CN102743428A - Applications of dalbergia odorifera t.chen leaves and preparation method for extract of the same - Google Patents
Applications of dalbergia odorifera t.chen leaves and preparation method for extract of the same Download PDFInfo
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- CN102743428A CN102743428A CN2011104197231A CN201110419723A CN102743428A CN 102743428 A CN102743428 A CN 102743428A CN 2011104197231 A CN2011104197231 A CN 2011104197231A CN 201110419723 A CN201110419723 A CN 201110419723A CN 102743428 A CN102743428 A CN 102743428A
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Abstract
The present invention discloses applications of dalbergia odorifera t.chen leaves in prevention and treatment of high blood pressure. The present invention further provides a dalbergia odorifera t.chen leaf extract, a preparation method for the dalbergia odorifera t.chen leaf extract by using a supercritical CO2 extraction method or a steam distillation method, and applications of the dalbergia odorifera t.chen leaf extract. According to the present invention: the dalbergia odorifera t.chen leaves are adopted as raw materials, such that agriculture and forestry wastes are completely utilized, and comprehensive development and utilization values of the dalbergia odorifera t.chen are increased; ethanol and water are adopted as extraction solvents, and the obtained extract does not contain organic solvents harmful for human body, such that safety is high; when the extract is used for treatment of high blood pressure diseases, an advantage of rapid onset is provided, blood pressure can maintain stability after drug discontinuance 3 days, and no side effect is provided; and the dalbergia odorifera t.chen leaf extract of the present invention can be used for drugs for prevention and treatment of high blood pressure, health products and daily necessities.
Description
Technical field
The present invention relates to the hypertensive Lignum Dalbergiae Odoriferae wingceltis of a kind of treatment leaf extract, be specially a kind of application and preparation method of extract thereof of Lignum Dalbergiae Odoriferae wingceltis leaf.
Background technology
Hypertension be meant under quiescent condition SAP and/or diastolic pressure increase (＞=140/90mmHg), often with organ dysfunction property or organic changes such as fat and sugar metabolism disorder and the heart, brain, kidney and retinas.Hypertension is the common cardiovascular and cerebrovascular diseases of many in the world countries; Especially sickness rate is high in mid-aged population; And be a kind of common frdquently encountered disease, the Chang Keyin rupture of blood vessel in brain and cause Hemorrhagic strokes or because of the supply heart coronary thrombosis cause serious consequences such as cardiac dysfunction, myocardial infarction, coronary heart disease, cerebral thrombosis.China's hypertension prevalence obviously rises, and according to present fashion trend investigation, the control form allows of no optimist, and China has become one of the most serious country of hypertension harm in the world.
Though it is a variety of to be used to treat hypertensive medicine at present; Certain curative effect is also all arranged in clinical use; But all in various degree have that side effect is big, curative effect is definite inadequately, can not treating both the principal and secondary aspects of a disease, also be unfavorable for fundamentally eliminating disease, the hypertensive medicine of comparatively ideal treatment is also few; And active substance is more in the natural drug, has good effect, the little characteristics of side effect, and it is significant therefore from natural drug, to seek an ideal hypotensor.
Lignum Dalbergiae Odoriferae wingceltis (Dalbergia odorifera T.Chen) be leguminous plant; Have another name called Hemerocallis citrina Baroni pears, rosewood, Lignum Dalbergiae Odoriferae, Dalbergia odorifera etc.; The dry duramen of its trunk and root is China's Chinese medicine Lignum Dalbergiae Odoriferae; Effect with promoting flow of QI and blood, pain relieving, hemostasis is good analgesics, and normal and other blood circulation promoting and blood stasis dispelling want compatibility to be used for the treatment of cardiovascular disease.The Lignum Dalbergiae Odoriferae wingceltis is with luxuriant foliage and spreading branches in leafy profusion, and annual the pruning all can remain a large amount of leaves, and these branch and leaf are not utilized, and all go out of use basically, cause the great wasting of resources.At present, do not find the effect of Lignum Dalbergiae Odoriferae wingceltis leaf and the value of development and use thereof.
Summary of the invention
The purpose of this invention is to provide the application of Lignum Dalbergiae Odoriferae wingceltis leaf in prevention and treatment hypertension.
Second purpose of the present invention provides above a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract that can be used for preventing and treating hypertension medicine, health product and articles for daily use.
The 3rd purpose of the present invention provides the method for preparing of the above Lignum Dalbergiae Odoriferae wingceltis leaf extract.
The 4th purpose of the present invention provides the application of the above Lignum Dalbergiae Odoriferae wingceltis leaf extract, the particularly application aspect medical and health, health product and article of everyday use, thus significantly improve using value and the economic benefit of Lignum Dalbergiae Odoriferae wingceltis.
For achieving the above object, technical scheme of the present invention is: the application of Lignum Dalbergiae Odoriferae wingceltis leaf in prevention and treatment hypertension.
A kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract is that Lignum Dalbergiae Odoriferae wingceltis leaf powder makes through supercritical CO 2 extraction or vapor distillation extraction.
A kind of method for preparing of Lignum Dalbergiae Odoriferae wingceltis leaf extract adopts supercritical CO
2Extraction, its concrete steps comprise as follows: get Lignum Dalbergiae Odoriferae wingceltis leaf, be crushed to the 10-80 order; Put in the extraction kettle, the vaporizer jar is cooled off design temperature: 25-40 ℃ of extraction kettle temperature; 25-40 ℃ of the first separating still temperature, 25-40 ℃ of the second separating still temperature heats extraction kettle, first separating still, second separating still; When refrigerator temps drops to 0-2 ℃, when extraction kettle, first separating still, the second separating still temperature reach above-mentioned preset value respectively, carry out supercritical CO
2CO is opened in extraction
2Gas cylinder is supplied gas, and opens high-pressure pump to extraction kettle, first separating still, the pressurization of second separating still, extracting pressure 20-30Kpa; After the pressure stability, open the atmospheric valve residual air of draining, reduce pressure after; Close atmospheric valve, primer pump carries out cycling extraction, and adds Lignum Dalbergiae Odoriferae wingceltis leaf weight 0.5-2 dehydrated alcohol doubly as entrainer; Constant temperature and pressure extraction 1-4 hour can obtain Lignum Dalbergiae Odoriferae wingceltis leaf extract.
A kind of method for preparing of Lignum Dalbergiae Odoriferae wingceltis leaf extract adopts steam distillation, and its concrete steps comprise as follows: get Lignum Dalbergiae Odoriferae wingceltis leaf; Be crushed to the 10-80 order, put in the round-bottomed flask, 3-8 times of water gaging of perfuming wingceltis leaf weight and bead number; After jolting mixes, connect volatile oil determination apparatus and reflux condensing tube.Add the scale position that water is full of volatile oil determination apparatus from reflux condensing tube upper end, and overflow when going into flask till.Put in the electric jacket or slowly be heated to other proper method and boil, and keep little and boiled about 2-8 hour, oil mass no longer increases to the determinator; Stop heating, place a moment, collect the oil of water layer top in the volatile oil determination apparatus; Preserve at other container, promptly get Lignum Dalbergiae Odoriferae wingceltis leaf extract.
The invention provides Lignum Dalbergiae Odoriferae wingceltis leaf extract and can be used for prevention, treatment high blood pressure disease, can significantly bring high blood pressure down, improve NO content in the blood, reduce the effect of Ang II, ET-1 content in the blood.
The application of Lignum Dalbergiae Odoriferae wingceltis leaf extract on medicine, health product and the articles for daily use of prevention, treatment high blood pressure disease.
Lignum Dalbergiae Odoriferae wingceltis leaf extract is in the application of treatment essential hypertension and secondary hypertension disease.
Lignum Dalbergiae Odoriferae wingceltis leaf extract can be used for any one dosage form of approving on the pharmaceuticss such as liniment, cream, patch, ointment, membrane.
Lignum Dalbergiae Odoriferae wingceltis leaf is used to comprise health product such as blood pressure lowering medicated pillow, blood pressure lowering car mat, the fragrant bag of blood pressure lowering.
Lignum Dalbergiae Odoriferae wingceltis leaf extract is used to comprise articles for daily use such as mosquito incense, perfume.
Compared with prior art; The present invention has following advantage: with Lignum Dalbergiae Odoriferae wingceltis leaf is raw material; Fully utilize the agriculture and forestry garbage, the comprehensive development and utilization that has strengthened the Lignum Dalbergiae Odoriferae wingceltis is worth, and with ethanol, water as extracting solvent; Do not contain harmful organic solvent in extract obtained, safety is higher.Extract for treating high blood pressure disease according to the invention is rapid-action, and it is steady to keep blood pressure in 3 days after the drug withdrawal, and has no side effect; Can be applicable to prevent, treat on medicine, health product and the articles for daily use of high blood pressure disease.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is carried out detailed explanation.
A kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract is that Lignum Dalbergiae Odoriferae wingceltis leaf powder passes through to pulverize, and sieves, and makes after supercritical CO 2 extraction or vapor distillation extract.With Lignum Dalbergiae Odoriferae wingceltis leaf is raw material, abundant utilizes the agriculture and forestry garbage, and the comprehensive development and utilization that has strengthened the Lignum Dalbergiae Odoriferae wingceltis is worth, and this extract for treating high blood pressure disease is rapid-action, and it is steady to keep blood pressure in back 3 days after the drug withdrawal, and has no side effect.
Embodiment 1
The method for preparing of above-described Lignum Dalbergiae Odoriferae wingceltis leaf extract adopts supercritical CO
2Extraction, its concrete steps are following: get Lignum Dalbergiae Odoriferae wingceltis leaf, be crushed to 10 orders; Put in the extraction kettle, the vaporizer jar is cooled off design temperature: 25 ℃ of extraction kettle temperature; 25 ℃ of the first separating still temperature, 25 ℃ of the second separating still temperature heat extraction kettle, first separating still, second separating still; When refrigerator temps drops to 0-2 ℃, when extraction kettle, first separating still, the second separating still temperature reach said design temperature respectively, carry out supercritical CO
2CO is opened in extraction
2Gas cylinder is supplied gas, and opens high-pressure pump to extraction kettle, first separating still, the pressurization of second separating still, extracting pressure 20Kpa; After the pressure stability, open the atmospheric valve residual air of draining, reduce partial pressure after; Close atmospheric valve, primer pump carries out cycling extraction, and the dehydrated alcohol that adds 0.5 times of amount is as entrainer; Constant temperature and pressure extraction 1-4 hour can obtain Lignum Dalbergiae Odoriferae wingceltis leaf extract.
Embodiment 2
The method for preparing of above-described Lignum Dalbergiae Odoriferae wingceltis leaf extract adopts supercritical CO
2Extraction, its concrete steps are following: get Lignum Dalbergiae Odoriferae wingceltis leaf, be crushed to 80 orders; Put in the extraction kettle, the vaporizer jar is cooled off design temperature: 40 ℃ of extraction kettle temperature; 40 ℃ of the first separating still temperature, 40 ℃ of the second separating still temperature heat extraction kettle, first separating still, second separating still; When refrigerator temps drops to 0-2 ℃, when extraction kettle, first separating still, the second separating still temperature reach above-mentioned preset value respectively, carry out supercritical CO
2CO is opened in extraction
2Gas cylinder is supplied gas, and opens high-pressure pump to extraction kettle, first separating still, the pressurization of second separating still, extracting pressure 30Kpa; After the pressure stability, open the atmospheric valve residual air of draining, reduce partial pressure after; Close atmospheric valve, primer pump carries out cycling extraction, and the dehydrated alcohol that adds 2 times of amounts is as entrainer; Constant temperature and pressure extraction 1-4 hour can obtain Lignum Dalbergiae Odoriferae wingceltis leaf extract.
Embodiment 3
Get Lignum Dalbergiae Odoriferae wingceltis leaf 800 grams, put in the extraction kettle, the vaporizer jar is cooled off; Setting the extraction kettle temperature is 40 ℃; 40 ℃ of the first separating still temperature, 40 ℃ of the second separating still temperature are when refrigerator temps drops to 0-2 ℃; Extraction kettle, first separating still, when the second separating still temperature reaches preset value respectively, carry out supercritical CO
2CO is opened in extraction
2Gas cylinder is supplied gas, and opens high-pressure pump to extraction kettle, first separating still, the pressurization of second separating still, extracting pressure 20-30Kpa;, after the pressure stability, open the atmospheric valve residual air of draining; After reducing partial pressure, close atmospheric valve, primer pump carries out cycling extraction; And the dehydrated alcohol that adds 1 times of amount is as entrainer, and constant temperature and pressure extraction 2 hours can obtain Lignum Dalbergiae Odoriferae wingceltis leaf extract.
Embodiment 4
A kind of method for preparing of Lignum Dalbergiae Odoriferae wingceltis leaf extract adopts steam distillation, and its concrete steps are following: get Lignum Dalbergiae Odoriferae wingceltis leaf; Be crushed to 10 orders, put in the round-bottomed flask, add 3 times of water gagings and bead number; After jolting mixes, connect volatile oil determination apparatus and reflux condensing tube.Add the scale position that water is full of volatile oil determination apparatus from reflux condensing tube upper end, and overflow when going into flask till.Put in the electric jacket or slowly be heated to other proper method and boil, and keep little and boiled about 2 hours, oil mass no longer increases to the determinator; Stop heating, place a moment, collect the oil of water layer top in the volatile oil determination apparatus; Preserve at other container, promptly get Lignum Dalbergiae Odoriferae wingceltis leaf extract.
Embodiment 5
A kind of method for preparing of Lignum Dalbergiae Odoriferae wingceltis leaf extract adopts steam distillation, and its concrete steps are following: get Lignum Dalbergiae Odoriferae wingceltis leaf; Be crushed to 80 orders, put in the round-bottomed flask, add 8 times of water gagings and bead number; After jolting mixes, connect volatile oil determination apparatus and reflux condensing tube.Add the scale position that water is full of volatile oil determination apparatus from reflux condensing tube upper end, and overflow when going into flask till.Put in the electric jacket or slowly be heated to other proper method and boil, and keep little and boiled about 8 hours, oil mass no longer increases to the determinator; Stop heating, place a moment, collect the oil of water layer top in the volatile oil determination apparatus; Preserve at other container, promptly get Lignum Dalbergiae Odoriferae wingceltis leaf extract.
Embodiment 6
Get Lignum Dalbergiae Odoriferae wingceltis leaf 800 gram, put in the round-bottomed flask, add 5000mL water and bead number, after jolting mixes, connection volatile oil determination apparatus and reflux condensing tube.Autocondensation pipe upper end adds water makes the scale position that is full of volatile oil determination apparatus, and overflow when going into flask till.Put in the electric jacket or slowly be heated to other proper method and boil, and keep little and boiled about 5 hours, oil mass no longer increases to the determinator; Stop heating, place a moment, collect the oil of water layer top in the volatile oil determination apparatus; In container preservation in addition, promptly get Lignum Dalbergiae Odoriferae wingceltis leaf extract.
Above-described Lignum Dalbergiae Odoriferae wingceltis leaf extract can significantly bring high blood pressure down; Improve NO content in the blood; Reduce the effect of Ang II, ET-1 content in the blood, can play good medical health effect preventing, treat in high blood pressure disease medicine and the health product and the application aspect the article of everyday use.
Lignum Dalbergiae Odoriferae wingceltis leaf extract can obtain checking through following experiment to the effect of prevention, treatment high blood pressure disease.
One, Lignum Dalbergiae Odoriferae wingceltis leaf extract is to the influence of spontaneous hypertensive rat systolic pressure
(1) gets Lignum Dalbergiae Odoriferae wingceltis leaf 800 grams,, add the 400mL dehydrated alcohol according to the supercritical CO 2 extraction; Preparation Lignum Dalbergiae Odoriferae wingceltis leaf extract, gained Lignum Dalbergiae Odoriferae wingceltis leaf extract is called for short extract A, gets wherein 2/3 as the high dose extract A; One times of other 1/3 dilution is as the low dosage extract A; Get 2400 grams, prepare Lignum Dalbergiae Odoriferae wingceltis leaf extract according to steam distillation and be called for short extract B, get 2/3 extract B; Be settled to 100mL with dehydrated alcohol,, get 1/3 extract B as the high dose extract B; Be settled to 100mL with dehydrated alcohol, as the low dosage extract B.
(2) select 12 all spontaneous hypertensive rat in age (SHR rats) 70 for use, male, after one week of nursing adapts to, be divided into 7 groups at random.
Grouping and dosage see the following form.
Divide into groups and dose form
Administering mode and index determining: the depilation of abdominal cavity and thoracic cavity, smear administration, administration sooner or later each once, the medicine of half, successive administration drug withdrawal after 15 days are respectively given with the thoracic cavity in each abdominal cavity.
Index measurement: noinvasive arteria caudalis blood pressure determination analysis-e/or determining SHR rat systolic pressure, measured SHR rat systolic pressure on the 7th day after the administration, successive administration drug withdrawal in 15 days was measured SHR rat systolic pressure on the 1st, 3 day after drug withdrawal, and concrete data see the following form.
Lignum Dalbergiae Odoriferae wingceltis leaf extract is to influence (mmHg, the x ± s) show of SHR rat systolic pressure
Annotate: " * " compares with dehydrated alcohol matched group blood pressure difference for the blood pressure difference, P＜0.05; " * * " compares with dehydrated alcohol matched group blood pressure difference for the blood pressure difference, P＜0.01
Statistical procedures: the blood pressure before different time points institute measuring blood pressure and the administration is compared, compared, carry out the t check with its difference.
The result: difference and model control group that dehydrated alcohol matched group different time points blood pressure is reduced compare, and adopt the t check, and its difference does not have statistical significance, so do not have antihypertensive effect as the dehydrated alcohol of extract retarder thinner.Difference and dehydrated alcohol matched group that administration group, positive drug control group different time points blood pressure are reduced compare; Positive drug, high dose extract A, low dosage extract A and high dose extract B, low dosage extract B all have the effect that brings high blood pressure down; Adopt the t check; The blood pressure difference of positive drug control group and four administration groups and dehydrated alcohol matched group all has statistical significance; Therefore Lignum Dalbergiae Odoriferae wingceltis leaf extract all has hypotensive activity, and it is steady after drug withdrawal, can to keep blood pressure in three days.Concrete data are seen the influence table of above Lignum Dalbergiae Odoriferae wingceltis leaf extract to SHR rat systolic pressure.
Two, Lignum Dalbergiae Odoriferae wingceltis leaf extract is to the influence of spontaneous hypertensive rat serum NO level, Ang II, ET-1 content
Get above-mentioned Lignum Dalbergiae Odoriferae wingceltis leaf extract to the Lignum Dalbergiae Odoriferae wingceltis leaf extract laboratory animal that influence is tested to the spontaneous hypertensive rat systolic pressure in the influence test of spontaneous hypertensive rat systolic pressure; After the intact systolic pressure index to be determined; Each treated animal is with 10% chloral hydrate 0.3mL/100g intraperitoneal injection of anesthesia, rapidly from abdominal aortic blood, and separation of serum; Spectrophotography detects serum NO content, and the ELISA method is measured ANG-II and ET-1 content in the serum.Concrete data see the following form:
Lignum Dalbergiae Odoriferae wingceltis leaf is to the influence of NO, Ang II, ET-1 content in the SHR rat blood serum (x ± s)
Annotate: " * " for to compare with the dehydrated alcohol matched group, P＜0.05; " * * " for to compare with the dehydrated alcohol matched group, P＜0.01
The dehydrated alcohol matched group is compared with model control group; The numerical value of NO, Ang II, three indexs of ET-1 does not significantly raise or reduces; Adopt the t check; Its difference does not have statistical difference, and the dehydrated alcohol that therefore is the extract retarder thinner is to not influence of the NO in the SHR rat blood serum, Ang II, ET-1.Difference and dehydrated alcohol matched group that administration group, positive drug control group different time points blood pressure are reduced compare; Administration group, the positive drug control group serum NO content that can raise; Reduce Ang II, ET-1 content in the serum, adopt the t check, its difference all has statistical significance.Therefore Lignum Dalbergiae Odoriferae wingceltis leaf extract has rising serum NO content, reduces the effect of Ang II, ET-1 content in the serum.
Above result of experiment is consistent at other embodiment and with above-mentioned same supercritical CO 2 extraction with steam distillation; Explain that Lignum Dalbergiae Odoriferae wingceltis leaf extract has effect at prevention, treatment high blood pressure disease; And have rising serum NO content, reduce the effect of Ang II, ET-1 content in the serum.
Said Lignum Dalbergiae Odoriferae wingceltis leaf extract can separately or add one or more adjuvants, processes the various dosage forms of prevention, treatment high blood pressure disease.Said any one dosage form approved on the pharmaceuticss such as liniment, cream, patch, ointment, membrane that comprises.
Embodiment 7
A kind of medicine of treating prevention, treatment high blood pressure disease, its prescription and manufacture method are following:
Method for distilling by above-mentioned Lignum Dalbergiae Odoriferae wingceltis leaf extract prepares Lignum Dalbergiae Odoriferae wingceltis leaf extract; The extract obtained anhydrous alcohol solution of using; Add Borneolum Syntheticum, Mentholum; Stirring makes dissolving, promptly gets Lignum Dalbergiae Odoriferae wingceltis leaf blood pressure lowering liniment, smear with the nasal cavity forefathers in locate, the position can reach blood pressure lowering behind the chest, ear etc. effect.
Embodiment 8
Get Lignum Dalbergiae Odoriferae wingceltis leaf 800g, make Lignum Dalbergiae Odoriferae wingceltis leaf extract by above-mentioned Lignum Dalbergiae Odoriferae wingceltis leaf extract method for preparing.Other gets sorbitol 20g, glycerin 5g, parabens 5g, sodium benzoate 2g, gallic acid 5g, propyl gallate 5g, xanthan gum 5g, guar gum 2g, Radix Acaciae senegalis 5g, menthol 5g, dimethyl sulfoxide as substrate 2g; Mixing; 90 ℃ are heated and stirring and dissolving, make ointment base.Lignum Dalbergiae Odoriferae wingceltis leaf extract is added in the ointment base, stir and make abundant mixing, remember the agent of Lignum Dalbergiae Odoriferae wingceltis leaf extract decompression unction.
Lignum Dalbergiae Odoriferae wingceltis leaf extract has volatility, and therefore its abnormal smells from the patient delicate fragrance can be pulverized Lignum Dalbergiae Odoriferae wingceltis leaf, sieves, and processes Lignum Dalbergiae Odoriferae wingceltis leaf powder, processes prevention or treats hypertensive health product or articles for daily use.Hypertensive health product and articles for daily use are perhaps treated in said prevention can comprise blood pressure lowering medicated pillow, blood pressure lowering automobile cushion, the fragrant bag of blood pressure lowering, blood pressure lowering mosquito incense, perfume etc.Can use separately or with the combination of other Chinese medicine extract or effective site or effective ingredient, be used to prepare the medicine that hypertension is had prevention and treatment.Described other Chinese medicine extract combination is preferably with any or multiple combination of extracts such as Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Rhizoma Chuanxiong extract, Radix Puerariae extract, Radix Angelicae Sinensis extract, Radix Notoginseng extract, dogbane leaf extractive, Flos Chrysanthemi extract.
Embodiment 9
Lignum Dalbergiae Odoriferae wingceltis leaf is pulverized, processed coarse powder, put into pillow core, the pillowcase of packing into is a Lignum Dalbergiae Odoriferae wingceltis leaf blood pressure lowering medicated pillow.Blood pressure lowering car mat, blood pressure lowering perfume wrap also similar.
Choose 50 of hyperpietics, wherein 30～40 years old 15,41～60 years old 15; More than 60 years old 20, the men and women half and half, and blood pressure is all between 170～185mmHg; Nighttime sleep uses Lignum Dalbergiae Odoriferae wingceltis leaf blood pressure lowering medicated pillow, use a week continuously after, blood pressure is reduced to 150～160mmHg; Use continuously bleeding from anus pressure drop in 20 days to the 120mmHg, and blood pressure is continual and steady, concrete data see the following form:
Lignum Dalbergiae Odoriferae wingceltis leaf blood pressure lowering medicated pillow treatment hypertension effect
Embodiment 10
Get Lignum Dalbergiae Odoriferae wingceltis leaf 800g; Make Lignum Dalbergiae Odoriferae wingceltis leaf extract by above-mentioned Lignum Dalbergiae Odoriferae wingceltis leaf extract method for preparing, be dissolved among the 80%-100% ethanol 100mL, filter; Remove the insoluble matter in the solution; Then gained is filtrated to 4 ℃ of placements 12-24 hour, more refrigerated alcoholic solution is filtered, gained filtrating is Lignum Dalbergiae Odoriferae wingceltis leaf extract perfume.
Embodiment 11
Get Lignum Dalbergiae Odoriferae wingceltis leaf air-dry, be ground into the end, other gets edible glue and Cortex ulmi pumilae, according to weight ratio Lignum Dalbergiae Odoriferae wingceltis leaf powder 80%-90%, edible glue 5%-15%, the mixed of Cortex ulmi pumilae 5%-15% is even, compression molding is drying to obtain Lignum Dalbergiae Odoriferae wingceltis leaf blood pressure lowering mosquito incense.
The foregoing description is not to be limitation of the present invention; The those of ordinary skill in relevant technologies field; Under the situation that does not break away from the spirit and scope of the present invention; Can also make various variations and modification, so all technical schemes that are equal to also should belong to category of the present invention, scope of patent protection of the present invention should be limited each claim.
Claims (9)
1. the application of Lignum Dalbergiae Odoriferae wingceltis leaf in prevention and treatment hypertension.
2. the application of Lignum Dalbergiae Odoriferae wingceltis leaf according to claim 1 in prevention and treatment hypertension is characterized in that, Lignum Dalbergiae Odoriferae wingceltis leaf is used to make blood pressure lowering medicated pillow, blood pressure lowering car mat, the fragrant bag of blood pressure lowering or blood pressure lowering mosquito incense.
3. a Lignum Dalbergiae Odoriferae wingceltis leaf extract is to pass through supercritical CO after Lignum Dalbergiae Odoriferae wingceltis leaf is ground into powder
2Extraction or vapor distillation extraction make.
4. according to the method for preparing of the said a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract of claim 3, it is characterized in that step comprises: get Lignum Dalbergiae Odoriferae wingceltis leaf; Be crushed to the 10-80 order, put in the extraction kettle, the vaporizer jar is cooled off; Design temperature: 25-40 ℃ of extraction kettle temperature, 25-40 ℃ of the first separating still temperature, 25-40 ℃ of the second separating still temperature; Extraction kettle, first separating still, second separating still are heated; When refrigerator temps drops to 0-2 ℃, when extraction kettle, first separating still, the second separating still temperature reach said setting value respectively, carry out supercritical CO
2CO is opened in extraction
2Gas cylinder is supplied gas, and opens high-pressure pump to extraction kettle, first separating still, the pressurization of second separating still, extracting pressure 20-30Kpa; After the pressure stability; The residual air of draining, primer pump carries out cycling extraction, and the 0.5-2 dehydrated alcohol doubly that adds Lignum Dalbergiae Odoriferae wingceltis leaf weight is as entrainer; Constant temperature and pressure extraction 1-4 hour obtains Lignum Dalbergiae Odoriferae wingceltis leaf extract.
5. according to the method for preparing of the said a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract of claim 3, it is characterized in that step comprises: get Lignum Dalbergiae Odoriferae wingceltis leaf; Be crushed to the 10-80 order; Put in the container, after adding 3-8 times of water jolting of Lignum Dalbergiae Odoriferae wingceltis leaf weight and mixing, connect volatile oil determination apparatus and reflux condensing tube; Container is heated to boils, and keep little and boiled about 2-8 hour, collect the oil of water layer top in the volatile oil determination apparatus, promptly get Lignum Dalbergiae Odoriferae wingceltis leaf extract.
6. according to claim 4 or 5 said a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extracts, it is characterized in that, in the application that prevents, treats medicine, health product and the articles for daily use of high blood pressure disease.
7. according to the said a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract of claim 6, it is characterized in that, in the application of treatment essential hypertension and secondary hypertension disease.
8. according to the said a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract of claim 6, it is characterized in that, be used for liniment, cream, patch, ointment or membrane.
9. according to the said a kind of Lignum Dalbergiae Odoriferae wingceltis leaf extract of claim 6, it is characterized in that, be used for comprising perfume.
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| CN111803396A (en) * | 2020-06-30 | 2020-10-23 | 黑龙江省医院 | Cosmetic composition based on retinaldehyde and glycylglycine oleamide and preparation method thereof |
| CN112755063A (en) * | 2021-01-19 | 2021-05-07 | 江西中医药大学 | Application of dalbergia odorifera leaf extract in preparation of hypolipidemic drugs and effervescent tablets thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102265957A (en) * | 2011-08-25 | 2011-12-07 | 广东志康药业股份有限公司 | Dalbergia wood tea and preparation method thereof |
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2011
- 2011-12-14 CN CN2011104197231A patent/CN102743428A/en active Pending
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|---|---|---|---|---|
| CN102265957A (en) * | 2011-08-25 | 2011-12-07 | 广东志康药业股份有限公司 | Dalbergia wood tea and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郭清泉等: "超临界CO_2萃取降香叶中药用有效成分及与水蒸气蒸馏法比较研究", 《中华中医药学刊》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726895A (en) * | 2016-12-06 | 2017-05-31 | 蔡日芬 | A kind of Huanghua Pear eyeshield frost and preparation method thereof |
| CN111803396A (en) * | 2020-06-30 | 2020-10-23 | 黑龙江省医院 | Cosmetic composition based on retinaldehyde and glycylglycine oleamide and preparation method thereof |
| CN112755063A (en) * | 2021-01-19 | 2021-05-07 | 江西中医药大学 | Application of dalbergia odorifera leaf extract in preparation of hypolipidemic drugs and effervescent tablets thereof |
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Application publication date: 20121024 |