CN102727408B - Bio-environment friendly antiviral cold prevention toothpaste and preparation method thereof - Google Patents
Bio-environment friendly antiviral cold prevention toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a biological environmental antiviral cold prevention toothpaste and a preparation method thereof. The toothpaste contains the following components of: alkyl polyglucoside (APG), precipitated silica, lysozyme, neutral protease, hydrolyzed protein, immunoglobulin, recombinant human epidermal growth factor, strontium chloride, sorbitol, butylparaben, CMC (Carboxyl methyl Cellulose), xanthan gum, glucolase, enzyme, and a skin penetrating agent, etc. The invention is directed at the pathogenic mechanism that illness finds its way in by the mouth and nose, and the biological environmental antiviral cold prevention toothpaste with bio-environmental protection, virus resisting, cold prevention, as well as disease prevention and treatment effects is designed and prepared. During use, the toothpaste of the invention has cool, refreshing, icy and fragrant mouthfeel, and decomposes rapidly after entering the mouth. After tooth brushing, the ice-cold and refreshing feel remains for a long time, the bacteriostatic control time is long, the mouthfeel is refreshing, the taste is fragrant and bittersweet, and the spirit can be made cheerful, so that the toothpaste of the invention is beneficial to human health.
Description
Technical field
The present invention relates to medicated toothpaste, relate in particular to a kind of biological environmental production antiviral cold prevention toothpaste and preparation method thereof.
Background technology
Present medicated toothpaste, mainly have effects such as cleaning oral cavity, anti-decayed tooth, antiallergic, preventing parodontitis, anti-oral disease, the effect of performance mainly is confined to tooth and oral cavity itself, has better action in the disease at tooth and oral cavity, go into basic pathogeny but seldom have at disease from mouth and nose, design construction has the toothpaste of biological environmental production, antiviral, anti-flu, the effect of disease preventing and treating aspect.
Summary of the invention
The object of the present invention is to provide a kind of biological environmental production antiviral cold prevention toothpaste and preparation method thereof.
For addressing the above problem, the technical solution used in the present invention is:
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 4～6%, precipitated silica 38～48%, lysozyme 0.05～0.9%, neutral protease 0.5～0.8%, hydrolyzed protein 0.5～0.8%, immunoglobulin 0.03～0.06%, recombinant human epidermal growth factor 0.08～0.2%, strontium chloride 0.8～1.2%, sorbitol 18～28%, butoben 0.02～0.03%, CMC 0.3～0.6%, HANSHENGJIAO 0.3～0.6%, glucose enzyme 0.5～0.8%, skin penetrant 1.5～2%, Flos Lonicerae extract 3～8%, Fructus Forsythiae oil 1.2～2.2%, oil of Radix Sapshnikoviae 0.5～0.8%, Radix Et Rhizoma Rhei anthraquinone 0.4～0.8%, baicalin 0.3～0.8%, astragalus polysaccharides 1.5～1.8%, ribavirin 0.8～1.8%, hypericin 7～12%, Radix Glycyrrhizae is extracted extractum 0.6～1.2%, Rhizoma Osmundae extract 1～1.8%, Herba Schizonepetae oil 0.8～1.2%, Rhizoma Chuanxiong extract 0.6～1.1%, extract of taraxacum 0.5～1.6%, Oleum menthae 0.2～0.8%, Radix Bupleuri extractum 1.2～1.6%, Herba Pogostemonis extractum 0.6～0.8%, Folium Nelumbinis extract 6～8%, surplus are water.
Preferably, a kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 5～6%, silicon dioxide 38～41%, lysozyme 0.06～0.09%, neutral protease 0.6～0.8%, hydrolyzed protein 0.5～0.8%, immunoglobulin 0.05～0.06%, recombinant human epidermal growth factor 0.1～0.15%, strontium chloride 0.9～1.2%, sorbitol 18～22%, butoben 0.02～0.03%, CMC0.3～0.6%, HANSHENGJIAO 0.5～0.6%, glucose enzyme 0.5～0.6%, skin penetrant 1.6～1.8%, Flos Lonicerae extract 6～8%, Fructus Forsythiae oil 1.2～1.6%, oil of Radix Sapshnikoviae 0.5～0.6%, Radix Et Rhizoma Rhei anthraquinone 0.5～0.6%, baicalin 0.4～0.6%, astragalus polysaccharides 1.6～1.8%, ribavirin 0.8～1.8%, hypericin 7.5～11%, Radix Glycyrrhizae is extracted extractum 0.6～0.8%, Rhizoma Osmundae extract 1.2～1.6%, Herba Schizonepetae oil 0.8～1.1%, Rhizoma Chuanxiong extract 0.7～0.9%, extract of taraxacum 0.8～1.2%, Oleum menthae 0.4～0.8%, Radix Bupleuri extractum 1.2～1.5%, Herba Pogostemonis extractum 0.7～0.8%, Folium Nelumbinis extract 6～8%, surplus are water.
Preferably, skin penetrant is azone.
The preparation method of above-mentioned biological environmental production antiviral cold prevention toothpaste may further comprise the steps:
1) in sorbitol, adds CMC, HANSHENGJIAO, stir, add water intensification again, treat that CMC, HANSHENGJIAO fully dissolve, filter if any insoluble matter and remove, get composite solution;
2) add surplus stock successively in composite solution, stir and make paste, and regulate pH to 6.6～6.8, vacuum outgas gets mastic.
Preferably, the gained mastic is further processed: mastic is ground to form thin paste, vacuum outgas, filling and package.
Preferably, be warming up to 85～95 ℃.
Immunoglobulin of the present invention is the bioactive substance that extracts in animal body, has immunity and substitutes and immunoregulatory dual function, can strengthen body immunity, has functions such as antibiotic, antiviral, protection intestinal, facilitating digestion.
The invention has the beneficial effects as follows:
The present invention is directed to disease and go into basic pathogeny from mouth and nose, the biological environmental production antiviral cold prevention toothpaste of design construction, the effect with biological environmental production, antiviral, anti-flu, disease preventing and treating aspect.Volunteers use among the people through 16 years experimental results show that: adhere to using toothpaste of the present invention, get up every morning and brush teeth, gargle after meal, gargle after the lunch, lunch break gets up to brush teeth, and gargle evening after meal, brushes teeth before sleeping.Adhere to using 3 months persons, after the flu, compare with the flu disease before using toothpaste of the present invention again, disease alleviates; Adhere to half a year～one year volunteer, oral disease does not take place in the volunteer more than 95%, flu sickness rate slip 85%; Adhere to a year and a half～twos' year volunteer, 99% volunteer does not catch a cold during 16 years of experiment.
Toothpaste of the present invention, in use, toothpaste entrance cool taste, refreshing, the delicate fragrance of ice, speed is fast behind the toothpaste entrance decomposes, after brushing teeth, the ice-cold salubrious time of staying is long, and the antibacterial control time is long, and mouthfeel is pure and fresh, taste delicate fragrance sweetness and bitterness, in high spirits, be conducive to health.
The specific embodiment
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component: alkyl polyglucoside (APG), precipitated silica, lysozyme, neutral protease, hydrolyzed protein, immunoglobulin, recombinant human epidermal growth factor, strontium chloride, sorbitol, butoben, CMC, HANSHENGJIAO, glucose enzyme, skin penetrant, Flos Lonicerae extract, Fructus Forsythiae oil, oil of Radix Sapshnikoviae, Radix Et Rhizoma Rhei anthraquinone, baicalin, astragalus polysaccharides, ribavirin, hypericin, Radix Glycyrrhizae is extracted extractum, Rhizoma Osmundae extract, Herba Schizonepetae oil, the Rhizoma Chuanxiong extract, extract of taraxacum, Oleum menthae, Radix Bupleuri extractum, Herba Pogostemonis extractum, Folium Nelumbinis extract, surplus are water.Its preparation method may further comprise the steps:
1) in sorbitol, adds CMC, HANSHENGJIAO, stir, add pure water again and be heated to 85～95 ℃, treat that CMC, HANSHENGJIAO fully dissolve, filter, get composite solution;
2) under agitation, add composite solution, surplus stock successively in multiple-effect cream still processed, until the formation paste, and regulate pH to 6.6～6.8, vacuum outgas gets mastic;
3) mastic is joined colloid mill and grind, through the mastic that the colloid machine grinds, light is fine and smooth, vacuum outgas, filling and package.
The present invention is further illustrated below in conjunction with specific embodiment, but do not limit to so.
The medical grade azone wins the production of imperial Fine Chemical Co., Ltd by Dangshan County among the embodiment; Baicalin, astragalus polysaccharides are produced by source, Guangzhou combustion biotechnology company; Hypericin is produced by Xi'an sincere edge biological engineering company limited; Flos Lonicerae extract, Fructus Forsythiae oil, oil of Radix Sapshnikoviae, Herba Schizonepetae oil, Oleum menthae, Radix Et Rhizoma Rhei anthraquinone, Radix Glycyrrhizae are extracted extractum, Rhizoma Osmundae extract, Rhizoma Chuanxiong extract, extract of taraxacum, Radix Bupleuri extractum, Herba Pogostemonis extractum, Folium Nelumbinis extract by Guilin City's love bio tech ltd production, and be all on sale on the other products market.
Embodiment 1
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 5.5%, precipitated silica 40%, lysozyme 0.08%, neutral protease 0.7%, hydrolyzed protein 0.7%, immunoglobulin 0.055%, recombinant human epidermal growth factor 0.12%, strontium chloride 1.0%, sorbitol 27%, butoben 0.025%, the CMC(hydroxymethyl cellulose sodium) 0.5%, HANSHENGJIAO 0.55%, glucose enzyme 0.55%, medical grade azone 1.7%, Flos Lonicerae extract 7%, Fructus Forsythiae oil 1.5%, oil of Radix Sapshnikoviae 0.55%, Radix Et Rhizoma Rhei anthraquinone 0.55%, baicalin 0.5%, astragalus polysaccharides 1.7%, ribavirin 1.0%, hypericin 10%, Radix Glycyrrhizae is extracted extractum 0.7%, Rhizoma Osmundae extract 1.5%, Herba Schizonepetae oil 1.0%, Rhizoma Chuanxiong extract 0.8%, extract of taraxacum 1.0%, Oleum menthae 0.6%, Radix Bupleuri extractum 1.3%, Herba Pogostemonis extractum 0.7%, Folium Nelumbinis extract 7%, surplus are pure water.
Embodiment 2
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 4%, precipitated silica 48%, lysozyme 0.05%, neutral protease 0.8%, hydrolyzed protein 0.8%, immunoglobulin 0.06%, recombinant human epidermal growth factor 0.08%, strontium chloride 1.2%, sorbitol 18%, butoben 0.02%, CMC 0.6%, HANSHENGJIAO 0.6%, glucose enzyme 0.5%, medical grade azone 2%, Flos Lonicerae extract 3%, Fructus Forsythiae oil 1.2%, oil of Radix Sapshnikoviae 0.5%, Radix Et Rhizoma Rhei anthraquinone 0.8%, baicalin 0.3%, astragalus polysaccharides 1.5%, ribavirin 0.8%, hypericin 7%, Radix Glycyrrhizae is extracted extractum 0.6%, Rhizoma Osmundae extract 1.8%, Herba Schizonepetae oil 1.2%, Rhizoma Chuanxiong extract 1.1%, extract of taraxacum 1.6%, Oleum menthae 0.2%, Radix Bupleuri extractum 1.6%, Herba Pogostemonis extractum 0.8%, Folium Nelumbinis extract 8%, surplus are water.
Embodiment 3
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 6%, precipitated silica 38%, lysozyme 0.9%, neutral protease 0.5%, hydrolyzed protein 0.5%, immunoglobulin 0.03%, recombinant human epidermal growth factor 0.2%, strontium chloride 0.8%, sorbitol 28%, butoben 0.03%, CMC 0.3%, HANSHENGJIAO 0.3%, glucose enzyme 0.8%, medical grade azone 1.5%, Flos Lonicerae extract 8%, Fructus Forsythiae oil 2.2%, oil of Radix Sapshnikoviae 0.8%, Radix Et Rhizoma Rhei anthraquinone 0.4%, baicalin 0.8%, astragalus polysaccharides 1.8%, ribavirin 1.8%, hypericin 12%, Radix Glycyrrhizae is extracted extractum 1.2%, Rhizoma Osmundae extract 1%, Herba Schizonepetae oil 0.8%, Rhizoma Chuanxiong extract 0.6%, extract of taraxacum 0.5%, Oleum menthae 0.8%, Radix Bupleuri extractum 1.2%, Herba Pogostemonis extractum 0.6%, Folium Nelumbinis extract 6%, surplus are water.
Embodiment 4
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 6%, silicon dioxide 41%, lysozyme 0.06%, neutral protease 0.6%, hydrolyzed protein 0.8%, immunoglobulin 0.05%, recombinant human epidermal growth factor 0.1%, strontium chloride 0.9%, sorbitol 18%, butoben 0.03%, CMC 0.6%, HANSHENGJIAO 0.6%, glucose enzyme 0.6%, skin penetrant 1.8%, Flos Lonicerae extract 6%, Fructus Forsythiae oil 1.2%, oil of Radix Sapshnikoviae 0.6%, Radix Et Rhizoma Rhei anthraquinone 0.5%, baicalin 0.4%, astragalus polysaccharides 1.6%, ribavirin 0.8%, hypericin 7.5%, Radix Glycyrrhizae is extracted extractum 0.8%, Rhizoma Osmundae extract 1.6%, Herba Schizonepetae oil 1.1%, Rhizoma Chuanxiong extract 0.7%, extract of taraxacum 0.8%, Oleum menthae 0.8%, Radix Bupleuri extractum 1.2%, Herba Pogostemonis extractum 0.8%, Folium Nelumbinis extract 6%, surplus are water.
Embodiment 5
A kind of biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 5%, silicon dioxide 38%, lysozyme 0.09%, neutral protease 0.8%, hydrolyzed protein 0.5%, immunoglobulin 0.05%, recombinant human epidermal growth factor 0.15%, strontium chloride 1.2%, sorbitol 22%, butoben 0.02%, CMC 0.3%, HANSHENGJIAO 0.5%, glucose enzyme 0.5%, skin penetrant 1.6%, Flos Lonicerae extract 8%, Fructus Forsythiae oil 1.6%, oil of Radix Sapshnikoviae 0.5%, Radix Et Rhizoma Rhei anthraquinone 0.6%, baicalin 0.4%, astragalus polysaccharides 1.8%, ribavirin 1.8%, hypericin 11%, Radix Glycyrrhizae is extracted extractum 0.6%, Rhizoma Osmundae extract 1.2%, Herba Schizonepetae oil 0.8%, Rhizoma Chuanxiong extract 0.9%, extract of taraxacum 1.2%, Oleum menthae 0.4%, Radix Bupleuri extractum 1.5%, Herba Pogostemonis extractum 0.7%, Folium Nelumbinis extract 8%, surplus are water.
Use experimental results show that through the volunteers among the people in 16 years (initial 500 people): adhere to using toothpaste of the present invention, get up every morning and brush teeth, gargle after meal, gargle after the lunch, lunch break gets up to brush teeth, and gargle evening after meal, brushes teeth before sleeping.Adhere to using 3 months persons (402 people), after the flu, compare with the flu disease before using toothpaste of the present invention again, disease alleviates; Adhere to half a year～one year volunteer (200 people), oral disease does not take place in the volunteer more than 95%, flu sickness rate slip 85%; Adhere to a year and a half～twos' year volunteer (50 people), 98% volunteer does not catch a cold during 16 years of experiment.
The present invention controls, prevents and treats combination, anxious Zhi Qibiao, delays the Zhi Qiben rule according to biochemistry and Chinese and western medical science theoretical direction principle and prevention of diseae, anti-overweighting, provide a kind of not only biological environmental production, but also can antiviral, the toothpaste of preventing cold.At first hold mouth and nose and close, make oral cavity cleaning by the toothpaste process of brushing teeth, reach the Chinese medicine effect that suppresses virus simultaneously; Allow human body slowly absorb wherein antiviral active drug composition by repeatedly using of toothpaste then, be stored in people's the body, be accumulated to the amount of effective drug effect, opposing virus gradually, thereby strengthen human body immunity and anti-virus ability, reach and to prevent oral disease, double effects that again can the antiviral preventing cold.Toothpaste of the present invention has antiinflammatory, sterilization, branch toxolysin, prevents virus replication, controls the effect that flu takes place.
Contain in the toothpaste of the present invention have antiinflammatory, effective ingredient such as the biological extraction liquid of sterilization, blood circulation promoting and blood stasis dispelling, wound healing, antiviral, branch toxolysin and biological preparation.Antiviral drugs has Fructus Forsythiae oil, hypericin, Radix Et Rhizoma Rhei anthraquinone, ribavirin (virazole), Rhizoma Osmundae, Herba Taraxaci, Radix Bupleuri, Herba Pogostemonis, Radix Scutellariae, Flos Lonicerae, lysozyme etc., add skin penetrant (azone) in the prescription, in the process of using toothpaste, can make the medicine fast Absorption in the toothpaste, and absorbability 40～80 times have been improved.And buccal absorption speed is 4.5 times that stomach absorbs, by the oral cavity fast Absorption, slowly store ingredient in the blood of human body, storage reaches certain amount, improve body immunity and anti-virus ability gradually, control cold virus clone alleviates cold symptoms, reduce the generation of flu, adhere to using as requested generally can not catch a cold more than 18 months.
Claims (6)
1. biological environmental production antiviral cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 4～6%, precipitated silica 38～48%, lysozyme 0.05～0.9%, neutral protease 0.5～0.8%, hydrolyzed protein 0.5～0.8%, immunoglobulin 0.03～0.06%, recombinant human epidermal growth factor 0.08～0.2%, strontium chloride 0.8～1.2%, sorbitol 18～28%, butoben 0.02～0.03%, CMC 0.3～0.6%, HANSHENGJIAO 0.3～0.6%, glucose enzyme 0.5～0.8%, skin penetrant 1.5～2%, Flos Lonicerae extract 3～8%, Fructus Forsythiae oil 1.2～2.2%, oil of Radix Sapshnikoviae 0.5～0.8%, Radix Et Rhizoma Rhei anthraquinone 0.4～0.8%, baicalin 0.3～0.8%, astragalus polysaccharides 1.5～1.8%, ribavirin 0.8～1.8%, hypericin 7～12%, Radix Glycyrrhizae is extracted extractum 0.6～1.2%, Rhizoma Osmundae extract 1～1.8%, Herba Schizonepetae oil 0.8～1.2%, Rhizoma Chuanxiong extract 0.6～1.1%, extract of taraxacum 0.5～1.6%, Oleum menthae 0.2～0.8%, Radix Bupleuri extractum 1.2～1.6%, Herba Pogostemonis extractum 0.6～0.8%, Folium Nelumbinis extract 6～8%, surplus are water.
2. the described biological environmental production antiviral of claim 1 cold prevention toothpaste, it contains following component by mass percent: alkyl polyglucoside (APG) 5～6%, silicon dioxide 38～41%, lysozyme 0.06～0.09%, neutral protease 0.6～0.8%, hydrolyzed protein 0.5～0.8%, immunoglobulin 0.05～0.06%, recombinant human epidermal growth factor 0.1～0.15%, strontium chloride 0.9～1.2%, sorbitol 18～22%, butoben 0.02～0.03%, CMC0.3～0.6%, HANSHENGJIAO 0.5～0.6%, glucose enzyme 0.5～0.6%, skin penetrant 1.6～1.8%, Flos Lonicerae extract 6～8%, Fructus Forsythiae oil 1.2～1.6%, oil of Radix Sapshnikoviae 0.5～0.6%, Radix Et Rhizoma Rhei anthraquinone 0.5～0.6%, baicalin 0.4～0.6%, astragalus polysaccharides 1.6～1.8%, ribavirin 0.8～1.8%, hypericin 7.5～11%, Radix Glycyrrhizae is extracted extractum 0.6～0.8%, Rhizoma Osmundae extract 1.2～1.6%, Herba Schizonepetae oil 0.8～1.1%, Rhizoma Chuanxiong extract 0.7～0.9%, extract of taraxacum 0.8～1.2%, Oleum menthae 0.4～0.8%, Radix Bupleuri extractum 1.2～1.5%, Herba Pogostemonis extractum 0.7～0.8%, Folium Nelumbinis extract 6～8%, surplus are water.
3. biological environmental production antiviral cold prevention toothpaste according to claim 1 and 2, it is characterized in that: skin penetrant is azone.
4. the preparation method of claim 1 or 2 described biological environmental production antiviral cold prevention toothpastes may further comprise the steps:
1) in sorbitol, adds CMC, HANSHENGJIAO, stir, add water intensification again, treat that CMC, HANSHENGJIAO fully dissolve, filter if any insoluble matter and remove, get composite solution;
2) add surplus stock successively in composite solution, stir and make paste, and regulate pH to 6.6～6.8, vacuum outgas gets mastic.
5. the preparation method of biological environmental production antiviral cold prevention toothpaste according to claim 4, it is characterized in that: the gained mastic is further processed: mastic is ground to form thin paste, vacuum outgas, filling and package.
6. the preparation method of biological environmental production antiviral cold prevention toothpaste according to claim 4 is characterized in that: be warming up to 85～95 ℃.
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| CN102973468A (en) * | 2012-12-25 | 2013-03-20 | 江南大学 | Face wash containing rhubarb anthraquinone |
| CN107693438A (en) * | 2017-11-27 | 2018-02-16 | 大连丹特生物技术有限公司 | A kind of daystart toothpaste and preparation method thereof |
| CN111329818A (en) * | 2020-02-08 | 2020-06-26 | 刘洋熙 | Improved toothpaste |
| CN112336663A (en) * | 2020-12-02 | 2021-02-09 | 陈倩倩 | Traditional Chinese medicine mouth wash |
| CN112716854B (en) * | 2021-01-27 | 2022-12-13 | 新乡博凯生物技术有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN113633558B (en) * | 2021-09-07 | 2022-09-23 | 重庆登康口腔护理用品股份有限公司 | Composition with good biocompatibility and application thereof in oral products |
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| CN1078882A (en) * | 1992-05-20 | 1993-12-01 | 吴海元 | Multipurpose anti-caries liquid tooth-paste and compound method thereof |
| CN1192898A (en) * | 1997-03-07 | 1998-09-16 | 杨云平 | Tooth-paste sheet and mfg. method thereof |
| CN101579296B (en) * | 2009-06-10 | 2011-09-14 | 汪洪涛 | Chinese medicament cold prevention toothpaste |
| CN101721324B (en) * | 2010-01-14 | 2012-01-11 | 江苏雪豹日化有限公司 | Biological complex enzyme toothpaste and preparation method thereof |
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