CN102784154B - 一种美沙拉嗪肠溶片及其制备方法 - Google Patents
一种美沙拉嗪肠溶片及其制备方法 Download PDFInfo
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- CN102784154B CN102784154B CN 201210318122 CN201210318122A CN102784154B CN 102784154 B CN102784154 B CN 102784154B CN 201210318122 CN201210318122 CN 201210318122 CN 201210318122 A CN201210318122 A CN 201210318122A CN 102784154 B CN102784154 B CN 102784154B
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- parts
- coating
- enteric
- mesalazine
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- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 229960004963 mesalazine Drugs 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000002662 enteric coated tablet Substances 0.000 title 1
- 238000009505 enteric coating Methods 0.000 claims abstract description 16
- 239000002702 enteric coating Substances 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 44
- 239000011248 coating agent Substances 0.000 claims description 31
- 238000000576 coating method Methods 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 23
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 9
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 9
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 9
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 8
- 239000004375 Dextrin Substances 0.000 claims description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 229920000881 Modified starch Polymers 0.000 claims description 8
- 229920003081 Povidone K 30 Polymers 0.000 claims description 8
- 235000019425 dextrin Nutrition 0.000 claims description 8
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000011812 mixed powder Substances 0.000 claims description 8
- 239000001814 pectin Substances 0.000 claims description 8
- 235000010987 pectin Nutrition 0.000 claims description 8
- 229920001277 pectin Polymers 0.000 claims description 8
- 238000005453 pelletization Methods 0.000 claims description 8
- 238000012056 up-stream process Methods 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 7
- 239000007888 film coating Substances 0.000 claims description 7
- 238000009501 film coating Methods 0.000 claims description 7
- 235000010603 pastilles Nutrition 0.000 claims description 7
- 239000006187 pill Substances 0.000 claims description 7
- 239000000741 silica gel Substances 0.000 claims description 7
- 229910002027 silica gel Inorganic materials 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 18
- 229940079593 drug Drugs 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 7
- 210000001072 colon Anatomy 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 201210318122 CN102784154B (zh) | 2012-09-01 | 2012-09-01 | 一种美沙拉嗪肠溶片及其制备方法 |
Applications Claiming Priority (1)
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CN 201210318122 CN102784154B (zh) | 2012-09-01 | 2012-09-01 | 一种美沙拉嗪肠溶片及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102784154A CN102784154A (zh) | 2012-11-21 |
CN102784154B true CN102784154B (zh) | 2013-10-09 |
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CN 201210318122 Active CN102784154B (zh) | 2012-09-01 | 2012-09-01 | 一种美沙拉嗪肠溶片及其制备方法 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111700871A (zh) * | 2020-06-24 | 2020-09-25 | 杭州巴洛特生物科技有限公司 | 一种美沙拉嗪组合物及其制备方法 |
CN112641747A (zh) * | 2020-12-07 | 2021-04-13 | 南京森博医药研发有限公司 | 一种高纯度美沙拉嗪肠溶缓释片制剂及其制备方法 |
CN112546009A (zh) * | 2020-12-23 | 2021-03-26 | 南京爱文医药研发有限公司 | 一种美沙拉嗪肠溶缓释片及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1318625B1 (it) * | 2000-07-14 | 2003-08-27 | Roberto Valducci | Formulazioni farmaceutiche solide orali a rilascio multifasicoph-dipendente. |
JP2007523664A (ja) * | 2003-04-23 | 2007-08-23 | フェリング ベスローテン フェンノートシャップ | 医薬組成物用サシェ |
EP1547601A1 (en) * | 2003-12-23 | 2005-06-29 | Ferring B.V. | Coating method |
CN100571694C (zh) * | 2004-04-26 | 2009-12-23 | 沈阳药科大学 | 美沙拉嗪结肠定位释药微丸制剂及其制备方法 |
CN101721385B (zh) * | 2008-10-13 | 2012-10-24 | 重庆医药工业研究院有限责任公司 | 一种美沙拉嗪口服控释药物组合物 |
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C14 | Grant of patent or utility model | ||
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ASS | Succession or assignment of patent right |
Owner name: SUNFLOWER PHARMACEUTICAL GROUP JIAMUSI LULING PHAR Free format text: FORMER OWNER: ZHU WENJUN Effective date: 20150626 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150626 Address after: 154005, No. 91 Li Jiang Street, Dongfeng District, Heilongjiang, Jiamusi Patentee after: JIAMUSI LULING PHARMACEUTICAL CO., LTD., SUNFLOWER PHARMACEUTICAL GROUP Address before: 710 room 90, No. 150000, Xiangjiang Road, Harbin Development Zone, Heilongjiang, China Patentee before: Zhu Wenjun |