CN102772630A - Medicine for treating type-II diabetes mellitus - Google Patents
Medicine for treating type-II diabetes mellitus Download PDFInfo
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- CN102772630A CN102772630A CN2012102840457A CN201210284045A CN102772630A CN 102772630 A CN102772630 A CN 102772630A CN 2012102840457 A CN2012102840457 A CN 2012102840457A CN 201210284045 A CN201210284045 A CN 201210284045A CN 102772630 A CN102772630 A CN 102772630A
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Abstract
The invention discloses a medicine for treating type-II diabetes mellitus, which is prepared by uniformly mixing radix rehmanniae, radix scrophulariae, fructus ligustri lucidi, herba epimedii, gecko, semen cuscutae, rhizoma coptidis, rhizoma anemarrhenae, euonymus alatus, radix arnebiae seu lithospermi, panax notoginseng, polygonum cuspidatum, fructus gardeniae, spica prunellae, astragalus mongholicus, rhizoma atractylodis, rhizoma atractylodis macrocephalae and semen plantaginis; grinding the mixture into medicinal powder with particle size of 100-120 meshes; adding an excipient; and preparing into tablets after sterilization and disinfection according to the conventional method. The medicine provided by the invention has the effects of nourishing kidney yin, clearing stomach and moistening lung, warming yang, cleaning liver and invigorating spleen and promoting circulation and removing stasis, and has the characteristics of definite treatment effect, cheap price and safety when being used for the treatment of the diabetes mellitus. The effective rate of the medicine is 81% by the clinical observation.
Description
Technical field
The present invention relates to a kind of medicine of treating type ii diabetes, particularly relating to a kind of is the Chinese medicine of the treatment type ii diabetes of feedstock production with Chinese medicine.
Background technology
Diabetes be a kind of because defect of insulin secretion and (or) its biological action obstacle causes is the metabolic disease of characteristic with the hyperglycemia; Be on hereditary basis; The genetic predisposition disease that has environmental factors to participate in is a kind of chronic general metabolic disease.The pathogenic factor of diabetes mainly be since in the body insulin secretion definitely lack or owing to health increases the insulin relative deficiency that causes to the demand of insulin; Or because insulin resistant, thereby to cause with the carbohydrate metabolism disturbance be the metabolism disorder of main sugar, protein, fat.Along with the course of disease prolongs, can cause the complication of histoorgans such as eye, nerve, blood vessel, kidney, be the incretion metabolism disease of serious harm human body.Wherein insulin resistant is the main pathogenesis of type ii diabetes.
At present to the main thiazolidinediones medicine of the treatment Western medicine of type ii diabetes.Such medicine can be taken for a long time and can have untoward reaction such as secondary failure, gastrointestinal reaction, obesity, hypoglycemic reaction in varying degrees, and is big to health harm.
Summary of the invention
The purpose of this invention is to provide a kind of medicine of treating type ii diabetes, this medicine has adjust the dual power of negative and positive principles, the liver heat removing spleen invigorating, and the effect of blood circulation promoting and blood stasis dispelling can play treating both the principal and secondary aspects of a disease, the purpose that therapeutic effect is good to the treatment type ii diabetes.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
The Radix Rehmanniae 10~14 Radix Scrophulariae 10~14 Fructus Ligustri Lucidi 10~14
Herba Epimedii 10~14 Geckos 1~4 Semen Cuscutae 3~5
Rhizoma Coptidis 3~5 Rhizoma Anemarrhenaes 1~4 Ramulus Euonymi 10~14
Radix Arnebiae (Radix Lithospermi) 1~4 Radix Notoginseng 1~4 Rhizoma Polygoni Cuspidati 10~14
Fructus Gardeniae 3~5 Spica Prunellaes 10~14 Radixs Astragali 10~14
Rhizoma Atractylodis 10~14 Rhizoma Atractylodis Macrocephalaes 10~14 Semen Plantaginiss 10~14.
Can said medicine be processed any dosage form on the pharmaceutics, like tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a tablet.
The concrete method for preparing of medicine of the present invention being processed tablet is:
Said medicine by said parts by weight mix homogeneously, is ground into 100-120 purpose medicated powder, adds excipient, process tablet by the conventional method sterilization.
The main cause of type ii diabetes is the kidney yin loss, and stomach-fire is too vigorous and cause negative and positive of qi and blood imbalance, is this with the deficiency of the kidney yin, and burning hot the Sheng is mark.Simultaneously the type ii diabetes patient is attended by the phenomenon of liver-heat, yang deficiency, insufficiency of the spleen, blood stasis toward contact, like liver-heat, in the type ii diabetes patient; Much all exist triglyceride to raise, fatty liver and transaminase raise, and the patient has usually showed the bitter taste conjunctival congestion; Vertigo and tinnitus, auditory meatus is itched, the yellow fur stringy pulse; Yang deficiency: early stage at type ii diabetes, through the islets of langerhans release test, move after promptly showing the insulin secretion peak, this is the prompting folder yang deficiency of also holding concurrently just, the sign of miopragia; Insufficiency of the spleen: the type ii diabetes patient, post-prandial glycemia raises, and the extremity fatigue and weak, is that spleen is not due to the diffusing essence of fortune; Blood stasis: type ii diabetes patient, the biochemical and hemorheology inspection discovery of blood, whole blood contrast viscosity; Plasma viscosity; Packed cell volume, erythrocyte electrophoretic time all are higher than normally, and that blood is is dense, coagulate, glue, gather state; From pathology, find that also there are symptom such as glomerular sclerosis and arteriosclerosis in primary disease, explains that blood stasis runs through in the process of type ii diabetes.The Therapeutic Principle should be main with clearing stomach lung moistening, nourishing kidney-yin, liver heat removing spleen invigorating, warming YANG, blood circulation promoting and blood stasis dispelling.Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; The Radix Scrophulariae replenishing YIN and removing heat; The Fructus Ligustri Lucidi liver and kidney tonifying; Clearind deficient heat; The Herba Epimedii kidney-replenishing, bone and muscle strengthening; The Gecko invigorating the lung and the kidney, supporing yang benefit is smart; The Semen Cuscutae the kidney invigorating and essence nourishing, the solid tire of spleen invigorating; The Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication; Rhizoma Anemarrhenae clearing away heat-fire promotes the production of body fluid and moisturizes; The Ramulus Euonymi promoting the circulation of blood is stimulated the menstrual flow, eliminating stasis to stop pain; The Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, detoxifcation; The hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain; The Rhizoma Polygoni Cuspidati expelling wind and removing dampness, the dissipating blood stasis analgesic therapy; Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat and cooling blood; Spica Prunellae relieves inflammation or internal heat and makes eye bright, mass dissipating and swelling eliminating; Radix Astragali invigorating QI to consolidate the body surface resistance, the diuresis poison holding; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, the dampness diuretic; The Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria.All medicines share, and can play the effect of nourishing kidney-yin, clearing stomach lung moistening, warming YANG, liver heat removing spleen invigorating, blood circulation promoting and blood stasis dispelling, are used for the treatment of type ii diabetes, have determined curative effect,, cheap, take safe characteristics.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 100 routine type ii diabetes patients that the curative effect of medicine of the present invention has been carried out clinical observation, wherein male 47 examples, women 53 examples.In age 28-78 year, the course of disease is the shortest 2 months, and is the longest 7 years.
All case all is diagnosed as type ii diabetes with reference to diagnosis basis and typing in the WHO standard in 1999, gets rid of (1) severe cardiac hepatorenal disease person; (2) there is ketosis high diabetes acute complications person such as to ooze; (3) serious stress state person such as severe infections is arranged; (4) women breast-feeding their children or anemia of pregnant woman (5) hyperthyroidism medical history person; (6) sulphanylureas secondary failure person; (7) serious organ disease, the intestines and stomach malabsorption property disease, excessive drinking or history of drug abuse person.
Therapeutic Method
Adopt tablet medicine of the present invention to treat, take every day 3 times, each 8 (every 0.5 gram).Take half an hour ante cibum.Three months is a course of treatment.
Criterion of therapeutical effect
Criterion of therapeutical effect: detect fasting glucose (FPG) before and after the treatment, 2 hours after the meal blood glucose (2hPG), glycolated hemoglobin (HbA1c).Criterion of therapeutical effect is according to " new Chinese medicine clinical research guideline "
(1) produce effects: fasting glucose and 2 hours after the meal blood glucose drop to normal range or reach 2 hours after the meal blood glucose on an empty stomach and descends above treatment preceding 40%.The glycolated hemoglobin value drops to normal or descends and surpasses treatment preceding 30%.;
(2) effective: on an empty stomach and 2 hours after the meal blood glucose descend that to surpass treatment preceding 20%, but do not reach the produce effects standard.The glycolated hemoglobin value drops to normal or descends and surpasses treatment preceding 10%.But do not reach the produce effects standard.
(3) invalid: on an empty stomach and 2 hours after the meal blood glucose do not have to descend or descend and do not reach effective standard.The glycolated hemoglobin value does not have decline or decline does not reach effective standard.
All case treatment back curative effect is seen table 1.
Table 1 is case treatment back curative effect all
Group | The example number | Produce effects n (%) | Effective n (%) | Invalid n (%) | Total effective rate n (%) |
The treatment group | 100 | 29(29) | 52(52) | 19(19) | 81(81) |
The specific embodiment
Embodiment 1
Get Radix Rehmanniae 10g, Radix Scrophulariae 10 g, Fructus Ligustri Lucidi 10 g, Herba Epimedii 10 g, Gecko 1 g, Semen Cuscutae 3 g, Rhizoma Coptidis 3 g, the Rhizoma Anemarrhenae 1 g, Ramulus Euonymi 10 g, Radix Arnebiae (Radix Lithospermi) 1 g, Radix Notoginseng 1 g, Rhizoma Polygoni Cuspidati 10 g, Fructus Gardeniae 3 g, Spica Prunellae 10 g, the Radix Astragali 10 g, Rhizoma Atractylodis 10 g, the Rhizoma Atractylodis Macrocephalae 10 g, Semen Plantaginis 10 g mix homogeneously selected, that clear water is cleaned; Be ground into 100-120 purpose medicated powder; Add excipient, process tablet by the conventional method sterilization.
Embodiment 2
Get the Radix Ginseng Radix Rehmanniae 14 g, Radix Scrophulariae 14 g, Fructus Ligustri Lucidi 14 g, Herba Epimedii 14 g, Gecko 4 g, Semen Cuscutae 5 g, Rhizoma Coptidis 5 g, the Rhizoma Anemarrhenae 4 g, Ramulus Euonymi 14 g, Radix Arnebiae (Radix Lithospermi) 4 g, Radix Notoginseng 4 g, Rhizoma Polygoni Cuspidati 14 g, Fructus Gardeniae 5 g, Spica Prunellae 14 g, the Radix Astragali 14 g, Rhizoma Atractylodis 14 g, the Rhizoma Atractylodis Macrocephalae 14 g, Semen Plantaginis 14 g mix homogeneously selected, that clear water is cleaned; Be ground into 100-120 purpose medicated powder; Add excipient, process tablet by the conventional method sterilization.
Claims (2)
1. medicine of treating type ii diabetes is that feedstock production obtains by the Chinese medicine of following portions by weight:
The Radix Rehmanniae 10~14 Radix Scrophulariae 10~14 Fructus Ligustri Lucidi 10~14
Herba Epimedii 10~14 Geckos 1~4 Semen Cuscutae 3~5
Rhizoma Coptidis 3~5 Rhizoma Anemarrhenaes 1~4 Ramulus Euonymi 10~14
Radix Arnebiae (Radix Lithospermi) 1~4 Radix Notoginseng 1~4 Rhizoma Polygoni Cuspidati 10~14
Fructus Gardeniae 3~5 Spica Prunellaes 10~14 Radixs Astragali 10~14
Rhizoma Atractylodis 10~14 Rhizoma Atractylodis Macrocephalaes 10~14 Semen Plantaginiss 10~14.
2. the medicine of treatment type ii diabetes according to claim 1 is characterized in that said medicine is processed tablet.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101700354A (en) * | 2009-11-20 | 2010-05-05 | 宁夏千宗宝糖尿病肾病研究所 | Traditional Chinese medicine for treating diabetes |
CN102188613A (en) * | 2011-05-16 | 2011-09-21 | 纳正林 | Traditional Chinese medicine preparation for treating diabetes |
CN102579674A (en) * | 2012-03-15 | 2012-07-18 | 郭世伟 | Chinese herba astragalus powder for curing diabetes mellitus |
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2012
- 2012-08-11 CN CN201210284045.7A patent/CN102772630B/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101700354A (en) * | 2009-11-20 | 2010-05-05 | 宁夏千宗宝糖尿病肾病研究所 | Traditional Chinese medicine for treating diabetes |
CN102188613A (en) * | 2011-05-16 | 2011-09-21 | 纳正林 | Traditional Chinese medicine preparation for treating diabetes |
CN102579674A (en) * | 2012-03-15 | 2012-07-18 | 郭世伟 | Chinese herba astragalus powder for curing diabetes mellitus |
Non-Patent Citations (3)
Title |
---|
张雪亮 等: "当今中医遣方用药流派之我见", 《中国实验方剂学杂志》, vol. 15, no. 5, 31 May 2009 (2009-05-31), pages 94 * |
李维林 等: "《治疗糖尿病的中草药》", 31 May 2006, 东南大学出版社, article "治疗糖尿病的中草药介绍", pages: 1-2 * |
高新彦 等: "《糖尿病中医诊疗经验集》", 31 March 2012, 西安交通大学出版社, article "章真如医论", pages: 173-175 * |
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