CN102696654A - Composition having antiviral action, pesticide and application thereof - Google Patents
Composition having antiviral action, pesticide and application thereof Download PDFInfo
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- CN102696654A CN102696654A CN2012101748415A CN201210174841A CN102696654A CN 102696654 A CN102696654 A CN 102696654A CN 2012101748415 A CN2012101748415 A CN 2012101748415A CN 201210174841 A CN201210174841 A CN 201210174841A CN 102696654 A CN102696654 A CN 102696654A
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- moroxydine hydrochloride
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- nonylphenolsulfonate copper
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- BITDLWAQPKSXTF-UHFFFAOYSA-M 1-[(3-nitrophenyl)methoxymethyl]pyridin-1-ium;chloride Chemical compound [Cl-].[O-][N+](=O)C1=CC=CC(COC[N+]=2C=CC=CC=2)=C1 BITDLWAQPKSXTF-UHFFFAOYSA-M 0.000 claims abstract description 40
- 229960002581 moroxydine hydrochloride Drugs 0.000 claims abstract description 40
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 34
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a composition having an antiviral action, a pesticide and application thereof. The composition is prepared from moroxydine hydrochloride and nonylphenolsulfonate copper in a weight ratio of 1:50-50:1, preferably 1:25-25:1. As for the control of cucumber mosaic viruses, tobacco mosaic viruses, pepper mosaic viruses and tomato mosaic viruses, the pesticide consists of the composition serving as an active ingredient and pesticide acceptable auxiliary materials has a good effect compared with the single preparation of moroxydine hydrochloride and the single preparation of nonylphenolsulfonate copper; furthermore, the pesticide has an obvious synergetic action, and can delay the generation of drug resistance, pesticide consumption is reduced, and cost is lowered; and moreover, the application range of pesticide is widened, and the pesticide has obvious promotional value.
Description
Technical field
The present invention relates to a kind of composition with antiviral function, the antiviral composition of particularly forming by Moroxydine Hydrochloride and nonylphenolsulfonate copper, and be the corresponding agricultural chemicals of active ingredient and the application in crop disease control with the said composition.
Background technology
(Tobaccomosaicvirus TMV) all can take place in product cigarette district tobacco mosaic virus, and the incidence of disease generally can be 5 ~ 20%, and the cigarette strain of its contiguous field piece often keeps healthy and strong.The seedling phase infects or the land for growing field crops initial stage infects, and loss can reach 30 ~ 50%, but the later infection of buddingging is not remarkable to yield effect.Sick leaf irregular colour after modulating is even, jealous relatively poor, and quality descends.The sick whole growing of tobacco mosaic viruses all can take place, and after the cigarette strain is susceptible, shows as whole strain systemic symptom.Under high temperature high light condition, just show symptom in 5 ~ 7 days.The TMV host range is wide, except that tobacco, and the solanaceous crops such as tomato, potato, eggplant, capsicum, black nightshade in addition of often being encroached under field conditions (factors), host range can reach 350 various plants.
Pepper virus disease also has serious harmfulness, the lighter's underproduction 20-30%, and loss 50-60% when serious is the important disease in the cultivation of sweet (peppery) green pepper.Sweet (peppery) green pepper virus disease is mainly caused by cucumber mosaic virus and tobacco mosaic virus.The host of cucumber mosaic virus is very extensive, comprising many vegetable crops, is mainly propagated by aphid (the red aphid of beech etc.).Tobacco mosaic virus can be in the residual branch of the diseased plant of drying long term survival, also can infect via the juice contact transmission by kind of a subband poison.Usually high temperature and drought, during the aphid serious harm cucumber mosaic virus harm also serious, continuous cropping for many years, low-lying land, fertilizer deficiency or use the fertilizer that does not become thoroughly decomposed all can increase the weight of the harm of tobacco mosaic virus.
Due to the cucumber virus disease is mainly infected by cucumber mosaic virus (CMV), tobacco mosaic virus (TMV) and pumpkin mosaic virus.Virus is retained in field wintering with perennial perennial root plant with diseased plant remnant tissue; Also can survive the winter by kind of a subband poison.Virus mainly through being transmitted on the host plant through seed, juice friction, the malicious vector insect of biography and the operation of field farming, repeatedly infects again.The environment of virus happiness high temperature and drought, the righttest onset environment temperature is 20～25 ℃, relative moisture about 80%; The righttest illness performance phase is for becoming the strain fruiting period.15～25 days incubation periods of morbidity.In high temperature and little rainfall, it is heavy that aphid, Trialeurodes vaporariorum Westwood, thrips etc. pass the time morbidity of the big generation of malicious vector insect.The field piece morbidity that control media insect is untimely, rich water is not enough, field management is extensive is heavy.
Moroxydine Hydrochloride is the agent for prevention and control of virus of a kind of wide spectrum, low toxicity, and structural formula is shown in (I).After soup after the dilution sprayed application to plant leaf surface, medicament can get in the plant corpus through the aqueous vapor hole, suppresses or destroy the formation of nucleic acid and lipoprotein, stops the reproduction process of virus, plays the effect of control virus.But the agent of Moroxydine Hydrochloride list causes pathogen that it has been produced resistance owing to use in a large number the lasting for many years of field, and preventive effect has very big decline, and it does not have good therapeutic action to the plant that has fallen ill.
Nonylphenolsulfonate copper belongs to organic copper sterilization of phenyl ring class and agent for prevention and control of virus, and structural formula is shown in (II).Nonyl phenol group in its structure is therapeutic agent efficiently in plant corpus; But copper ion is both sterilizations then, have antiviral effect again.Because large usage quantity when the agent of nonylphenolsulfonate copper list is used in the field is easy to generate poisoning, therefore crop there is certain security risks.
Summary of the invention
To above-mentioned situation, the invention provides a kind of composition, and be the corresponding agricultural chemicals of active ingredient and the application in crop disease control with the said composition with antiviral function.
The present invention has the composition of antiviral function, is 1 by Moroxydine Hydrochloride and nonylphenolsulfonate copper with part by weight
:50 ~ 50
:1 forms.The further preferred weight proportion of composing of Moroxydine Hydrochloride and nonylphenolsulfonate copper is 1
:25 ~ 25
:1.
With above-mentioned composition is active ingredient, with acceptable auxiliary element in the agricultural chemicals, can form corresponding antiviral agricultural chemicals jointly.Wherein, said auxiliary element comprises at present existing report and the/usual auxiliaries used, and like excipient such as dispersant, diffusant, antifoaming agent, wetting agent, emulsifier.Said preparation method and technology and conventional pesticide preparation technology are as good as, and do not have special requirement and restriction.
In the above-mentioned agricultural chemicals of the present invention, be preferably the agricultural chemicals of aqueous emulsion or microemulsion form.Wherein:
Aqueous emulsion (Ew) is the former medicine of liquid pesticidal that makes with liquid or with solvent is scattered in the preparation in the water with 0.5 ~ 1.5 micron droplet, and outward appearance is a milky milk shape liquid;
Microemulsion (ME) is made up of liquid pesticide, surfactant, water, stabilizing agent etc.Characteristics are to be medium with water, do not contain or contain organic solvent less, thereby do not fire not quick-fried, production operation, storing is safe, low in the pollution of the environment; Save a large amount of organic solvents, the agricultural chemicals dispersity is high, reaches the miniaturization degree; The agricultural chemicals particle is generally 0.1 ~ 0.01 micron, and outward appearance is similar to transparent or sub-translucent liquid.It is good dispersion in water, the application of the good described bactericidal composition of, adhesive force strong to the target body permeability aspect crop pests such as control vegetables, tobacco.
Result of the test shows, antiviral composition that the present invention is above-mentioned and corresponding agricultural chemicals are through Moroxydine Hydrochloride and two kinds of active ingredients of the nonylphenolsulfonate copper different effects mechanism and mode of action to the disease microorganism; Be used for comprising cucumber virus disease, tobacco virus, pepper virus disease is in the control of the viral diseases of crop such as tomato virus disease; Can have remarkable role in synergy; Can effectively reduce the wherein amount of application of each composition list agent, help delaying the drug-fast generation of plant, prolong the lasting period; The expanding prevention range of application has tangible promotional value.
Below again foregoing of the present invention is done further to specify through the embodiment of embodiment.But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following instance.Do not breaking away under the above-mentioned technological thought situation of the present invention, various replacements or change according to ordinary skill knowledge and customary means are made all should comprise within the scope of the invention.
Embodiment
Embodiment 1: 51% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form (w%, as follows): Moroxydine Hydrochloride 1,
Nonylphenolsulfonate copper 50,
AEO 13,
Si Pan-80 4.5,
Ethylene glycol 5,
The water complementary.
Preparation: in a usual manner, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 2: 51% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form: Moroxydine Hydrochloride 50,
Nonylphenolsulfonate copper 1,
Calcium dodecyl benzene sulfonate 12,
APES 4,
Ethylene glycol 5,
Propylene glycol monomethyl ether 2,
The water complementary.
Preparation: with conventional method, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 3: 24% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone aqueous emulsion
Form: Moroxydine Hydrochloride 4,
Nonylphenolsulfonate copper 20,
Si Pan-80 5.5,
AEO 3.0,
Alkyl phenol polyether phosphate 1.5,
Ethylene glycol 5.0,
Xanthans 0.3,
The water complementary.
Preparation: press usual manner, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stir and use high shear dispersion machine shearing 30min after mixing get final product.
Embodiment 4: 26% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form: Moroxydine Hydrochloride 1,
Nonylphenolsulfonate copper 25,,
AEO 10,
DBSA amine 4.5,
Ethylene glycol 5,
The water complementary.
Preparation: with conventional method, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 5: 24% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form: Moroxydine Hydrochloride 20,
Nonylphenolsulfonate copper 4,
AEO 1,
DBSA amine 15,
Ethylene glycol 5,
The water complementary.
Preparation: with conventional method, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 6: 26% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone aqueous emulsion
Form: Moroxydine Hydrochloride 25,
Nonylphenolsulfonate copper 1,
Phosphate polyethers 5,
Alkyl phenol polyether class 2,
Ethylene glycol 6,
XG 0.25，
Silicone defoaming agent 0.6,
The water complementary.
Preparation: press usual manner, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stir and use high shear dispersion machine shearing 30min after mixing get final product.
Embodiment 7: 26% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone aqueous emulsion
Form: Moroxydine Hydrochloride 10,
Nonylphenolsulfonate copper 10,
Phosphate APEO 3,
Alkyl phenol polyether 2,
Si Pan-80 6,
Ethylene glycol 6,
The water complementary.
Preparation: press usual manner, with Moroxydine Hydrochloride water-soluble after, add surfactant, nonylphenolsulfonate copper stir and use high shear dispersion machine shearing 30min after mixing get final product.
With following Toxicity Determination and the field trial that the above embodiments are carried out, proved to have remarkable role in synergy and preventive effect.
One, Toxicity Determination test:
1, supplies the examination pathogen: tobacco virus.
2, test method: adopt the live body pot-culture method, each handles repetition 10 times, 7d " Invest, Then Investigate ".Wherein, co-toxicity coefficient (CTC)>=120 expression has synergistic effect; 80＜CTC＜120 expression summation actions; CTC≤80 expressions have antagonism.Experimental result is as shown in table 1.
The composite Toxicity Determination of table 1 Moroxydine Hydrochloride and nonylphenolsulfonate copper to tobacco virus
| Supply the reagent agent | EC 50 | Regression equation | CTC |
| Moroxydine Hydrochloride (A) | 43.1543 | Y=4.1058+0.5469x | — |
| Nonylphenolsulfonate copper (B) | 31.1819 | Y=3.8774+0.7154x | — |
| (A :B) 50:1 | 28.0061 | Y=3.9194+0.7446x | 152.93 |
| 25:1 | 20.4707 | Y=3.9127+0.7642x | 190.65 |
| 5:1 | 18.8486 | Y=3.9796+0.7408x | 199.06 |
| 1:1 | 17.3364 | Y=4.1689+0.6708x | 208.83 |
| 1:5 | 14.7461 | Y=4.2487+0.6428x | 221.70 |
| 1:25 | 13.7962 | Y=42569+0.6520x | 228.45 |
| 1:50 | 17.2508 | Y=4.2854+0.5778x | 151.74 |
The Toxicity Determination result of table 1 shows that composition of the present invention has very obvious synergistic effect to tobacco virus, and what effect was superior to Moroxydine Hydrochloride or nonylphenolsulfonate copper two compositions singly uses effect.
Two, control pepper virus disease test:
1, test is handled: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established three concentration of treatment respectively according to the difference of each composition.
2, test method: each sub-district area is 50m
2, repeating 4 times, the inspection drug effect method before the dispenser after investigation and the control is: every sub-district diagonal is got a little, and every is extracted 10 strains investigation, and the disease grade scale is following:
0 grade: whole strain is anosis;
1 grade: bright arteries and veins, light floral leaf;
3 grades: lobus cardiacus and middle leaf sheet floral leaf;
5 grades: lobus cardiacus and middle leaf sheet floral leaf, minority leaf malformation, shrinkage or plant are slightly downgraded;
7 grades: heavy floral leaf, most leaf malformation, shrinkage or plant are downgraded;
9 grades: heavy floral leaf, blade obviously deformity, line leaf, plant are seriously downgraded, even dead.
Result of the test is seen table 2.
The field efficacy result of
table 2 shows; Agricultural chemicals of the present invention has good control efficiency to pepper virus disease, and control efficiency is better than single agent kind.
Three, control potato virus disease test:
1, test is handled: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively 25% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each sub-district area is 50m
2, repeating 4 times, the inspection drug effect method before the dispenser after investigation and the control is: every sub-district diagonal is got a little, and every is extracted the investigation of 10 strain fixed point location, and result of the test is seen table 3.
The field efficacy result of table 3 shows that Moroxydine Hydrochloride and nonylphenolsulfonate copper composition also have good control efficiency to potato virus disease, and control efficiency is better than single agent kind.
Four, control tobacco virus test:
1, test is handled: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively commercially available agricultural chemicals 25% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each sub-district area is 50m
2, repeating 4 times, the inspection drug effect method before the dispenser after investigation and the control is: diagonal sampling in every sub-district whenever clicks 10 strains.Result of the test is seen table 4.
Table 4 field efficacy is the result show, agricultural chemicals of the present invention also has good control efficiency to the eggplant virus disease, and control efficiency is better than single agent kind.
Five, control cucumber virus disease test:
1, test is handled: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively 20% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each sub-district area is 50m
2, repeating 4 times, the inspection drug effect method before the dispenser after investigation and the control is: diagonal sampling in every sub-district whenever clicks 10 strains.Result of the test is seen table 5.
Table 5 field efficacy is the result show, Moroxydine Hydrochloride and nonylphenolsulfonate copper composition also have good control efficiency to the cucumber virus disease, and control efficiency is better than single agent kind.
Six, the pesticidal preparations control tomato virus disease test that makes with the foregoing description:
1, test is handled: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively 20% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each sub-district area is 50m
2, repeating 4 times, the inspection drug effect method before the dispenser after investigation and the control is: diagonal sampling in every sub-district whenever clicks 10 strains.Result of the test is seen table 6.
The field efficacy result of table 6 shows that agricultural chemicals of the present invention also has good control efficiency to tomato virus disease, and control efficiency is better than single agent kind.
Claims (5)
1. the composition that has antiviral function is 1 by Moroxydine Hydrochloride and nonylphenolsulfonate copper with part by weight
:50 ~ 50
:1 forms.
2. composition as claimed in claim 1, the part by weight that it is characterized in that said Moroxydine Hydrochloride and nonylphenolsulfonate copper is 1
:25 ~ 25
:1.
3. the agricultural chemicals that has antiviral function is characterized in that the composition with claim 1 or 2 is an active ingredient, forms jointly with acceptable auxiliary element in the agricultural chemicals.
4. antiviral agricultural chemicals as claimed in claim 3 is characterized in that the agricultural chemicals for aqueous emulsion or microemulsion form.
5. preventing and treating cucumber virus disease, tobacco virus, pepper virus disease, the application of tomato virus disease aspect like the composition or the agricultural chemicals of one of claim 1 to 4.
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| CN 201210174841 CN102696654B (en) | 2012-05-31 | 2012-05-31 | Composition having antiviral action, pesticide and application thereof |
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|---|---|---|---|
| CN 201210174841 CN102696654B (en) | 2012-05-31 | 2012-05-31 | Composition having antiviral action, pesticide and application thereof |
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| CN102696654A true CN102696654A (en) | 2012-10-03 |
| CN102696654B CN102696654B (en) | 2013-10-30 |
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| CN (1) | CN102696654B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109964958A (en) * | 2019-03-14 | 2019-07-05 | 江苏辉丰生物农业股份有限公司 | A kind of microbicide compositions |
| CN110627572A (en) * | 2019-11-01 | 2019-12-31 | 新疆农业大学 | Pesticide fertilizer for preventing diseases and promoting growth of cotton and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993633A (en) * | 2017-05-15 | 2017-08-01 | 杨新兰 | A kind of sterilization synergistic composition for being applied to preventing and treating tomato virus disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101870747A (en) * | 2010-05-28 | 2010-10-27 | 北京欧凯纳斯科技有限公司 | Heavy metal chelate resin, preparation method thereof and use thereof |
| CN101899002A (en) * | 2010-07-22 | 2010-12-01 | 浙江海正化工股份有限公司 | Method for preparing oxine copper, and product of oxine copper |
| CN102217638A (en) * | 2011-04-27 | 2011-10-19 | 成都科利隆生化有限公司 | Pesticide composition for preventing and treating plant virus diseases |
-
2012
- 2012-05-31 CN CN 201210174841 patent/CN102696654B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101870747A (en) * | 2010-05-28 | 2010-10-27 | 北京欧凯纳斯科技有限公司 | Heavy metal chelate resin, preparation method thereof and use thereof |
| CN101899002A (en) * | 2010-07-22 | 2010-12-01 | 浙江海正化工股份有限公司 | Method for preparing oxine copper, and product of oxine copper |
| CN102217638A (en) * | 2011-04-27 | 2011-10-19 | 成都科利隆生化有限公司 | Pesticide composition for preventing and treating plant virus diseases |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109964958A (en) * | 2019-03-14 | 2019-07-05 | 江苏辉丰生物农业股份有限公司 | A kind of microbicide compositions |
| CN110627572A (en) * | 2019-11-01 | 2019-12-31 | 新疆农业大学 | Pesticide fertilizer for preventing diseases and promoting growth of cotton and preparation method thereof |
| CN110627572B (en) * | 2019-11-01 | 2023-03-14 | 新疆农业大学 | Pesticide fertilizer for preventing diseases and promoting growth of cotton and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN102696654B (en) | 2013-10-30 |
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