CN102716195B - 用于治疗或预防口腔疾病的头花蓼组合物 - Google Patents
用于治疗或预防口腔疾病的头花蓼组合物 Download PDFInfo
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- CN102716195B CN102716195B CN201210203104.3A CN201210203104A CN102716195B CN 102716195 B CN102716195 B CN 102716195B CN 201210203104 A CN201210203104 A CN 201210203104A CN 102716195 B CN102716195 B CN 102716195B
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Abstract
本发明涉及用于治疗或预防口腔疾病的头花蓼组合物。具体地讲，本发明涉及头花蓼或其提取物在制备用于治疗或预防口腔炎性疾病的组合物中的用途；还涉及用于治疗或预防口腔炎性疾病的组合物，其包括头花蓼或其提取物，以及赋形剂或载体。本发明所述口腔炎性疾病是指与发生于口腔内的炎症有关的疾病或病症，包括但不限于：口腔粘膜溃疡或疱疹、急性咽炎、牙龈炎、牙周炎等疾病及其并发症例如口腔溃疡疼痛、咽痛、牙龈痛、牙周痛、牙痛。本发明组合物是口用组合物，例如地例如是口含片、口嚼胶、颗粒、漱口液、牙膏、粘膜粘附片、喷雾液等形式。本发明的组合物可以有效地治疗口腔炎性疾病。
Description
发明领域
本发明涉及用于治疗或预防口腔炎性疾病的头花蓼组合物，还涉及头花蓼在制备用于治疗或预防口腔炎性疾病的产品中的用途。
背景技术
口腔炎症是一类常见的口腔疾患，见于口颊、舌边、上腭、齿龈、牙周等处发生溃疡、红肿作痛，甚至溃面糜烂。一组常见的口腔炎症表现为口腔粘膜溃疡或疱疹，严重时会产生多个溃疡或疱疹，除产生疼痛感外，还会有发热、口干、口渴、五心烦燥、失眠、盗汗、舌脉象等症状出现，影响人的健康和进食。中医认为阴虚火旺是口腔炎症的致病因素。另一组常见的口腔炎症表现为急性咽炎、牙龈炎、牙周炎等口腔炎病性疾病，它们都属于临床中的常见病、多发病，其中又以肺胃实热及风热之证最为常见。但临床上两证常相互兼挟，其病之初起，多因外感风热毒邪，循经上逆犯肺；或饮食不当，嗜烟好酒，熏灼肺胃；或嗜食辛辣炙博之品，化热化火；或肺胃素有积热，复因感受外邪，风火相煽而致。火为阳邪，其性上炎，故而热邪最易循经上扰。咽喉为肺之门户，热邪壅肺则呕喉疼痛或见红肿之象，胃络于龈，冒火循经上熏，热盛肉腐，气血壅滞，则牙龈红肿、疼痛；肺胃热毒，邪热壅盛传里，火热蒸腾，则疼痛可放射及耳根、颌下腮颊；肺胃热毒炽盛，迫血妄行，则可出观牙龈出血；风热犯表，热郁肌腠，则见身热，或微恶寒，大便干，小便黄赤，舌红，苔薄白或黄，脉浮滑数等也是肺胃实热兼挟风热之征。。
发明内容
本发明人经研究现已发现将头花蓼或者它的提取物在治疗或预防口腔炎性疾病方面具有明显的治疗或预防效果，例如可以用于治疗或预防口腔粘膜溃疡或疱疹、急性咽炎、牙龈炎、牙周炎。
因此，本发明一个方面涉及头花蓼或其提取物在制备用于治疗或预防口腔炎性疾病的组合物中的用途。
本发明一个方面涉及一种用于治疗或预防口腔炎性疾病的组合物，其包括头花蓼或其提取物，以及赋形剂或载体。本发明还涉及一种用于治疗或预防口腔炎性疾病的组合物，其由包括头花蓼或其提取物的活性组分，以及和赋形剂或载体制成。所述活性组分除了头花蓼或其提取物以外，还可以包括其它中药材或提取物，例如金银花或其提取物等。即，本发明组合物可以是由头花蓼或其提取物以及任选的赋形剂或载体制成；或者是由头花蓼或其提取物、其它中药材或其提取物(例如金银花或其提取物)、以及任选的赋形剂或载体制成。
根据本发明，本发明中所用术语“口腔炎性疾病”是指与发生于口腔内的炎症有关的疾病或病症，包括但不限于：口腔粘膜溃疡或疱疹、急性咽炎、牙龈炎、牙周炎等疾病及其并发症例如口腔溃疡疼痛、咽痛、牙龈痛、牙周痛、牙痛。
根据本发明，本发明所用术语“头花蓼提取物”选自头花蓼药材(全草或地上部分)经的选自下列溶剂提取所得的提取物：水、含水乙醇(例如5～95％乙醇)、乙醇、乙酸乙酯、丙酮、等等有机溶剂或者这些溶剂的组合。根据本发明，本发明所用术语“头花蓼提取物”可以是现有文献中公开的任何一种由头花蓼药材经提取处理而得到的提取物。
根据本发明，本发明的组合物可以是包含头花蓼或其提取物的任何形式的组合物。特别地，本发明的组合物是口用组合物。在本发明中，术语“口用组合物”表示一种产品，它在一般使用中，并不通过吞咽以达到体内吸收特定治疗药剂的目的，而是通过在口腔内停留足够长的时间，以基本上与全部牙齿表面和/或口腔接触，从而增强该产品针对口腔炎症的活性。特别地，本发明的组合物可以是包括但不限于下列的产品形式：口含片、口嚼胶、颗粒、漱口液、牙膏、粘膜粘附片、喷雾液等。本发明的组合物特别优选的是选自下列的产品形式：口含片、口嚼胶、漱口液、牙膏、粘膜粘附片等。术语“口含片”例如可以参见本领域技术人员使用的药剂学教科书中所描述的。术语“口嚼胶”例如是一种固体状物，其中包含胶粘材料例如阿拉伯胶、西黄鳍胶、果胶、蜂胶等，在例如口腔咀嚼的情况下会慢慢释放其中的活性物质，“口嚼胶”的一种常见形式是人们公知的口香糖。此外，漱口液、牙膏、粘膜粘附片等形式的产品亦是人们公知的产品形式。上述这些产品形式的一个共同特点是它们均可以在口腔(例如口腔粘膜、牙龈、舌)中停留较长时间，并由此延长药物在口腔中释放的时间。在本发明中，如果本发明组合物为牙膏形式，则该组合物包含5-50％的头花蓼提取物以及余量的牙膏基质，该牙膏基质可以是市售的牙膏，或者是参考牙膏一般配方配制的牙膏。
根据本发明，本发明所用的赋形剂或载体选自一种或多种下面物质：皮肤渗透促进剂、稀释剂、助溶剂、增溶剂、乳化剂、增稠剂、稳定剂、芳香剂及pH调节剂等，或者它们的组合。
本发明中皮肤渗透促进剂可选自下面一种或多种物质：(1)胆酸盐类：甘胆酸盐、胆酸盐、去氧胆酸盐、牛磺胆酸盐、葡萄糖胆酸盐、鹅去氧胆酸盐、鸟索去氧胆酸盐等；(2)饱和或不饱和脂肪酸及其酯：如月桂酸、油酸、肉豆寇酸、癸酸、月桂酸酯、辛酸酯、癸酸酯、棕榈酸酯、乳酸乙酯、三醋酸甘油酯；(3)醇类；如丙二醇、异丙醇、十六醇、月桂醇、油醇等；(4)醚类：聚氧乙烯月桂醚、聚氧乙烯辛醚等(5)亚砜类：如十二烷基甲基亚砜、二甲基亚砜等；(6)酰胺类：如N，N甲基甲酰胺、N，N-二甲基乙酰胺、环己月桂酰胺；(7)内酰胺类：十二烷基氮卓酮、拢牛儿基氮卓酮等；(8)离子型、非离子型表面活性剂：如十二烷基硫酸钠、辛酸单甘油酯、吐温80、司盘20等；和/或(9)β环糊精或烷基取代的β环糊精类：如二甲基β环糊精、羟丙基β环糊精等。如果存在的话，皮肤渗透促进剂的用量是占组合物总量的0.5～5％，优选0.5～2％。
本发明组合物中所加入的稳定剂有抗氧化剂，举例讲有：焦亚硫酸钠、亚硫酸钠、亚硫酸氢钠、硫代硫酸钠、抗坏血酸、硫脲、半胱氨酸、生育酚或卵磷脂等。上述稳定剂用量的优选占组合物重的0.01％-5％(w/v)。本发明组合物中的pH缓冲剂举例讲有枸橼酸缓冲盐、醋酸缓冲盐或磷酸缓冲盐等，用量为0.1mol/L-0.2mol/L。
本发明中所谈到的β环糊精及其烷基取代物举例讲有：β环糊精、羟丙基β环糊精、二甲基β环糊精等。
本发明组合物或产品中还可以使用增稠剂。如果存在的话，增稠剂的用量是占组合物总量的0.5～5％，优选0.5～2％。这些增稠剂例如但不限于羟丙甲基纤维素、聚丙烯酸、聚乙烯醇、卡波普等，或者它们的组合。
本发明组合物中还可使用纤维素类衍生物如羧甲基纤维素、羟丙甲基纤维素，上述β环糊精类化合物或纤维素类衍生物均能形成组合物中有效成分如维安酯或甲硝唑的包合物；聚乙二醇类、聚维酮等能形成产品中有效成分的固体分散物，从而有利于产品中有效成分的吸收；同时上述化合物可用于制剂粘稠性的调节，延长产品的接触时间，提高生物利用度。这类物质还有聚丙烯酸、聚乙烯醇、卡波普等。
本发明组合物中所使用的头花蓼提取物的含量约占组合物总重的1-90％(w/w)，优选为2-75％(w/w)，还优选为5-50％(w/w)，还优选为10-50％(w/w)。
本发明中组合物或产品还可含有壬二酸、维生素C或维生素E等物质，或者它们的组合，含量约占组合物或产品总重的0.5-5％(w/w)。
本发明中组合物或产品中可以含有赋形剂，其用量可以是本领域常规用量，例如加至组合物全量的量，例如以基质理解的用量，例如加至组合物或产品配方100％的量，因此其用量可以不固定。本发明中组合物或产品中，这类赋形剂可以选自：水、甘油、丙二醇、乙醇、液态聚乙二醇(例如分子量为200-600的聚乙二醇)，或者它们的组合。
根据本发明，所述组合物或者产品中包含：
| 头花蓼提取物 | 1-90％， |
| 赋形剂 | 适量，加至100％。 |
本发明组合物使用方便、安全、顺应性好，并且可以有效地治疗和/或预防口腔炎性疾病。
具体实施方式
下面的实施例用来进一步说明本发明，但不意味着对本发明的任何限制。
实施例1本发明组合物及其制备
配方中的头花蓼提取物是按如下方法制备的：取头花蓼(地上部分，干品)10kg，加6倍量水煎煮2次，每次1.5小时，合并煎液，滤过，滤液浓缩至在75℃时相对密度约1.25后，滤过，滤液喷雾干燥，得干燥的头花蓼提取物1.01kg。
组合物制法：将处方量的各物料混合均匀，在45℃下搅拌直到溶解完全，即得本发明组合物，其为呈牙膏形式的产品。
实施例2本发明组合物及其制备
配方中的头花蓼提取物是按如下方法制备的：取头花蓼(地上部分，干品)10kg，加6倍量65％乙醇提取2次，每次1小时，合并提取液，滤过，滤液浓缩至在75℃时相对密度约1.25后，滤过，滤液喷雾干燥，得干燥的头花蓼提取物0.95kg。
组合物制法：将处方量的各物料混合均匀，在60℃下搅拌直到溶解完全，即得本发明组合物，其为呈漱口液形式的产品。
实施例3本发明组合物及其制备
配方中的头花蓼提取物是按如下方法制备的：取头花蓼(全草，干品)10kg，加6倍量水煎2次，每次1小时，合并提取液，滤过，滤液浓缩成膏，用5倍量60％的乙醇回流提取2次，乙醇提取液在70-80℃下除去乙醇，喷雾干燥，得干燥的头花蓼提取物0.83kg。
组合物制法：将处方量的各物料混合均匀，在60℃下搅拌直到溶解完全，即得本发明组合物，其为呈漱口液形式的产品。
实施例4本发明组合物及其制备
配方中的头花蓼提取物是按如下方法制备的：取头花蓼(全草，干品)10kg，加8倍量水煎2次，每次1小时，合并提取液，滤过，滤液浓缩成相对密度为1.1(24℃)；加入98％乙醇调至含醇量为50％，静至12小时，分取上清液。向沉淀中加入98％乙醇调至含醇量为60％，静至12小时，分取上清液，合并两次上清液，除乙醇，75℃减压干燥，得头花蓼提取物0.51kg。
组合物制法：将处方量的头花蓼提取物、蔗糖、乳糖、淀粉和薄荷混合均匀，用5％淀粉浆制软材、制湿颗粒、干燥，加入硬脂酸镁，混合均匀，压片，片重约500mg，即得本发明组合物，其为呈口含片形式的产品。
本发明通过以上描述和实施例进行了说明，其描述为非限制性的，并不限制本发明的权利要求范围。
试验1临床疗效的观察
患者一般资料：牙龈炎43例、牙周炎26例、口腔溃疡31例、咽炎19例，它们尽可能地平均分配到A、B、C的3个试验组中。A组以刷牙的方式使用实施例1的组合物，每天分5次使用，总日剂量折算成头花蓼药材(全草，干品)计为20g。B组以口含的方式使用实施例4的组合物，每天分5次使用，总日剂量折算成头花蓼药材(全草，干品)计为20g。C组以口中嚼碎并立即含水吞咽服入的方式使用实施例4的组合物，每天分5次使用，总日剂量折算成头花蓼药材(全草，干品)计为100g。以及三组各使用本发明组合物3天。结果显示3天后，对于牙龈炎、牙周炎、口腔溃疡、咽炎四种疾病或病症，A组和B组痊愈分别为67％和71％。结果如下
| 组别 | 痊愈 | 显效 | 好转 | 无效 |
| A | 67.3％ | 25.5％ | 4.0％ | 3.2％ |
| B | 71.2％ | 21.4％ | 7.4％ | 0 |
| C | 0 | 0 | 12.7％ | 87.3％ |
由以上结果可见，本发明组合物具有良好的临床治疗效果。
Claims (12)
1.头花蓼提取物在制备用于治疗或预防口腔炎性疾病的组合物中的用途；所述头花蓼提取物是头花蓼药材经选自下列溶剂提取所得的提取物：水、含水乙醇、乙醇；并且所述组合物是口用组合物。
2.根据权利要求1的用途，其中所述口腔炎性疾病是指与发生于口腔内的炎症有关的疾病或病症。
3.根据权利要求1的用途，其中所述口腔炎性疾病选自：口腔粘膜溃疡或疱疹、急性咽炎、牙龈炎、牙周炎及其并发症。
4.根据权利要求3的用途，其中所述并发症选自口腔溃疡疼痛、咽痛、牙龈痛、牙周痛、牙痛。
5.根据权利要求1的用途，其中，所述组合物呈牙膏形式，并且其具有以下配方：
头花蓼提取物 20%
氟化钠 0.2%
焦磷酸四钠 5%
甘油 15%
聚乙二醇300 3%
羧甲基纤维素 0.7%
碳酸钠 3%
碳酸氢钠 10%
沉淀二氧化硅 18%
二氧化钛 0.35%
28%的烷基硫酸钠溶液 4%
糖精钠 0.5%
香味剂 0.5%
5%山梨醇溶液 9%
水，适量 至100%。
6.根据权利要求1的用途，其中所述组合物呈漱口液形式，并且其具有以下配方：
头花蓼提取物 30g
羟丙基甲基纤维素 2g
月桂氮卓酮 2ml
丙二醇 10ml
水 至100ml。
7.根据权利要求1的用途，其中所述组合物呈漱口液形式，并且其具有以下配方：
头花蓼提取物 10g
卡波姆 0.1g
月桂氮卓酮 1ml
丙二醇 5ml
水 至100ml。
8.根据权利要求1的用途，其中所述组合物呈口含片形式，并且其具有以下配方：
头花蓼提取物 50g
蔗糖 30g
乳糖 10g
淀粉 3g
薄荷 1g
5%淀粉浆 适量
硬脂酸镁 1g。
9.根据权利要求1的用途，其中所述组合物是选自下列的产品形式：口含片、口嚼胶、颗粒、漱口液、牙膏、粘膜粘附片、喷雾液。
10.根据权利要求1的用途，其中所述组合物中包括头花蓼提取物以及赋形剂或载体，所述赋形剂或载体是选自一种或多种下面的物质：皮肤渗透促进剂、稀释剂、助溶剂、增溶剂、乳化剂、增稠剂、稳定剂、芳香剂及pH调节剂。
11.根据权利要求10的用途，其中所述皮肤渗透促进剂是选自下面的一种或多种物质：
(1)胆酸盐类，其选自：甘胆酸盐、胆酸盐、去氧胆酸盐、牛磺胆酸盐、葡萄糖胆酸盐、鹅去氧胆酸盐、鸟索去氧胆酸盐；
(2)饱和或不饱和脂肪酸及其酯，其选自：月桂酸、油酸、肉豆寇酸、 癸酸、月桂酸酯、辛酸酯、癸酸酯、棕榈酸酯、乳酸乙酯、三醋酸甘油酯；
(3)醇类，其选自：丙二醇、异丙醇、十六醇、月桂醇、油醇；
(4)醚类，其选自：聚氧乙烯月桂醚、聚氧乙烯辛醚；
(5)亚砜类，其选自：十二烷基甲基亚砜、二甲基亚砜；
(6)酰胺类，其选自：N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、环己月桂酰胺；
(7)内酰胺类，其选自：十二烷基氮卓酮、拢牛儿基氮卓酮；
(8)离子型或非离子型表面活性剂，其选自：十二烷基硫酸钠、辛酸单甘油酯、吐温80、司盘20；和/或
(9)β环糊精或烷基取代的β环糊精类，其选自：二甲基β环糊精、羟丙基β环糊精。
12.根据权利要求1的用途，其中所述组合物中所使用的头花蓼提取物的重量占组合物总重量的1-90%。
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Non-Patent Citations (4)
| Title |
|---|
| 张予.苗药_头花蓼的研究进展.《贵阳中医学院学报》.2003,201-203. |
| 苗药_头花蓼的研究进展;张予;《贵阳中医学院学报》;20031130;201-203 * |
| 贵州野生与栽培头花蓼的主要药效质量评价研究;钱海兵;《时珍国医国药》;20090730;第20卷(第7期);1597-1598 * |
| 钱海兵.贵州野生与栽培头花蓼的主要药效质量评价研究.《时珍国医国药》.2009,第20卷(第7期),1597-1598. |
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