CN1027371C - 二萜内酯化合物的合成方法 - Google Patents

二萜内酯化合物的合成方法 Download PDF

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Publication number
CN1027371C
CN1027371C CN 89106941 CN89106941A CN1027371C CN 1027371 C CN1027371 C CN 1027371C CN 89106941 CN89106941 CN 89106941 CN 89106941 A CN89106941 A CN 89106941A CN 1027371 C CN1027371 C CN 1027371C
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CN
China
Prior art keywords
compound
triptolide
group
synthetic
diterpenic lactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 89106941
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English (en)
Chinese (zh)
Other versions
CN1050021A (zh
Inventor
吕燮余
郑家润
马鹏程
张崇璞
陈沄
于德泉
吴若
梁晓天
张正行
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INSTITUTE OF DERMATOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES
Institute of Materia Medica of CAMS
Institute of Dermatology and Skin Disease Hospital of CAMS
Original Assignee
INSTITUTE OF DERMATOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES
Institute of Materia Medica of CAMS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INSTITUTE OF DERMATOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES, Institute of Materia Medica of CAMS filed Critical INSTITUTE OF DERMATOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES
Priority to CN 89106941 priority Critical patent/CN1027371C/zh
Priority to JP21360890A priority patent/JPH03178977A/ja
Publication of CN1050021A publication Critical patent/CN1050021A/zh
Application granted granted Critical
Publication of CN1027371C publication Critical patent/CN1027371C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN 89106941 1989-09-08 1989-09-08 二萜内酯化合物的合成方法 Expired - Fee Related CN1027371C (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN 89106941 CN1027371C (zh) 1989-09-08 1989-09-08 二萜内酯化合物的合成方法
JP21360890A JPH03178977A (ja) 1989-09-08 1990-08-10 ジテルペンラクトン化合物及びその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 89106941 CN1027371C (zh) 1989-09-08 1989-09-08 二萜内酯化合物的合成方法

Publications (2)

Publication Number Publication Date
CN1050021A CN1050021A (zh) 1991-03-20
CN1027371C true CN1027371C (zh) 1995-01-11

Family

ID=4856988

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 89106941 Expired - Fee Related CN1027371C (zh) 1989-09-08 1989-09-08 二萜内酯化合物的合成方法

Country Status (2)

Country Link
JP (1) JPH03178977A (ja)
CN (1) CN1027371C (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843452A (en) * 1992-11-09 1998-12-01 Pharmagenesis, Inc. Immunotherapy composition and method
US5759550A (en) * 1993-05-06 1998-06-02 Pharmagenesis, Inc. Method for suppressing xenograft rejection
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods
US5962516A (en) * 1997-02-28 1999-10-05 Pharmagenesis, Inc. Immunosuppressive compounds and methods
EP1375488B1 (en) * 1998-09-02 2006-08-02 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
AU764123B2 (en) * 1998-09-02 2003-08-07 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
US7847109B2 (en) 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN1726025A (zh) * 2002-12-17 2006-01-25 泛华医药公司 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
WO2005062913A2 (en) 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (zh) 2004-02-09 2007-02-21 美国泛华医药公司 从雷公藤多苷中分离雷公藤内酯醇化合物的方法
ATE554758T1 (de) 2004-03-02 2012-05-15 Pharmagenesis Inc Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
US8268882B2 (en) * 2009-02-05 2012-09-18 Pharmagenesis, Inc. Triptolide C-ring derivatives as anticancer agents and immune modulators
CN106883284B (zh) * 2017-03-03 2018-10-16 广东省中医院 雷公藤内酯三醇的快速安全制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用

Also Published As

Publication number Publication date
JPH03178977A (ja) 1991-08-02
CN1050021A (zh) 1991-03-20

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