CN102712641B - Mk2抑制剂 - Google Patents

Mk2抑制剂 Download PDF

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Publication number
CN102712641B
CN102712641B CN201080056801.XA CN201080056801A CN102712641B CN 102712641 B CN102712641 B CN 102712641B CN 201080056801 A CN201080056801 A CN 201080056801A CN 102712641 B CN102712641 B CN 102712641B
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China
Prior art keywords
pyrrolo
pyridine
piperidine
base
compound
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Expired - Fee Related
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CN201080056801.XA
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English (en)
Chinese (zh)
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CN102712641A (zh
Inventor
T.A.巴夫
A.欧布里
C.舒尔茨－费登雷希特
E.W.斯瓦特
N.胡根布姆
S.M.德维尔德
A.卡普泰因
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Organic Agricultural Biological Sciences Holland Co ltd
Merck Sharp and Dohme BV
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Merck Sharp and Dohme BV
Organon NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Toxicology (AREA)
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CN201080056801.XA 2009-12-14 2010-12-13 Mk2抑制剂 Expired - Fee Related CN102712641B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28609109P 2009-12-14 2009-12-14
US61/286091 2009-12-14
EP09179043 2009-12-14
EP09179043.6 2009-12-14
PCT/EP2010/069465 WO2011073119A1 (en) 2009-12-14 2010-12-13 Mk2 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510037679.6A Division CN104710423A (zh) 2009-12-14 2010-12-13 Mk2抑制剂

Publications (2)

Publication Number Publication Date
CN102712641A CN102712641A (zh) 2012-10-03
CN102712641B true CN102712641B (zh) 2015-12-09

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201080056801.XA Expired - Fee Related CN102712641B (zh) 2009-12-14 2010-12-13 Mk2抑制剂
CN201510037679.6A Pending CN104710423A (zh) 2009-12-14 2010-12-13 Mk2抑制剂

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Application Number Title Priority Date Filing Date
CN201510037679.6A Pending CN104710423A (zh) 2009-12-14 2010-12-13 Mk2抑制剂

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US (3) US8772286B2 (enExample)
EP (1) EP2513111B1 (enExample)
JP (2) JP5859454B2 (enExample)
KR (1) KR20120104241A (enExample)
CN (2) CN102712641B (enExample)
AU (1) AU2010333024B2 (enExample)
BR (1) BR112012013199A8 (enExample)
CA (1) CA2780290C (enExample)
HK (1) HK1210159A1 (enExample)
IN (1) IN2012DN04978A (enExample)
MX (1) MX2012006778A (enExample)
RU (1) RU2012129887A (enExample)
WO (1) WO2011073119A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102712641B (zh) * 2009-12-14 2015-12-09 默沙东有限责任公司 Mk2抑制剂
CN102936216B (zh) * 2012-12-05 2015-03-04 南京药石药物研发有限公司 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法
KR20150133172A (ko) 2013-03-15 2015-11-27 셀진 아빌로믹스 리서치, 인코포레이티드 Mk2 억제제 및 이의 용도
CA2950952C (en) 2014-06-10 2023-01-10 Sanford-Burnham Medical Research Institute Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof
CN108794496B (zh) * 2018-04-28 2020-04-24 北京施安泰医药技术开发有限公司 一类cdk抑制剂、其药物组合物、制备方法及用途
EP3820567A1 (en) * 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
CN114105834B (zh) * 2022-01-26 2023-04-25 寿光诺盟化工有限公司 一种n,n,n,n-四烯丙基氧代双苯磺酰胺的制备方法
TW202440577A (zh) * 2022-12-11 2024-10-16 大陸商江蘇豪森藥業集團有限公司 哌啶酮衍生物、其製備方法及其醫藥用途

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2005013986A1 (en) * 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyridylpyrrole derivatives active as kinase inhibitors
WO2005014572A1 (en) * 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyrimidylpyrrole derivatives active as kinase inhibitors
WO2009010488A1 (en) * 2007-07-16 2009-01-22 Novartis Ag Heterocyclic compounds useful as mk2 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003301226A1 (en) * 2002-12-20 2004-07-22 Pharmacia Corp Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2
MY167260A (en) * 2005-11-01 2018-08-14 Targegen Inc Bi-aryl meta-pyrimidine inhibitors of kinases
CN102712641B (zh) * 2009-12-14 2015-12-09 默沙东有限责任公司 Mk2抑制剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005013986A1 (en) * 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyridylpyrrole derivatives active as kinase inhibitors
WO2005014572A1 (en) * 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyrimidylpyrrole derivatives active as kinase inhibitors
WO2009010488A1 (en) * 2007-07-16 2009-01-22 Novartis Ag Heterocyclic compounds useful as mk2 inhibitors

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CN102712641A (zh) 2012-10-03
EP2513111A1 (en) 2012-10-24
US9102676B2 (en) 2015-08-11
IN2012DN04978A (enExample) 2015-09-25
AU2010333024B2 (en) 2014-09-18
BR112012013199A8 (pt) 2018-01-02
JP2013513585A (ja) 2013-04-22
WO2011073119A1 (en) 2011-06-23
MX2012006778A (es) 2012-07-23
CA2780290A1 (en) 2011-06-23
KR20120104241A (ko) 2012-09-20
US20160159800A1 (en) 2016-06-09
EP2513111B1 (en) 2013-10-02
CA2780290C (en) 2018-01-02
US8772286B2 (en) 2014-07-08
US20120245175A1 (en) 2012-09-27
CN104710423A (zh) 2015-06-17
JP2016128412A (ja) 2016-07-14
RU2012129887A (ru) 2014-01-27
US20140288109A1 (en) 2014-09-25
JP5859454B2 (ja) 2016-02-10
BR112012013199A2 (pt) 2016-03-01
HK1210159A1 (en) 2016-04-15
AU2010333024A1 (en) 2012-06-14

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