CN102688178B - Application of rape bee pollen extract in anti-aging skin care products - Google Patents
Application of rape bee pollen extract in anti-aging skin care products Download PDFInfo
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Abstract
The invention discloses application of rape bee pollen extract in anti-aging skin care products. The rape bee pollen extract is prepared by ultrasonic extraction of rape bee pollen, vacuum concentration and twice ethanol precipitation. The rape bee pollen extract disclosed by the invention can be used for preparing anti-aging skin care products including anti-aging toner, anti-aging facial cream, anti-aging lotion and the like; and the products are natural and environment-friendly without toxic side effects, and can obviously improve the skin aging symptom.
Description
The application is for dividing an application
The applying date of original application is: on 05 06th, 2011
The application number of original application is: 201110116408.1
The denomination of invention of original application is: Brassica campestris L pollen extract and preparation method thereof and the application in the defying age skin care item
Technical field
The present invention relates to a kind of application of bee product, be specifically related to the application of a kind of pollen extract in cosmetics.
Background technology
The develop rapidly of modern science and technology and extensive use have brought brand-new opportunity to develop to cosmetic industry, cosmetics have been that the basic skin care item of purpose develop to slow down aging, the effect type cosmetics direction that beautifies the complexion to purpose from clean skin, skin moistening, chemical beauty treatment, plant beauty have been experienced in the research and development of cosmetics, and just the target towards biological beauty and gene beauty treatment strides forward.
According to the human senility free radical theory, superfluous free radical can cause body injury, and unsaturated fatty acid is oxidized to superoxides, forms lipofuscin.Oxygen-derived free radicals too much also can destroy cell membrane and other important component, makes protein and enzyme denaturation.Can make like this that human body skin shows as that skin is nonelastic, matt, senile plaque and xerosis cutis, desquamation, wrinkle etc.And polysaccharide is the important biological macromole, is the important composition composition of human body skin skin corium, and many polysaccharide have outstanding regulating action in the skin metabolism process.Bioactive polysaccharide is as the application of effect type cosmetics additive in cosmetics, it is an important directions of biological beauty, can produce preserve moisture, slow down aging, promotion epithelium fibrous layer cell proliferation and multiple function such as beautify the complexion, this will be that effect type cosmetic development is injected new vitality.
Brassica campestris L pollen is the Brassica campestris L male sex-cell that Apis is gathered, and it not only contains many nutritional labelings, also contains many active ingredient relevant with life sciences.The CN101978864A Chinese patent literature discloses a kind of Brassica campestris L pollen extract and application thereof, its extracting method is earlier Brassica campestris L pollen to be carried out water to carry, use precipitation with alcohol, dissolve with methanol, acetone precipitation then, obtain a kind of Brassica campestris L pollen extract at last, this extract has antiinflammatory, analgesia, drug effect such as antibacterial.Yet, also contain a lot of other active component in the Brassica campestris L pollen, the function of these active component and value also are familiar with and are known by people far away, for example, up to now, the relevant report with regard to not occurring as yet Brassica campestris L pollen extract being applied to make the defying age skin care item.
Summary of the invention
Technical problem to be solved by this invention is: at the deficiencies in the prior art, provide the application of the good Brassica campestris L pollen extract of a kind of oxidation resistance in preparation defying age skin care item.
For solving the problems of the technologies described above, the present invention is by the following technical solutions: the application of a kind of Brassica campestris L pollen extract in preparation defying age skin care item, described Brassica campestris L pollen extract are to prepare behind ultrasonic extraction, vacuum concentration and twice precipitation with alcohol by Brassica campestris L pollen is carried out.
In the application of above-mentioned Brassica campestris L pollen extract in preparation defying age skin care item, described Brassica campestris L pollen extract is preferably prepared by the preparation method that comprises following processing step:
(1) ultrasonic extraction: choose Brassica campestris L pollen, add the water of its 2～10 times of quality, ultrasonic extraction 10～60 minutes obtains filtrate after the isolated by filtration, with described filtrate vacuum concentration to 1/4～1/2 of original volume;
(2) precipitation with alcohol: in the filtrate after concentrate, the alcoholic solution (mass concentration is preferably 75%～95%) that adds its 1～5 times of quality, leave standstill (time of repose is preferably 24 hours), vacuum filtration is to remove ethanol, solid content behind the sucking filtration is used water dissolution again, and carry out secondary precipitation with alcoholic solution (mass concentration is preferably 75%～95%), and get secondary precipitate and carry out low-temperature vacuum drying, make Brassica campestris L pollen extract.
In the above-mentioned application, preferred, described defying age skin care item can be the defying age cosmetic water, and this defying age cosmetic water of per 100 mass parts mainly is to make after composite by each component of the described Brassica campestris L pollen extract of 3 mass parts and following mass fraction:
3～10 parts of glycerol,
3～10 parts of propylene glycol,
0.01～0.03 part of hydroxyethyl-cellulose,
0.05～0.15 part of allantoin,
2～6 parts of Radix Hamamelidis Mollis extracts
2～10 parts of dehydrated alcohol
0～1 part in essence,
0.1～0.5 part of antiseptic and
Water surplus.
In the above-mentioned application, preferred, described defying age skin care item can be anti-aging face creams, and this anti-aging face cream of per 100 mass parts mainly is to make after composite by each component of the described Brassica campestris L pollen extract of 3 mass parts and following mass fraction:
2～3 parts of cetearyl glucoside,
1～2 part of PEG-100 stearate,
2～6 parts of isopropyl myristates,
2～6 parts of caprylic/capric triglyceride,
0.5～4 part of dimethyl siloxane,
1～5 part of shea butter,
2～6 parts of cetearyl alcohol,
0.5～2 part of acrylamide/acrylate copolymer,
0.1～0.3 part of methyl hydroxybenzoate,
0.1～0.3 part of propylparaben,
2～8 parts of glycerol,
0.05～0.2 part of disodiumedetate,
0.05～0.2 part of allantoin,
0～2 part in essence,
0.05～0.2 part of diazonium alkyl imidazole urea and
Water surplus.
In the above-mentioned application, preferred, described defying age skin care item can be the defying age emulsions, and this defying age emulsion of per 100 mass parts mainly is to make after composite by each component of the described Brassica campestris L pollen extract of 3 mass parts and following mass fraction:
2 1～3 parts of fatty alcohol-polyoxyethylene ether,
21 1～3 parts of fatty alcohol-polyoxyethylene ether,
1～6 part of cetearyl alcohol,
0.5～4 part of glyceryl stearate,
2～8 parts of squalanes,
2～8 parts of Jojoba oils,
0.5～3 part of dimethyl siloxane,
0.1～0.3 part of methyl hydroxybenzoate,
0.1～0.3 part of propylparaben,
2～8 parts of glycerol,
0.1～0.4 part of carbomer,
0.1～0.4 part of triethanolamine,
0.05～0.2 part of diazonium alkyl imidazole urea,
0～2 part in essence and
Water surplus.
In the above-mentioned defying age emulsion, described fatty alcohol-polyoxyethylene ether 2 is preferably ceteareth-2; Described fatty alcohol-polyoxyethylene ether 21 is preferably ceteareth-21.
Compared with prior art, the invention has the advantages that: Brassica campestris L pollen extract of the present invention has good oxidation resistance, can effectively remove free radical; In the optimized technical scheme of the present invention, the preparation method of Brassica campestris L pollen extract is with low cost, technology is simple; Brassica campestris L pollen extract of the present invention is applied to skin-care cosmetics, can obviously improves the skin aging symptom.Contain abundant active bio polysaccharide in the Brassica campestris L pollen extract, therefore, Brassica campestris L pollen extract can be applied in the cosmetics.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1: the application of Brassica campestris L pollen extract of the present invention in cosmetics (defying age cosmetic water).
A kind of Brassica campestris L pollen extract is applied to the defying age skin care item, specifically is with this Brassica campestris L pollen extract of 3 mass parts and a kind of defying age cosmetic water of the composite back preparation of each component of following mass fraction:
4.0 parts of glycerol,
5.0 parts of propylene glycol,
0.02 part of hydroxyethyl-cellulose,
0.1 part of allantoin,
5.0 parts of Radix Hamamelidis Mollis extracts,
4.0 parts of dehydrated alcohol,
0.5 part in essence,
0.2 part of antiseptic,
Water is mended to gross weight and is reached 100 parts.
Concrete preparation technology's flow process of the defying age cosmetic water of present embodiment is: after pre-dispersed the getting well of hydroxyethyl-cellulose usefulness glycerol with above-mentioned mass parts, add 5 mass parts water while stirring, and be heated to 50 ℃, fully be uniformly dispersed, add other each component according to above-mentioned formula proportion in the mixture after be uniformly dispersed then, stir and namely make the defying age cosmetic water.
Practical application: this defying age cosmetic water is provided to the part crowd on probation, provided 40 parts altogether, receive 37 parts of effective investigation, 85% feedback result reflects that this cosmetic water is keeping moisture of skin and suppressing aspect the wrinkle of skin satisfied effect is being arranged.
Embodiment 2: the application of Brassica campestris L pollen extract of the present invention in cosmetics (anti-aging face cream).
A kind of Brassica campestris L pollen extract is applied to the defying age skin care item, specifically is with this Brassica campestris L pollen extract of 3 mass parts and a kind of anti-aging face cream of the composite back preparation of each component of following mass fraction:
The A phase:
2.5 parts of cetearyl glucoside,
1.5 parts of PEG-100 stearates,
4.0 parts of isopropyl myristates,
5.0 parts of caprylic/capric triglyceride,
1.5 parts of dimethyl siloxanes,
2.0 parts of shea butters,
3.5 parts of cetearyl alcohol,
1.0 parts of acrylamide/acrylate copolymers,
0.2 part of methyl hydroxybenzoate,
0.1 part of propylparaben,
The B phase:
4.0 parts of glycerol,
0.1 part of disodiumedetate (EDTA-Na),
0.1 part of allantoin,
The C phase:
0.8 part in essence,
0.1 part of diazonium alkyl imidazole urea (using 3 parts of water dissolutioies during preparation in advance),
Water is mended to gross weight and is reached 100 parts.
The anti-aging face cream of present embodiment mainly prepares according to following technological process: according to each component of above-mentioned prescription difference weighing A phase and B phase, again respectively with A phase, B heat phase to 75 ℃ and be incubated 10 minutes, while stirring B is added to A mutually in, used the homogenizer homogenizing then 3 minutes; At last mixture is cooled to 45 ℃ while stirring, adds C each material and Brassica campestris L pollen extract mutually, make the anti-aging face cream of present embodiment.
Practical application: the anti-aging face cream of present embodiment is provided to the part crowd on probation, provided 45 parts altogether, receive 41 parts of effective investigation, 89% feedback result reflects that this anti-aging face cream has satisfied effect removing senile plaque and improve skin gloss.
Embodiment 3: the application of Brassica campestris L pollen extract of the present invention in cosmetics (defying age emulsion).
A kind of Brassica campestris L pollen extract is applied to the defying age skin care item, specifically is a kind of defying age emulsion of the composite back preparation of each component with this Brassica campestris L pollen extract and the following mass fraction of 3 mass parts:
The A phase:
Ceteareth-2 1.5 part,
Ceteareth-21 1.5 part,
2.0 parts of cetearyl alcohol,
1.0 parts of glyceryl stearate,
5 parts of squalanes,
4 parts of Jojoba oils,
1.0 parts of dimethyl siloxanes,
0.2 part of methyl hydroxybenzoate,
0.1 part of propylparaben,
The B phase:
0.3 part of triethanolamine,
0.1 part of diazonium alkyl imidazole urea (dissolving in advance with 3 parts of water during preparation),
1 part in essence,
The C phase:
4.0 parts of glycerol,
0.3 part of carbomer (be made in advance during preparation 1% solution),
Water is mended to gross weight and is reached 100 parts.
The defying age emulsion of present embodiment mainly prepares by following technological process: according to each component of above-mentioned prescription difference weighing A phase and C phase, again respectively with A mutually and C heat phase to 75 ℃ and be incubated 10 minutes, while stirring C is added to A mutually in, used the homogenizer homogenizing then 3 minutes; Mixture is cooled to 45 ℃ while stirring, adds B each material and Brassica campestris L pollen extract mutually, make the defying age emulsion of present embodiment.
Practical application: the defying age emulsion of present embodiment is provided to the part crowd on probation, provided 40 parts altogether, receive 39 parts of effective investigation, 91% feedback result reflects that this defying age emulsion removing chloasma and keeping moisture of skin that satisfied effect is arranged.
Show that by on probation three kinds of cosmetics of above-described embodiment 1～embodiment 3 have extraordinary effect improving on the various senile symptoms of skin.
The Brassica campestris L pollen extract of using among above-described embodiment 1～embodiment 3 all is to prepare behind ultrasonic extraction, vacuum concentration and twice precipitation with alcohol by Brassica campestris L pollen is carried out.The preparation method of above-mentioned Brassica campestris L pollen extract specifically comprises following processing step:
(1) ultrasonic extraction: choose Brassica campestris L pollen, add the water of 6 times of weight, ultrasonic extraction 40 minutes obtains filtrate after the isolated by filtration, with the filtrate vacuum concentration to 1/4 of original volume;
(2) precipitation with alcohol: in the filtrate after concentrate, the mass concentration that adds its 2 times of weight is 95% ethanol, left standstill 24 hours, remove ethanol behind the vacuum filtration, solid content behind the sucking filtration is used water dissolution again, carry out secondary precipitation with 95% ethanol again, get the secondary precipitate low-temperature vacuum drying, make the Brassica campestris L pollen extract of the various embodiments described above.
The above-mentioned Brassica campestris L pollen extract that makes is carried out oxidation resistance to be measured.
Accurately take by weighing DPPH free radical 20mg, in the 500mL volumetric flask, then the mass concentration of DPPH free radical reagent is 0.04 mg/mL with anhydrous alcohol solution and standardize solution, and it is standby to keep in Dark Place.The above-mentioned Brassica campestris L pollen extract that makes is mixed with 1%, 2% and the Brassica campestris L pollen extract solution of 3% 3 kind of concentration respectively with water dissolution.Measure the oxidation resistance of three kinds of Brassica campestris L pollen extracts under the different quality concentration respectively by following assay method.
In first test tube, add the 1% Brassica campestris L pollen extract solution that 2mL aforementioned DPPH free radical reagent solution and 2mL prepare, fully mix; In second test tube, add 1% Brassica campestris L pollen extract solution and the 2ml pure water that 2mL prepares; In the 3rd test tube, add 2mL aforementioned DPPH free radical reagent solution and 2mL pure water.Under 517 nm conditions, measure solution absorbency in three test tubes behind 30 min respectively.Solution is to the clearance rate K of DPPH free radical in first test tube
1Available following formula calculates:
K
1=?[Ac?－（Ai－Aj）]?/?Ac?×?100%
In the following formula:
Solution absorbency in Ai=first test tube;
Solution absorbency in A j=second test tube;
Solution absorbency in Ac=3rd test tube.
The K of said determination
1Value is the oxidation resistance clearance rate of DPPH free radical (namely to) of 1% Brassica campestris L pollen extract.Measure the oxidation resistance of 2% and 3% Brassica campestris L pollen extract equally as stated above respectively, the clearance rate of the DPPH free radical of the variable concentrations sample that records is as shown in table 1 below:
Table 1: the clearance rate of different samples
| Sample concentration | 1% | 2% | 3% |
| Clearance rate (K) | 51.71% | 86.64% | 98.65 |
Can find out that from last table 1 Brassica campestris L pollen extract of using in the present embodiment is higher to the clearance rate of DPPH free radical, along with the increase gradually of concentration, clearance rate is also more and more higher.When concentration reached 3%, the clearance rate of free radical had reached 98.65%.
The above only is preferred implementation of the present invention, and protection scope of the present invention also not only is confined to above-described embodiment, and all technical schemes that belongs under the thinking of the present invention all belong to protection scope of the present invention.
Claims (6)
1. the Brassica campestris L pollen extract application in preparation defying age skin care item, described Brassica campestris L pollen extract are to prepare behind ultrasonic extraction, vacuum concentration and twice precipitation with alcohol by Brassica campestris L pollen is carried out;
Described defying age skin care item refer to the defying age cosmetic water, and this defying age cosmetic water of per 100 mass parts mainly is to make after composite by each component of the described Brassica campestris L pollen extract of 3 mass parts and following mass fraction:
3～10 parts of glycerol,
3～10 parts of propylene glycol,
0.01～0.03 part of hydroxyethyl-cellulose,
0.05～0.15 part of allantoin,
2～6 parts of Radix Hamamelidis Mollis extracts
2～10 parts of dehydrated alcohol
0～1 part in essence,
0.1～0.5 part of antiseptic and
Water surplus.
2. the Brassica campestris L pollen extract application in preparation defying age skin care item, described Brassica campestris L pollen extract are to prepare behind ultrasonic extraction, vacuum concentration and twice precipitation with alcohol by Brassica campestris L pollen is carried out; Described defying age skin care item refer to anti-aging face cream, and this anti-aging face cream of per 100 mass parts mainly is to make after composite by each component of the described Brassica campestris L pollen extract of 3 mass parts and following mass fraction:
2～3 parts of cetearyl glucoside,
1～2 part of PEG-100 stearate,
2～6 parts of isopropyl myristates,
2～6 parts of caprylic/capric triglyceride,
0.5～4 part of dimethyl siloxane,
1～5 part of shea butter,
2～6 parts of cetearyl alcohol,
0.5～2 part of acrylamide/acrylate copolymer,
0.1～0.3 part of methyl hydroxybenzoate,
0.1～0.3 part of propylparaben,
2～8 parts of glycerol,
0.05～0.2 part of disodiumedetate,
0.05～0.2 part of allantoin,
0～2 part in essence,
0.05～0.2 part of diazonium alkyl imidazole urea and
Water surplus.
3. the Brassica campestris L pollen extract application in preparation defying age skin care item, described Brassica campestris L pollen extract are to prepare behind ultrasonic extraction, vacuum concentration and twice precipitation with alcohol by Brassica campestris L pollen is carried out; Described defying age skin care item refer to the defying age emulsion, and this defying age emulsion of per 100 mass parts mainly is to make after composite by each component of the described Brassica campestris L pollen extract of 3 mass parts and following mass fraction:
2 1～3 parts of fatty alcohol-polyoxyethylene ether,
21 1～3 parts of fatty alcohol-polyoxyethylene ether,
1～6 part of cetearyl alcohol,
0.5～4 part of glyceryl stearate,
2～8 parts of squalanes,
2～8 parts of Jojoba oils,
0.5～3 part of dimethyl siloxane,
0.1～0.3 part of methyl hydroxybenzoate,
0.1～0.3 part of propylparaben,
2～8 parts of glycerol,
0.1～0.4 part of carbomer,
0.1～0.4 part of triethanolamine,
0.05～0.2 part of diazonium alkyl imidazole urea,
0～2 part in essence and
Water surplus.
4. application according to claim 3 is characterized in that, described fatty alcohol-polyoxyethylene ether 2 refers to ceteareth-2; Described fatty alcohol-polyoxyethylene ether 21 refers to ceteareth-21.
5. according to each described application in the claim 1～4, it is characterized in that described Brassica campestris L pollen extract is to be prepared by the preparation method that comprises following processing step:
(1) ultrasonic extraction: choose Brassica campestris L pollen, add the water of its 2～10 times of quality, ultrasonic extraction 10～60 minutes obtains filtrate after the isolated by filtration, with described filtrate vacuum concentration to 1/4～1/2 of original volume;
(2) precipitation with alcohol: in the filtrate after concentrate, the alcoholic solution that adds its 1～5 times of quality, leave standstill, vacuum filtration is to remove ethanol, solid content behind the sucking filtration is used water dissolution again, and carry out secondary precipitation with alcoholic solution, and get secondary precipitate and carry out low-temperature vacuum drying, make Brassica campestris L pollen extract.
6. application according to claim 5 is characterized in that, the mass concentration of described alcoholic solution is 75%～95%.
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| CN108938504B (en) * | 2018-09-30 | 2021-05-07 | 台州中知英健机械自动化有限公司 | Whitening skin care product and preparation method thereof |
| CN109394580A (en) * | 2018-12-04 | 2019-03-01 | 珠海依赛思生物科技有限公司 | A kind of ceramide is releived moisturizing maintenance frost and preparation method thereof |
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|---|---|---|---|---|
| CN1650971A (en) * | 2004-11-19 | 2005-08-10 | 浙江康恩贝制药股份有限公司 | Preparation method of rape myricyl powder effective portion group |
| CN101978864A (en) * | 2010-09-28 | 2011-02-23 | 中国农业科学院蜜蜂研究所 | Rape bee-pollen extract and use thereof |
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650971A (en) * | 2004-11-19 | 2005-08-10 | 浙江康恩贝制药股份有限公司 | Preparation method of rape myricyl powder effective portion group |
| CN101978864A (en) * | 2010-09-28 | 2011-02-23 | 中国农业科学院蜜蜂研究所 | Rape bee-pollen extract and use thereof |
Non-Patent Citations (1)
| Title |
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| 李福高等.蜂花粉及其提取物的应用研究进展.《2008年全国蜂产品市场信息交流会暨中国（郑州）蜂业博览会论文集》.2008, * |
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Effective date of registration: 20170726 Address after: 410126, No. 30, Chong Chong Road, Furong district, Hunan, Changsha Patentee after: Hunan Mingyuan Bee Industry Co., Ltd. Address before: 410126, No. 30, Chong Chong Road, Furong district, Hunan, Changsha Patentee before: Hunan Mingyuan Apiculture Technology Co., Ltd. |