CN102741226B - 4-取代的-2-苯氧基-苯胺δ阿片类受体调节剂 - Google Patents
4-取代的-2-苯氧基-苯胺δ阿片类受体调节剂 Download PDFInfo
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- CN102741226B CN102741226B CN201080059871.0A CN201080059871A CN102741226B CN 102741226 B CN102741226 B CN 102741226B CN 201080059871 A CN201080059871 A CN 201080059871A CN 102741226 B CN102741226 B CN 102741226B
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- phenyl
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- 0 **c(cc1)cc(O*)c1N(*)* Chemical compound **c(cc1)cc(O*)c1N(*)* 0.000 description 10
- PABLOPMZCFQFHB-SFYZADRCSA-N CC(C)(C)OC(N(C[C@@H](C1)F)[C@@H]1C=O)=O Chemical compound CC(C)(C)OC(N(C[C@@H](C1)F)[C@@H]1C=O)=O PABLOPMZCFQFHB-SFYZADRCSA-N 0.000 description 1
- JZWHWZCRZGPWNH-QMMMGPOBSA-N CC(C)(C)OC(N1C=CC[C@H]1C=O)=O Chemical compound CC(C)(C)OC(N1C=CC[C@H]1C=O)=O JZWHWZCRZGPWNH-QMMMGPOBSA-N 0.000 description 1
- JMMLUBGVSAZNOW-UHFFFAOYSA-N N#Cc1cc(BO)cnc1 Chemical compound N#Cc1cc(BO)cnc1 JMMLUBGVSAZNOW-UHFFFAOYSA-N 0.000 description 1
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| PCT/US2010/054497 WO2011053706A1 (en) | 2009-10-30 | 2010-10-28 | 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators |
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| EP3205644A1 (en) | 2005-12-29 | 2017-08-16 | Celtaxsys Inc. | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| WO2011053696A1 (en) * | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | Pyrazines as delta opioid receptor modulators |
| JP5770198B2 (ja) * | 2009-10-30 | 2015-08-26 | ヤンセン ファーマシューティカ エヌ.ベー. | オピオイド受容体調節因子としてのフェノキシ置換ピリミジン |
| WO2014164658A1 (en) | 2013-03-12 | 2014-10-09 | Celtaxsys, Inc. | Methods of inhibiting leukotriene a4 hydrolase |
| CA2906084A1 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| EP2968264A4 (en) | 2013-03-14 | 2016-11-02 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
| CN103788019B (zh) * | 2014-01-22 | 2015-10-07 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| AU2016275764B8 (en) * | 2015-06-11 | 2021-03-04 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
| ES3014615T3 (en) | 2018-05-31 | 2025-04-23 | Celltaxis Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
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| CN101115751A (zh) * | 2004-12-22 | 2008-01-30 | 詹森药业有限公司 | 三环δ-阿片样物质调节剂 |
| US20080318937A1 (en) * | 2005-01-06 | 2008-12-25 | Coats Steven J | Tricyclic delta-opioid modulators |
| CN101511808A (zh) * | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 二芳基醚衍生物及其用途 |
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| PT86407B (pt) * | 1986-12-31 | 1990-11-20 | Fujisawa Pharmaceutical Co | Processo para a preparacao de novos derivados de alcano-sulfonanilida, e de composicoes farmaceuticas compreendendo os mesmos |
| JP4302207B2 (ja) * | 1997-08-04 | 2009-07-22 | 大正製薬株式会社 | アリールオキシアニリン誘導体 |
| WO1999033806A1 (en) * | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101115751A (zh) * | 2004-12-22 | 2008-01-30 | 詹森药业有限公司 | 三环δ-阿片样物质调节剂 |
| US20080318937A1 (en) * | 2005-01-06 | 2008-12-25 | Coats Steven J | Tricyclic delta-opioid modulators |
| CN101511808A (zh) * | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 二芳基醚衍生物及其用途 |
Non-Patent Citations (1)
| Title |
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| m-Opioid receptor desensitization by b-arrestin-2 determines morphine tolerance but not dependence;Laura M. Bohn,等;《letters to nature》;20001207;第408卷;第720-723页 * |
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| CA2779108A1 (en) | 2011-05-05 |
| RU2553453C2 (ru) | 2015-06-20 |
| AU2010313402B2 (en) | 2015-12-03 |
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| US8846655B2 (en) | 2014-09-30 |
| CA2779108C (en) | 2018-01-02 |
| BR112012011443A2 (pt) | 2020-09-08 |
| JP2013509428A (ja) | 2013-03-14 |
| WO2011053706A1 (en) | 2011-05-05 |
| IN2012DN03846A (enExample) | 2015-08-28 |
| EP2493852B1 (en) | 2014-04-09 |
| RU2012122208A (ru) | 2013-12-10 |
| US20120302541A1 (en) | 2012-11-29 |
| AU2010313402A1 (en) | 2012-05-24 |
| CN102741226A (zh) | 2012-10-17 |
| JP5781527B2 (ja) | 2015-09-24 |
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