CN102812132A - 用于检测发生颌骨坏死风险因子的方法和试剂盒及其治疗方法 - Google Patents

用于检测发生颌骨坏死风险因子的方法和试剂盒及其治疗方法 Download PDF

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Publication number
CN102812132A
CN102812132A CN2010800648762A CN201080064876A CN102812132A CN 102812132 A CN102812132 A CN 102812132A CN 2010800648762 A CN2010800648762 A CN 2010800648762A CN 201080064876 A CN201080064876 A CN 201080064876A CN 102812132 A CN102812132 A CN 102812132A
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bonj
snp
gene
biomarker
patients
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CN2010800648762A
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Chinese (zh)
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J·凯兹
T·Y·兰盖伊
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University of Florida
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University of Florida
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2010800648762A 2010-01-06 2010-12-13 用于检测发生颌骨坏死风险因子的方法和试剂盒及其治疗方法 Pending CN102812132A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29273010P 2010-01-06 2010-01-06
US61/292,730 2010-01-06
PCT/US2010/060139 WO2011084387A2 (en) 2010-01-06 2010-12-13 Methods and kits for detecting risk factors for development of jaw osteonecrosis and methods of treatment thereof

Publications (1)

Publication Number Publication Date
CN102812132A true CN102812132A (zh) 2012-12-05

Family

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Family Applications (1)

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CN2010800648762A Pending CN102812132A (zh) 2010-01-06 2010-12-13 用于检测发生颌骨坏死风险因子的方法和试剂盒及其治疗方法

Country Status (9)

Country Link
US (1) US20130035314A1 (https=)
EP (1) EP2521793A4 (https=)
CN (1) CN102812132A (https=)
AU (1) AU2010340161A1 (https=)
BR (1) BR112012016744A2 (https=)
CA (1) CA2786545A1 (https=)
IN (1) IN2012DN06571A (https=)
RU (1) RU2012133434A (https=)
WO (1) WO2011084387A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112410413A (zh) * 2020-09-24 2021-02-26 吉林大学 Onfh易感相关vdr、mmp2、mmp3、mmp9基因snp的检测物质及应用
RU2837396C1 (ru) * 2024-12-28 2025-03-31 Общество с ограниченной ответственностью "Клиника новых медицинских технологий АрхиМед" Панель для определения генетической предрасположенности к нарушению остеогенеза

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010005939A1 (en) * 2008-07-07 2010-01-14 University Of Florida Research Foundation, Inc. Methods and kits for detecting risk factors for development of jaw osteonecrosis and methods of treatment thereof
WO2015083163A1 (en) * 2013-12-04 2015-06-11 Micromedic Technologies Ltd. Methods and kits for identifying susceptability to antiresorptive-agent-induced osteonecrosis of the jaw
CN111518882B (zh) * 2019-02-03 2022-06-28 陈卫衡 通过分子标志物辨识激素性股骨头坏死的中医证型的系统
ES2994026A1 (es) * 2023-07-11 2025-01-16 Fundacion Instituto De Investig Sanitaria De Santiago De Compostela Metodo in vitro para identificar si un sujeto tratado con agentes modificadores de los huesos puede desarrollar osteonecrosis de los maxilares

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062465A1 (es) * 2002-01-25 2003-07-31 Universidad De Barcelona Compuestos para el diagnóstico de la predisposición a la osteoporosis
WO2010005939A1 (en) * 2008-07-07 2010-01-14 University Of Florida Research Foundation, Inc. Methods and kits for detecting risk factors for development of jaw osteonecrosis and methods of treatment thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LEHRER S. ET AL.: "Bisphosphonate-induced osteonecrosis of the jaws,bone markers,and a hypothesized candidated gene", 《JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY》 *
MARIA E. SARASQUETE ET AL.: "Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis", 《BLOOD》 *
SARASQUETE M. E. ET AL.: "Bisphosphonate-related osteonecrosis:genetic and acquired risk factors", 《ORAL DISEASES》 *
SCHEPER M. A. ET AL.: "Effect of Zoledronic acid on oral fibroblasts and epitherlial cells:a potential mechanism of bisphosphonate-associated osteonecrosis", 《BRITISH JOURNAL OF HAEMATOLOGY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112410413A (zh) * 2020-09-24 2021-02-26 吉林大学 Onfh易感相关vdr、mmp2、mmp3、mmp9基因snp的检测物质及应用
RU2837396C1 (ru) * 2024-12-28 2025-03-31 Общество с ограниченной ответственностью "Клиника новых медицинских технологий АрхиМед" Панель для определения генетической предрасположенности к нарушению остеогенеза

Also Published As

Publication number Publication date
CA2786545A1 (en) 2011-07-14
RU2012133434A (ru) 2014-02-27
EP2521793A4 (en) 2013-07-03
AU2010340161A1 (en) 2012-07-26
US20130035314A1 (en) 2013-02-07
IN2012DN06571A (https=) 2015-10-23
EP2521793A2 (en) 2012-11-14
BR112012016744A2 (pt) 2017-06-13
WO2011084387A2 (en) 2011-07-14
WO2011084387A3 (en) 2011-10-27

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Application publication date: 20121205