CN102696654B - Composition having antiviral action, pesticide and application thereof - Google Patents
Composition having antiviral action, pesticide and application thereof Download PDFInfo
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- CN102696654B CN102696654B CN 201210174841 CN201210174841A CN102696654B CN 102696654 B CN102696654 B CN 102696654B CN 201210174841 CN201210174841 CN 201210174841 CN 201210174841 A CN201210174841 A CN 201210174841A CN 102696654 B CN102696654 B CN 102696654B
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Abstract
The invention provides a composition having an antiviral action, a pesticide and application thereof. The composition is prepared from moroxydine hydrochloride and nonylphenolsulfonate copper in a weight ratio of 1:50-50:1, preferably 1:25-25:1. As for the control of cucumber mosaic viruses, tobacco mosaic viruses, pepper mosaic viruses and tomato mosaic viruses, the pesticide consists of the composition serving as an active ingredient and pesticide acceptable auxiliary materials has a good effect compared with the single preparation of moroxydine hydrochloride and the single preparation of nonylphenolsulfonate copper; furthermore, the pesticide has an obvious synergetic action, and can delay the generation of drug resistance, pesticide consumption is reduced, and cost is lowered; and moreover, the application range of pesticide is widened, and the pesticide has obvious promotional value.
Description
Technical field
The present invention relates to a kind of composition with antiviral functions, the antiviral composition that is particularly formed by Moroxydine Hydrochloride and nonylphenolsulfonate copper, and the corresponding agricultural chemicals take said composition as active ingredient and the application in crop disease control.
Background technology
Tobacco mosaic virus (Tobaccomosaicvirus, TMV) all can occur in product cigarette district, and the incidence of disease generally can be 5 ~ 20%, and the cigarette strain of its contiguous field often keeps healthy and strong.Seedling Stage infects or the land for growing field crops treating initial infection, and loss can reach 30 ~ 50%, but the later infection of buddingging is not remarkable to yield effect.Sick leaf irregular colour after modulation is even, jealous relatively poor, and quality descends.Tobacco mosaic viruses all can occur sick whole breeding time, after the cigarette strain is susceptible, shows as whole strain system symptom.Under high temperature high light condition, just show symptom in 5 ~ 7 days.The TMV host range is wide, except tobacco, and the in addition solanaceous crops such as tomato, potato, eggplant, capsicum, black nightshade of often being encroached under field conditions (factors), host range can reach 350 various plants.
Pepper virus disease also has serious harmfulness, the lighter's underproduction 20-30%, and loss 50-60% when serious is the important disease in the cultivation of sweet (peppery) green pepper.Sweet (peppery) green pepper virus disease is mainly caused by cucumber mosaic virus and tobacco mosaic virus.The host of cucumber mosaic virus is very extensive, comprising many vegetable crops, is mainly propagated by aphid (the red aphid of beech etc.).Tobacco mosaic virus can be in the residual branch of the diseased plant of drying long term survival, also can be malicious by seed belt, infect via the juice contact transmission.Usually high temperature and drought, during the aphid serious harm cucumber mosaic virus harm also serious, for many years continuous cropping, low-lying land, fertilizer deficiency or use the fertilizer that does not become thoroughly decomposed all can increase the weight of the harm of tobacco mosaic virus.
Due to the cucumber virus disease is mainly infected by cucumber mosaic virus (CMV), tobacco mosaic virus (TMV) and pumpkin mosaic virus.Virus is retained in field wintering with the perennial root plant with diseased plant remnant tissue; Also can be survived the winter by the seed belt poison.Virus mainly by being transmitted on the host plant by seed, juice friction, the malicious vector insect of biography and the operation of field farming, repeatedly infects again.The environment of virus happiness high temperature and drought, the suitableeest onset environment temperature is 20～25 ℃, relative moisture about 80%; The suitableeest illness performance phase is the strain fruiting period.15～25 days incubation periods of morbidity.In high temperature and little rainfall, it is heavy that aphid, Trialeurodes vaporariorum Westwood, thrips etc. pass the time morbidity of the large generation of malicious vector insect.The field morbidity that control medium insect is untimely, rich water is not enough, field management is extensive is heavy.
Moroxydine Hydrochloride is the agent for prevention and control of virus of a kind of wide spectrum, low toxicity, and structural formula is shown in (I).After liquid after the dilution sprayed application to plant leaf surface, medicament can enter in the plant corpus by the aqueous vapor hole, suppressed or destroy the formation of nucleic acid and lipoprotein, stoped the reproduction process of virus, played the effect of control virus.But the Moroxydine Hydrochloride single dose since the field continue for many years a large amount of the use, cause pathogen that it has been produced resistance, preventive effect has very large decline, and its to the plant that fallen ill without good therapeutic action.
Nonylphenolsulfonate copper belongs to the organic copper sterilization of phenyl ring class and agent for prevention and control of virus, and structural formula is shown in (II).Nonyl phenol group in its structure is efficient therapeutic agent in plant corpus; But copper ion is both sterilizations then, have again antiviral effect.Because large usage quantity when the nonylphenolsulfonate copper single dose is used in the field produces poisoning easily, therefore crop there is certain security risks.
Summary of the invention
For above-mentioned situation, the invention provides a kind of composition with antiviral functions, and the corresponding agricultural chemicals take said composition as active ingredient and the application in crop disease control.
The present invention has the composition of antiviral functions, by Moroxydine Hydrochloride and nonylphenolsulfonate copper take part by weight as 1
:50 ~ 50
:1 forms.The further preferred weight proportion of composing of Moroxydine Hydrochloride and nonylphenolsulfonate copper is 1
:25 ~ 25
:1.
Take above-mentioned composition as active ingredient, with acceptable auxiliary element in the agricultural chemicals, can jointly form corresponding antiviral agricultural chemicals.Wherein, said auxiliary element comprise currently reported and/usual auxiliaries used, and such as excipient such as dispersant, diffusant, defoamer, wetting agent, emulsifier.Said preparation method and technique and conventional pesticide preparation technology are as good as, and there is no special requirement and restriction.
In the above-mentioned agricultural chemicals of the present invention, be preferably the agricultural chemicals of aqueous emulsion or microemulsion form.Wherein:
Aqueous emulsion (Ew) is the former medicine of liquid pesticidal that makes with liquid or with solvent is scattered in preparation in the water with 0.5 ~ 1.5 micron droplet, and outward appearance is milky milk shape liquid;
Microemulsion (ME) is comprised of liquid pesticide, surfactant, water, stabilizing agent etc.Characteristics are take water as medium, do not contain or contain less organic solvent, thereby do not fire not quick-fried, production operation, storing is safe, low in the pollution of the environment, save a large amount of organic solvents, the pesticide dispersion degree is high, reaches the miniaturization degree, the agricultural chemicals particle is generally 0.1 ~ 0.01 micron, and outward appearance is similar to transparent or sub-translucent liquid.It is good dispersion in water, the application of the good described bactericidal composition of, adhesive force strong to the target body permeability aspect the crop pests such as control vegetables, tobacco.
Result of the test shows, the antiviral composition that the present invention is above-mentioned and corresponding agricultural chemicals, by different mechanism of action and the mode of action of two kinds of active ingredients of Moroxydine Hydrochloride and nonylphenolsulfonate copper to the disease microorganism, be used for comprising cucumber virus disease, tobacco virus, pepper virus disease, in the control of the crop Diseases such as tomato virus disease, can have significant synergistic function, can effectively reduce the wherein amount of application of each composition single dose, be conducive to delay the drug-fast generation of plant, prolong the lasting period, the expanding prevention range of application has obvious promotional value.
Embodiment by the following examples is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.Do not breaking away from the above-mentioned technological thought situation of the present invention, various replacements or change according to ordinary skill knowledge and customary means are made all should comprise within the scope of the invention.
Embodiment
Embodiment 1: 51% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form (w%, as follows): Moroxydine Hydrochloride 1,
Nonylphenolsulfonate copper 50,
Fatty alcohol-polyoxyethylene ether 13,
Si Pan-80 4.5,
Ethylene glycol 5,
The water complementary.
Preparation: in a usual manner, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 2: 51% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form: Moroxydine Hydrochloride 50,
Nonylphenolsulfonate copper 1,
Calcium dodecyl benzene sulfonate 12,
Alkylphenol polyoxyethylene 4,
Ethylene glycol 5,
Propylene glycol monomethyl ether 2,
The water complementary.
Preparation: with conventional method, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 3: 24% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone aqueous emulsion
Form: Moroxydine Hydrochloride 4,
Nonylphenolsulfonate copper 20,
Si Pan-80 5.5,
Fatty alcohol-polyoxyethylene ether 3.0,
Alkyl phenol polyether phosphate 1.5,
Ethylene glycol 5.0,
Xanthans 0.3,
The water complementary.
Preparation: in the usual way, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stir and use the high shear dispersion machine to shear 30min after mixing get final product.
Embodiment 4: 26% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form: Moroxydine Hydrochloride 1,
Nonylphenolsulfonate copper 25,,
Fatty alcohol-polyoxyethylene ether 10,
DBSA amine 4.5,
Ethylene glycol 5,
The water complementary.
Preparation: with conventional method, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 5: 24% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone microemulsion
Form: Moroxydine Hydrochloride 20,
Nonylphenolsulfonate copper 4,
Fatty alcohol-polyoxyethylene ether 1,
DBSA amine 15,
Ethylene glycol 5,
The water complementary.
Preparation: with conventional method, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stirs and gets final product.
Embodiment 6: 26% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone aqueous emulsion
Form: Moroxydine Hydrochloride 25,
Nonylphenolsulfonate copper 1,
Phosphate polyethers 5,
Alkyl phenol polyether class 2,
Ethylene glycol 6,
XG 0.25，
Silicone defoaming agent 0.6,
The water complementary.
Preparation: in the usual way, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stir and use the high shear dispersion machine to shear 30min after mixing get final product.
Embodiment 7: 26% Moroxydine Hydrochloride bacterium in ninth of the ten Heavenly Stems ketone aqueous emulsion
Form: Moroxydine Hydrochloride 10,
Nonylphenolsulfonate copper 10,
Phosphate APEO 3,
Alkyl phenol polyether 2,
Si Pan-80 6,
Ethylene glycol 6,
The water complementary.
Preparation: in the usual way, Moroxydine Hydrochloride is water-soluble after, add surfactant, nonylphenolsulfonate copper stir and use the high shear dispersion machine to shear 30min after mixing get final product.
With following Toxicity Determination and the field trial that the above embodiments are carried out, proved to have significant synergistic function and preventive effect.
One, Toxicity Determination test:
1, for the examination pathogen: tobacco virus.
2, test method: adopt the live body pot-culture method, each is processed and repeats the 7d " Invest, Then Investigate " 10 times.Wherein, co-toxicity coefficient (CTC) 〉=120 expression has synergistic effect; 80＜CTC＜120 expression summation actions; CTC≤80 expressions have antagonism.Experimental result is as shown in table 1.
The composite Toxicity Determination to tobacco virus of table 1 Moroxydine Hydrochloride and nonylphenolsulfonate copper
| Reagent agent | EC 50 | Regression equation | CTC |
| Moroxydine Hydrochloride (A) | 43.1543 | Y=4.1058+0.5469x | — |
| Nonylphenolsulfonate copper (B) | 31.1819 | Y=3.8774+0.7154x | — |
| (A :B) 50:1 | 28.0061 | Y=3.9194+0.7446x | 152.93 |
| 25:1 | 20.4707 | Y=3.9127+0.7642x | 190.65 |
| 5:1 | 18.8486 | Y=3.9796+0.7408x | 199.06 |
| 1:1 | 17.3364 | Y=4.1689+0.6708x | 208.83 |
| 1:5 | 14.7461 | Y=4.2487+0.6428x | 221.70 |
| 1:25 | 13.7962 | Y=42569+0.6520x | 228.45 |
| 1:50 | 17.2508 | Y=4.2854+0.5778x | 151.74 |
The Toxicity Determination result of table 1 shows that composition of the present invention has very significantly synergistic effect to tobacco virus, and effect is better than the alone effect of Moroxydine Hydrochloride or nonylphenolsulfonate copper two compositions.
Two, control pepper virus disease test:
1, test is processed: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition.
2, test method: each residential quarter area is 50m
2, repeating 4 times, the inspection drug effect method behind the front Investigation and Prevention of dispenser is: every residential quarter diagonal is got a little, and every is extracted 10 strains investigation, and the disease scale standard is as follows:
0 grade: whole strain is anosis;
1 grade: bright arteries and veins, light floral leaf;
3 grades: lobus cardiacus and middle leaf sheet floral leaf;
5 grades: lobus cardiacus and middle leaf sheet floral leaf, minority leaf malformation, shrinkage or plant are slightly downgraded;
7 grades: heavy floral leaf, most leaf malformation, shrinkage or plant are downgraded;
9 grades: heavy floral leaf, blade obviously deformity, line leaf, plant are seriously downgraded, even dead.
Result of the test sees Table 2.
Three, control potato virus disease test:
1, test is processed: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition, and the contrast medicament is respectively 25% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each residential quarter area is 50m
2, repeating 4 times, the inspection drug effect method behind the front Investigation and Prevention of dispenser is: every residential quarter diagonal is got a little, and every is extracted the investigation of 10 strain fixed point location, and result of the test sees Table 3.
The field efficacy result of table 3 shows that Moroxydine Hydrochloride and nonylphenolsulfonate copper composition also have good control efficiency to potato virus disease, and control efficiency is better than the single dose kind.
Four, control tobacco virus test:
1, test is processed: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition, and the contrast medicament is respectively commercially available agricultural chemicals 25% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each residential quarter area is 50m
2, repeating 4 times, the inspection drug effect method behind the front Investigation and Prevention of dispenser is: diagonal sampling in every residential quarter whenever clicks 10 strains.Result of the test sees Table 4.
Table 4 field efficacy is the result show, agricultural chemicals of the present invention also has good control efficiency to the eggplant virus disease, and control efficiency is better than the single dose kind.
Five, control cucumber virus disease test:
1, test is processed: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition, and the contrast medicament is respectively 20% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each residential quarter area is 50m
2, repeating 4 times, the inspection drug effect method behind the front Investigation and Prevention of dispenser is: diagonal sampling in every residential quarter whenever clicks 10 strains.Result of the test sees Table 5.
Table 5 field efficacy is the result show, Moroxydine Hydrochloride and nonylphenolsulfonate copper composition also have good control efficiency to the cucumber virus disease, and control efficiency is better than the single dose kind.
Six, the pesticidal preparations control tomato virus disease test that makes with above-described embodiment:
1, test is processed: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition, and the contrast medicament is respectively 20% Moroxydine Hydrochloride wetting powder and 30% nonylphenolsulfonate copper microemulsion and the test of blank clear water.
2, test method: each residential quarter area is 50m
2, repeating 4 times, the inspection drug effect method behind the front Investigation and Prevention of dispenser is: diagonal sampling in every residential quarter whenever clicks 10 strains.Result of the test sees Table 6.
The field efficacy result of table 6 shows that agricultural chemicals of the present invention also has good control efficiency to tomato virus disease, and control efficiency is better than the single dose kind.
Claims (5)
1. the composition that has antiviral functions, by Moroxydine Hydrochloride and nonylphenolsulfonate copper take part by weight as 1
:25 ~ 25
:1 forms.
2. the agricultural chemicals that has antiviral functions is characterized in that composition take claim 1 as active ingredient, forms jointly with acceptable auxiliary element in the agricultural chemicals.
3. the agricultural chemicals that has as claimed in claim 2 antiviral functions is characterized in that the agricultural chemicals for aqueous emulsion or microemulsion form.
4. composition as claimed in claim 1 is in control cucumber virus disease, tobacco virus, pepper virus disease, the application of tomato virus disease aspect.
5. as described in claim 2 or 3, has the agricultural chemicals of antiviral functions in control cucumber virus disease, tobacco virus, pepper virus disease, the application of tomato virus disease aspect.
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|---|---|---|---|
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| CN102696654B true CN102696654B (en) | 2013-10-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993633A (en) * | 2017-05-15 | 2017-08-01 | 杨新兰 | A kind of sterilization synergistic composition for being applied to preventing and treating tomato virus disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109964958A (en) * | 2019-03-14 | 2019-07-05 | 江苏辉丰生物农业股份有限公司 | A kind of microbicide compositions |
| CN110627572B (en) * | 2019-11-01 | 2023-03-14 | 新疆农业大学 | Pesticide fertilizer for preventing diseases and promoting growth of cotton and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101870747A (en) * | 2010-05-28 | 2010-10-27 | 北京欧凯纳斯科技有限公司 | Heavy metal chelate resin, preparation method thereof and use thereof |
| CN101899002A (en) * | 2010-07-22 | 2010-12-01 | 浙江海正化工股份有限公司 | Method for preparing oxine copper, and product of oxine copper |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102217638B (en) * | 2011-04-27 | 2013-02-06 | 成都科利隆生化有限公司 | Pesticide composition for preventing and treating plant virus diseases |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101870747A (en) * | 2010-05-28 | 2010-10-27 | 北京欧凯纳斯科技有限公司 | Heavy metal chelate resin, preparation method thereof and use thereof |
| CN101899002A (en) * | 2010-07-22 | 2010-12-01 | 浙江海正化工股份有限公司 | Method for preparing oxine copper, and product of oxine copper |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993633A (en) * | 2017-05-15 | 2017-08-01 | 杨新兰 | A kind of sterilization synergistic composition for being applied to preventing and treating tomato virus disease |
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