CN102727595B - Chinese compound hair growth promoting composition and preparation method thereof - Google Patents
Chinese compound hair growth promoting composition and preparation method thereof Download PDFInfo
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- CN102727595B CN102727595B CN201210230628.1A CN201210230628A CN102727595B CN 102727595 B CN102727595 B CN 102727595B CN 201210230628 A CN201210230628 A CN 201210230628A CN 102727595 B CN102727595 B CN 102727595B
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Abstract
The invention relates to a Chinese compound hair growth promoting composition and a preparation method thereof, relating to the Chinese traditional medicine. The composition comprises the following materials by weight: 150-200 parts of Herba Ecliptae, 80-120 parts of Radix Polygoni Multiflori Preparata, 60-120 parts of Herba Speranskiae Tuberculatae, 60-120 parts of Flos Carthami, 60-120 parts of Folium Platycladi and 40-100 parts of Fructus Psoraleae. The preparation method comprises the steps of pulverizing above materials into particles not larger than 20 meshes, mixing to obtain mixture, adding water medium 15-25 times volume of the mixture, extracting at 50-70 DEG C for not less than 30 min, collecting extractive solution, and concentrating. Clinical comparison tests show that the Chinese compound hair growth promoting composition has curative rate up to 57.38% and effective rate up to 93.44%.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly hair growth promoter and preparation method thereof.
Background technology
Alopecia refers to the phenomenon of alopecia.General alopecia can be divided into two kinds of fundamental types, the permanent alopecia causing because hair follicle is impaired, and the temporary alopecia causing because the hair follicle short time is impaired.Permanent alopecia is that common male is bald.The alopecia process of permanent alopecia (being male pattern alopecia) produces gradually.During beginning, an obvious retrude in forehead material hair edge, head exiguous human hair; Then progressively development, finally can develop into only remaining back of head ，Tou both sides one circle thin hair, and its main cause has three: inherited genetic factors, the shortage of androgen or imbalance in blood circulation; Be too obese.In addition, the injured cicatrix staying of multiple dermatosis or skin, born hair dysplasia, and the grievous injury that chemical substance or physical cause cause hair follicle all can cause permanent alopecia.By obtaining, the disease of having a high fever caused often in temporary alopecia.But, according to X-ray, take in metal (as thallium, stannum and arsenic) or take in drugs, malnutrition, some dermatosis with inflammation, Chronic consumptions, and endocrine disturbance etc. also can cause temporary alopecia.
Therapeutic scheme has two kinds.The first is hair grafting, exactly the hair transplantation of going back the scalp in long hair place is arrived to the not place of long hair, moves on to front portion from back of head that is:.Second method is the local drug of topical application.The continuation alopecia that can effectively stop many reasons to cause, promotes the hair restoration at bald or exiguous human hair position.
Summary of the invention
One of object of the present invention is to provide a kind of formula of hair growth promoter, and this formula is pure Chinese medicine formula, uses the hair growth promoter hair of this formula preparation obviously to become many, and blackening chap.
For achieving the above object, technical scheme of the present invention is:
Chinese medicine compound formula for growing hair, composed of the following components according to weight portion meter:
150～200 parts of Herba Ecliptaes;
80～120 parts of Radix Polygoni Multiflori Preparata;
60～120 parts of Herba speranskiae tuberculataes;
60～120 parts, Flos Carthami;
60～120 parts of Cacumen Platycladis;
40～100 parts of Fructus Psoraleaes.
Preferably, Chinese medicine compound formula for growing hair is composed of the following components according to weight portion meter:
180 parts of Herba Ecliptaes;
100 parts of Radix Polygoni Multiflori Preparata;
80 parts of Herba speranskiae tuberculataes;
80 parts, Flos Carthami;
80 parts of Cacumen Platycladis;
60 parts of Fructus Psoraleaes.
Two of object of the present invention is to provide the preparation method of hair growth promoter and the hair growth promoter of acquisition thereof, and the technology stability of the method is good, is applicable to large-scale production.The hair growth promoting of this hair growth promoter is effective, uses short treating period.
For achieving the above object, technical scheme of the present invention is:
Described Chinese medicine compound formula for growing hair is prepared the method for hair growth promoter, specifically comprises the following steps:
A pulverizes
Take described Chinese medicine compound formula for growing hair, be crushed to particle diameter and be not more than 20 object granules, fully mix, obtain mixture;
B extraction
In steps A gained mixture, add the aqueous medium that is equivalent to mixture 15-25 times volume, under 50-70 ℃ of condition, extraction is no less than 30 minutes, collects extract;
C is concentrated
Step B gained extract is concentrated, obtain hair growth promoter.
Further, before step B extraction step, also comprise infiltration step, be specially: in steps A gained mixture, add the aqueous medium that is equivalent to mixture 3-5 times volume, infiltrate and be no less than after 40 minutes.
Further, in step B, add the aqueous medium that is equivalent to 20 times of volumes of mixture.
Further, in step B, extraction temperature is 70 ℃, and extraction time is 1 hour.
Further, in described extract, add active carbon, and be standingly no less than 12 hours.
Further, it is characterized in that, standing standing liquid is later filtered with diatom filter.
Further, in step C, with dynamic circulation evaporation concentration equipment, extract is concentrated into the concentrated solution that is equivalent to 4 times of raw material volumes.
Said method is prepared the hair growth promoter of gained.
Beneficial effect of the present invention is: the good medicine that Radix Polygoni Multiflori Preparata is invigorating the liver and kidney simply, benefiting essence-blood, nourish heart and allay excitement, be mainly used in the diseases such as soreness of the waist and knees that treatment causes because of the loss of deficiency of the liver and kindey, essence and blood, dizziness and blurred vision, palpitation and insomnia, early whitening of hair, its black hair function is to bring into play by the kidney invigorating, benefit essence, the effect of allaying excitement of nourishing blood.Herba speranskiae tuberculatae is that the young stem and leaf of leguminous plant Herba Viciae Amoenae has wind-damp dispelling, invigorates blood circulation, and relaxing muscles and tendons, the function of pain relieving, cures mainly rheumatalgia, sprain and contusion wound, innominate toxic swelling, the diseases such as eczema scrotum.Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius L., warm in nature, acrid in the mouth, tool promoting blood circulation to restore menstrual flow, the effect of scattered silt pain relieving.Cacumen Platycladi: cold in nature, bitter and puckery flavor has removing heat from blood, hemostasis, wind-damp dispelling, the function of loose toxic swelling.Fructus Psoraleae is the fruit of legumes psoraleae.Property is pungent, and temperature, has kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, the effect of temperature compensation antidiarrheal.Herba Ecliptae is the herb of dicotyledon medicine feverfew Eclipta prostrata, sweet acid, and cool have a removing heat from blood, hemostasis, the kidney invigorating, the effect of tonifying YIN.The present invention is through clinical comparison evidence, and cure rate of the present invention can reach 57.38%, and obvious effective rate can reach 93.44%.
The specific embodiment
Embodiment 1 Chinese medicine compound formula for growing hair
Chinese medicine compound formula for growing hair 1, composed of the following components according to weight portion meter: 150 parts of Herba Ecliptaes; 80 parts of Radix Polygoni Multiflori Preparata; 60 parts of Herba speranskiae tuberculataes; 120 parts, Flos Carthami; 120 parts of Cacumen Platycladis; 100 parts of Fructus Psoraleaes.
Chinese medicine compound formula for growing hair 2, composed of the following components according to weight portion meter: 200 parts of Herba Ecliptaes; 120 parts of Radix Polygoni Multiflori Preparata; 120 parts of Herba speranskiae tuberculataes; 60 parts, Flos Carthami; 60 parts of Cacumen Platycladis; 40 parts of Fructus Psoraleaes.
Chinese medicine compound formula for growing hair 3, composed of the following components according to weight portion meter: 180 parts of Herba Ecliptaes; 100 parts of Radix Polygoni Multiflori Preparata; 80 parts of Herba speranskiae tuberculataes; 80 parts, Flos Carthami; 80 parts of Cacumen Platycladis; 60 parts of Fructus Psoraleaes.
The preparation of embodiment 2 hair growth promoters
Described Chinese medicine compound formula for growing hair is prepared the method for hair growth promoter, specifically comprises the following steps: take respectively 3 kinds of described Chinese medicine compound formula for growing hairs in embodiment 1, pulverize and fully mix, obtain 3 kinds of different mixtures.The object of pulverizing is abundant effective component extracting, so, be crushed to particle diameter and be not more than 20 object granules and all can.
In 3 kinds of mixture of gained, add deionized water respectively, extract, obtain extract.In extract, contain the required active drug composition of described Chinese medicine compound formula for growing hair.By the mixture of Chinese medicine compound formula for growing hair 1-3 gained successively called after mixture 1, mixture 2 and mixture 3.The volume of the deionized water adding respectively in mixture 1-3 is equivalent to 15 times, 20 times and 25 times of mixture itself, and extraction temperature is respectively 50 ℃, 70 ℃ and 60 ℃, and in order fully to extract effective ingredient, extraction time is chosen 1 hour.
As the optimal way of the present embodiment, before extraction, also comprise infiltration step, be specially: in gained mixture 1-3, add the deionized water that is equivalent to mixture 3-5 times volume, fully infiltrate after 40-120 minute.
As the optimal way of the present embodiment, in described extract, add active carbon, and be standingly no less than 12 hours.The addition of active carbon is 0.5g/mL.
As the optimal way of the present embodiment, standing standing liquid is later filtered with diatom filter.
As the optimal way of the present embodiment, will filter and with dynamic circulation evaporation concentration equipment, extract is concentrated into the concentrated solution that is equivalent to 4 times of raw material volumes with diatom filter.The hair growth promoter of mixture 1, mixture 2 and mixture 3 preparations is called after hair growth promoter 1, hair growth promoter 2 and hair growth promoter 3 respectively.
The clinical practice of embodiment 3 hair growth promoters
120 routine patients, are divided into treatment group 61 example and matched group 59 examples at random.Male 42 examples in treatment group, female's 19 examples; 18～55 years old age, average 31.6 years old; The course of disease 12 days to 3 months, average 1.7 months; Alopecia area 2.5～8.5cm
2.Male 41 examples in matched group, female's 18 examples; 18～54 years old age, average 33.7 years old; The course of disease 25 days to 3 months, average 1.5 months; Alopecia area 2.0～8.0cm
2.Two groups of sexes, age, the course of disease, alopecia areas are learned processing by statistics, and the equal not statistically significant of difference (P > 0.05), has comparability.
Test method: 1, treatment group: patient's hair and scalp are cleaned, with hair-dryer, blow hot scalp and hair, then at hair growth promoter 2 described in scalp and root of hair place obliterating 10～15ml, and massage 5～10 minutes, then be with bathing cap insulation within 1 hour, to be convenient to above drug absorption and performance drug effect.Every two days repeat seance process, are monthly a course for the treatment of.2, matched group: the organoleptic indicators such as the color and luster of the medicament that the imitation treatment groups such as employing pure water, caramel color, thickening agent, medicine essence are used, odor type.Using method and the course for the treatment of same treatment group.
Observational technique: observed and itemized record patient hair loss area area change and natural on-off cycles of hair growth situation weekly the untoward reaction situation of while record patient, statistical result after 3 months by a specialist.
Criterion of therapeutical effect: the criterion of therapeutical effect proposing with reference to WEISS etc., recovery from illness: newly all grow, distribution density, hair thickness, the same normal hair of color and luster, gently draw negative.Effective: new growth more than 50%, has more fine hair on birds or animals hair to become terminal hair, gently draws negative.Effective: new growth more than 10% (comprises fine hair on birds or animals hair), but poor growth is gently drawn negative or the positive.Invalid: without new growth or new growth, lower than growth limit, 10%Huo limit, to come off.
Result: two groups of curative effect comparisons (example) refer to list:
Untoward reaction: two groups of patients are showed no untoward reaction in therapeutic process, and before treatment, have a blood test while finishing routine, routine urinalysis, hepatic and renal function for the treatment of be all no abnormal.
Individual example is introduced:
Mrs Huang: 26 years old, puerperal alopecia.In child's 5 wheat harvesting periods, sensation hair is more oily, and finds alopecia especially severe.Every morning, comb one's hair, wash hair after all serious alopecias, fall a large amount of, many alopecias half a year phenomenon is not felt any better at all.Use after this hair growth promoter 10 times, alopecia obviously reduces.Use after the course for the treatment of, just have a lot of hairs longer.Through the treatment of three courses for the treatment of, hair recovers as before.
Mr. Chen, 48 years old is typical " the local central authorities that support " head dummy.Use the present invention after three months, it is many that hair obviously becomes, and blackening chap.
Below in conjunction with embodiment, further set forth the present invention.Should be understood that these embodiment are only for the present invention is described, but not limit the scope of the invention.In the following example, the method for unreceipted actual conditions and the reagent of undeclared formula are according to normal condition and carry out or configure, and the product in unreceipted source all can obtain by market approach.
Claims (10)
1. Chinese medicine compound hair growth composition, is characterized in that, composed of the following components according to weight portion meter:
150～200 parts of Herba Ecliptaes;
80～120 parts of Radix Polygoni Multiflori Preparata;
60～120 parts of Herba speranskiae tuberculataes;
60～120 parts, Flos Carthami;
60～120 parts of Cacumen Platycladis;
40～100 parts of Fructus Psoraleaes.
2. Chinese medicine compound hair growth composition according to claim 1, is characterized in that, composed of the following components according to weight portion meter:
180 parts of Herba Ecliptaes;
100 parts of Radix Polygoni Multiflori Preparata;
80 parts of Herba speranskiae tuberculataes;
80 parts, Flos Carthami;
80 parts of Cacumen Platycladis;
60 parts of Fructus Psoraleaes.
3. by Chinese medicine compound hair growth composition described in claim 1 or 2, prepared the method for hair growth promoter, it is characterized in that, specifically comprise the following steps:
A pulverizes
Take described Chinese medicine compound formula for growing hair, be crushed to particle diameter and be not more than 20 object granules, fully mix, obtain mixture;
B extraction
In steps A gained mixture, add the aqueous medium that is equivalent to mixture 15-25 times volume, under 50-70 ℃ of condition, extraction is no less than 30 minutes, collects extract;
C is concentrated
Step B gained extract is concentrated, obtain hair growth promoter.
4. method according to claim 3, is characterized in that, before step B extraction step, also comprises infiltration step, is specially: in steps A gained mixture, add the aqueous medium that is equivalent to mixture 3-5 times volume, infiltrate and be no less than after 40 minutes.
5. according to the method for claim 3, it is characterized in that, in step B, add the aqueous medium that is equivalent to 20 times of volumes of mixture.
6. according to the method for claim 3, it is characterized in that, in step B, extraction temperature is 70 ℃, and extraction time is 1 hour.
7. according to the method for claim 3, it is characterized in that, in described extract, add active carbon, and be standingly no less than 12 hours.
8. according to the method for claim 7, it is characterized in that, standing standing liquid is later filtered with diatom filter.
9. according to the method for claim 3, it is characterized in that, in step C, with dynamic circulation evaporation concentration equipment, extract is concentrated into the concentrated solution that is equivalent to 4 times of raw material volumes.
10. in claim 3-9, described in any one, method is prepared the hair growth promoter of gained.
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| CN103690660B (en) * | 2013-12-05 | 2015-06-03 | 黄荣 | Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof |
| CN105878418B (en) * | 2016-06-06 | 2019-12-06 | 成都中医药大学附属医院 | Hair growth medicinal composition and preparation method thereof |
| CN107693563A (en) * | 2017-10-13 | 2018-02-16 | 上海运佳黄浦制药有限公司 | Traditional Chinese medicine for external application compound safflower tincture of hair growth and preparation method thereof |
| CN110141650A (en) * | 2019-01-17 | 2019-08-20 | 刘秀 | External medicine composition, Chinese medicine composition combination and the preparation for treating hoariness and alopecia |
| CN110141649A (en) * | 2019-01-17 | 2019-08-20 | 刘秀 | It is a kind of to treat white hair, the Chinese medicine composition of alopecia, Chinese materia medica preparation and its application |
| CN113952444A (en) * | 2021-12-06 | 2022-01-21 | 长春市臻心诚壹生物科技有限公司 | Traditional Chinese medicine composition with effects of nourishing and blackening hair and preparation method thereof |
| CN114392303B (en) * | 2022-02-17 | 2023-08-29 | 浙江卫未生物医药科技有限公司 | Exosome mixture for treating alopecia areata |
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| CN101513520A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating alopecia and promoting hair growth |
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| CN101513520A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating alopecia and promoting hair growth |
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