CN103417738B - Preparation method of ointment for treatment of eczema rhagadiforme - Google Patents
Preparation method of ointment for treatment of eczema rhagadiforme Download PDFInfo
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Abstract
The invention discloses a preparation method of ointment for the treatment of eczema rhagadiforme and solves the treatment problem of eczema rhagadiforme. The preparation method is characterized in that the ointment is made with traditional Chinese medicines, including, by weight, 30-50 parts of tea oil, 8-15 parts of baical skullcap root, 8-15 parts of coptis root, 6-10 parts of corktree bark, 6-10 parts of all-grass of annual saltmarsh aster, 8-15 parts of Chinese maple leaf, 6-10 parts of talc, 8-15 parts of resin of Japanese pagodatree, and 3-6 parts of borneol. The preparation method includes: 1, drying water extract of the baical skullcap root, coptis root, corktree bark, all-grass of annual saltmarsh aster and Chinese maple leaf to obtain ointment powder; 2, crushing the talc and borneol to obtain fine powders of the talc and borneol; 3, heating the tea oil to 60 DEG C, adding the resin of Japanese pagodatree, mixing well, cooling to the room temperature, adding the ointment powder obtained in step 1 and the fine powders of the talc and borneol obtained in the step 2, and mixing well. Clinical experiments show that the ointment has good curative effect and high safety and is worthy of clinical application and popularization.
Description
Technical field
The present invention is application on August 1st, 2012, and application number is the division of the patent of invention " a kind of medicine for the treatment of eczema rhagadiforme and preparation method thereof " of 2012102710222.The present invention relates to the field of Chinese medicines, be specifically related to the medicine for the treatment of eczema rhagadiforme.
Background technology
Eczema rhagadiforme belongs to chronic eczema, is dermatology common disease autumn and winter.Its cause of disease is complicated, it is generally acknowledged that hereditary allergic constitution is relevant, often brings out because contacting the stimulus object such as cleaning agent, soap, dyestuff, paint and daylight in daily life or increase the weight of, and occurs chapping, pain, thus affects normal live and work.In lysis, the factor such as psychic trauma, endocrine disturbance all can increase the weight of the state of an illness.Multiple being born in refers to the back of the body and finger tip facies palmaris and palmar hand, can spread to the back of the hand and wrist portion, and skin lesion be subacute or chronic eczema shows.Skin lesion form of diverse during acute onset, obscure boundary, shows as flushing, erosion, sepage, incrustation; To time chronic, pachyderma is coarse, and horny layer also thickens, heavy then occur chapping, and the course of disease is longer, obstinately difficultly to heal.Except the chapping of some secondary, some patient can not find reason accurately.Modern medicine thinks that this disease causes by environmental stimuli for a long time, is a kind of allergy, inflammatory dermatoses, close with immune relationship.With antiallergic and topical steroid hormone therapy eczema rhagadiforme, after medication, the state of an illness can take a turn for the better rapidly, but easy recurrent exerbation, and life-time service has more side effect.Clinical majority research shows, steroid ointment steroid hormones is only for treatment that is interim and short-term.
Chinese medicine eczema rhagadiforme is respond well, is generally Chinese medicine decocting at present, soaks or washout local skin lesion with warm medicine juice.But due to this patient, to slap sole of the foot portion illing skin coarse, acanthokeratodermia, drug absorption ability, and soak time needed more than 1 hour can onset, uses inconvenience.
Summary of the invention
Technical assignment of the present invention is for the deficiencies in the prior art, provides medicine of a kind of curative effect treatment eczema rhagadiforme certainly and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of eczema rhagadiforme, it is characterized in that being processed by plurality of Chinese, its raw material comprises: Oleum Camelliae 30 ~ 50 parts, Radix Scutellariae 8 ~ 15 parts, Rhizoma Coptidis 8 ~ 15 parts, Cortex Phellodendri 6 ~ 10 parts, auspicious even grass 6 ~ 10 parts, Folium Evodiae trichotomae 8 ~ 15 parts, 6 ~ 10 parts, Talcum, Resina sophorae 8 ~ 15 parts, Borneolum Syntheticum 3 ~ 6 parts.
Its optimum weight proportioning is: Oleum Camelliae 40 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 10 parts, Cortex Phellodendri 8 parts, auspicious even grass 8 parts, Folium Evodiae trichotomae 10 parts, 8 parts, Talcum, Resina sophorae 10 parts, Borneolum Syntheticum 5 parts.
The preparation method of the medicine of described treatment eczema rhagadiforme, comprises the following steps:
(1) Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Rui Liancao, Folium Evodiae trichotomae are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume is the clear paste of 1.18 to relative density, and spraying dry makes extract powder;
(2) Talcum and Borneolum Syntheticum are pulverized respectively, cross 200 mesh sieves, obtain Talcum fine powder and Borneolum Syntheticum fine powder respectively;
(3) Oleum Camelliae is heated to 60 DEG C, puts into Resina sophorae, after stirring, be down to room temperature, add step 1 gained extract powder and step 2 gained Talcum fine powder and Borneolum Syntheticum fine powder, stir.
Wherein said: Oleum Camelliae, the fatty oil that the mature seed milling process for plant of theaceae oil tea Camellia oleifera Abel or Camellia yuansienensis Camellia meiocarpa Hu.ms. obtains.Sweet, cool.Return large intestine channel.Clearing away heat and eliminating dampness, parasite killing detoxifies.
Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor are bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Merit can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Rhizoma Coptidis is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..Nature and flavor are bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Merit can heat clearing and damp drying, eliminating fire and detoxication.
Cortex Phellodendri is the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..Nature and flavor are bitter, cold.Return kidney, urinary bladder channel.Merit can heat clearing and damp drying, pathogenic fire purging except steaming, detoxification sore treatment.
Auspicious even grass is the auspicious company of Compositae careless Aster subulatus Michx., with all herbal medicine.Bitter in the mouth; Acid; Cool in nature.Merit can heat-clearing and toxic substances removing.
Folium Evodiae trichotomae is the leaf of rutaceae mountain Fructus Evodiae Tetradium trichotoma Lour..Nature and flavor are pungent; Bitter; Temperature.Return lung; Stomach warp.Merit can expelling wind and removing dampness; Dispersing cold for relieving pain.
Talcum, the Ore of silicates mineral talc race Talcum.Nature and flavor are sweet, light, cold.Return stomach, urinary bladder channel.Merit can clearing away heat and promoting diuresis treating stranguria, removing summer-heat.
Resina sophorae is the resin of leguminous plant Chinese scholartree Sphora japonica L..Bitter in the mouth; Cold in nature.Return Liver Channel.Merit can suppressing the hyperactive liver; Endogenous wind stopping; Reduce phlegm.
Borneolum Syntheticum is the processed goods of Spore density Borneolum Syntheticum resin, or chemically synthesize for Camphora, Lignum Pini Nodi wet goods be processed into product.Nature and flavor are pungent, bitter, are slightly cold.GUIXIN, spleen, lung meridian.Merit can be had one's ideas straightened out refreshment, clearing away heat to alleviate pain.
Composition principle: eczema rhagadiforme is a kind of special type eczema, belongs to the category of Chinese medicine " fungal infection of hand and foot " " BI-syndrome related to skin ", belongs to one of dermatosis pertinacious disease." Yizong Jinjian surgery heart method gist fungal infection of hand and foot " is said: " this card is born in the centre of the palm ... initial stage purple white dirt, stacks Rhizoma Euonymus, hard and thick, witheredly cracks from dryness, and prolongs and all over hands." Ming Dynasty's " Waike Zhengzong, Orthodox Manual of External Diseases " records: " and dry by the burning hot blood of the stomach channel of foot-Yang-ming, outer to coagulate by cold and cool, cause skin withered." its cause of disease is innate deficiency, instability of surface, rheumatic fever is attacked, caused by pathogenic fire lies prostrate deeply.For above pathogenesis, the method for heat-clearing and toxic substances removing, expelling wind and removing dampness should be imposed on.Side of the present invention gets the removing toxic substances of Oleum Camelliae clearing away heat and eliminating dampness, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri clearing away heat-damp and expelling toxic material; The careless heat-clearing and toxic substances removing of auspicious company; Folium Evodiae trichotomae expelling wind and removing dampness; Talcum heat clearing away; Resina sophorae endogenous wind stopping; Borneolum Syntheticum clearing away heat to alleviate pain.Divided by outside upper pharmacological action, part material also has pharmaceutics effect: Oleum Camelliae, except clearing away heat and eliminating dampness removing toxic substances, also doublely does oleaginous base; Talcum except heat clearing away, also as abrasivus; Resina sophorae except endogenous wind stopping, also as adhesive agent; Borneolum Syntheticum is except clearing away heat to alleviate pain, and also cutaneous permeable agent is urged in conduct.
Compared with the prior art, there is following technical advantage:
1, clearing away heat-damp and expelling toxic material matches, and medicament selection is reasonable;
2, preparation process is unique, and pharmacological action and pharmacy effect combine, and saves raw material.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Oleum Camelliae 30g, Radix Scutellariae 8g, Rhizoma Coptidis 8g, Cortex Phellodendri 6g, the careless 6g of auspicious company, Folium Evodiae trichotomae 8g, Talcum 6g, Resina sophorae 8g, Borneolum Syntheticum 3g.
Embodiment 2, crude drug weight proportion: Oleum Camelliae 50g, Radix Scutellariae 15g, Rhizoma Coptidis 15g, Cortex Phellodendri 10g, the careless 10g of auspicious company, Folium Evodiae trichotomae 15g, Talcum 10g, Resina sophorae 15g, Borneolum Syntheticum 6g.
Embodiment 3, crude drug weight proportion: Oleum Camelliae 40g, Radix Scutellariae 10g, Rhizoma Coptidis 10g, Cortex Phellodendri 8g, the careless 8g of auspicious company, Folium Evodiae trichotomae 10g, Talcum 8g, Resina sophorae 10g, Borneolum Syntheticum 5g.
The preparation method of embodiment 1 ~ 3 comprises:
(1) Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Rui Liancao, Folium Evodiae trichotomae are decocted with water secondary, first time 1.5 hours, second time 1 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.18(75 DEG C) clear paste, spraying dry makes extract powder;
(2) Talcum and Borneolum Syntheticum are pulverized respectively, cross 200 mesh sieves, obtain Talcum fine powder and Borneolum Syntheticum fine powder respectively;
(3) Oleum Camelliae is heated to 60 DEG C, puts into Resina sophorae, after stirring, be down to room temperature, add step 1 gained extract powder and step 2 gained Talcum fine powder and Borneolum Syntheticum fine powder, stir.
The efficient combination of said medicine, coordinates mutually, effectively can reach the object for the treatment of eczema rhagadiforme, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows, and wherein drugs uses is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 objects: in March, 2011 ~ 2012 routine eczema rhagadiforme patient 60 example in year June 60.MethodsThe cases enrolled standard is with reference to the diagnostic criteria of " clinical dermatology " third edition.All have drug allergy person, trimester of pregnancy, women breast-feeding their children and accepted in nearly 1 month primary disease treatment patient not in selected scope.
1.2 method.
1.2.1 divide into groups: 60 examples are divided at random matched group and each 30 examples for the treatment of group.Treatment group 30 example, man 17 example, female 13 example; 23 ~ 70 years old age, average (42.5 ± 10.1) year; The course of disease 2 months ~ 15 years, average 5.5 ± 6.6 years; Matched group 30 example, man 16 example, female 14 example; 26 ~ 66 years old age, average 35.8 ± 11.6 years old; The course of disease 6 months ~ 14 years, average 14.6 ± 5.3 years.Between two groups, the physical data such as sex, age, course of disease is through statistical test no significant difference (P>0.05).
1.2.2 Therapeutic Method: matched group adopts external hydrocortisone butyrate ointment, every day 3 times.Treatment group adopts the medicine obtained by the embodiment of the present invention 3 to be applied to affected part.Two groups of treatments are 2 weeks the course for the treatment of.
1.2.3 curative effect determinate standard: clinical recovery: cutaneous lesion recovers normal, skin smooth, deflorescence, and keratinization and plumpness disappear, drug withdrawal January is without recurrence; Effective: skin lesion disappears and is greater than 80%, be only less than the slight plumpness of 0.5cm by friction position, the cutaneous lesion recurrence that drug withdrawal had after 1 month, but alleviate before relatively treating; Effective: skin lesion alleviates, deliquescing, thinning 50%, infringement alleviates, and basic recovery is normal, drug withdrawal 1 month, have the patient of 20% because of edible irritable food recurrence, but before relatively treating, symptom alleviates; Invalid: skin lesion disappears and is less than 30%, or after drug withdrawal 1 month, recurrent lesions is with before treatment.
1.2.5 statistical analysis SPSS 13.0 carries out statistical analysis, and P< 0.05 indicates significant.
2 results.
The comparitive study of two groups of cases sees the following form:
| Number of cases (example) | Effective (%) | Effectively (%) | Invalid (%) | Total effective rate (%) | |
| Matched group | 43 | 44.2 | 37.2 | 18.6 | 81.4 |
| Treatment group | 47 | 63.8 | 31.9 | 4.3 | 95.7 |
Obvious effective rate and total effective rate treatment group are obviously better than matched group (P<0.01).Untoward reaction is there is not during treatment group patient treatment.Follow up a case by regular visits to after half a year, satisfactory effect, do not recur.
3. conclusion: this result of study shows, and the present invention treats eczema rhagadiforme determined curative effect, is worthy of promotion and application.
Claims (1)
1. treat a preparation method for eczema rhagadiforme ointment, it is characterized in that, its raw material weight proportioning is Oleum Camelliae 30 ~ 50 parts, Radix Scutellariae 8 ~ 15 parts, Rhizoma Coptidis 8 ~ 15 parts, Cortex Phellodendri 6 ~ 10 parts, auspicious even grass 6 ~ 10 parts, Folium Evodiae trichotomae 8 ~ 15 parts, 6 ~ 10 parts, Talcum, Resina sophorae 8 ~ 15 parts, Borneolum Syntheticum 3 ~ 6 parts; Comprise the following steps:
(1) Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Rui Liancao, Folium Evodiae trichotomae are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume is the clear paste of 1.18 to relative density, and spraying dry makes extract powder;
(2) Talcum and Borneolum Syntheticum are pulverized respectively, cross 200 mesh sieves, obtain Talcum fine powder and Borneolum Syntheticum fine powder respectively;
(3) Oleum Camelliae is heated to 60 DEG C, puts into Resina sophorae, after stirring, be down to room temperature, add step 1 gained extract powder and step 2 gained Talcum fine powder and Borneolum Syntheticum fine powder, stir.
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| CN108210639B (en) * | 2018-02-05 | 2021-01-05 | 福建春辉生物工程有限公司 | Tea oil essential oil cream for preventing and treating infantile eczema |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136003C (en) * | 2001-06-15 | 2004-01-28 | 姜莉蔚 | Exterior-applied ointment for treating dermatitis |
| CN102145072A (en) * | 2011-04-14 | 2011-08-10 | 江西中医学院 | Traditional Chinese medicine composition for treating infantile eczema and dermatitis skin diseases |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136003C (en) * | 2001-06-15 | 2004-01-28 | 姜莉蔚 | Exterior-applied ointment for treating dermatitis |
| CN102145072A (en) * | 2011-04-14 | 2011-08-10 | 江西中医学院 | Traditional Chinese medicine composition for treating infantile eczema and dermatitis skin diseases |
Non-Patent Citations (1)
| Title |
|---|
| 从心脾论治"鹅掌风";贾育容;《甘肃中医》;20041231;第17卷(第9期);第26-27页 * |
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| CN103417738A (en) | 2013-12-04 |
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