CN102770121B - 包含溶剂混合物和维生素d衍生物或类似物的药物组合物 - Google Patents

包含溶剂混合物和维生素d衍生物或类似物的药物组合物 Download PDF

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Publication number
CN102770121B
CN102770121B CN201080064576.4A CN201080064576A CN102770121B CN 102770121 B CN102770121 B CN 102770121B CN 201080064576 A CN201080064576 A CN 201080064576A CN 102770121 B CN102770121 B CN 102770121B
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CN
China
Prior art keywords
composition according
composition
solvent
fatty acid
acid ester
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Expired - Fee Related
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CN201080064576.4A
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English (en)
Chinese (zh)
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CN102770121A (zh
Inventor
K·彼得松
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Leo Pharma AS
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Leo Pharma AS
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Publication of CN102770121A publication Critical patent/CN102770121A/zh
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Publication of CN102770121B publication Critical patent/CN102770121B/zh
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080064576.4A 2009-12-22 2010-12-22 包含溶剂混合物和维生素d衍生物或类似物的药物组合物 Expired - Fee Related CN102770121B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK2009000264 2009-12-22
DKPCT/DK2009/000264 2009-12-22
US29310810P 2010-01-07 2010-01-07
US61/293,108 2010-01-07
PCT/DK2010/000184 WO2011076209A2 (en) 2009-12-22 2010-12-22 Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue

Publications (2)

Publication Number Publication Date
CN102770121A CN102770121A (zh) 2012-11-07
CN102770121B true CN102770121B (zh) 2014-10-15

Family

ID=43618136

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080064576.4A Expired - Fee Related CN102770121B (zh) 2009-12-22 2010-12-22 包含溶剂混合物和维生素d衍生物或类似物的药物组合物

Country Status (14)

Country Link
US (1) US20130023501A1 (https=)
EP (1) EP2515866B1 (https=)
JP (1) JP5732471B2 (https=)
CN (1) CN102770121B (https=)
AU (1) AU2010335656B2 (https=)
BR (1) BR112012015437A2 (https=)
CA (1) CA2785254A1 (https=)
ES (1) ES2452872T3 (https=)
IL (1) IL220517A (https=)
MX (1) MX2012007225A (https=)
NZ (1) NZ601001A (https=)
RU (1) RU2559084C2 (https=)
WO (1) WO2011076209A2 (https=)
ZA (1) ZA201204622B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ630169A (en) * 2013-02-27 2017-07-28 Laurie Robert Batt Anhydrous transdermal formulations
KR102486797B1 (ko) * 2016-03-09 2023-01-11 삼성전자 주식회사 전자 장치 및 전자 장치의 디스플레이 구동 방법
CN107643354B (zh) * 2016-07-22 2022-02-01 重庆华邦胜凯制药有限公司 卡泊三醇起始原料a及相关杂质的分离与测定方法
CN106265485A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种稳定性改善的卡泊三醇组合物
CN106265511A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种性能优异的卡泊三醇倍他米松自微乳制剂
CN108904445A (zh) * 2018-08-06 2018-11-30 江苏知原药业有限公司 钙泊三醇纳米悬浮液
CA3157812C (en) * 2019-10-25 2024-10-22 Cardiol Therapeutics Inc. Cannabidiol compositions for use in treating heart conditions
BR112023001283A2 (pt) 2020-07-28 2023-02-14 Arcutis Biotherapeutics Inc Composição farmacêutica tópica; método para tratar uma doença, distúrbio ou afecção inflamatória de pele em um indivíduo que necessita do mesmo; e método para intensificar a penetração em pele em um indivíduo de uma formulação farmacêutica tópica
KR20240125610A (ko) 2021-12-15 2024-08-19 아큐티스 바이오테라퓨틱스, 인크. Shr0302의 안정된 제형

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064450A1 (en) * 1999-04-23 2000-11-02 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Pharmaceutical composition
WO2006134272A1 (fr) * 2005-06-17 2006-12-21 Galderma Research & Development Composition pharmaceutique comprenant un elastomere organopolysiloxane et un principe actif solubilise
WO2008065316A2 (fr) * 2006-11-30 2008-06-05 Galderma S.A. Compositions sous forme d'onguent comprenant un derive de vitamine d

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US4083974A (en) * 1977-03-07 1978-04-11 The Upjohn Company Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
GB9300763D0 (en) 1993-01-15 1993-03-03 Leo Pharm Prod Ltd Chemical compound
GB9611603D0 (en) * 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
BR0214679A (pt) * 2001-12-03 2004-12-14 Novacea Inc Composições farmacêuticas compreendendo compostos a base de vitamina d ativa
DK1658263T3 (da) 2003-07-24 2010-09-27 Leo Pharma As Aminobenzophenonforbindelser
US8741333B2 (en) * 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
FR2871694B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises
KR101260236B1 (ko) 2004-12-13 2013-05-06 레오 파마 에이/에스 트리아졸 치환된 아미노벤조페논 화합물
EP2125736B1 (en) 2006-12-22 2011-03-30 Leo Pharma A/S Substituted acetophenones useful as pde4 inhibitors
CA2676933C (en) 2007-02-28 2015-09-29 Leo Pharma A/S Novel phosphodiesterase inhibitors
US7909624B2 (en) 2007-03-26 2011-03-22 Belkin International, Inc. Carabiner universal serial bus hub
JP2010524864A (ja) 2007-04-19 2010-07-22 レオ ファーマ アクティーゼルスカブ Ｓｒｃファミリーキナーゼ阻害剤
PL2148661T3 (pl) * 2007-04-25 2013-07-31 Cytochroma Inc Doustne kompozycje o kontrolowanym uwalnianiu zawierające związek będący witaminą D i woskowy nośnik
CA2685516A1 (en) 2007-05-11 2008-11-20 Sonneborn Inc. Petrolatums having silicone-like properties
RU2544011C2 (ru) 2008-12-19 2015-03-10 Лео Фарма А/С Триазолопиридины в качестве ингибиторов фосфодиэстеразы для лечения кожных заболеваний

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064450A1 (en) * 1999-04-23 2000-11-02 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Pharmaceutical composition
WO2006134272A1 (fr) * 2005-06-17 2006-12-21 Galderma Research & Development Composition pharmaceutique comprenant un elastomere organopolysiloxane et un principe actif solubilise
WO2008065316A2 (fr) * 2006-11-30 2008-06-05 Galderma S.A. Compositions sous forme d'onguent comprenant un derive de vitamine d

Also Published As

Publication number Publication date
NZ601001A (en) 2014-07-25
EP2515866A2 (en) 2012-10-31
EP2515866B1 (en) 2014-02-19
JP5732471B2 (ja) 2015-06-10
AU2010335656A1 (en) 2012-07-19
JP2013515020A (ja) 2013-05-02
MX2012007225A (es) 2012-07-30
BR112012015437A2 (pt) 2016-03-15
WO2011076209A2 (en) 2011-06-30
RU2012130411A (ru) 2014-01-27
ZA201204622B (en) 2013-09-25
ES2452872T3 (es) 2014-04-03
HK1177696A1 (en) 2013-08-30
RU2559084C2 (ru) 2015-08-10
IL220517A (en) 2016-08-31
IL220517A0 (en) 2012-08-30
CA2785254A1 (en) 2011-06-30
CN102770121A (zh) 2012-11-07
AU2010335656B2 (en) 2015-05-07
US20130023501A1 (en) 2013-01-24
WO2011076209A3 (en) 2012-02-23

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