CN102755449B - Medicament for treating eczema rhagadiforme and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating eczema rhagadiforme, which is used for solving the treatment problem of eczema rhagadiforme. The medicament is characterized by being processed from a plurality of Chinese medicinal raw materials in parts by weight: 30-50 parts of tea seed oil, 8-15 parts of baikal skullcap root, 8-15 parts of coptis root, 6-10 parts of amur corktree bark, 6-10 parts of all-grass of annual saltmarsh aster, 8-15 parts of southern evodia leaf, 6-10 parts of talc, 8-15 parts of Japanese pagodatree resin and 3-6 parts of borneol. A preparation method of the medicament comprises the following steps of: (1) extracting the baikal skullcap root, coptis root, amur corktree bark, all-grass of annual saltmarsh aster and southern evodia leaf with water, concentrating and drying into extract powder; (2) smashing talc and borneol to obtain talc fine powder and borneol fine powder; and (3) heating tea seed oil to 60 DEG C, adding Japanese pagodatree resin, stirring uniformly, cooling to the room temperature, adding the extract powder obtained in the step (1) and the talc fine powder and borneol fine powder obtained in the step (2), and stirring uniformly. As proved by a clinical experiment, the medicament has the characteristics of good curative effect and high safety when used for treating eczema rhagadiforme, and is worthy of clinical application and popularization.

Description

A kind of medicine for the treatment of eczema rhagadiforme and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to treat the medicine of eczema rhagadiforme.

Background technology

Eczema rhagadiforme belongs to chronic eczema, is dermatology common disease autumn and winter.Its cause of disease complexity it is generally acknowledged that hereditary allergic constitution is relevant, often brings out or increases the weight of because contacting stimulus object such as cleaning agent, soap, dyestuff, paint and daylight in the daily life, occurs chapping, pain, thereby influences normal live and work.In lysis, factors such as psychic trauma, endocrine disturbance all can increase the weight of the state of an illness.Multiple being born in refers to the back of the body and finger tip facies palmaris and palmar hand, can spread to the back of the hand and wrist portion, and skin lesion is subacute or the chronic eczema performance.The skin lesion form is various during acute onset, and obscure boundary shows as flushing, erosion, sepage, incrustation; When chronic, pachyderma is coarse, and horny layer also thickens, and is heavy then occur chapping, and the course of disease is longer, obstinate difficult healing.Except the chapping of some secondary, some patient can not find reason accurately.Modern medicine thinks that this disease is caused by environmental stimuli, is a kind of allergy, inflammatory skin disease, and is in close relations with immunity.With antiallergic and topical class steroid hormone treatment eczema rhagadiforme, the state of an illness can take a turn for the better rapidly after the medication, but outbreak repeatedly easily, and life-time service has more side effect.Clinical majority studies show that steroid ointment steroid hormone is used for the treatment of interim and short-term only.

The Chinese medicine eczema rhagadiforme is respond well, generally is the Chinese medicine decocting at present, soaks or the local skin lesion of washout with warm medicine juice.But since this patient to slap sole of the foot portion illing skin coarse, acanthokeratodermia, drug absorption ability, soak time need surpass 1 hour can onset, uses inconvenience.

Summary of the invention

Technical assignment of the present invention is at the deficiencies in the prior art, and medicine of the sure treatment eczema rhagadiforme of a kind of curative effect and preparation method thereof is provided.

The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of eczema rhagadiforme, it is characterized in that being processed by plurality of Chinese, its raw material comprises: 30 ~ 50 parts of Oleum Camelliae, 8 ~ 15 parts of Radix Scutellariaes, 8 ~ 15 parts of Rhizoma Coptidis, 6 ~ 10 parts of Cortex Phellodendris, auspicious 6 ~ 10 parts of grass, 8 ~ 15 parts of Folium Evodiae trichotomae, 6 ~ 10 parts in the Talcum of connecting, 8 ~ 15 parts of Resina sophorae, 3 ~ 6 parts of Borneolum Syntheticums.

Its optimum weight proportioning is: 40 parts of Oleum Camelliae, 10 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 8 parts of Cortex Phellodendris, auspicious 8 parts of grass, 10 parts of Folium Evodiae trichotomae, 8 parts in Talcum, 10 parts of Resina sophorae, 5 parts of the Borneolum Syntheticums of connecting.

The preparation method of the medicine of described treatment eczema rhagadiforme may further comprise the steps:

(1) Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Rui Liancao, Folium Evodiae trichotomae are decocted with water secondary, collecting decoction filters, and it is 1.18 clear paste that filtrate decompression is concentrated into relative density, and spray drying is made extract powder;

(2) Talcum and Borneolum Syntheticum are pulverized respectively, crossed 200 mesh sieves, get Talcum fine powder and Borneolum Syntheticum fine powder respectively;

(3) Oleum Camelliae is heated to 60 ℃, puts into Resina sophorae, be down to room temperature after stirring, add step 1 gained extract powder and step 2 gained Talcum fine powder and Borneolum Syntheticum fine powder, stir.

Wherein said: Oleum Camelliae, the fatty oil that obtains with milling process for the mature seed of plant of theaceae oil tea Camellia oleifera Abel or lobule oil tea Camellia meiocarpa Hu.ms..Sweet, cold.Return large intestine channel.Clearing away heat and eliminating dampness, the parasite killing detoxifcation.

Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.The nature and flavor hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.But the merit heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.

Rhizoma Coptidis is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..The nature and flavor hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.But the merit heat clearing and damp drying, eliminating fire and detoxication.

Cortex Phellodendri is the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..The nature and flavor hardship, cold.Return kidney, urinary bladder channel.But the merit heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.

The auspicious grass that connects is for the careless Aster subulatus Michx. of the auspicious company of Compositae, with all herbal medicine.Bitter in the mouth; Acid; Cool in nature.But merit heat-clearing and toxic substances removing.

Folium Evodiae trichotomae is the leaf of rutaceae mountain Fructus Evodiae Tetradium trichotoma Lour..The nature and flavor suffering; Bitter; Temperature.Return lung; The stomach warp.But merit expelling wind and removing dampness; Dispersing cold for relieving pain.

Talcum, the Ore of silicates mineral talc family Talcum.Nature and flavor are sweet, light, and are cold.Return stomach, urinary bladder channel.But the merit clearing away heat and promoting diuresis is treating stranguria, removing summer-heat.

Resina sophorae is the resin of leguminous plant Chinese scholartree Sphora japonica L..Bitter in the mouth; Cold in nature.Return Liver Channel.But merit suppressing the hyperactive liver; Endogenous wind stopping; Reduce phlegm.

Borneolum Syntheticum is the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or is the product of being processed into that Camphora, Lignum Pini Nodi wet goods synthesize with chemical method.Nature and flavor suffering, hardship are slightly cold.GUIXIN, spleen, lung meridian.The merit refreshment of can having one's ideas straightened out, clearing away heat to alleviate pain.

Composition principle: eczema rhagadiforme is a kind of special type eczema, belongs to the category of Chinese medicine " fungal infection of hand and foot " " BI-syndrome related to skin ", belongs to one of dermatosis pertinacious disease." Yizong Jinjian surgery heart method gist fungal infection of hand and foot " said: " this card is born in the centre of the palm ... purple white dirt of initial stage, stacks Rhizoma Euonymus, and is hard and thick, and withered cracking from dryness prolonged and time hands." Ming Dynasty's " Waike Zhengzong, Orthodox Manual of External Diseases " record: " and dry by the burning hot blood of the stomach channel of foot-Yang-ming, be subjected to cold and cool coagulating outward, it is withered to cause skin." its cause of disease is innate deficiency, instability of surface, the rheumatic fever invasion and attack are due to the dark volt of pathogenic fire.At above pathogenesis, should impose on the method for heat-clearing and toxic substances removing, expelling wind and removing dampness.Side of the present invention gets the detoxifcation of Oleum Camelliae clearing away heat and eliminating dampness, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri clearing away heat-damp and expelling toxic material; The careless heat-clearing and toxic substances removing of auspicious company; The Folium Evodiae trichotomae expelling wind and removing dampness; The Talcum heat clearing away; The Resina sophorae endogenous wind stopping; The Borneolum Syntheticum clearing away heat to alleviate pain.Outside last pharmacological action, part material also has the pharmaceutics effect: Oleum Camelliae except clearing away heat and eliminating dampness detoxifcation, the double oleaginous base of doing also; Talcum is except heat clearing away, also as abrasivus; Resina sophorae is except endogenous wind stopping, also as adhesive agent; Borneolum Syntheticum is except clearing away heat to alleviate pain, also as short cutaneous permeable agent.

Compared with the prior art, have following technical advantage:

1, clearing away heat-damp and expelling toxic material matches, and medicament selection is reasonable;

2, preparation process uniqueness, pharmacological action and medicament effect combine, and save raw material.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, the crude drug weight proportion: Oleum Camelliae 30g, Radix Scutellariae 8g, Rhizoma Coptidis 8g, Cortex Phellodendri 6g, the careless 6g of auspicious company, Folium Evodiae trichotomae 8g, Talcum 6g, Resina sophorae 8g, Borneolum Syntheticum 3g.

Embodiment 2, the crude drug weight proportion: Oleum Camelliae 50g, Radix Scutellariae 15g, Rhizoma Coptidis 15g, Cortex Phellodendri 10g, the careless 10g of auspicious company, Folium Evodiae trichotomae 15g, Talcum 10g, Resina sophorae 15g, Borneolum Syntheticum 6g.

Embodiment 3, the crude drug weight proportion: Oleum Camelliae 40g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Cortex Phellodendri 8g, the careless 8g of auspicious company, Folium Evodiae trichotomae 10g, Talcum 8g, Resina sophorae 10g, Borneolum Syntheticum 5g.

The preparation method of embodiment 1 ~ 3 comprises:

(1) Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Rui Liancao, Folium Evodiae trichotomae are decocted with water secondary, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, and it is 1.18(75 ℃ that filtrate decompression is concentrated into relative density) clear paste, spray drying is made extract powder;

(2) Talcum and Borneolum Syntheticum are pulverized respectively, crossed 200 mesh sieves, get Talcum fine powder and Borneolum Syntheticum fine powder respectively;

(3) Oleum Camelliae is heated to 60 ℃, puts into Resina sophorae, be down to room temperature after stirring, add step 1 gained extract powder and step 2 gained Talcum fine powder and Borneolum Syntheticum fine powder, stir.

Effective combination of said medicine is coordinated mutually, can effectively reach the purpose for the treatment of eczema rhagadiforme, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies drug use and is the crude drug weight proportion among the embodiment 3.

1 object and method.

1.1 object: in March, 2011 ~ 2012 routine eczema rhagadiforme patient 60 examples in year June 60.The diagnostic criteria of MethodsThe cases enrolled standard reference " clinical dermatology " third edition.All have a drug allergy person, and trimester of pregnancy, women breast-feeding their children and the patient that accepted the primary disease treatment in nearly 1 month be not in selected scope.

1.2 method.

1.2.1 grouping: 60 examples are divided into matched group and each 30 example for the treatment of group at random.30 examples are organized in treatment, male 17 examples, women 13 examples; 23 ~ 70 years old age, average (42.5 ± 10.1) year; The course of disease 2 months ~ 15 years, average 5.5 ± 6.6 years; Matched group 30 examples, male 16 examples, women 14 examples; 26 ~ 66 years old age, average 35.8 ± 11.6 years old; The course of disease 6 months ~ 14 years, average 14.6 ± 5.3 years.Physical data such as sex, age, the course of disease are learned check difference by statistics between two groups does not have significance (P〉0.05).

1.2.2 Therapeutic Method: matched group adopts external hydrocortisone butyrate ointment, every day 3 times.The treatment group adopts the embodiment of the invention 3 prepared medicines to be applied to the affected part.Treat for two groups and be for 2 weeks the course for the treatment of.

1.2.3 curative effect determinate standard: clinical recovery: the skin lesion position recovers normal, skin smooth, and deflorescence, keratinization and plumpness disappear, and drug withdrawal does not have recurrence January; Produce effects: skin lesion disappears greater than 80%, and the position that only rubbed is less than the slight plumpness of 0.5cm, the skin lesion position recurrence that drug withdrawal had after 1 month, but alleviate before the treatment relatively; Effectively: skin lesion alleviates, deliquescing, attenuation 50%, and infringement alleviates, and basic recovery is normal, and drug withdrawal 1 month has 20% patient to recur because of edible irritable food, but sx before treating relatively; Invalid: skin lesion disappears less than 30%, or after the drug withdrawal 1 month, the recurrence infringement with treatment before.

1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, P＜0.05 expression has the significance meaning.

2 results.

The curative effect of two groups of cases relatively sees the following form, and obvious effective rate and total effective rate treatment group obviously are better than matched group (P＜0.01).Untoward reaction does not appear during the treatment group patient treatment.Follow up a case by regular visits to satisfactory effect, not recurrence after half a year.

3. conclusion: this result of study shows that the present invention treats the eczema rhagadiforme determined curative effect, is worthy of promotion and application.

Claims (2)

1. a medicine for the treatment of eczema rhagadiforme is characterized in that being processed by plurality of Chinese, and its raw material is: 30 ~ 50 parts of Oleum Camelliae, 8 ~ 15 parts of Radix Scutellariaes, 8 ~ 15 parts of Rhizoma Coptidis, 6 ~ 10 parts of Cortex Phellodendris, auspicious 6 ~ 10 parts of grass, 8 ~ 15 parts of the Folium Evodiae trichotomae of connecting, 6 ~ 10 parts in Talcum, 8 ~ 15 parts of Resina sophorae, 3 ~ 6 parts of Borneolum Syntheticums.

2. a kind of medicine for the treatment of eczema rhagadiforme according to claim 1 is characterized in that its weight proportion is: 40 parts of Oleum Camelliae, 10 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 8 parts of Cortex Phellodendris, auspicious 8 parts of grass, 10 parts of Folium Evodiae trichotomae, 8 parts in Talcum, 10 parts of Resina sophorae, 5 parts of the Borneolum Syntheticums of connecting.