CN102670765A - Traditional Chinese medicine composition for treating cancer pain - Google Patents
Traditional Chinese medicine composition for treating cancer pain Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cancer pain, comprising the following components by weight: 2-4 parts of rhizoma corydalis, 2-4 parts of Hypeccum C Linesis Fr, 2-4 parts of chelidonium majus, 1-2 parts of angelica dahurica, 2-4 parts of semen ziziphi spinosae, and 2-4 parts of Ganoderma lucidum; the traditional Chinese medicine components are traditional Chinese medicine raw powders or traditional Chinese medicine extracts equivalent to crude drug dose of the traditional Chinese medicines; the traditional Chinese medicine composition provided by the invention can be used for treating cancer pain.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, is a kind of Chinese medicine composition that is used to treat cancer pain, and the component of said composition can be directly to be ground into Chinese crude drug that powder is used as medicine and/or through extracting the Chinese medicine extract that obtains.
Background technology
Cancer pain is one of the most frightened symptom of tumor patient, and is often more fearful than the death that cancer causes.Cancer pain not only makes the patient agonize, but also can bring a series of seriously influencing, and can quicken the development of tumor; Nausea and vomiting, loss of appetite, anxiety, fear, depression, be reluctant to associate with the people; Various body functions go down, and mobility descends; Life and treatment are lost the confidence etc.The huge infringement that pain causes health, physiology and psychological aspects not only obviously has influence on patient's quality of life, but also can have influence on the enforcement and the effect of disease treatment.Part patient does not lose patience because of pain obtains Satisfactory Control, even can abandon effecting a radical cure the chance of cancer.
Therefore, cancer pain can cause serious harm, and each phase cancer patient should actively accept pain management.
Now the medicine of treatment cancer pain is divided into 3 big types: 1. non-opium medicine is used for mild to moderate pain; 2. opioid drug divides weakly, strong 2 kinds, is respectively applied for and alleviates moderate to severe pain, and morphine is represented medicine for it; 3. auxiliary medicaments comprises other drugs such as the effective CI of specific type, antianxiety drug, anticonvulsant and corticosteroid.The cancer pain three stepped care principles that WH0 formulates: first ladder is that application non-opium medicine such as acetaminophen, aspirin or other nonsteroidal antiinflammatory drugs are treated mild to moderate pain; Second ladder is if pain continues or aggravation, just should increase (not being to replace) weak opioid drug, like cocaine; Rest pain or pain from the beginning of in promptly showing as to the patient of severe, should select strong effect opioid drug such as morphine, fentanyl or methadone etc. or improve the dosage of opioid drug, be i.e. the 3rd ladder.When stating medicine in the use in addition, should unite according to the pain situation clinically and use auxiliary analgesic, to reach better therapeutic.The Drug therapy that WHO recommends has 5 main points: oral, on time, press ladder, individual administration, attention detail.Recur owing to the dosage by rule can make vivo medicine concentration keep constant and help prevent irritation,, should increase dosage in case of necessity more on time to be the basis therefore for the persistence cancer pain.Use morphine slow releasing tablet and controlled release tablet mainly treat in, severe pain, it is better that this medicine soaks into pain caused effect to osteodynia, Encelialgia, soft tissue, not good enough to the neuralgia effect, common adverse effect has constipation with nauseating, old person has drowsiness performance.
Therefore, the medicine that exploitation has that Chinese medicine characteristics, clinical efficacy are definite, taking convenience, patient can life-time service forms the distinct compound Chinese medicinal preparation of characteristic and has important society and economic implications.
Summary of the invention
The present invention observes at clinical practice Chinese medicine cancer pain patient to confirm that Chinese herb decoction treatment cancer pain has significantly curative effect, can obviously improve symptom, improves patient's life quality.
The present invention repeatedly practises the effective Chinese medicine compound that sums up through the clinical treatment cancer pain, is made up of Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma etc., and having eases pain sleeps peacefully, regulates the flow of vital energy detoxicating functions, and better curative effect is arranged in the clinical treatment cancer pain.
The present invention is through clinical observation; Effective Chinese medicine compound of research summary treatment cancer pain; Be refining through extracting by Chinese medicines such as Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganodermas, the pure Chinese medicinal preparation that makes, having eases pain sleeps peacefully, regulates the flow of vital energy Detoxication; And determined curative effect, safety and stability.
The medicine that the object of the invention is that a kind of Chinese medicine composition is provided and comprises said composition, this medicine can be treated cancer pain.
The object of the invention also is to provide the method for preparing of above-mentioned composition and medicine, through this method, can obtain being used to treating evident in efficacy, the sophisticated technologies of cancer pain, stay-in-grade pharmaceutical composition.
The object of the invention also is to provide above-mentioned composition to be used to treat the purposes of cancer pain.
In order to achieve the above object; The invention provides a kind of Chinese medicine composition; Said composition comprises following parts by weight of Chinese traditional medicine component: Rhizoma Corydalis 2-4 part, throat grass 2-4 part, Herba Chelidonii 2-4 part, Radix Angelicae Dahuricae 1-2 part, Semen Ziziphi Spinosae 2-4 part, Ganoderma 2-4 part, said Chinese medicinal components is above-mentioned Chinese crude drug fecula or be equivalent to the Chinese medicine extract of above-mentioned Chinese crude drug crude drug amount.
In a preferred embodiment of the invention; Above-mentioned Chinese medicine composition is made up of following parts by weight of Chinese traditional medicine component: 2 parts of Rhizoma Corydalis, 2 parts of throat grass, 2 parts of Herba Chelidoniis, 1 part of the Radix Angelicae Dahuricae, 2 parts of Semen Ziziphi Spinosaes, 2 parts of Ganodermas, said Chinese medicinal components can be above-mentioned Chinese crude drug fecula or the Chinese medicine extract that is equivalent to the crude drug amount of above-mentioned Chinese crude drug.
Wherein, above-mentioned Semen Ziziphi Spinosae, Semen Ziziphi Spinosae and the Rhizoma Corydalis of Rhizoma Corydalis for concocting, wherein, the Semen Ziziphi Spinosae of the process of preparing Chinese medicine is the Semen Ziziphi Spinosae of parch, the Rhizoma Corydalis of the process of preparing Chinese medicine is the vinegar Rhizoma Corydalis; This concocting method is approach well known.
And above-mentioned Chinese medicinal components comprises Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma, and it is the aqueous extract of this Chinese crude drug.
The medicine of above-mentioned treatment cancer pain is preferably peroral dosage form, comprises dosage forms such as honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum, oral liquid or syrup; This medicine is granule, capsule, tablet or powder more preferably.
Through overtesting, the pharmacy acceptable auxiliary that screening obtains is preferably arbitrary or its combination in microcrystalline Cellulose, starch, the dextrin, and more preferably microcrystalline Cellulose, starch or dextrin most preferably are dextrin; The weight of this pharmacy acceptable auxiliary accounts for the 0.1-50% of this drug weight.
Compositions of the present invention and medicine are made up of Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma etc., have the effect that analgesia is slept peacefully, detoxified and regulate the flow of vital energy, and are used for cancer pain.The present invention has at first selected mixture according to the characteristics of its medication, and technology is easy, taking convenience, but clinical response and the less stable of finding mixture in the practice process; The inventor preferably selects the for example oral solid formulation of tablet again according to modern patient's medication characteristics, because of each Chinese medicinal components of the present invention is to be used as medicine through the form of extracting the aqueous extract that obtains; Therefore it is fast to obey post-absorption, and easy and simple to handle, preparation stabilization; Finished-product volume reduces, taking convenience.Through experimentation, preparation technology is easy, steady quality, controlled, preparation safety, effectively, the clinical verification effect is also good, so in a preferred embodiment of the invention, the dosage form of medicine of the present invention is confirmed as tablet.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition; This method for preparing is in many-sided factors such as the property of medicine of the comprehensive above-mentioned medicine of respectively distinguishing the flavor of, clinical, productions; Consulting on the basis of documents and materials; In conjunction with physicochemical property, the pharmacologically active of the effective ingredient of each flavour of a drug, through repetition test research, the process route of the product of the present invention of design.
Therefore, the method for preparing of Chinese medicine composition of the present invention comprises: get Chinese crude drug decocte with water such as Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma; The weight that adds water is 1-30 times of this Chinese crude drug weight, and the decocting liquid that obtains is this Chinese medicine composition.Also can this decocting liquid drying be obtained dried cream powder, be this solid-state Chinese medicine composition (or dried cream powder of title Chinese medicine composition).
The preferred for preparation method of above-mentioned Chinese medicine composition comprises: gets Chinese crude drug decocte with water such as Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma three times, was respectively heat time heating time 2 hours, and 1 hour, 1 hour; The weight that adds water is 1-26 times of this Chinese crude drug weight, is respectively 10 times, 8 times, and 8 times; Collecting decoction is concentrated into thick paste, and drying, pulverizing, molding can obtain Chinese medicine composition of the present invention.
General Chinese crude drug is used with decoction clinically basically, and the method that adopts decocting to boil just can extract it basically, thereby guarantees the curative effect of preparation.
Below be to be example, carry out the Orthogonal Experiment and Design of extraction and preparation technique with 6 flavor medicines (total crude drug amount 110g) such as 2 parts of 2 parts of Rhizoma Corydalis, throat grass, 2 parts of Herba Chelidoniis, 1 part of the Radix Angelicae Dahuricae, 2 parts of Semen Ziziphi Spinosaes, 2 parts of Ganodermas.
Through overtesting, investigate the factor that decocting boils that influences in many ways, select amount of water, extraction time, extraction time for to influence the main factor that decocting boils, and three reasonable level of corresponding selection make an experiment.Take by weighing totally 9 parts of Six-element medicines such as Rhizoma Corydalis 20g, throat grass 20g, Herba Chelidonii 20g, Radix Angelicae Dahuricae 10g, Semen Ziziphi Spinosae 20g, Ganoderma 20g, press L
9(3
4) orthogonal test table makes an experiment, and is controllability and the advance that guarantees product quality, to the index property composition tetrahydropalmatine content of the main test data paste-forming rate of reflection product quality and Rhizoma Corydalis as investigating index.
The mensuration of paste-forming rate: after the medicinal liquid of every part of test gained concentrated, be settled to 100mL, shake up, the accurate 50mL that draws is transferred in the dry evaporating dish of having weighed, and water-bath is steamed near and done, and the baking oven of putting 70 ℃ carries out drying under reduced pressure to constant weight, calculates paste-forming rate.
The Rhizoma Corydalis Determination on content: the employing HPLC (" an appendix VI of Chinese pharmacopoeia version in 2010 D), " assay " item method is down measured.
According to The results of analysis of variance of the present invention, method for distilling does not have the significance influence to result of the test, in conjunction with producing practical situation, confirms that the technology that decocting boils is: decocte with water 3 times was respectively 10 times of amounts 2 hours; Measured 1 hour for 8 times; Measured 1 hour for 8 times.
Verify that by above-mentioned preparation technology experimental result and orthogonal experiments are close, explain that this extraction process stablizes feasible.
By above-mentioned definite technology the prescription Chinese crude drug is extracted, filter, filtrating merges mixing.Obtain 4 parts of the medicinal liquids of equal volume, be concentrated into suitable relative density respectively, adopt the investigation of drying process with atomizing, following table 1 as a result.
Table 1 drying process is investigated the result
The result shows that the spray drying condition: it is 1.20～1.25 (60 ℃) that medicinal liquid is concentrated into relative density, 160 ℃ of intake air temperatures, and 90 ℃ of air outlet temperature are processed dried cream powder, and outward appearance is better, and hygroscopicity is less, so that next step moulding process is used.
With medicine of the present invention is that tablet is an example, and bound drug self-characteristic, preparations shaping standard and big Financial cost of producing need, and adopt wet granulation, add appropriate amount of auxiliary materials and process tablet.
This preparation is a tablet, considers the crowd that takes of this medicine, take for making things convenient for it, and factory's preparations shaping and big Financial cost of producing, add appropriate amount of auxiliary materials, adopt 80% ethanol wet granulation, tabletting, both.
Adopt wet granulation, the selection and the consumption of wetting agent are most important.At first draft the proportioning prescription, confirm wetting agent and consumption through testing, the result sees table 2.
Table 2 wetting agent, amount of ethanol and concentration are to particulate influence
Conclusion: wetting agent is selected 80% ethanol, and addition is 5%.
Actual in conjunction with producing, the principle of saving manufacturing cost is considered from the finished product of preparation simultaneously, in semi-finished product, adds appropriate amount of auxiliary materials; Total amount is processed in adjusting and sheet is heavy, and granule and the tabletting processed all meet the requirements, and therefore adopts starch adjustment semi-finished product amount; Granulate tabletting, coating.
The present invention also provides the process for preparing medicine of the treatment cancer pain that contains above-mentioned Chinese medicine composition, and the method for preparing of this medicine comprises: get Chinese crude drug decocte with water such as Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma; The weight that adds water is 1-26 times of this Chinese crude drug weight, and decocting liquid filters, and relative density was 1.20～1.25 when filtrating was concentrated into 60 ℃, and spray drying gets extract powder, and adding pharmacy acceptable auxiliary gets final product.
If said medicine is an oral dosage form, the method for preparing of this medicine comprises: will comprise the Chinese crude drug decocte with water of Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma; The weight that adds water is 1-26 times of this Chinese crude drug weight, and decocting liquid filters, and relative density was 1.20～1.25 thick pastes when filtrating was concentrated into 60 ℃, drying; Get extract powder, add the pharmacy acceptable auxiliary, mixing, spray is with alcohol granulation; Drying, tabletting, coating promptly gets this medicine.
In a preferred embodiment of the invention; The process for preparing medicine of the above-mentioned Chinese medicine composition of the described the present invention of containing comprises: get 6 flavor Chinese crude drug decocte with water such as Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma three times; Decocting time was respectively 2 hours, and 1 hour, 1 hour; The weight that adds water is 1-26 times of this Chinese crude drug weight, is respectively 10 times, 8 times, and 8 times; Collecting decoction filters, and it is 1.20～1.25 (60 ℃) that filtrating is concentrated into relative density, spray drying, (160 ℃ of intake air temperatures; 90 ℃ of air outlet temperature), extract powder, add pharmacy acceptable auxiliary (for example dextrin, starch an amount of), mixing; Spray 80% alcohol granulation, drying, granulate; Tabletting is processed 1000, promptly gets medicine of treating cancer pain of the present invention.
According to this area routine techniques; Compositions of the present invention also can be made into honeyed pill, water-honeyed pill, the watered pill, paste pill, wax pill, concentrated pill; Its processing step is routine operation, and visual medical material situation difference takes the circumstances into consideration to change process conditions, and it is conventionally known to one of skill in the art.
If medicine of the present invention is capsule, then the dried cream powder processed of said method adds adjuvant, for example dextrin, or also add or other binding agent, abundant mixing, drying is pulverized, and incapsulates, and promptly gets.
The Chinese crude drug that is adopted in the compositions of the present invention is the medical material that version Chinese Pharmacopoeia in 2010 is recorded, through identifying the equal conformance with standard regulation of each item index.
The inspection of arsenic salt and heavy metal in the medicine of the present invention: press one one of Chinese Pharmacopoeia version in 2010, the regulation under appendix IXE, the IXF item checks that to the arsenic salt and the heavy metal of these article 3 lot sample article the result does not list in the standard preparation in prescribed limit.
Health examination in the medicine of the present invention meets pharmacopeia appendix preparation regulation hygiology standard-required.
The present invention also provides the application of above-mentioned Chinese medicine composition in preparation treatment cancer pain.
Medicine of the present invention is example with the tablet, and clinical dosage is recommended as 3-4 sheet/inferior, 3 times/day.
The pharmacology pharmacodynamic experimental study
1. medicine and animal thereof
1.1 medicine: compound pain sheet extract provides lot number by the Ministry of Education of resource institute of Beijing Normal University resource medicine engineering institute: 20090901.Compound method: accurately take by weighing a certain amount of compound pain sheet extract,, be made into the medicinal liquid of 3.25%, 6.5% and 13% concentration with the dissolved in distilled water dilution, subsequent use.Indometacin is produced lot number: 20090401 by Shijiazhuang China imperial Pharmaceutical limited company.Compound method: accurately take by weighing a certain amount of indometacin medicated powder, use distilled water diluting, be made into the medicinal liquid of 0.07% concentration, subsequent use.
1.2 animal: healthy mice, the Kunming kind, body weight 20 ± 1g raises in 20-22 ℃ room temperature environment, and 10 one cages freely absorb feedstuff and water, and animal is provided by Beijing Vital River Experimental Animals Technology Co., Ltd..The quality certification number: the capital is moving is betrothed to: SOXK (capital) 2009-0002.Before the test at the center animal housing's adaptability raise a week, the quality certification number: SYXK (capital) 2009-0002.
2. test method
Kunming mouse, 50, ♀ ♂ half and half, body weight 20 ± 1g.Be divided into 6 groups at random by the fasting body weight: matched group; The compound pain sheet little (0.325g crude drug/kg), in (0.65g crude drug/kg), big (1.3g crude drug/kg); Positive drug group (indometacin 7.0mg/kg).Every group 10.Each group is irritated stomach by body weight and is given each medicine 0.1ml/10g, and matched group gives the equal-volume distilled water, successive administration 8d.40min behind the 7d medicine puts into mice on the hot plate of constant temperature water bath, observes mice and licks the incubation period of metapedes reaction and the reaction times in the 1min, and every mice interval 10min measures 1 time, and METHOD FOR CONTINUOUS DETERMINATION 2 times is averaged.Behind 8d administration 40min, lumbar injection 1% acetic acid normal saline solution 0.1ml/10g.Behind injection acetic acid normal saline solution 10min, observe the number of times of animal generation writhing response in the 15min.Data are represented with Mean ± sd, relatively adopt one factor analysis of variance between group.
3. result of the test
The compound pain sheet is little, in, heavy dose of all can significant prolongation hot plate method mice licking metapedes incubation period; Reduce hot plate method reaction times and acetic acid twisting number of times; Relatively there were significant differences (P＜0.05, P＜0.01 or P＜0.001) with matched group, and prompting compound pain sheet has analgesic activity.The result sees table 3.
Table 3 compound pain sheet is to the analgesic activity (hot plate method, acetic acid twisting method) of mice (M ± sd)
Annotate: compare with matched group,
*P＜0.05,
*P＜0.01,
* *P＜0.001
In sum, the present composition has therapeutical effect to cancer pain, and the clinical application result shows determined curative effect, and is safe and effective, and long-time stability are investigated and also shown present composition steady quality, reliable.
The specific embodiment
For more clear explanation goal of the invention and technical scheme, further detail by following embodiment.
Embodiment 1:
The prescription of compositions of the present invention:
Rhizoma Corydalis 200g is because of larynx grass 200g Herba Chelidonii 200g
Radix Angelicae Dahuricae 100g Semen Ziziphi Spinosae 200g Ganoderma 200g
Method for preparing:
Get Six-element medical materials such as Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma, decocte with water three times, 2 hours, 10 times, 1 hour, 8 times; 1 hour, 8 times, filter, collecting decoction, being concentrated into relative density is 1.20～1.25 (60 ℃); Spray drying, the powder that gets dry extract add filleies such as pharmacy acceptable auxiliary (for example dextrin, starch an amount of) and magnesium stearate, sprays 80% alcohol granulation; Tabletting, the bag film-coat is processed 1000, is compositions.
Embodiment 2:
The prescription of compositions of the present invention:
Rhizoma Corydalis 200g throat grass 200g Herba Chelidonii 200g
Radix Angelicae Dahuricae 100g Semen Ziziphi Spinosae 200g Ganoderma 200g
Method for preparing:
Preparation of compositions is with embodiment 1;
Capsule: in compositions, add an amount of dextrin, mixing sprays 80% alcohol granulation, and drying adds filler granulations such as magnesium stearate, and is encapsulated, promptly gets capsule of the present invention.
The result shows: present composition capsule meets the relevant each item regulation under the capsule item.
Claims (8)
1. Chinese medicine composition; Said composition comprises following parts by weight of Chinese traditional medicine component: Rhizoma Corydalis 2-4 part, throat grass 2-4 part, Herba Chelidonii 2-4 part, Radix Angelicae Dahuricae 1-2 part, Semen Ziziphi Spinosae 2-4 part, Ganoderma 2-4 part, said Chinese medicinal components is above-mentioned Chinese crude drug fecula or the Chinese medicine extract that is equivalent to the crude drug amount of above-mentioned Chinese crude drug.
2. Chinese medicine composition as claimed in claim 1, wherein, described Semen Ziziphi Spinosae is the Semen Ziziphi Spinosae of parch; Described Rhizoma Corydalis is a Rhizoma Corydalis (processed with vinegar).
3. Chinese medicine composition as claimed in claim 1, wherein, described Chinese medicinal components is that the aqueous extract of Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma is formed.
4. medicine of treating cancer pain is comprising each described Chinese medicine composition of claim 1-3 and pharmacy acceptable auxiliary.
5. medicine as claimed in claim 4, wherein, described medicine is a peroral dosage form, this peroral dosage form comprises honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum, oral liquid or syrup.
6. medicine as claimed in claim 5, wherein, described medicine is granule, capsule, tablet or powder, described pharmacy acceptable auxiliary is arbitrary or its combination in microcrystalline Cellulose, starch, the dextrin; The weight of described pharmacy acceptable auxiliary accounts for the 0.15-50% of this drug weight.
7. the method for preparing of the described medicine of claim 4, wherein, this method comprises: the Chinese crude drug decocte with water of Rhizoma Corydalis, throat grass, Herba Chelidonii, the Radix Angelicae Dahuricae, Semen Ziziphi Spinosae, Ganoderma; The weight that adds water is 1-26 times of this Chinese crude drug weight, and decocting liquid filters, and relative density was 1.20～1.25 when filtrating was concentrated into 60 ℃, and drying gets extract powder, and adding pharmacy acceptable auxiliary, mixing, and alcohol granulation, drying, tabletting, coating promptly obtains this medicine.
8. the application of the described Chinese medicine composition of claim 1 in preparation treatment cancer pain.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266918A (en) * | 2016-09-20 | 2017-01-04 | 陈亚平 | A kind of Chinese medicine composition treating cancer pain and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005341964A (en) * | 2004-05-06 | 2005-12-15 | Takashi Kondo | Health food containing deer horn shaped ganoderma lucidum, and method for producing the same |
| CN1931286A (en) * | 2005-10-08 | 2007-03-21 | 周小明 | Chinese medicine composition for treating lung cancer caused pain |
| WO2008127302A2 (en) * | 2006-10-27 | 2008-10-23 | Genyous BioMed International, Inc. | Compositions for treatment and inhibition of pain |
-
2012
- 2012-05-28 CN CN2012101711232A patent/CN102670765A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005341964A (en) * | 2004-05-06 | 2005-12-15 | Takashi Kondo | Health food containing deer horn shaped ganoderma lucidum, and method for producing the same |
| CN1931286A (en) * | 2005-10-08 | 2007-03-21 | 周小明 | Chinese medicine composition for treating lung cancer caused pain |
| WO2008127302A2 (en) * | 2006-10-27 | 2008-10-23 | Genyous BioMed International, Inc. | Compositions for treatment and inhibition of pain |
Non-Patent Citations (2)
| Title |
|---|
| 张勇忠等: "镇痛汤活性成分的研究", 《中草药》 * |
| 彭媛等: "植物药镇痛作用的研究进展", 《中国野生植物资源》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266918A (en) * | 2016-09-20 | 2017-01-04 | 陈亚平 | A kind of Chinese medicine composition treating cancer pain and preparation method thereof |
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Application publication date: 20120919 |