CN102793892A - 一种治疗痛风的中药 - Google Patents
一种治疗痛风的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗痛风的中药，它是由以下重量配比的原料药材制备而成：柴胡3份、杜仲6份、鹅不食草3份、片姜黄3份、天山雪莲6份、郁李仁10份、泽泻8份、淫羊藿4份、苍术6份、葱花12份、党参9份、桂皮18份、花椒9份。临床实验证明，本发明能够安全有效治疗痛风。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗痛风的中药。
背景技术
痛风又称“高尿酸血症”，病因为嘌呤代谢障碍，属于关节炎一种。痛风是人体内嘌呤的物质的新陈代谢发生紊乱，尿酸的合成增加或排出减少，造成高尿酸血症，血尿酸浓度过高时，尿酸以钠盐的形式沉积在关节、软骨和肾脏中，引起组织异物炎性反应，即痛风。床特点是：高尿酸血症、急性关节炎反复发作、痛风石形成、慢性关节炎和关节畸形，以及在病程后期出现肾尿酸结石和痛风性肾实质病变。
目前痛风治疗主要是根据临床症状针对给药，主要是在发作期吃秋水仙碱加止痛药，以便快速消炎，解除痛苦，间歇期吃别嘌呤等药物降低尿酸，预防再次发作。消炎止痛药治标不治本；秋水仙碱有严重的毒副反应；别嘌呤等降尿酸药物，不但停药反弹较快，而且经常因为尿酸溶解过快而引起转移性痛风发作。最可怕的是，长期吃这些药物，会损伤肝肾脾，导致无法逆转的痛风反复加剧发作。所以目前很多痛风患者宁可忍着剧痛也不肯吃药。因此研究开发一种安全有效治疗痛风的中药非常有临床实用价值。
本发明中药所涉及药材的研究现状如下：
柴胡：本品为伞形科植物柴胡BupleurumchinenseDC.或狭叶柴胡BupleurumscorzonerifoliumWilld.的干燥根。【性味与归经】辛、苦，微寒。归肝、胆、肺经。【功能与主治】疏散退热，疏肝解郁，升举阳气。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子宫脱垂，脱肛。【用法与用量】3～10g。
杜仲：本品为杜仲科植物杜仲EucommiaulmoidesOliv.的干燥树皮。【性味与归经】甘，温。归肝、肾经。【功能与主治】补肝肾，强筋骨，安胎。用于肝肾不足，腰膝酸痛，筋骨无力，头晕目眩，妊娠漏血，胎动不安。【用法与用量】6～10g。
鹅不食草：本品为菊科植物鹅不食草Centipedaminima(L.)A.Br.etAschers.的干燥全草。【性味与归经】辛，温。归肺经。【功能与主治】发散风寒，通鼻窍，止咳。用于风寒头痛，咳嗽痰多，鼻塞不通，鼻渊流涕。【用法与用量】6～9g。外用适量。
片姜黄：本品为姜科植物温郁金CurcumawenyuJinY.H.ChenetC.Ling的干燥根茎。【性味与归经】辛、苦，温。归脾、肝经。【功能与主治】破血行气，通经止痛。用于胸胁刺痛，胸痹心痛，痛经经闭，瘕瘕，风湿肩臂疼痛，跌扑肿痛。【用法与用量】3～9g。【注意】孕妇慎用。
天山雪莲：本品系维吾尔族习用药材。为菊科植物天山雪莲Saussureainvolucrata(Kar.etKir.)Sch.Bip.的干燥地上部分。【功能与主治】维吾尔医：补肾活血，强筋骨，营养神经，调节异常体液。用于风湿性关节炎，关节疼痛，肺寒咳嗽，肾与小腹冷痛，白带过多等。中医：温肾助阳，祛风胜湿，通经活血。用于风寒湿痹痛、类风湿性关节炎，小腹冷痛，月经不调。【用法与用量】3～6g，水煎或酒浸服。外用适量。【禁忌】孕妇忌用。
郁李仁：本品为蔷薇科植物欧李PrunushumilisBge.、郁李PrunusjaponicaThunb.或长柄扁桃PrunuspedunculataMaxim.的干燥成熟种子。【性味与归经】辛、苦、甘，平。归脾、大肠、小肠经。【功能与主治】润肠通便，下气利水。用于津枯肠燥，食积气滞，腹胀便秘，水肿，脚气，小便不利。【用法与用量】6～10g。【注意】孕妇慎用。
泽泻：本品为泽泻科植物泽泻Alismaorientalis(Sam.)Juzep.的干燥块茎。【性味与归经】甘、淡，寒。归肾、膀胱经。【功能与主治】利水渗湿，泄热，化浊降脂。用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高脂血症。【用法与用量】6～10g。
淫羊藿：本品为小檗科植物淫羊藿EpimediumbrevicornuMaxim.、箭叶淫羊藿Epimediumsagittatum(Sieb.etZucc.)Maxim.、柔毛淫羊藿Epimediumpubescens.Maxim.或朝鲜淫羊藿EpimediumkoreanumNakai的干燥叶。【性味与归经】辛、甘，温。归肝、肾经。【功能与主治】补肾阳，强筋骨，祛风湿。用于肾阳虚衰，阳痿遗精，筋骨痿软，风湿痹痛，麻木拘挛。【用法与用量】6～10g。
苍术：本品为菊科植物茅苍术Atractylodes lancea （Thunb.） DC.或北苍术Atractylodes chinensis （DC.） Koidz.的干燥根茎。【性味】辛、苦，温。【归经】归脾、胃、肝经。【功能主治】燥湿健脾，祛风散寒，明目。用于脘腹胀满，泄泻，水肿，脚气痿躄，风湿痹痛，风寒感冒，夜盲。【用法用量】 3～9g。
葱花：为百合科植物葱的花。【性味】味辛；性温【归经】脾；胃经。【功能主治】散寒通阳。主脘腹冷痛；胀满。【用法用量】内服：煎汤，6-12g。
党参：本品为桔梗科植物党参 Codonopsis pilosula （Franch.） Nannf.、素花党参（西党参）Codonopsis pilosula Nannf. var. modesta （Nannf.） L. T. Shen或川党参Codonopsis tangshen Oliv.的干燥根。【性味】甘，平。【归经】归脾、肺经。【功能主治】补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。【用法用量】 9～30g。
桂皮：为樟科植物天竺桂、阴香、细叶香桂或川桂等的树皮。【性味】辛；甘；性温【归经】脾；胃；肝；肾【功能主治】温脾胃；暖肝肾；祛寒止痛；散瘀消肿。主脘腹冷痛；呕吐泄泻；腰膝酸冷；寒疝腹痛；寒湿痹痛；瘀滞痛经；血痢；肠风；跌打肿痛【用法用量】内服：煎汤，6-12g。
花椒：【来源】本品为芸香科植物青椒（香椒、青花椒、山椒、狗椒）Zanthoxylum schinifolium Sieb. et Zucc.或花椒（蜀椒、川椒、红椒、红花椒、大红袍）Zantho xylum bungeanum Maxim.的干燥成熟果皮（花椒）及种子（椒目）入药。【性味】辛，温。【归经】归脾、胃、肾经。【功能主治】温中止痛，杀虫止痒。用于脘腹冷痛，呕吐泄泻，虫积腹痛，蛔虫症；外治湿疹瘙痒。【用法用量】 3～6g。外用适量，煎汤熏洗。
发明内容
本发明旨在提供一种治疗痛风的中药，通过选择合适的药材及其配比，达到安全有效治愈痛风的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗痛风的中药，其特征在于，它是由以下重量配比的原料药材制备而成：柴胡3份、杜仲6份、鹅不食草3份、片姜黄3份、天山雪莲6份、郁李仁10份、泽泻8份、淫羊藿4份、苍术6份、葱花12 份、党参9份、桂皮18 份、花椒9份。
下面结合中医理论说明本方明的有益效果：
发明人认为治疗痛风应从温阳纠正根本，兼之利尿排毒、健脾行气。本发明运用：桂皮、花椒、葱花、淫羊藿、柴胡、杜仲、鹅不食草、天山雪莲温肾助阳、通经散寒；郁李仁、泽泻利水渗湿、化浊降脂；苍术、片姜黄、党参健脾行气。诸药合用，从而温阳活血、利尿排毒、健脾行气，从根本上治疗痛风。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年4月-2010年2月间共收集75例痛风患者，其中男55例，女20例，年龄43-65岁，病程2天-3年。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗方法
对照组口服别嘌醇片，按照说明书服用。疗程1个月。
治疗组口服本发明按照具体实施例1制得的胶囊，每日2次。疗程1个月。
2.2观察项目：实验前后，对关节肿痛、发作频率、疼痛程度、病痛蔓延情况等进行观察，实验室检测患者血尿酸、血糖、血脂。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，半年内未见复发。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状、实验室检查无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 50 | 32 | 16 | 2 | 1（2%） | 96% |
| 对照组 | 25 | 0 | 13 | 12 | 22（88%） | 52% |
可见，本发明制得的药物能够安全有效治疗痛风。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取柴胡3g、杜仲6g、鹅不食草3g、片姜黄3g、天山雪莲6g、郁李仁10g、泽泻8g、淫羊藿4g、苍术6g、葱花12 g、党参9g、桂皮18 g、花椒9g；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗痛风。口服，每日分早晚两次服用。
具体实施例2
称取柴胡3g、杜仲6g、鹅不食草3g、片姜黄3g、天山雪莲6g、郁李仁10g、泽泻8g、淫羊藿4g、苍术6g、葱花12 g、党参9g、桂皮18 g、花椒9g；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗痛风。口服，每日一次。
具体实施例3
称取柴胡3g、杜仲6g、鹅不食草3g、片姜黄3g、天山雪莲6g、郁李仁10g、泽泻8g、淫羊藿4g、苍术6g、葱花12 g、党参9g、桂皮18 g、花椒9g；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗痛风。口服，每日分早中晚三次服用。
Claims (1)
1.一种治疗痛风的中药，其特征在于，它是由以下重量配比的原料药材制备而成：柴胡3份、杜仲6份、鹅不食草3份、片姜黄3份、天山雪莲6份、郁李仁10份、泽泻8份、淫羊藿4份、苍术6份、葱花12 份、党参9份、桂皮18 份、花椒9份。
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| WO2019203827A1 (en) * | 2018-04-19 | 2019-10-24 | Kibow Biotech Inc . | Composition and method for preventing or treating hyperuricemia or gout |
| CN112402475A (zh) * | 2019-08-20 | 2021-02-26 | 李连福 | 一种降尿酸、降血压的中药组合物 |
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