Chinese medicine compound hair growth promoter and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, particularly hair growth promoter and preparation method thereof.
Background technology
Alopecia is meant the phenomenon of alopecia.General alopecia can be divided into two kinds of fundamental types, because impaired permanent alopecia that causes of hair follicle and because the impaired temporary alopecia that causes of hair follicle short time.Permanent alopecia is that common male is bald.The alopecia process of permanent alopecia (being male pattern alopecia) produces gradually.During beginning, contract after a forehead material hair edge is obvious, the head hair is rare; Progressively development can develop into only remaining back of head at last then, a both sides one circle thin hair, and its main cause has three: inherited genetic factors, the shortage of androgen or imbalance in the blood circulation; Be too obese.In addition, the injured cicatrix that stays of various skin disease or skin, born hair dysplasia, and chemical substance or physical cause all can cause permanent alopecia to the grievous injury that hair follicle causes.The disease of having a high fever caused by getting often in temporary alopecia.But, according to X-ray, take in metal (like thallium, stannum and arsenic) or take in dermatosis, the Chronic consumptions of drugs, malnutrition, some band inflammation, and endocrine disturbance etc. also can cause temporary alopecia.
Therapeutic scheme has two kinds.First kind is hair grafting, arrives the not place of long hair to the hair transplantation of going back the local scalp of long hair exactly, moves on to the front portion from back of head that is:.Second method is the local drug of topical application.The continuation alopecia that can effectively stop multiple reason to cause promotes the hair restoration at bald or the rare position of hair.
Summary of the invention
One of the object of the invention is to provide a kind of prescription of hair growth promoter, and this prescription is pure Chinese medicine preparation, uses the hair growth promoter hair of this formulation obviously to become many, and the blackening chap.
For realizing above-mentioned purpose, technical scheme of the present invention is:
Chinese medicine compound hair growth promoting prescription, composed of the following components according to the weight portion meter:
150~200 parts of Herba Ecliptaes;
80~120 parts of Radix Polygoni Multiflori Preparata;
60~120 parts of Herba speranskiae tuberculataes;
60~120 parts on Flos Carthami;
60~120 parts of Cacumen Platycladis;
40~100 parts of Fructus Psoraleaes.
Preferably, Chinese medicine compound hair growth promoting prescription is composed of the following components according to the weight portion meter:
180 parts of Herba Ecliptaes;
100 parts of Radix Polygoni Multiflori Preparata;
80 parts of Herba speranskiae tuberculataes;
80 parts on Flos Carthami;
80 parts of Cacumen Platycladis;
60 parts of Fructus Psoraleaes.
Two of the object of the invention is to provide the method for preparing of hair growth promoter and the hair growth promoter of acquisition thereof, and the technology stability of this method is good, is fit to large-scale production.The hair growth promoting of this hair growth promoter is effective, uses short treating period.
For realizing above-mentioned purpose, technical scheme of the present invention is:
The method of said Chinese medicine compound hair growth promoting formulation hair growth promoter specifically may further comprise the steps:
A pulverizes
Take by weighing said Chinese medicine compound hair growth promoting prescription, be crushed to particle diameter and be not more than 20 purpose granules, fully mix, get mixture;
The B extraction
In steps A gained mixture, add the aqueous medium that is equivalent to mixture 15-25 times volume, extraction is no less than 30 minutes under 50-70 ℃ of condition, collects extract;
C concentrates
Step B gained extract is concentrated, get hair growth promoter.
Further, before step B extraction step, also comprise the infiltration step, be specially: in steps A gained mixture, add the aqueous medium that is equivalent to mixture 3-5 times volume, after infiltration is no less than 40 minutes.
Further, in step B, add the aqueous medium that is equivalent to 20 times of volumes of mixture.
Further, in step B, extraction temperature is 70 ℃, and the extraction time is 1 hour.
Further, add active carbon in the said extract, and leave standstill and be no less than 12 hours.
Further, it is characterized in that, filter with the diatom filter leaving standstill the liquid that leaves standstill later.
Further, in step C, extract is concentrated into the concentrated solution that is equivalent to 4 times of raw material volumes with the dynamic circulation evaporation concentration equipment.
The hair growth promoter of method for preparing gained.
Beneficial effect of the present invention is: the good medicine that Radix Polygoni Multiflori Preparata is invigorating the liver and kidney simply, benefiting essence-blood, nourish heart and allay excitement; Be mainly used in diseases such as soreness of the waist and knees that treatment causes because of the loss of deficiency of the liver and kindey, essence and blood, dizziness and blurred vision, palpitation and insomnia, early whitening of hair, its black hair function is that, the nourish blood effect of allaying excitement smart through the kidney invigorating, benefit brought into play.Herba speranskiae tuberculatae is that the young stem and leaf of leguminous plant Herba Viciae Amoenae has wind-damp dispelling, invigorates blood circulation, and Shujin, the analgesic function cures mainly rheumatalgia, and sprain and contusion are hindered, innominate toxic swelling, diseases such as eczema scrotum.Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius L., and is warm in nature, acrid in the mouth, tool promoting blood circulation to restore menstrual flow, the silt analgesic effect of loosing.Cacumen Platycladi: cold in nature, bitter and puckery flavor has removing heat from blood, hemostasis, wind-damp dispelling, the function of the toxic swelling that looses.Fructus Psoraleae is the fruit of legumes psoraleae.The property hot, temperature has kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, temperature compensation antidiarrheal effect.Herba Ecliptae is the herb of dicotyledon medicine feverfew Eclipta prostrata, sweet acid, and cold has removing heat from blood, hemostasis, the kidney invigorating, the effect of tonifying YIN.The present invention is through the clinical comparison evidence, and cure rate of the present invention can reach 57.38%, and obvious effective rate can reach 93.44%.
The specific embodiment
Embodiment 1 Chinese medicine compound hair growth promoting prescription
Chinese medicine compound hair growth promoting prescription 1, composed of the following components according to the weight portion meter: 150 parts of Herba Ecliptaes; 80 parts of Radix Polygoni Multiflori Preparata; 60 parts of Herba speranskiae tuberculataes; 120 parts on Flos Carthami; 120 parts of Cacumen Platycladis; 100 parts of Fructus Psoraleaes.
Chinese medicine compound hair growth promoting prescription 2, composed of the following components according to the weight portion meter: 200 parts of Herba Ecliptaes; 120 parts of Radix Polygoni Multiflori Preparata; 120 parts of Herba speranskiae tuberculataes; 60 parts on Flos Carthami; 60 parts of Cacumen Platycladis; 40 parts of Fructus Psoraleaes.
Chinese medicine compound hair growth promoting prescription 3, composed of the following components according to the weight portion meter: 180 parts of Herba Ecliptaes; 100 parts of Radix Polygoni Multiflori Preparata; 80 parts of Herba speranskiae tuberculataes; 80 parts on Flos Carthami; 80 parts of Cacumen Platycladis; 60 parts of Fructus Psoraleaes.
The preparation of embodiment 2 hair growth promoters
The method of said Chinese medicine compound hair growth promoting formulation hair growth promoter specifically may further comprise the steps: take by weighing among the embodiment 13 kinds of said Chinese medicine compound hair growth promotings prescriptions respectively, pulverize and fully mix, 3 kinds of different mixtures.The purpose of pulverizing is abundant effective component extracting, so, be crushed to particle diameter and be not more than 20 purpose granules and all can.
In 3 kinds of mixture of gained, add deionized water respectively, extract, get extract.Contain the required active drug composition of said Chinese medicine compound hair growth promoting prescription in the extract.With the mixture of Chinese medicine compound hair growth promoting prescription 1-3 gained called after mixture 1, mixture 2 and mixture 3 successively.The volume of the deionized water that adds respectively among the mixture 1-3 is equivalent to 15 times, 20 times and 25 times of mixture itself, and extraction temperature is respectively 50 ℃, 70 ℃ and 60 ℃, and in order fully to extract effective ingredient, the extraction time is chosen 1 hour.
As the optimal way of present embodiment, before extraction, also comprise the infiltration step, be specially: in gained mixture 1-3, add the deionized water be equivalent to mixture 3-5 times volume, fully soak into 40-120 minute after.
As the optimal way of present embodiment, add active carbon in the said extract, and leave standstill and be no less than 12 hours.The addition of active carbon is 0.5g/mL.
As the optimal way of present embodiment, filter with the diatom filter leaving standstill the liquid that leaves standstill later.
As the optimal way of present embodiment, will filter with the diatom filter and extract will be concentrated into the concentrated solution that is equivalent to 4 times of raw material volumes with the dynamic circulation evaporation concentration equipment.The hair growth promoter of mixture 1, mixture 2 and mixture 3 preparations is called after hair growth promoter 1, hair growth promoter 2 and hair growth promoter 3 respectively.
The clinical practice of embodiment 3 hair growth promoters
120 routine patients are divided into treatment group 61 example and matched group 59 examples at random.Male 42 examples in the treatment group, women 19 examples; 18~55 years old age, average 31.6 years old; The course of disease 12 days to 3 months, average 1.7 months; Alopecia area 2.5~8.5cm
2Male 41 examples in the matched group, women 18 examples; 18~54 years old age, average 33.7 years old; The course of disease 25 days to 3 months, average 1.5 months; Alopecia area 2.0~8.0cm
2Two groups of sexes, age, the course of disease, alopecia area are through statistical procedures, and the equal not statistically significant of difference (P>0.05) has comparability.
Test method: 1, treatment group: patient's hair and scalp are cleaned; Blow hot scalp and hair with hair-dryer; Then at scalp and the said hair growth promoter 2 of root of hair place obliterating 10~15ml, and massaged 5~10 minutes, be with the bathing cap insulation to be convenient to drug absorption and performance drug effect more than 1 hour again.Per two days repeat the seance process, and every month is a course of treatment.2, matched group: organoleptic indicators such as the color and luster of the medicament that imitation treatment groups such as employing pure water, caramel color, thickening agent, medicine essence are used, odor type.The method for using and the course of treatment are with the treatment group.
Observational technique: observe and itemized record patient hair loss area area change and natural on-off cycles of hair growth situation the untoward reaction situation of while record patient, statistical result after 3 months weekly by a specialist.
Criterion of therapeutical effect: with reference to the criterion of therapeutical effect of propositions such as WEISS, recovery from illness: New Development all grows, and distribution density, hair thickness, the same normal hair of color and luster gently draw test negative.Produce effects: New Development is grown more than 50%, has more fine hair on birds or animals hair to become terminal hair, gently draws test negative.Effectively: the New Development growth (comprises the fine hair on birds or animals hair) more than 10%, but poor growth gently draws test negative or positive.Invalid: growth of no New Development or New Development growth are lower than 10% or come off while growing.
The result: two groups of curative effects compare (example) and see tabulation for details:
Untoward reaction: two groups of patients all do not see untoward reaction in therapeutic process, and before treatment, when treatment finishes, have a blood test routine, routine urinalysis, hepatic and renal function are all no abnormal.
Individual example is introduced:
Mrs Huang: 26 years old, puerperal alopecia.In child's 5 wheat harvesting periods, the sensation hair is oil relatively, and find the alopecia especially severe.Every morning, comb one's hair, wash hair after all serious alopecia, a large amount of ground falls, many alopecias half a year phenomenon is not felt any better at all.After using this hair growth promoter 10 times, alopecia obviously reduces.After using a course of treatment, just there are a lot of hairs longer.Through the treatment of three courses of treatment, hair recovers as before.
Mr. Chen, 48 years old is typical " the local central authorities that support " head dummy.Use the present invention after three months, it is many that hair obviously becomes, and the blackening chap.
Further set forth the present invention below in conjunction with embodiment.Should be understood that these embodiment only are used to explain the present invention, and unrestricted scope of the present invention.The reagent of the method for unreceipted actual conditions and undeclared prescription is according to normal condition and carries out or dispose in the following example, and the product in unreceipted source all can obtain through the market approach.