734851B (en) * | 2018-07-19 | 2023-03-14 | 深圳华大生命科学研究院 | Liquid changing device and gene sequencer |
| CN110734963A (en) * | 2019-09-28 | 2020-01-31 | 北京安博迪恩生物科技有限公司 | method for detecting 21-trisomy syndrome chromosome karyotype based on efficient chip washing and drying instrument |
| CN110734963B (en) * | 2019-09-28 | 2022-04-29 | 北京安博迪恩生物科技有限公司 | Method for detecting 21-trisomy syndrome chromosome karyotype based on efficient chip washing and drying instrument |
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| CN101196447B (en) | 2010-09-29 |
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