CN102791688B - 雌激素受体配体 - Google Patents

雌激素受体配体 Download PDF

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Publication number
CN102791688B
CN102791688B CN201080045502.6A CN201080045502A CN102791688B CN 102791688 B CN102791688 B CN 102791688B CN 201080045502 A CN201080045502 A CN 201080045502A CN 102791688 B CN102791688 B CN 102791688B
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China
Prior art keywords
compound
hydroxyphenyl
indole
alkyl
disease
Prior art date
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Expired - Fee Related
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CN201080045502.6A
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English (en)
Chinese (zh)
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CN102791688A (zh
Inventor
M·温纳斯达尔
P·罗恩斯塔德
程爱平
S·戈登
T·艾普尔克维斯特
L·哈格伯格
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Karo Healthcare AB
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Karo Bio AB
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Priority claimed from GB0917575A external-priority patent/GB0917575D0/en
Priority claimed from GBGB1004377.6A external-priority patent/GB201004377D0/en
Application filed by Karo Bio AB filed Critical Karo Bio AB
Publication of CN102791688A publication Critical patent/CN102791688A/zh
Application granted granted Critical
Publication of CN102791688B publication Critical patent/CN102791688B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Pregnancy & Childbirth (AREA)
CN201080045502.6A 2009-10-07 2010-10-06 雌激素受体配体 Expired - Fee Related CN102791688B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0917575.3 2009-10-07
GB0917575A GB0917575D0 (en) 2009-10-07 2009-10-07 Novel estrogen receptor ligands
GB1004377.6 2010-03-16
GBGB1004377.6A GB201004377D0 (en) 2010-03-16 2010-03-16 Novel estrogen receptor ligands
PCT/EP2010/064939 WO2011042473A2 (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands

Publications (2)

Publication Number Publication Date
CN102791688A CN102791688A (zh) 2012-11-21
CN102791688B true CN102791688B (zh) 2014-11-12

Family

ID=43857210

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080045502.6A Expired - Fee Related CN102791688B (zh) 2009-10-07 2010-10-06 雌激素受体配体

Country Status (10)

Country Link
US (1) US8710243B2 (enExample)
EP (1) EP2486010B1 (enExample)
JP (1) JP5687704B2 (enExample)
CN (1) CN102791688B (enExample)
AR (1) AR078537A1 (enExample)
DK (1) DK2486010T3 (enExample)
ES (1) ES2744219T3 (enExample)
IN (1) IN2012DN02555A (enExample)
TW (1) TW201124404A (enExample)
WO (1) WO2011042473A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
US9974776B2 (en) 2013-12-05 2018-05-22 Karo Pharma Ab Estrogen receptor beta agonists for use in treating mesothelioma
EP3782616B1 (en) 2014-09-02 2023-11-01 The Regents of The University of California Estrogen receptor ligand treatment for neurodegenerative diseases
WO2016097036A1 (en) * 2014-12-17 2016-06-23 Karo Bio Ab Estrogen receptor ligand for use in treating melanoma
US11624095B2 (en) 2017-09-27 2023-04-11 Case Western Reserve University Method of quantifying HIV reservoirs by induced transcription based sequencing
CN111704648B (zh) * 2020-06-23 2022-02-15 武汉大学 以氧桥双环庚烯类化合物为雌激素受体配体的蛋白水解靶向嵌合体化合物及制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220377A1 (en) * 2002-05-08 2003-11-27 Richard Chesworth Indole compounds and their use as estrogen agonists/antagonists
WO2005105213A2 (en) * 2004-04-30 2005-11-10 Nikem Research S.R.L. Indole and azaindole derivatives with antitumor action
WO2007087488A2 (en) * 2006-01-24 2007-08-02 Eli Lilly And Company Indole sulfonamide modulators of progesterone receptors

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JP2001122855A (ja) 1999-10-27 2001-05-08 Japan Tobacco Inc インドール化合物及びその医薬用途
FR2868779B1 (fr) * 2004-04-09 2008-08-22 Pierre Fabre Medicament Sa Procede de synthese et intermediaires de benzoxathiepines
EP1779848A1 (en) * 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
EP2074102A1 (en) 2006-10-13 2009-07-01 Karo Bio Ab 2-phenyl indene derivatives useful as estrogen receptor ligands
JP2010533668A (ja) 2007-07-20 2010-10-28 カロ バイオ アクチェブラーグ 新規エストロゲン受容体リガンド
GB0806656D0 (en) 2008-04-11 2008-05-14 Karobio Ab Novel estrogen receptor ligands
KR20160067981A (ko) 2008-04-16 2016-06-14 카로 바이오 아베 신규한 에스트로겐 수용체 리간드
GB0817221D0 (en) 2008-09-19 2008-10-29 Karobio Ab Novel estrogen receptor ligands

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220377A1 (en) * 2002-05-08 2003-11-27 Richard Chesworth Indole compounds and their use as estrogen agonists/antagonists
WO2005105213A2 (en) * 2004-04-30 2005-11-10 Nikem Research S.R.L. Indole and azaindole derivatives with antitumor action
WO2007087488A2 (en) * 2006-01-24 2007-08-02 Eli Lilly And Company Indole sulfonamide modulators of progesterone receptors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hydroxy-3-(hydroxyphenyl)indoles.R elationship between Structure and Estrogen Receptor Affinity;Josef Strohmeier et al.,;《Arch. Pharm.》;19851231;第318卷;421-431 *

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Publication number Publication date
WO2011042473A3 (en) 2011-06-03
EP2486010B1 (en) 2019-06-12
ES2744219T3 (es) 2020-02-24
JP5687704B2 (ja) 2015-03-18
WO2011042473A2 (en) 2011-04-14
US8710243B2 (en) 2014-04-29
DK2486010T3 (da) 2019-09-23
TW201124404A (en) 2011-07-16
EP2486010A2 (en) 2012-08-15
IN2012DN02555A (enExample) 2015-08-28
US20120202861A1 (en) 2012-08-09
CN102791688A (zh) 2012-11-21
AR078537A1 (es) 2011-11-16
JP2013507335A (ja) 2013-03-04

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