CN102772630B - Medicine for treating type-II diabetes mellitus - Google Patents

Abstract

The invention discloses a medicine for treating type-II diabetes mellitus, which is prepared by uniformly mixing radix rehmanniae, radix scrophulariae, fructus ligustri lucidi, herba epimedii, gecko, semen cuscutae, rhizoma coptidis, rhizoma anemarrhenae, euonymus alatus, radix arnebiae seu lithospermi, panax notoginseng, polygonum cuspidatum, fructus gardeniae, spica prunellae, astragalus mongholicus, rhizoma atractylodis, rhizoma atractylodis macrocephalae and semen plantaginis; grinding the mixture into medicinal powder with particle size of 100-120 meshes; adding an excipient; and preparing into tablets after sterilization and disinfection according to the conventional method. The medicine provided by the invention has the effects of nourishing kidney yin, clearing stomach and moistening lung, warming yang, cleaning liver and invigorating spleen and promoting circulation and removing stasis, and has the characteristics of definite treatment effect, cheap price and safety when being used for the treatment of the diabetes mellitus. The effective rate of the medicine is 81% by the clinical observation.

Description

A kind of medicine for the treatment of type ii diabetes

Technical field

The present invention relates to a kind of medicine for the treatment of type ii diabetes, particularly relate to a kind of Chinese medicine of the treatment type ii diabetes of preparing taking Chinese medicine as raw material.

Background technology

Diabetes be a kind of due to defect of insulin secretion and (or) metabolic disease taking hyperglycemia as feature that causes of its biological action obstacle, on hereditary basis, the Genetic predisposition to disease that has environmental factors to participate in is a kind of chronic general metabolic disease.The pathogenic factor of diabetes is mainly definitely to lack or because health increases the insulin relative deficiency causing to the demand of insulin due to insulin secretion in body, or due to insulin resistant, thereby cause taking carbohydrate metabolism disturbance as main sugar, the metabolism disorder of protein, fat.Along with the course of disease extends, can cause the complication of the histoorgans such as eye, nerve, blood vessel, kidney, be the incretion metabolism disease of serious harm human body.The main pathogenesis that wherein insulin resistant is type ii diabetes.

The main Thiazolidinediones for the treatment of Western medicine to type ii diabetes at present.Can there is the untoward reaction such as secondary failure, gastrointestinal reaction, obesity, hypoglycemic reaction by long-term taking in such medicine, to health harm large in varying degrees.

Summary of the invention

The object of this invention is to provide a kind of medicine for the treatment of type ii diabetes, this medicine has adjust the dual power of negative and positive principles, liver heat removing spleen invigorating, and effect of blood circulation promoting and blood stasis dispelling, can play treating both the principal and secondary aspects of a disease, the object that therapeutic effect is good to treatment type ii diabetes.

Medicine of the present invention is to be that crude drug prepares by the Chinese medicine of following parts by weight:

The Radix Rehmanniae 10～14 Radix Scrophulariae 10～14 Fructus Ligustri Lucidi 10～14

Herba Epimedii 10～14 Gecko 1～4 Semen Cuscutae 3～5

Rhizoma Coptidis 3～5 Rhizoma Anemarrhenae 1～4 Ramulus Euonymis 10～14

Radix Arnebiae (Radix Lithospermi) 1～4 Radix Notoginseng 1～4 Rhizoma Polygoni Cuspidati 10～14

Fructus Gardeniae 3～5 Spica Prunellae 10～14 Radixs Astragali 10～14

Rhizoma Atractylodis 10～14 Rhizoma Atractylodis Macrocephalae 10～14 Semen Plantaginiss 10～14.

Said medicine can be made to any dosage form on pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is tablet.

The concrete preparation method of medicine of the present invention being made to tablet is:

Said medicine, by described parts by weight mix homogeneously, is ground into 100-120 object medicated powder, adds excipient, sterilization is made tablet according to a conventional method.

The main cause of type ii diabetes is kidney yin loss, and stomach-fire is too vigorous and cause negative and positive of qi and blood imbalance, taking deficiency of the kidney yin as this, and burning hot Sheng as mark.Simultaneously type ii diabetes patient is attended by the phenomenon of liver-heat, yang deficiency, insufficiency of the spleen, blood stasis toward contact, as liver-heat, in type ii diabetes patient, much all exist triglyceride to raise, fatty liver and transaminase raise, and patient has usually showed bitter taste conjunctival congestion, vertigo and tinnitus, auditory meatus is itched, yellow fur stringy pulse; Yang deficiency: early stage at type ii diabetes, by insulin release test, move after showing insulin secretion peak, this is the prompting folder yang deficiency of also holding concurrently just, the sign of miopragia; Insufficiency of the spleen: type ii diabetes patient, post-prandial glycemia raises, and extremity fatigue and weak is that spleen is not due to the loose essence of transporting; Blood stasis: type ii diabetes patient, blood biochemistry and Hemorheology inspection are found, whole blood contrast viscosity, plasma viscosity, packed cell volume, erythrocyte electrophoretic time is all higher than normally, blood is dense, solidifying, sticky, poly-state, from pathology, also find that primary disease exists the symptom such as glomerular sclerosis and arteriosclerosis, illustrate that blood stasis runs through in the process of type ii diabetes.Therapeutic Principle should be taking clearing stomach lung moistening, nourishing kidney-yin, liver heat removing spleen invigorating, warming YANG, blood circulation promoting and blood stasis dispelling as main.Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Scrophulariae replenishing YIN and removing heat; Fructus Ligustri Lucidi liver and kidney tonifying; Clearind deficient heat; Herba Epimedii kidney-replenishing, bone and muscle strengthening; Gecko invigorating the lung and the kidney, supporing yang benefit essence; Semen Cuscutae the kidney invigorating and essence nourishing, the solid tire of spleen invigorating; Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication; Rhizoma Anemarrhenae clearing away heat-fire, promotes the production of body fluid and moisturizes; Ramulus Euonymi promoting the circulation of blood is stimulated the menstrual flow, eliminating stasis to stop pain; Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, removing toxic substances; The hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain; Rhizoma Polygoni Cuspidati expelling wind and removing dampness, dissipating blood stasis analgesic therapy; Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat and cooling blood; The Spica Prunellae improving eyesight of relieving inflammation or internal heat, mass dissipating and swelling eliminating; Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic; Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria.All medicines share, and can play effect of nourishing kidney-yin, clearing stomach lung moistening, warming YANG, liver heat removing spleen invigorating, blood circulation promoting and blood stasis dispelling, for the treatment of type ii diabetes, have determined curative effect,, cheap, take safe feature.

For further investigating clinical efficacy and the safety of medicine of the present invention, select 100 routine type ii diabetes patients the curative effect of medicine of the present invention to be carried out to clinical observation, wherein male 47 examples, female's 53 examples.In age 28-78 year, the course of disease is the shortest 2 months, the longest 7 years.

All cases is all diagnosed as type ii diabetes with reference to diagnosis basis and typing in WHO standard in 1999, gets rid of (1) severe cardiac hepatorenal disease person; (2) there is the high Diabetic Acute complications such as ooze of ketosis; (3) there are the serious stress state persons such as severe infections; (4) women breast-feeding their children or anemia of pregnant woman (5) hyperthyroidism medical history person; (6) sulphanylureas secondary failure person; (7) serious organ disease, the intestines and stomach malabsorption disease, excessive drinking or history of drug abuse person.

Therapeutic Method

Adopt tablet medicine of the present invention to treat, take every day 3 times, each 8 (every 0.5 gram).Take half an hour ante cibum.It within three months, is a course for the treatment of.

Criterion of therapeutical effect

Criterion of therapeutical effect: detect fasting glucose (FPG) before and after treatment, 2 hours blood glucoses (2hPG), glycolated hemoglobin (HbA1c) after the meal.Criterion of therapeutical effect is according to " new Chinese medicine guideline of clinical investigations "

(1) effective: fasting glucose and after the meal 2 hours blood glucoses drop to and normal range or empty stomach and 2 hours blood glucoses declines after the meal exceed treatment front 40%.Glycolated hemoglobin value drops to normally or declines and exceedes treatment front 30%.；

(2) effective: on an empty stomach and after the meal 2 hours blood glucoses decline, and to exceed treatment front 20%, but do not reach effective standard.Glycolated hemoglobin value drops to normally or declines and exceedes treatment front 10%.But do not reach effective standard.

(3) invalid: empty stomach and after the meal 2 hours blood glucoses do not reach effective standard without declining or declining.Glycolated hemoglobin value does not reach effective standard without declining or declining.

After all cases treatment, curative effect is in table 1.

Curative effect after the treatment of table 1 all cases

Group	Number of cases	Effective n(%)	Effectively n(%)	Invalid n(%)	Total effective rate n(%)
						Treatment group	100	29（29）	52（52）	19（19）	81（81）

Detailed description of the invention

Embodiment 1

Get the Radix Rehmanniae 10g selected, clear water is clean, Radix Scrophulariae 10 g, Fructus Ligustri Lucidi 10 g, Herba Epimedii 10 g, Gecko 1 g, Semen Cuscutae 3 g, Rhizoma Coptidis 3 g, the Rhizoma Anemarrhenae 1 g, Ramulus Euonymi 10 g, Radix Arnebiae (Radix Lithospermi) 1 g, Radix Notoginseng 1 g, Rhizoma Polygoni Cuspidati 10 g, Fructus Gardeniae 3 g, Spica Prunellae 10 g, the Radix Astragali 10 g, Rhizoma Atractylodis 10 g, the Rhizoma Atractylodis Macrocephalae 10 g, Semen Plantaginis 10 g mix homogeneously, be ground into 100-120 object medicated powder, add excipient, sterilization is made tablet according to a conventional method.

Embodiment 2

Get the Radix Ginseng Radix Rehmanniae 14 g selected, clear water is clean, Radix Scrophulariae 14 g, Fructus Ligustri Lucidi 14 g, Herba Epimedii 14 g, Gecko 4 g, Semen Cuscutae 5 g, Rhizoma Coptidis 5 g, the Rhizoma Anemarrhenae 4 g, Ramulus Euonymi 14 g, Radix Arnebiae (Radix Lithospermi) 4 g, Radix Notoginseng 4 g, Rhizoma Polygoni Cuspidati 14 g, Fructus Gardeniae 5 g, Spica Prunellae 14 g, the Radix Astragali 14 g, Rhizoma Atractylodis 14 g, the Rhizoma Atractylodis Macrocephalae 14 g, Semen Plantaginis 14 g mix homogeneously, be ground into 100-120 object medicated powder, add excipient, sterilization is made tablet according to a conventional method.

Claims (1)

1. treating a medicine for type ii diabetes, is to be crude drug mix homogeneously by the Chinese medicine of following portions by weight, is ground into 100～120 object medicated powder, adds excipient, and sterilization prepares tablet according to a conventional method:

The Radix Rehmanniae 10～14 Radix Scrophulariae 10～14 Fructus Ligustri Lucidi 10～14

Herba Epimedii 10～14 Gecko 1～4 Semen Cuscutae 3～5

Rhizoma Coptidis 3～5 Rhizoma Anemarrhenae 1～4 Ramulus Euonymis 10～14

Radix Arnebiae (Radix Lithospermi) 1～4 Radix Notoginseng 1～4 Rhizoma Polygoni Cuspidati 10～14

Fructus Gardeniae 3～5 Spica Prunellae 10～14 Radixs Astragali 10～14

Rhizoma Atractylodis 10～14 Rhizoma Atractylodis Macrocephalae 10～14 Semen Plantaginiss 10～14.