CN102670868B - Medicinal plaster for treating allergic dermatitis, anal itching and vulvar itching, and preparation method thereof - Google Patents

Abstract

The invention discloses a medicinal plaster for treating allergic dermatitis, anal itching and vulvar itching, and a preparation method of the medicinal plaster. The plaster is prepared from Oleum ricini, Radix Saposhnikoviae, Herba Asari, Caulis Piperis Futokadsurae and Stigma Croci Sativi proportionally. The medicinal plaster provided by the invention has effects of dispelling dampness and wind, removing toxic substances and promoting granulation; and is used for treating allergic dermatitis, skin itching, anal itching and vulvar itching, with high curative rate.

Description

A kind of ointment and preparation method for the treatment of allergic dermatitis pruritus ani pruritus vulvae

Technical field

The present invention relates to a kind of medicine for the treatment of allergic dermatitis, pruritus ani, pruritus vulvae, belong to the field of Chinese medicines.

Background technology

Allergic dermatitis, pruritus ani, pruritus vulvae are a kind of common scytitiss, and morbidity is how excited relevant with the inhibition dysequilibrium with cerebral cortex, digestive system disease, and dyshormonia, living environment changes or other local excitations all can be brought out morbidity.Common with the adult, the play of patient's paroxysmal is itched, and more so have a strong impact on sleep and work night.The doctor trained in Western medicine medication is main mainly with symptomatic treatment, but the Western medicine side effect is large, and easily recurrence can not be effected a radical cure, and curative effect is also undesirable.

Summary of the invention

Therefore there is great demand in people to the Chinese medicine of effective treatment allergic dermatitis and anus, pruritus vulvae, up to now, also do not find the relevant report about medicine of the present invention, the inventor is through a large amount of development tests, and by clinical checking, finally work out the Chinese medicine composition of better curative effect, thereby finished the present invention.

Purpose of the present invention just provides a kind of composition of medicine for the treatment of allergic dermatitis, pruritus ani, pruritus vulvae.

Another object of the present invention has just provided the preparation method of this Chinese medicine composition.

The present invention selects Oleum Ricini, Radix Saposhnikoviae, Herba Asari, Herba Abri, Caulis Piperis Kadsurae, Radix Stephaniae Tetrandrae, Cortex Acanthopancis, Stigma Croci, Colophonium, Realgar, Benzoinum, Cera Flava, Camphora to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby can treat the recurrence of allergic dermatitis, anus, pruritus vulvae, wherein select Oleum Ricini to be because it controls constipation due to dry stool, the skin ulcer scabies, the function of burn.Selecting Radix Saposhnikoviae is that temperature enters bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and wins and wets, and the function of pain relieving is controlled affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Select Herba Asari to be because its nature and flavor are hot, temperature enters lung, kidney channel, dispel the wind, and cold expelling, row water is opened the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Herba Abri to be because its nature and flavor are sweet, cold has heat-clearing and toxic substances removing, the function of soothing liver-QI dissipating blood stasis, and the subcutaneous ulcer of harnessing the Yellow River hepatitis, stomachache, acute mastitis, scrofula, traumatic injury is hindered pain due to blood stasis.Select Caulis Piperis Kadsurae to be because its nature and flavor are arduous, tepor enters the heart, kidney two warps, and wind-damp dispelling is arranged, the meridian dredging, and the function of regulating the flow of vital energy is controlled anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.Select Radix Stephaniae Tetrandrae to be because its nature and flavor are bitter, cold, enter wing thorax, spleen, kidney channel, capable water is arranged, rush down the function of damp-heat in lower-JIAO, the swollen tympanites of harnessing the river, hygropyretic beriberi, brothers' spasm and pain, the tinea scabies is swollen.Select Cortex Acanthopancis to be because its property and flavor of peppery and warm is returned liver, kidney channel, wind-damp dispelling is arranged, strengthening bone and muscle, the function of blood circulation and promoting silt is controlled anemofrigid-damp arthralgia, and the sliding contraction of muscle is anxious, edema beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.Select Stigma Croci to be because its nature and flavor are sweet, flat, enter the heart, Liver Channel, blood circulation promoting and blood stasis dispelling is arranged, the function of dispersing stagnation and relieving accumulation of pathogens is controlled troubled thoughts pent-up, and the chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, and is frightened fear in a trance, women's amenorrhea, postnatal blood stasis stomachache, tumbling and swelling.Selecting Colophonium is that temperature enters liver, spleen channel because of its property bitter but sweet flavor, dispel the wind, and dampness, evacuation of pus is drawn out pus by applying a plaster to the affected part, granulation promoting, the function of pain relieving is controlled carbuncle, furunculosis, hemorrhoid complicated by anal fistula, malignant boil, scabies, bald in vain, incised wound is sprained, rheumatic arthralgia, leprosy pruritus.Select Realgar to be because its nature and flavor are arduous, temperature, poisonous, dampness is arranged, dispel the wind, parasite killing, the function of detoxifcation is controlled scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, snakeworm sting, bromhidrosis, ecthyma, asthma, sore throat ， Jing Epilepsy, hemorrhoid complicated by anal fistula.Select Benzoinum to be because its nature and flavor are arduous, temperature enters the heart, liver, spleen channel, has and has one's ideas straightened out, and wards off dirtyly, and the function of qi and blood circulation promotion is controlled the apoplexy sudden syncope, trusted subordinate's pain, puerperal blood faints, Xiao Jing Epilepsy, migratory arthralgia lumbago.Select Cera Flava to be because its nature and flavor are sweet, tepor is returned spleen, stomach, large intestine channel, and the astringent therapy sore is arranged, and the function of granulation promoting pain relieving is used for ulcer being unable to heal outward, and ecthyma is rotten to the corn, wound, burn and scald.Select Camphora to be because its nature and flavor are hot, enter heart spleen two warps, sensible, parasite killing, pain relieving are arranged, ward off dirty function, control trusted subordinate's distending pain, beriberi, skin infection scabies, toothache, traumatic injury.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the consumption of each component all has preferably curative effect in the following weight scope.

Oleum Ricini 500-800 gram Radix Saposhnikoviae 10-20 gram Herba Asari 20-30 gram

Herba Abri 20-30 gram Caulis Piperis Kadsurae 15-25 gram Radix Stephaniae Tetrandrae 10-20 gram

Cortex Acanthopancis 20-30 gram Stigma Croci 5-10 gram Colophonium 45-70 gram

Realgar 1-3 gram Benzoinum 0.5-1.5 gram Cera Flava 5-10 gram

Camphora 35-45 gram

Preferable amount is:

Oleum Ricini 660 gram Radix Saposhnikoviaes 15 gram Herba Asaris 25 grams

Herba Abri 25 gram Caulis Piperis Kadsuraes 20 gram Radixs Stephaniae Tetrandrae 15 grams

Cortex Acanthopancis 25 gram Stigma Crocis 6 gram Colophonium 56 grams

Realgar 2 gram Benzoinumes 1 gram Cera Flava 6 grams

Camphora 40 grams

The preparation method of medicine of the present invention is as follows:

One, get the raw materials ready:

1, Oleum Ricini: select faint yellow or be bordering on the high-quality Oleum Ricini of achromatism and clarity;

2, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

3, Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;

4, Herba Abri: clean, section is dried;

5, Caulis Piperis Kadsurae: former medicine is put and is soaked 30-60 minute in the clear water, takes out to put in the square-bottomed bamboo basket to moisten 16-24 hour, and section is dried;

6, Radix Stephaniae Tetrandrae: former medicine washes, and pulls out to run through, and section is dried;

7, Cortex Acanthopancis: choose clean impurity, wash, slightly after the profit, cut into slices drying;

8, Stigma Croci: choose decontamination, and remove yellow feeler;

9, Colophonium: put in the copper pot, use the low baking temperature heat fused, drag for decontamination, in the impouring water, wait cool rear taking-up, drying;

10, Realgar: be ground into impalpable powder, or water flies, dry;

11, Benzoinum: get crude drug, remove impurity, break into fritter;

12, Cera Flava: get crude drug, add the suitable quantity of water fusing, remove impurity, let cool rear collection wax stone, scrape off bottom impurity;

13, Camphora: the 9-12 month is cut down veteran, get its tree root, trunk, branch, be split into fragment, put in the distillator and distill, the Camphora and the volatile oil that contain in the Lignum cinnamomi camphorae distillate with steam, namely get rough Camphora after the cooling, rough Camphora again through sublimation purifying, is namely got the Gum Camphor powder, camphor powder is entered in the model to squeeze, then become transparent camphor tablet, the time spent smashes and grinds into powder.

Two, preparation:

1, gets a container with cover or aluminum pot with cover, add Oleum Ricini, Radix Saposhnikoviae, Herba Asari, Herba Abri, Caulis Piperis Kadsurae, Radix Stephaniae Tetrandrae, Cortex Acanthopancis, Stigma Croci, close the lid, be placed in the cauldron, add clear water in the cauldron, water is difficult for too much, be splashed in the container when preventing that water from opening, then intense fire boils, and simmers in water to boil 20-30 minute again, the cooling of stopping burning is removed slag and is stayed liquid.

2, add Colophonium, Realgar, Benzoinum, Cera Flava in medicinal liquid, boil with fire again, the limit is boiled while stirring and to be melted, and after medicine melts, puts into Camphora again and closes the lid, after Camphoraization is even, the container of decoct medicinal herbs is taken out in cauldron, cooling Flos Carthami cream of the present invention.

Medicine of the present invention has dampness, dispels the wind, draws out pus by applying a plaster to the affected part, the function of life, pain relieving, parasite killing, and it is fast to be used for the treatment of allergic dermatitis, skin pruritus, pruritus ani, pruritus vulvae, tinea corporis, arthritis, infantile asthma, cold injury curative effect, and cure rate is high.

The specific embodiment:

Below further set forth the beneficial effect of medicine of the present invention by test example.

The report of [test example 1] animal toxicity test

1, get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, and 10 every group, wherein one group is female group, and another group is for male group.

2, smear the pudendum place with ointment for female group, be used in conjunction 7 days every day six times, smear the anus position with ointment for male group, be used in conjunction 7 days every day six times, observe the medication reaction every day, two groups of rabbit diet activities are normal.

3, the result shows: ointment of the present invention has no side effect.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data:

Accept out-patient's 300 examples for medical treatment, male 218 examples wherein, women 82 examples, age 2-12 year 30 people, 13-20 year 35 people, 21-30 year 39 people, 31-40 year 47 people, 41-50 year 73 people, 76 people more than 50 years old.

2, diagnostic criteria:

(1) allergic dermatitis: primary disease is a kind of hereditary anaphylactic disease, concurrent asthma is often arranged among patient and the kinsfolk, pollinosis, the medical history such as allergic rhinitis and urticaria, patient's lower limb often have ichthyosiform to change, Eosinophilia in the blood, skin lesion mostly are general drying property pimple or the lichenified speckle of limitation, and blood crusts, squama and pigmentation are arranged after grabbing.

(2) pruritus ani, pruritus vulvae all belong to skin pruritus, be divided into clinically two kinds of general and local prurituses, general pruritus main manifestations is the whole body pruritus, is paroxysmal often, and night is heavier, from the beginning of without disease damage, owing to often scratch, blood crusts, pigmentation or lichenization widely strip or point-like scratch can appear,, but the enlargement of superficial lymph knot, the most incidental position of local pruritus is anus, scrotum, pudendum etc.

(3) tinea corporis is the superfical mycoses that occurs on the skin, light red pimple or vesicle from the beginning of infringement, later on gradually expansion, become the red annular of inflammatory or coin shape patch, can there be thin thin squama on the surface, and clear border is protuberance slightly, often is linked to be annular or arc by pimple or herpes, acute pruritus can cause that because scratching the eczema sample becomes or lichen sample shape.

(4) arthritis, early symptom are that the joint persistence is ached or prominent sense twinge when movable, and joint motion is dumb, and late period, sclerotin and joint were loose, produced joint deformity.

(5) infantile asthma: claim again bronchus to pant, with sudden onset, the tachypnea dyspnea with rapid respiration, and with wheezing, the difficult row of abundant expectoration, failing to lie flat due to dyspnea is main special disease.

(6) cold injury is that human body is subjected to low temperature to attack caused whole body or local damage, this disease be because it is attacked by the cold and evil, QI-blood circulation is not smooth, passages through which vital energy circulates checks, due to the blood stream stasis, slight affected part is red and swollen, the severe one diabrosis.

3, Therapeutic Method:

Get Flos Carthami cream every day and smear the affected part 3-4 time, 10 days courses for the treatment of, use continuously 2-3 the course for the treatment of.

Arthritis: smear Flos Carthami cream every day 3-5 time, when embrocating with have gentle hands by 3-5 minute; Infantile asthma: Flos Carthami cream is smeared to two newborn midpoint from throat, and (be positioned at anterior midline one section) every day 3-4 time, rubs with have gentle hands.

4, efficacy assessment standard:

Produce effects: various dermatosis are after treatment, and it is normal that skin and body constitution are recovered, and observes 6 months without the recidivist.

Take a turn for the better: accelerate recovery time, and skin and body constitution are progressively normal.

Invalid: as not reach improvement standard person.

5, therapeutic outcome:

In above-mentioned treatment, with medicinal ointment therapy allergic dermatitis patient 32 examples of the present invention, produce effects 29 examples, 2 examples that take a turn for the better, total effective rate is 96.88%; Treatment skin pruritus patient 48 examples, produce effects 42 examples, 6 examples that take a turn for the better, total effective rate is 100%; Treatment pruritus ani patient 38 examples, produce effects 36 examples, 2 examples that take a turn for the better, total effective rate 100%; Treatment pruritus vulvae patient 29 examples, produce effects 28 examples, 1 example that takes a turn for the better, total effective rate is 100%; Treatment tinea corporis patient 63 examples, produce effects 54 examples, 7 examples that take a turn for the better, total effective rate is 96.83%; Treatment of arthritis patient's 29 examples, produce effects 27 examples, 1 example that takes a turn for the better, total effective rate is 96.55%; Treatment infantile asthma patient 25 examples, produce effects 20 examples, 4 examples that take a turn for the better, total effective rate is 96%; Treatment cold injury patient 36 examples, produce effects 33 examples, 3 examples that take a turn for the better, total effective rate is 100%.

Claims (3)

1. ointment for the treatment of allergic dermatitis pruritus ani pruritus vulvae, it is characterized in that: it is to be made by the crude drug in the following weight scope:

Oleum Ricini 500-800 gram Radix Saposhnikoviae 10-20 gram Herba Asari 20-30 gram

Herba Abri 20-30 gram Caulis Piperis Kadsurae 15-25 gram Radix Stephaniae Tetrandrae 10-20 gram

Cortex Acanthopancis 20-30 gram Stigma Croci 5-10 gram Colophonium 45-70 gram

Realgar 1-3 gram Benzoinum 0.5-1.5 gram Cera Flava 5-10 gram

Camphora 35-45 gram;

Preparation process is as follows:

(1) gets the raw materials ready

(1) Oleum Ricini: select faint yellow or be bordering on the high-quality Oleum Ricini of achromatism and clarity;

(2) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(3) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;

(4) Herba Abri: clean, section is dried;

(5) Caulis Piperis Kadsurae: former medicine is put and is soaked 30-60 minute in the clear water, takes out to put in the square-bottomed bamboo basket to moisten 16-24 hour, and section is dried;

(6) Radix Stephaniae Tetrandrae: former medicine washes, and pulls out to run through, and section is dried;

(7) Cortex Acanthopancis: choose clean impurity, wash, slightly after the profit, cut into slices drying;

(8) Stigma Croci: choose decontamination, and remove yellow feeler;

(9) Colophonium: put in the copper pot, use the low baking temperature heat fused, drag for decontamination, in the impouring water, wait cool rear taking-up, drying;

(10) Realgar: be ground into impalpable powder, or water flies, dry;

(11) Benzoinum: get crude drug, remove impurity, break into fritter;

(12) Cera Flava: get crude drug, add the suitable quantity of water fusing, remove impurity, let cool rear collection wax stone, scrape off bottom impurity;

(13) Camphora: the 9-12 month is cut down veteran, get its tree root, trunk, branch, be split into fragment, put in the distillator and distill, the Camphora and the volatile oil that contain in the Lignum cinnamomi camphorae distillate with steam, namely get rough Camphora after the cooling, rough Camphora again through sublimation purifying, is namely got the Gum Camphor powder, camphor powder is entered in the model to squeeze, then become transparent camphor tablet, the time spent smashes and grinds into powder;

(2) preparation

(1) gets a container with cover, add Oleum Ricini, Radix Saposhnikoviae, Herba Asari, Herba Abri, Caulis Piperis Kadsurae, Radix Stephaniae Tetrandrae, Cortex Acanthopancis, Stigma Croci, close the lid, be placed in the cauldron, add clear water in the cauldron, water is too much unsuitable, be splashed in the container when preventing that water from opening, then intense fire boils, and simmers in water to boil 20-30 minute again, flame-out cooling is removed slag and is stayed liquid;

(2) add Colophonium, Realgar, Benzoinum, Cera Flava in medicinal liquid, boil with fire again, the limit is boiled while stirring and to be melted, and after medicine melts, puts into Camphora again and closes the lid, and after Camphoraization is even, the container of decoct medicinal herbs is taken out cooling and get final product in cauldron.

2. the ointment for the treatment of allergic dermatitis pruritus ani pruritus vulvae according to claim 1, it is characterized in that: wherein the consumption of each crude drug is:

Oleum Ricini 660 gram Radix Saposhnikoviaes 15 gram Herba Asaris 25 grams

Herba Abri 25 gram Caulis Piperis Kadsuraes 20 gram Radixs Stephaniae Tetrandrae 15 grams

Cortex Acanthopancis 25 gram Stigma Crocis 6 gram Colophonium 56 grams

Realgar 2 gram Benzoinumes 1 gram Cera Flava 6 grams

Camphora 40 grams;

Preparation process is as follows:

(1) gets the raw materials ready

(1) Oleum Ricini: select faint yellow or be bordering on the high-quality Oleum Ricini of achromatism and clarity;

(2) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(3) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;

(4) Herba Abri: clean, section is dried;

(5) Caulis Piperis Kadsurae: former medicine is put and is soaked 30-60 minute in the clear water, takes out to put in the square-bottomed bamboo basket to moisten 16-24 hour, and section is dried;

(6) Radix Stephaniae Tetrandrae: former medicine washes, and pulls out to run through, and section is dried;

(7) Cortex Acanthopancis: choose clean impurity, wash, slightly after the profit, cut into slices drying;

(8) Stigma Croci: choose decontamination, and remove yellow feeler;

(9) Colophonium: put in the copper pot, use the low baking temperature heat fused, drag for decontamination, in the impouring water, wait cool rear taking-up, drying;

(10) Realgar: be ground into impalpable powder, or water flies, dry;

(11) Benzoinum: get crude drug, remove impurity, break into fritter;

(12) Cera Flava: get crude drug, add the suitable quantity of water fusing, remove impurity, let cool rear collection wax stone, scrape off bottom impurity;

(13) Camphora: the 9-12 month is cut down veteran, get its tree root, trunk, branch, be split into fragment, put in the distillator and distill, the Camphora and the volatile oil that contain in the Lignum cinnamomi camphorae distillate with steam, namely get rough Camphora after the cooling, rough Camphora again through sublimation purifying, is namely got the Gum Camphor powder, camphor powder is entered in the model to squeeze, then become transparent camphor tablet, the time spent smashes and grinds into powder;

(2) preparation

(1) gets a container with cover, add Oleum Ricini, Radix Saposhnikoviae, Herba Asari, Herba Abri, Caulis Piperis Kadsurae, Radix Stephaniae Tetrandrae, Cortex Acanthopancis, Stigma Croci, close the lid, be placed in the cauldron, add clear water in the cauldron, water is too much unsuitable, be splashed in the container when preventing that water from opening, then intense fire boils, and simmers in water to boil 20-30 minute again, flame-out cooling is removed slag and is stayed liquid;

(2) add Colophonium, Realgar, Benzoinum, Cera Flava in medicinal liquid, boil with fire again, the limit is boiled while stirring and to be melted, and after medicine melts, puts into Camphora again and closes the lid, and after Camphoraization is even, the container of decoct medicinal herbs is taken out cooling and get final product in cauldron.

3. the preparation method of described ointment according to claim 1 and 2, it is characterized in that: it comprises the following steps:

(1) gets the raw materials ready

(1) Oleum Ricini: select faint yellow or be bordering on the high-quality Oleum Ricini of achromatism and clarity;

(2) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(3) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;

(4) Herba Abri: clean, section is dried;

(5) Caulis Piperis Kadsurae: former medicine is put and is soaked 30-60 minute in the clear water, takes out to put in the square-bottomed bamboo basket to moisten 16-24 hour, and section is dried;

(6) Radix Stephaniae Tetrandrae: former medicine washes, and pulls out to run through, and section is dried;

(7) Cortex Acanthopancis: choose clean impurity, wash, slightly after the profit, cut into slices drying;

(8) Stigma Croci: choose decontamination, and remove yellow feeler;

(9) Colophonium: put in the copper pot, use the low baking temperature heat fused, drag for decontamination, in the impouring water, wait cool rear taking-up, drying;

(10) Realgar: be ground into impalpable powder, or water flies, dry;

(11) Benzoinum: get crude drug, remove impurity, break into fritter;

(12) Cera Flava: get crude drug, add the suitable quantity of water fusing, remove impurity, let cool rear collection wax stone, scrape off bottom impurity;

(13) Camphora: the 9-12 month is cut down veteran, get its tree root, trunk, branch, be split into fragment, put in the distillator and distill, the Camphora and the volatile oil that contain in the Lignum cinnamomi camphorae distillate with steam, namely get rough Camphora after the cooling, rough Camphora again through sublimation purifying, is namely got the Gum Camphor powder, camphor powder is entered in the model to squeeze, then become transparent camphor tablet, the time spent smashes and grinds into powder;

(2) preparation

(1) gets a container with cover, add Oleum Ricini, Radix Saposhnikoviae, Herba Asari, Herba Abri, Caulis Piperis Kadsurae, Radix Stephaniae Tetrandrae, Cortex Acanthopancis, Stigma Croci, close the lid, be placed in the cauldron, add clear water in the cauldron, water is too much unsuitable, be splashed in the container when preventing that water from opening, then intense fire boils, and simmers in water to boil 20-30 minute again, flame-out cooling is removed slag and is stayed liquid;

(2) add Colophonium, Realgar, Benzoinum, Cera Flava in medicinal liquid, boil with fire again, the limit is boiled while stirring and to be melted, and after medicine melts, puts into Camphora again and closes the lid, and after Camphoraization is even, the container of decoct medicinal herbs is taken out cooling and get final product in cauldron.