CN102712956A - 肠易激综合征的诊断方法 - Google Patents
肠易激综合征的诊断方法 Download PDFInfo
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- CN102712956A CN102712956A CN2010800605536A CN201080060553A CN102712956A CN 102712956 A CN102712956 A CN 102712956A CN 2010800605536 A CN2010800605536 A CN 2010800605536A CN 201080060553 A CN201080060553 A CN 201080060553A CN 102712956 A CN102712956 A CN 102712956A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25671709P | 2009-10-30 | 2009-10-30 | |
| US61/256,717 | 2009-10-30 | ||
| US26458809P | 2009-11-25 | 2009-11-25 | |
| US61/264,588 | 2009-11-25 | ||
| US32617610P | 2010-04-20 | 2010-04-20 | |
| US61/326,176 | 2010-04-20 | ||
| PCT/US2010/054810 WO2011053831A1 (en) | 2009-10-30 | 2010-10-29 | Methods for diagnosing irritable bowel syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102712956A true CN102712956A (zh) | 2012-10-03 |
Family
ID=43922588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800605536A Pending CN102712956A (zh) | 2009-10-30 | 2010-10-29 | 肠易激综合征的诊断方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120315630A1 (enExample) |
| EP (1) | EP2494074A4 (enExample) |
| JP (1) | JP2013509593A (enExample) |
| KR (1) | KR20120101038A (enExample) |
| CN (1) | CN102712956A (enExample) |
| AU (1) | AU2010313292A1 (enExample) |
| BR (1) | BR112012010108A2 (enExample) |
| CA (1) | CA2778539A1 (enExample) |
| IL (1) | IL219317A0 (enExample) |
| MX (1) | MX2012005015A (enExample) |
| PH (1) | PH12012500850A1 (enExample) |
| RU (1) | RU2012122180A (enExample) |
| WO (1) | WO2011053831A1 (enExample) |
| ZA (1) | ZA201203718B (enExample) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103175971A (zh) * | 2013-02-28 | 2013-06-26 | 苏州和锐医药科技有限公司 | 一种IgA抗体检测试剂盒 |
| CN104884959A (zh) * | 2012-10-05 | 2015-09-02 | 雀巢产品技术援助有限公司 | 作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物 |
| CN106446599A (zh) * | 2015-08-11 | 2017-02-22 | 中国科学院青岛生物能源与过程研究所 | 一种筛选婴幼儿龋病的口腔致病性生物标记物的方法 |
| CN106990057A (zh) * | 2017-05-05 | 2017-07-28 | 贵州普洛迈德生物工程有限公司 | 一种检测5‑羟吲哚乙酸试剂及制备方法 |
| CN105687225B (zh) * | 2016-02-26 | 2018-07-06 | 四川好医生攀西药业有限责任公司 | 一种治疗肠易激综合征的药物组合物及其制备方法和应用 |
| CN109716134A (zh) * | 2016-03-24 | 2019-05-03 | 莫洛克有限公司 | 败血症的检测 |
| CN111784683A (zh) * | 2020-07-10 | 2020-10-16 | 天津大学 | 病理切片检测方法及装置、计算机设备及存储介质 |
| US10817778B2 (en) | 2016-06-27 | 2020-10-27 | International Business Machines Corporation | Customized cooking utilizing deep learning neuromorphic computing of hyperspectral input |
| CN111905111A (zh) * | 2020-09-16 | 2020-11-10 | 地奥集团成都药业股份有限公司 | 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法 |
| CN112921100A (zh) * | 2019-12-06 | 2021-06-08 | 宁波海尔施基因科技有限公司 | 一种检测人类压力敏感度基因型的试剂盒和方法 |
| CN114599382A (zh) * | 2019-10-17 | 2022-06-07 | 哥本哈根大学 | Tacr2的激动剂 |
| CN115328117A (zh) * | 2022-07-15 | 2022-11-11 | 大理大学 | 基于强化学习的蛋白质动态配体通道最优路径分析方法 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5857503B2 (ja) * | 2010-07-29 | 2016-02-10 | 小野薬品工業株式会社 | ストレス性疾患のバイオマーカー |
| WO2012158831A1 (en) | 2011-05-16 | 2012-11-22 | Prometheus Laboratories Inc. | Performance of a biomarker panel for irritable bowel syndrome |
| NZ702643A (en) * | 2012-05-19 | 2016-06-24 | Falk Pharma Gmbh | Compositions and methods for treatment of irritable bowel syndrome with 5-aminosalicylate |
| WO2014082034A1 (en) * | 2012-11-26 | 2014-05-30 | Lexicon Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome |
| EP3800470A1 (en) * | 2013-03-15 | 2021-04-07 | Sera Prognostics, Inc. | Biomarkers and methods for predicting preterm birth |
| GB201305708D0 (en) * | 2013-03-28 | 2013-05-15 | Clasado Inc | Novel use |
| RU2015155552A (ru) * | 2013-05-24 | 2017-06-27 | Нестек С.А. | Путеспецифические способы прогнозирования диагноза синдрома раздраженного кишечника |
| CA2930330A1 (en) * | 2013-12-27 | 2015-07-02 | Dignity Health | Diagnosing and treating alzheimer's disease |
| JP6713723B2 (ja) * | 2014-02-18 | 2020-06-24 | 小野薬品工業株式会社 | 過敏性腸症候群の診断用バイオマーカー |
| US10392665B2 (en) | 2015-06-19 | 2019-08-27 | Sera Prognostics, Inc. | Biomarker pairs for predicting preterm birth |
| AU2017325986B2 (en) * | 2016-09-16 | 2023-12-14 | Takeda Pharmaceutical Company Limited | Metabolite biomarkers for diseases associated with the contact activation system |
| RU2668496C2 (ru) * | 2017-03-16 | 2018-10-01 | Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр Департамента здравоохранения города Москвы | Способ диагностики тяжести течения синдрома раздраженного кишечника |
| US11662351B2 (en) | 2017-08-18 | 2023-05-30 | Sera Prognostics, Inc. | Pregnancy clock proteins for predicting due date and time to birth |
| US11488699B1 (en) | 2018-12-09 | 2022-11-01 | Cerner Innovation, Inc. | Microbiota activity sensor and decision support tool |
| US11842795B1 (en) * | 2018-12-17 | 2023-12-12 | Cerner Innovation, Inc. | Irritable bowel syndrome diagnostic sensor and decision support tool |
| KR102330639B1 (ko) * | 2019-01-18 | 2021-11-24 | 주식회사 천랩 | 과민성대장증후군 특이적 미생물 바이오마커와 이를 이용하여 과민성대장증후군의 위험도를 예측하는 방법 |
| US20220146527A1 (en) * | 2019-09-17 | 2022-05-12 | Chang Gung University | Method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying features of microorganisms |
| EP3913371A1 (en) * | 2020-05-18 | 2021-11-24 | Neuroimmun GmbH | Method and kit for diagnosting irritable bowel syndrome and for its relief through dietary interventions |
| US20220208375A1 (en) * | 2020-12-29 | 2022-06-30 | Kpn Innovations, Llc. | System and method for generating a digestive disease functional program |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303617B1 (en) * | 1998-05-04 | 2001-10-16 | Neotherapeutics, Inc. | Serotonin-like 9-substituted hypoxanthine and methods of use |
| WO2002020841A2 (en) * | 2000-09-06 | 2002-03-14 | Glaxo Group Limited | 5-hydroxytryptamine receptor gene polymorphisms and response to treatment |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2778685B1 (en) * | 2009-06-25 | 2017-04-26 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
-
2010
- 2010-10-29 EP EP10827556.1A patent/EP2494074A4/en not_active Withdrawn
- 2010-10-29 CA CA2778539A patent/CA2778539A1/en not_active Abandoned
- 2010-10-29 JP JP2012537132A patent/JP2013509593A/ja not_active Withdrawn
- 2010-10-29 MX MX2012005015A patent/MX2012005015A/es unknown
- 2010-10-29 CN CN2010800605536A patent/CN102712956A/zh active Pending
- 2010-10-29 WO PCT/US2010/054810 patent/WO2011053831A1/en not_active Ceased
- 2010-10-29 RU RU2012122180/15A patent/RU2012122180A/ru unknown
- 2010-10-29 PH PH1/2012/500850A patent/PH12012500850A1/en unknown
- 2010-10-29 KR KR1020127013948A patent/KR20120101038A/ko not_active Withdrawn
- 2010-10-29 BR BR112012010108A patent/BR112012010108A2/pt not_active IP Right Cessation
- 2010-10-29 AU AU2010313292A patent/AU2010313292A1/en not_active Abandoned
-
2012
- 2012-04-06 US US13/441,658 patent/US20120315630A1/en not_active Abandoned
- 2012-04-19 IL IL219317A patent/IL219317A0/en unknown
- 2012-05-22 ZA ZA2012/03718A patent/ZA201203718B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303617B1 (en) * | 1998-05-04 | 2001-10-16 | Neotherapeutics, Inc. | Serotonin-like 9-substituted hypoxanthine and methods of use |
| WO2002020841A2 (en) * | 2000-09-06 | 2002-03-14 | Glaxo Group Limited | 5-hydroxytryptamine receptor gene polymorphisms and response to treatment |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
Non-Patent Citations (10)
| Title |
|---|
| HEATHER L., ET AL.: "Stress Impairs Murine Intestinal Barrier Function: Improvement by Glucagon-Like Peptide-2", 《THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》, vol. 314, no. 1, 31 July 2005 (2005-07-31), pages 214 - 220 * |
| I POSSERUD, ET AL.: "Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress", 《GUT》, vol. 53, no. 8, 31 August 2004 (2004-08-31), pages 1102 - 1108 * |
| I. JILL KAROLYI, ET AL.: "Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice", 《PROC. NATL. ACAD. SCI. USA》, vol. 96, 30 September 1999 (1999-09-30), pages 11595 - 11600 * |
| JORG M. LAUFFER, ET AL.: "Biological relevance of pituitary adenylate cyclase-activating polypeptide (PACAP) in the gastrointestinal tract", 《REGULATORY PEPTIDES》, vol. 84, no. 13, 31 October 1999 (1999-10-31), pages 1 - 12 * |
| M SIMRÉN, ET AL.: "An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome", 《GUT》, vol. 48, no. 1, 31 January 2001 (2001-01-31), pages 20 - 27 * |
| M. D. GERSHON,ET AL.: "RADIOISOTOPIC STUDIES OF THE BINDING, EXCHANGE, AND DISTRIBUTION OF 5-HYDROXYTRYPTAMINE SYNTHESIZED FROM ITS RADIOACTIVE PRECURSOR", 《J. PHYSIOL.》, vol. 186, no. 2, 31 October 1966 (1966-10-31), pages 451 - 476 * |
| SIMON P. DUNLOP, ET AL.: "Abnormalities of 5-Hydroxytryptamine Metabolism in Irritable Bowel Syndrome", 《CLINICAL GASTROENTEROLOGY AND HEPATOLOGY》, vol. 3, no. 4, 30 April 2005 (2005-04-30), pages 349 - 357, XP005120725, DOI: doi:10.1016/S1542-3565(04)00726-8 * |
| T O C KILKENS, ET AL.: "Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls", 《GUT》, vol. 53, no. 12, 31 December 2004 (2004-12-31), pages 1794 - 1800 * |
| Y. TACHE´ ,ET AL.: "CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications alterations of colonic function and viscerosensitivity: implications", 《BRITISH JOURNAL OF PHARMACOLOGY》, vol. 141, no. 8, 30 April 2004 (2004-04-30), pages 1321 - 1330 * |
| YOSHIKO KISHMOTO, ET AL.: "Synthesis and Properties of Serotonin O-Sulfate", 《THE JOURNAL OF BIOCHEMISTRY》, vol. 49, no. 5, 31 May 1961 (1961-05-31), pages 436 - 440 * |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104884959A (zh) * | 2012-10-05 | 2015-09-02 | 雀巢产品技术援助有限公司 | 作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物 |
| CN104884959B (zh) * | 2012-10-05 | 2017-12-01 | 雀巢产品技术援助有限公司 | 作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物 |
| CN103175971B (zh) * | 2013-02-28 | 2016-10-05 | 苏州和锐医药科技有限公司 | 一种IgA抗体检测试剂盒 |
| CN103175971A (zh) * | 2013-02-28 | 2013-06-26 | 苏州和锐医药科技有限公司 | 一种IgA抗体检测试剂盒 |
| CN106446599A (zh) * | 2015-08-11 | 2017-02-22 | 中国科学院青岛生物能源与过程研究所 | 一种筛选婴幼儿龋病的口腔致病性生物标记物的方法 |
| CN105687225B (zh) * | 2016-02-26 | 2018-07-06 | 四川好医生攀西药业有限责任公司 | 一种治疗肠易激综合征的药物组合物及其制备方法和应用 |
| CN109716134A (zh) * | 2016-03-24 | 2019-05-03 | 莫洛克有限公司 | 败血症的检测 |
| CN109716134B (zh) * | 2016-03-24 | 2022-12-02 | 莫洛迪克有限公司 | 败血症的检测 |
| US10817778B2 (en) | 2016-06-27 | 2020-10-27 | International Business Machines Corporation | Customized cooking utilizing deep learning neuromorphic computing of hyperspectral input |
| CN106990057A (zh) * | 2017-05-05 | 2017-07-28 | 贵州普洛迈德生物工程有限公司 | 一种检测5‑羟吲哚乙酸试剂及制备方法 |
| CN114599382A (zh) * | 2019-10-17 | 2022-06-07 | 哥本哈根大学 | Tacr2的激动剂 |
| CN112921100A (zh) * | 2019-12-06 | 2021-06-08 | 宁波海尔施基因科技有限公司 | 一种检测人类压力敏感度基因型的试剂盒和方法 |
| CN111784683A (zh) * | 2020-07-10 | 2020-10-16 | 天津大学 | 病理切片检测方法及装置、计算机设备及存储介质 |
| CN111784683B (zh) * | 2020-07-10 | 2022-05-17 | 天津大学 | 病理切片检测方法及装置、计算机设备及存储介质 |
| CN111905111A (zh) * | 2020-09-16 | 2020-11-10 | 地奥集团成都药业股份有限公司 | 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法 |
| CN111905111B (zh) * | 2020-09-16 | 2023-03-31 | 地奥集团成都药业股份有限公司 | 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法 |
| CN115328117A (zh) * | 2022-07-15 | 2022-11-11 | 大理大学 | 基于强化学习的蛋白质动态配体通道最优路径分析方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20120315630A1 (en) | 2012-12-13 |
| ZA201203718B (en) | 2014-11-26 |
| RU2012122180A (ru) | 2013-12-10 |
| MX2012005015A (es) | 2012-06-12 |
| IL219317A0 (en) | 2012-06-28 |
| PH12012500850A1 (en) | 2013-01-07 |
| JP2013509593A (ja) | 2013-03-14 |
| CA2778539A1 (en) | 2011-05-05 |
| AU2010313292A1 (en) | 2012-06-07 |
| EP2494074A4 (en) | 2013-06-12 |
| KR20120101038A (ko) | 2012-09-12 |
| BR112012010108A2 (pt) | 2016-05-31 |
| WO2011053831A1 (en) | 2011-05-05 |
| EP2494074A1 (en) | 2012-09-05 |
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| JP5571951B2 (ja) | 試料が過敏性腸症候群と関連するか否かを決定する分類方法 | |
| JP6634544B2 (ja) | 過敏性腸症候群の診断方法 | |
| EP2710383B1 (en) | Performance of a biomarker panel for irritable bowel syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: NESTLE PRODUCTS TECHNICAL ASSISTANCE CO., LTD. Free format text: FORMER OWNER: PROMETHEUS LAB INC. Effective date: 20121012 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20121012 Address after: Vevey Applicant after: Nestle Products Technical Assistance Co., Ltd. Address before: American California Applicant before: Prometheus Lab Inc. |
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Application publication date: 20121003 |