CN102793167B - Rosemary antioxidant coenzyme Q10 capsule and preparation method thereof - Google Patents

Abstract

The invention discloses a rosemary antioxidant coenzyme Q10 capsule, which is composed of a capsule shell and contents. The capsule is characterized in that: the contents consist of the following raw materials: a rosemary antioxidant, coenzyme Q10, and rice bran oil that are in a mass ratio of 2-5:3-6:30-80. The invention also discloses a preparation method of the rosemary antioxidant coenzyme Q10 capsule. The rosemary antioxidant coenzyme Q10 capsule disclosed in the invention has the following outstanding advantages that: employment of the rosemary antioxidant which has oxidation resistance obviously superior to that of vitamin E and a low price as an adding raw material not only reduces the product cost, but also can achieve a good oxidation resisting effect, and the rosemary antioxidant is a powerful antioxidant and has an especially strong aging delaying effect; the rosemary antioxidant and the coenzyme Q10 have an excellent synergistic effect, the health care function of the coenzyme Q10 is improved and its action range is expanded; the rosemary antioxidant coenzyme Q10 capsule can be effective in treatment of heart diseases and hypertension; and the capsule can also strengthen the immune system and destroy pathogenic bacteria invading the body.

Description

Anti-oxidant coenzyme Q10 capsule of a kind of rosemary, Xue MingRosma rinus officinalis and preparation method thereof

Technical field

The present invention relates to coenzyme Q10 capsule, particularly anti-oxidant coenzyme Q10 capsule of a kind of rosemary, Xue MingRosma rinus officinalis and preparation method thereof.

Background technology

Rosemary, Xue MingRosma rinus officinalis is a kind of multiduty industrial crops, therefrom can extract antioxidant, Rosemary Oil and medicine intermediate.Rosemary antioxidant is from rosemary plant, to extract the powdered substance obtaining, and main component is phenol, acid, the flavones ingredient with anti-oxidation function.Rosmarinus officinalis extract has efficient, nontoxic antioxidant effect, its antioxidant effect is chemical synthesis antioxidant butylated hydroxyanisole (BHA) (BHA) and dibutyl hydroxy toluene (BHT) 2-4 times, 2 times that are Tea Polyphenols are also obviously better than vitamin E, be best natural, can be widely used in the industries such as food, functional food, spices and flavouring and daily-use chemical industry.

In recent years, both domestic and external studies confirm that, rosemary, Xue MingRosma rinus officinalis has stronger inhibition killing action to staphylococcus aureus, Escherichia coli etc.; Strengthen corticocerebral process of inhibition, there is good calmness, hypnosis, anticonvulsant action; Regulate blood pressure, make low blood pressure recover normal; Reduce permeability capillaceous, antiasthmatic-antitussive, treatment asthma attack and chronic bronchitis; Be used for the treatment of in intestines and infect, diarrhoea etc.The high antioxygenic property of rosemary, Xue MingRosma rinus officinalis research and development aspect cancer therapy drug shown go out prospect more allow researcher extremely excited, same, the exploitation potential quality of Rosmarinus officinalis extract in functional food field also caused scientific research personnel's abundant attention.Such as: 1) eliminate too much free radical in human body, the structure of Cell protection film, delaying human body caducity.A large number of experiments show that, the antioxygenic property of rosemary antioxidant is obviously better than vitamin E, if be used in conjunction with vitamin C and vitamin E, also has synergistic effect.Expert points out, because rosemary antioxidant has strong effect of dispelling free radical, can remove free radical, quencher creating singlet oxygen by using, can compare favourably with superoxide dismutase (SOD), and overcome these deadly defects of enzyme material unstable chemcial property such as SOD, for the product such as health drink, oral liquid, there are very large potentiality.2) reduce cholesterol, suppress atherosclerotic, the active ingredient in Rosmarinus officinalis extract produces important function to the fat metabolism of body, can obviously suppress the rising of cholesterol level in blood plasma and liver, prevents and treats atherosclerotic.3) fat-reducing, relies on its antioxidation activity, and Rosmarinus officinalis extract stimulates and accelerate the fat metabolism of human body, promotes lipoid substance to discharge from ight soil, reaches effect of fat-reducing, coordinates the anthraquinone components such as archen can develop the good diet products of effect.

Rice bran oil claims again rice bran oil, is the one of edible oil, with fur clothing (rice bran) refining of meter Gu after brown rice processing.Rice bran oil has very high nutritive value, has eighty per cant unrighted acid (monounsaturated fatty acid accounts for 47%, and polybasic unsaturated fatty acid accounts for 33%), and has abundant vitamin e and other polyphenoils.After rice bran oil food, absorptivity reaches more than 90%, aliphatic acid wherein, vitamin E, sterol, oryzanol etc. are conducive to the absorption of human body, there is the cholesterol removed in blood, reduce blood fat, promote the human body beneficial effect such as grow, thereby rice bran oil is generally acknowledged nutrient health oil both at home and abroad.

Co-Q10 is a kind of fat-soluble antioxidant, it is one of indispensable important element of human life, the nutrition of energy human activin cell and cellular energy, have improve body immunity, strengthen anti-oxidant, delay senility and strengthen the functions such as human activity, be medically widely used in the treatment of disease of cardiovascular system.In recent years, extensively use it for nutrient and healthcare products and food additives both at home and abroad.Co-Q10 structure is similar to vitamin E, and its content in human body can reduce with advancing age.More and more medical research shows, Co-Q10 contributes to: (1) cardioprotection: Co-Q10 contributes to for cardiac muscle provides sufficient oxygen, prevention sudden heart disease, especially Co-Q10 performance key effect in myocardial anoxia process; (2) promote Conversion of Energy, promote energy: it is the essential energy of cells survival (as ATP) food conversion that Co-Q10 helps, make cell keep optimum state, make people feel that energy is more abundant; (3) improve immunity, delay senility: Co-Q10 is the natural that cell self produces, and can stop the formation of free radical, contributes to safeguard immune normal operation and delays senility.Research in recent years shows, Co-Q10, in prevention coronary heart disease, is alleviated periodontitis, and also there is remarkable result treatment duodenal ulcer and gastric ulcer and allevating angina pectoris aspect, also has antitumor action simultaneously, clinical for late period metastatic cancer have certain curative effect.

Just because of Co-Q10 has so numerous good effect and curative effects, on market, there is at present diversified coenzyme Q10 capsule on sale.What wherein have that a kind of soft capsule adopts is that three kinds of Co-Q10, natural VE and rice bran oils mix, and has alleviating physical fatigue, strengthens the health care of immunity.But expensive due to vitamin E, causes product cost obviously to improve after interpolation; In addition, the antioxygenic property of vitamin E is not very outstanding, causes this soft capsule product to have certain shortcoming yet.

Summary of the invention

For the problems referred to above, the object of the present invention is to provide the anti-oxidant coenzyme Q10 capsule of a kind of rosemary, Xue MingRosma rinus officinalis, the raw material of use is all pure naturals, and it is the cardiopathic best nutritional element of control, and especially in unable etc. the treatment of heart failure, heart, curative effect spy is good.

For achieving the above object, technical scheme proposed by the invention is: the anti-oxidant coenzyme Q10 capsule of a kind of rosemary, Xue MingRosma rinus officinalis, formed by capsule shells and content, it is characterized in that: described content is made up of according to mass ratio following raw material, rosemary antioxidant: Co-Q10: rice bran oil=2-5:3-6:30-80.

Further, described capsule shells is the soft capsule material of commercially available edible.

A kind of rosemary, Xue MingRosma rinus officinalis of the present invention is anti-oxidant coenzyme Q10 capsule preparation method comprise the following steps:

Step 1: rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir, obtain content;

Step 2: adopt pressing preparation, content is wrapped into wherein by capsule shells, obtain the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.

Further, in step 1, described mixing time is 15-20min.

The anti-oxidant coenzyme Q10 capsule of a kind of rosemary, Xue MingRosma rinus officinalis of the present invention has following outstanding advantages:

1) adopt antioxygenic property be obviously better than vitamin E and low-cost rosemary antioxidant for add raw material, not only reduced product cost, also obtained good antioxidant effect simultaneously, be strong antioxidant, to the effect extra-heavy of delaying aging;

2) rosemary antioxidant and Co-Q10 have excellent synergy, have improved and expanded health care and the sphere of action of Co-Q10;

3) can effectively treat heart disease, hypertension, effective in cure to patient's Zhuo that heart expands, cardio-pulmonary function is bad;

4) can strengthen immune system, eliminate the germ in intrusive body, anti-curing cancers, chronic infection, beads germ and HIV are benefited;

5) can effectively prevent obesity, multiple sclerosis, periodontitis and diabetes etc.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention will be further described.

Embodiment 1

Rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content; Employing pressing preparation, wraps into content wherein by capsule shells, obtains the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.Each raw material is rosemary antioxidant 30mg by mass, Co-Q10 30mg, rice bran oil 400mg.

Embodiment 2

Rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content; Employing pressing preparation, wraps into content wherein by capsule shells, obtains the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.Each raw material is rosemary antioxidant 20mg by mass, Co-Q10 40mg, rice bran oil 300mg.

Embodiment 3

Rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content; Employing pressing preparation, wraps into content wherein by capsule shells, obtains the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.Each raw material is rosemary antioxidant 40mg by mass, Co-Q10 50mg, rice bran oil 600mg.

Embodiment 4

Rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content; Employing pressing preparation, wraps into content wherein by capsule shells, obtains the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.Each raw material is rosemary antioxidant 50mg by mass, Co-Q10 60mg, rice bran oil 800mg.

Embodiment 5

Rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content; Employing pressing preparation, wraps into content wherein by capsule shells, obtains the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.Each raw material is rosemary antioxidant 30mg by mass, Co-Q10 60mg, rice bran oil 700mg.

Embodiment 6

Rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content; Employing pressing preparation, wraps into content wherein by capsule shells, obtains the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.Each raw material is rosemary antioxidant 50mg by mass, Co-Q10 30mg, rice bran oil 600mg.

Embodiment 7: results of animal analysis

Adopt the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis of the present invention also to carry out zoopery, use small white mouse is experimental subjects, to normal feeding, add and feed Co-Q10, add the testing result of feeding commercially available vitamin E coenzyme Q10 capsule and the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis and compare, specifically small white mouse is added and fed 5 days, every day, feeding Co-Q10 amount was 20mg/Kg body weight, detect myocardial mitochondria is the growing amount of lipid peroxidation product MDA in conjunction with content, atpase activity and the radical damage product of Co-Q10 simultaneously, and concrete outcome is as following table:

Experimental result shows, feeding Co-Q10 can obviously improve the combination content of Co-Q10 in small white mouse mitochondria, manufactures ATP thereby be more conducive to mitochondria, therefore detects too that ATP synthase activity has significant raising.Also explanation of experiment, supplement the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis, Co-Q10 in small white mouse mitochondria all has significant raising than supplementary commercially available vitamin E coenzyme Q10 capsule in conjunction with content and ATP synthase activity, this explanation, because rosemary antioxidant adds, more contributes to Co-Q10 to be absorbed by animals utilization.Supplemented with exogenous Co-Q10 can make animal mitochondria be subject to the damage of oxygen radical, the side effect of Here it is Co-Q10, and the degree of its damage can judge according to the growing amount of the lipid peroxidation product MDA producing because of damage.According to the detection to radical damage product MDA growing amount, we are also easy to find, supplement the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis and commercially available vitamin E coenzyme Q10 capsule, all can greatly alleviate the supplementary caused radical damage due to Co-Q10, but the effect of the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis is still significantly better than commercially available vitamin E coenzyme Q10 capsule, can cause hardly radical damage, its basic reason should be because rosemary antioxidant has the oxidation resistance more much better than than vitamin E, can effectively remove the oxygen radical in body, the radical damage of avoiding taking in external source Co-Q10 and bring.

Although specifically show and introduced the present invention in conjunction with preferred embodiment; but those skilled in the art should be understood that; not departing from the spirit and scope of the present invention that appended claims limits; in the form and details the present invention is made a variety of changes, be protection scope of the present invention.

Claims (1)

1. the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis, is made up of capsule shells and content, it is characterized in that: described content is made up of according to weight ratio following raw material: rosemary antioxidant: Co-Q10: rice bran oil=2-5:3-6:30-80; Described capsule shells is the soft capsule material of commercially available edible,

Its preparation method is:

Step 1: rosemary antioxidant, Co-Q10 and rice bran oil are added in container, stir 15-20min, obtain content;

Step 2: adopt pressing preparation, content is wrapped into wherein by capsule shells, obtain the anti-oxidant coenzyme Q10 capsule of rosemary, Xue MingRosma rinus officinalis.