CN102695724B - 指向金黄葡萄球菌表位isaa或isab的抗体或其片段 - Google Patents

指向金黄葡萄球菌表位isaa或isab的抗体或其片段 Download PDF

Info

Publication number
CN102695724B
CN102695724B CN201080021810.5A CN201080021810A CN102695724B CN 102695724 B CN102695724 B CN 102695724B CN 201080021810 A CN201080021810 A CN 201080021810A CN 102695724 B CN102695724 B CN 102695724B
Authority
CN
China
Prior art keywords
antibody
fragment
variable region
fragments
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080021810.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN102695724A (zh
Inventor
克努特·奥尔森
乌多·洛伦茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Maximilians Universitaet Muenchen LMU
Original Assignee
Ludwig Maximilians Universitaet Muenchen LMU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Maximilians Universitaet Muenchen LMU filed Critical Ludwig Maximilians Universitaet Muenchen LMU
Publication of CN102695724A publication Critical patent/CN102695724A/zh
Application granted granted Critical
Publication of CN102695724B publication Critical patent/CN102695724B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
CN201080021810.5A 2009-05-18 2010-05-18 指向金黄葡萄球菌表位isaa或isab的抗体或其片段 Expired - Fee Related CN102695724B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17913309P 2009-05-18 2009-05-18
US61/179,133 2009-05-18
PCT/EP2010/056827 WO2010133600A1 (en) 2009-05-18 2010-05-18 Antibodies or fragments thereof directed against a staphylococcus aureus epitope of isaa or isab

Publications (2)

Publication Number Publication Date
CN102695724A CN102695724A (zh) 2012-09-26
CN102695724B true CN102695724B (zh) 2016-08-24

Family

ID=42316060

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080021810.5A Expired - Fee Related CN102695724B (zh) 2009-05-18 2010-05-18 指向金黄葡萄球菌表位isaa或isab的抗体或其片段

Country Status (13)

Country Link
US (3) US8609102B2 (https=)
EP (1) EP2432804B1 (https=)
JP (2) JP5882892B2 (https=)
CN (1) CN102695724B (https=)
AU (1) AU2010251156C1 (https=)
BR (1) BRPI1010911A2 (https=)
CA (1) CA2761886A1 (https=)
ES (1) ES2537437T3 (https=)
MX (1) MX2011012248A (https=)
PL (1) PL2432804T3 (https=)
PT (1) PT2432804E (https=)
RU (1) RU2560415C2 (https=)
WO (1) WO2010133600A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011012248A (es) * 2009-05-18 2012-02-29 Univ Wuerzburg J Maximilians Anticuerpos o sus fragmentos dirigidos contra un epitope de staphylococcus aureus de isaa o isab.
JP2014534169A (ja) * 2011-09-23 2014-12-18 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクＪｕｌｉｕｓ Ｍａｘｉｍｉｌｉａｎｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｗｕｅｒｚｂｕｒｇ Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓエピトープ結合部位を形成するペプチドまたはペプチドの配置
EP3080160B1 (en) * 2013-12-13 2022-07-06 Rijksuniversiteit Groningen Antibodies against staphylococcus aureus and uses thereof
JP7525471B2 (ja) 2018-07-24 2024-07-30 メディミューン，エルエルシー Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）クランピング因子Ａ（ＣｌｆＡ）に対する抗体
KR102341805B1 (ko) * 2019-11-27 2021-12-22 주식회사 하울바이오 황색포도상구균에 특이적으로 반응하는 항-IsaA G4 항체 및 이의 용도
KR102341804B1 (ko) * 2019-11-27 2021-12-22 주식회사 하울바이오 황색포도상구균을 억제하는 항-IsaA F10 항체 및 이의 용도
JP7750490B2 (ja) * 2019-12-17 2025-10-07 国立大学法人三重大学 線維症の評価および処置のための方法および組成物
WO2022250205A1 (ko) * 2021-05-25 2022-12-01 주식회사 하울바이오 항-IsaA F10 항체의 아토피 피부염 예방 및 개선 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437653A (zh) * 2000-06-20 2003-08-20 谢菲尔德大学 抗原多肽
CN101123980A (zh) * 2005-01-10 2008-02-13 Nabi生物制药公司 治疗金黄色葡萄球菌感染的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4238806A1 (en) 1991-11-18 1993-05-27 Dainabot Co Methicillin-resistant staphylococcus aureus (MRSA)detection method - by detection of MRSA penicillin binding protein (PBP)2 antigen-antibody complex, and synthetic MRSA PBP2 peptides
FR2746398B1 (fr) * 1996-03-21 1998-04-30 Bio Merieux Anticorps specifique de staphylococcus aureaus, et utilisations
RU2144190C1 (ru) * 1998-01-13 2000-01-10 Катханов Али Муратович Способ диагностики стафилококковой инфекции
GB0127983D0 (en) * 2001-11-22 2002-01-16 Neutec Pharma Plc Treatment of micro-organism infection
MX2011012248A (es) * 2009-05-18 2012-02-29 Univ Wuerzburg J Maximilians Anticuerpos o sus fragmentos dirigidos contra un epitope de staphylococcus aureus de isaa o isab.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437653A (zh) * 2000-06-20 2003-08-20 谢菲尔德大学 抗原多肽
CN101123980A (zh) * 2005-01-10 2008-02-13 Nabi生物制药公司 治疗金黄色葡萄球菌感染的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Development of antibody-based therapy targeting immunodominat antigents of Staphylococcus aureus;Ohlsen K. et al.;《International Journal of Medical Microbiology》;20071231;第297卷(第43期);128页 *

Also Published As

Publication number Publication date
EP2432804A1 (en) 2012-03-28
EP2432804B1 (en) 2015-02-25
CN102695724A (zh) 2012-09-26
AU2010251156C1 (en) 2015-02-05
BRPI1010911A2 (pt) 2019-09-24
AU2010251156B2 (en) 2014-10-09
US20120100151A1 (en) 2012-04-26
US20160109449A1 (en) 2016-04-21
US9658230B2 (en) 2017-05-23
JP2016047828A (ja) 2016-04-07
CA2761886A1 (en) 2010-11-25
PL2432804T3 (pl) 2015-08-31
WO2010133600A1 (en) 2010-11-25
JP2012527423A (ja) 2012-11-08
RU2011146424A (ru) 2013-06-27
US8609102B2 (en) 2013-12-17
RU2560415C2 (ru) 2015-08-20
US20140072570A1 (en) 2014-03-13
ES2537437T3 (es) 2015-06-08
US9260511B2 (en) 2016-02-16
AU2010251156A1 (en) 2011-11-24
PT2432804E (pt) 2015-06-25
MX2011012248A (es) 2012-02-29
JP5882892B2 (ja) 2016-03-09

Similar Documents

Publication Publication Date Title
CN102695724B (zh) 指向金黄葡萄球菌表位isaa或isab的抗体或其片段
US11773157B2 (en) Compositions and methods for treating and preventing Staphylococcus aureus infections
CN103906535B (zh) 与葡萄球菌蛋白a的抗体相关的组合物和方法
TWI719938B (zh) 多重細菌感染之治療
EP2464665B1 (en) Human monoclonal antibody against s. aureus derived alpha-toxin and its use in treating or preventing abscess formation
CN108473559A (zh) 特异性结合脂多糖的抗体分子-药物共轭物及其应用
JP2010013454A (ja) グラム陽性細菌のペプチドグリカンに対する多機能性モノクローナル抗体
JP2008179634A (ja) グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体
US7169903B2 (en) Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria
JP2005514053A6 (ja) グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体
US20210017257A1 (en) Compositions and Methods for Treating and Preventing Staphylococcus Aureus Infections
HK1229710A1 (en) Compositions and methods for treating and preventing staphylococcus aureus infections
HK1197654B (en) Compositions and methods related to antibodies to staphylococcal protein a
HK1197654A (en) Compositions and methods related to antibodies to staphylococcal protein a

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160824

Termination date: 20170518

CF01 Termination of patent right due to non-payment of annual fee