CN102670715B - Cordyceps sinensis mycelium oral liquid - Google Patents
Cordyceps sinensis mycelium oral liquid Download PDFInfo
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- CN102670715B CN102670715B CN201210138729.6A CN201210138729A CN102670715B CN 102670715 B CN102670715 B CN 102670715B CN 201210138729 A CN201210138729 A CN 201210138729A CN 102670715 B CN102670715 B CN 102670715B
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- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 241001248610 Ophiocordyceps sinensis Species 0.000 title abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 24
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 22
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 8
- 241000190633 Cordyceps Species 0.000 claims description 56
- 240000001008 Dimocarpus longan Species 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 6
- 239000005909 Kieselgur Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000002075 main ingredient Substances 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 230000036541 health Effects 0.000 abstract description 4
- 239000003086 colorant Substances 0.000 abstract description 2
- 235000012907 honey Nutrition 0.000 abstract description 2
- 244000139609 Euphoria longan Species 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 240000001307 Myosotis scorpioides Species 0.000 description 4
- -1 al Species 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000002398 materia medica Substances 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 241001672694 Citrus reticulata Species 0.000 description 2
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 2
- 241000222336 Ganoderma Species 0.000 description 2
- 235000006439 Lemna minor Nutrition 0.000 description 2
- 244000242291 Lemna paucicostata Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 2
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 2
- 235000013364 duck meat Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 235000007710 Grifola frondosa Nutrition 0.000 description 1
- 240000001080 Grifola frondosa Species 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to cordyceps sinensis mycelium oral liquid. The formula of the cordyceps sinensis mycelium oral liquid comprises the following components according to a mass ratio: 80 to 95 percent of cordyceps sinensis mycelium powder extract, 1 to 10 percent of longan extract and 1 to 10 percent of honey. According to the formula disclosed by the invention, any preservative and any colorant are not added, the preparation method is simple, the period is short, the production cost can be effectively controlled, the cordyceps sinensis mycelium oral liquid is safe to take, and the price is reasonable. The cordyceps sinensis mycelium oral liquid is suitable for the requirement of health care of more common people.
Description
Technical field
The present invention relates to a kind of health product, relate in particular to a kind of Cordyceps mycelium oral liquid.
Background technology
Cordyceps is as a kind of traditional Chinese medicine, for one of famous and precious tonic of China, at all times the medical value of Cordyceps is had to very high evaluation, < < Bencao Congxin > >, < < A Supplement to the Compendium of Materia Medica > > and < < Liu Ya compile > > outward, the little knowledge in < < Citrus chachiensis Hort. garden > >, < < book on Chinese herbal medicine usage studies > > etc. claims Cordyceps " sweet flat nontoxic ", " protect lung kidney tonifying, hemostasis and phlegm ", " control weakness ".Modern medicine study shows, contains the nutritions such as cordycepic acid, cordycepin and each seed amino acid in Cordyceps, can promote metabolism, raising immunocompetence, resisting fatigue, the anti-ageing effect of waiting for a long time of human body.Because the output of natural cs is few, expensive, people start gradually artificial culture Cordyceps mycelium and replace Cordyceps sporophore, but the cultivation cycle of the preparation method complexity of existing Cordyceps mycelium and bacterial strain is long, the Chinese caterpillar fungus oral liquid of preparation is expensive, can not meet the needs of general public.Cordyceps is one of famous and precious tonic of China, at all times the medical value of Cordyceps is had to very high evaluation, < < Bencao Congxin > >, < < A Supplement to the Compendium of Materia Medica > > and < < Liu Ya compile > > outward, the little knowledge in < < Citrus chachiensis Hort. garden > >, < < book on Chinese herbal medicine usage studies > > etc. claims Cordyceps " sweet flat nontoxic ", " protect lung kidney tonifying, hemostasis and phlegm ", " control weakness ".Modern medicine study shows, contains the nutritions such as cordycepic acid, cordycepin and each seed amino acid in Cordyceps, can promote metabolism, raising immunocompetence, resisting fatigue, the anti-ageing effect of waiting for a long time of human body.
Chinese Patent Application No. is that 92114131.9 patent of invention has disclosed a kind of Chinese caterpillar fungus oral liquid, a kind of Chinese caterpillar fungus oral liquid that contains old duck meat extracting solution particularly, this invention is converted the old duck meat extracting solution of upper 20% left and right with Cordyceps concentrated solution and is mixed with, the method is with reference to " stewing old duck method " in < < A Supplement to the Compendium of Materia Medica > >, there is obvious guarantor's kidney, lung, benefit marrow, the functions such as resolving phlegm and relieving asthma.China Patent No. is a kind of body-building oral liquid disclosing in 200610080421.5 patent of invention documents in addition, and it is synthesized according to a certain ratio by ten kinds of medical herbs such as Radix Glycyrrhizae, Radix Panacis Quinquefolii, Cordyceps, the Rhizoma Atractylodis Macrocephalae processed, Radix Salviae Miltiorrhizae, Poria, Semen Ginkgo, Radix Changii, Arillus Longan, Rhizoma Polygonati Odorati and Mel, and potion is fried to be formed.The application for a patent for invention that China Patent No. is 200610137751.3 in addition discloses a kind of cordyceps sinensis lucid ganoderma oral liquid, its formula is as follows: Cordyceps mycelium 40～80%, Ganoderma mycelium 5～15%, maitake mushroom mycelia 4～10%, Cordyceps extract concentrated solution 2～5%, extracts of Chinese herbal medicine 5～15%, agar powder 0.02～0.12%, proper honey, extract of protein and purified water.Adopt the preparation method that multiple strain ferments simultaneously to make product.Because natural cordyceps output is few, price is very expensive, although the Chinese caterpillar fungus oral liquid that above-mentioned several method is made has curative effect separately, but its production cost is higher, particularly the oral liquid of the second and the third processing technology in, adopt Chinese caterpilar fungus concentrated solution as raw material, its manufacturing cost is very high, and its technique is more complicated, is not suitable for industrial mass production.
Summary of the invention
The technical problem to be solved in the present invention, is to provide a kind of Cordyceps mycelium oral liquid and preparation method thereof, and its formula is more reasonable, and preparation method is simple, the cycle is short, has effectively controlled production cost, reasonable price, applicable most common people's health care demand.
Technical scheme of the present invention: a kind of Cordyceps mycelium oral liquid, is characterized in that: its formula is in mass ratio:
Cordyceps mycelium powder extracting solution 80 ~ 95%;
Arillus Longan extracting solution 1 ~ 10%;
Mel 1 ~ 10%.
The ratio of above-mentioned each component can be preferably:
Cordyceps mycelium powder extracting solution 94 %;
Arillus Longan extracting solution 1 %;
Mel 5 %.
A preparation method for Cordyceps mycelium oral liquid, is characterized in that technological process is:
A) prepare Cordyceps mycelium powder, and extract its active ingredient: Cordyceps mycelium is ground to form to powdery, again Cordyceps mycelium powder is put into and injected quantitative clear water extraction pot, be warming up to 90 ℃ and maintain 90min, when check Main Ingredients and Appearance PEARLITOL 25C content reaches about 100mg/L, can stop extracting;
B) filter: after flame filter press filters, obtain Cordyceps mycelium powder filtrate;
C) concentrated: above-mentioned Cordyceps mycelium powder filtrate concentrates through vacuum concentrator, check again, the product standard of its PEARLITOL 25C content >=120mg/L of take is terminal, obtains Cordyceps mycelium powder extracting solution;
D) extraction of Arillus Longan: inject clear water in extraction pot, Arillus Longan is dropped in extraction pot, be warming up to 100 ℃, and maintain 60min, then obtain Arillus Longan extracting solution after filtering;
E) preparation of oral liquid: the Cordyceps mycelium powder extracting solution after concentrated is pumped in material-compound tank, add Arillus Longan extracting solution, Mel and water, carry out accurate standardize solution, wherein, the mass ratio of each component is: Cordyceps mycelium powder extracting solution 80 ~ 95%; Arillus Longan extracting solution 1 ~ 10%; Mel 1 ~ 10%; Through diatomaceous earth filter, filter and obtain Cordyceps mycelium oral liquid again, through after the assay was approved, carry out going out finished product after fill, high temperature sterilize.
Wherein, described autoclaving can be specially: the oral liquid after fill is entered in high-pressure sterilizing pot, at 121 ℃, maintain 40min, take the dish out of the pot after cooling.
Tool of the present invention has the following advantages: because the output of natural cs is few, expensive, applicant is through experiment for many years, artificial culture Cordyceps mycelium is replaced to the raw material that Cordyceps sporophore is produced as oral liquid, and replace its acute toxicity test result of natural cs to show also to have advantages of less than natural cs toxicity with Cordyceps mycelium; The formula that the present invention adopts is in addition applicable to most of general populations, and preparation method is simple, the cycle is short, has effectively controlled production cost, reasonable price, can meet the health care demand of ordinary consumer, not add any antiseptic, coloring agent in formula of the present invention, consumer takes safer.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be described in detail.
A Cordyceps mycelium oral liquid, its formula is in mass ratio:
Cordyceps mycelium powder extracting solution 80 ~ 95%;
Arillus Longan extracting solution 1 ~ 10%;
Mel 1 ~ 10%;
The formula of a preferred embodiment of the present invention is:
Cordyceps mycelium powder extracting solution 94 %;
Arillus Longan extracting solution 1 %;
Mel 5 %.
The production 1000kg oral liquid of take is example, and the preparation method of the preferred embodiment is as follows:
A) extract the active ingredient (equipment: volume 6T extraction pot): first Cordyceps mycelium is ground to form to powdery of Cordyceps mycelium powder, in extraction pot, quantitatively inject 1100 L clear water, Cordyceps mycelium powder 50kg is put in extraction pot, be warming up to 90 ℃ and maintain 90min, when check Main Ingredients and Appearance PEARLITOL 25C content reaches about 100mg/L, can stop extracting;
B) filter (equipment: 30 ㎡ filter press): filter (the about 1000kg of amount that obtains filtrate) through flame filter press;
C) concentrated (1T/h concentration kettle): filtrate concentrates through 1T/h vacuum concentrator, check again, the product standard of its PEARLITOL 25C content >=120mg/L of take is terminal, (concentrated solution must be measured about 910kg);
D) extracting method of Arillus Longan: inject 50L clear water in the extraction pot of 500L, Arillus Longan 10kg is dropped in extraction pot, be warming up to 100 ℃, and maintain 60min, filter, filtrate must be measured about 40kg;
E) preparation (equipment: the material-compound tank of volume 6T,, 2 ㎡ diatomaceous earth filters): the extracting solution 910kg after concentrated is pumped in material-compound tank, adds Arillus Longan extracting solution 40kg, Mel 50kg, accurate standardize solution, at 1000kg, filters through diatomaceous earth filter, and filtrate is finally sent laboratory check;
F) standardize solution: will lose part moisture while extracting due to mycopowder and Arillus Longan, and therefore, need finally determine preparation capacity by the proportioning of above-mentioned each component, the object of standardize solution is exactly that to guarantee that production technology formula and this product effective ingredient are preset accurate;
G) fill (equipment: 6T receiver; The full-automatic filling production lines of 1000 bottles/h): significant index reaches after product standard to be delivered to racking room by infusion pump and enter automatic loading production line and carry out fill;
H) autoclaving (equipment: 4 cubes of high-pressure sterilizing pots): the oral liquid after fill enters in high-pressure sterilizing pot, maintain 40min at 121 ℃, take the dish out of the pot after cooling;
I) check (equipment: lamp inspection machine): to the oral liquid after taking the dish out of the pot by bottle lamp inspection;
Packing (equipment: labelling machine): enter labelling machine after lamp inspection and pack, end product.
Claims (4)
1. a Cordyceps mycelium oral liquid, is characterized in that: its component is in mass ratio:
Cordyceps mycelium powder extracting solution 80～95%;
Arillus Longan extracting solution 1～10%;
Mel 1～10%.
2. Cordyceps mycelium oral liquid according to claim 1, is characterized in that: its component is specially:
Cordyceps mycelium powder extracting solution 94%;
Arillus Longan extracting solution 1%;
Mel 5%.
3. a method of preparing Cordyceps mycelium oral liquid claimed in claim 1, is characterized in that: its technological process is:
A) prepare Cordyceps mycelium powder, and extract its active ingredient: Cordyceps mycelium is ground to form to powdery, again Cordyceps mycelium powder is put into and injected quantitative clear water extraction pot, be warming up to 90 ℃ and maintain 90 minutes, when check Main Ingredients and Appearance PEARLITOL 25C content reaches about 100mg/L, can stop extracting;
B) filter: after flame filter press filters, obtain Cordyceps mycelium powder extracting solution;
C) concentrated: above-mentioned Cordyceps mycelium powder extracting solution is concentrated through vacuum concentrator, check again, the product standard of its PEARLITOL 25C content >=120mg/L of take is terminal, obtains Cordyceps mycelium powder concentrated solution;
D) extraction of Arillus Longan: inject clear water in extraction pot, Arillus Longan is dropped in extraction pot, be warming up to 100 ℃, and maintain 60min, then obtain Arillus Longan extracting solution after filtering;
E) preparation of oral liquid: the Cordyceps mycelium powder concentrated solution after concentrated is pumped in material-compound tank, add Arillus Longan extracting solution, Mel and water, according to the proportion requirement of each component, carry out accurate standardize solution, wherein each component is specially in mass ratio: Cordyceps mycelium powder extracting solution 80～95%; Arillus Longan extracting solution 1～10%; Mel 1～10%; Through diatomaceous earth filter, filter and obtain Cordyceps mycelium oral liquid again, through after the assay was approved, carry out going out finished product after fill, high temperature sterilize.
4. the manufacture method of Cordyceps mycelium oral liquid according to claim 3, is characterized in that: described autoclaving can be specially: the oral liquid after fill is entered in high-pressure sterilizing pot, maintain 40 minutes at 121 ℃, take the dish out of the pot after cooling.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210138729.6A CN102670715B (en) | 2012-05-08 | 2012-05-08 | Cordyceps sinensis mycelium oral liquid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210138729.6A CN102670715B (en) | 2012-05-08 | 2012-05-08 | Cordyceps sinensis mycelium oral liquid |
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| Publication Number | Publication Date |
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| CN102670715A CN102670715A (en) | 2012-09-19 |
| CN102670715B true CN102670715B (en) | 2014-02-26 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103238712A (en) * | 2013-05-20 | 2013-08-14 | 北京绿源求证科技发展有限责任公司 | Anti-aging food health tea electuary |
| CN103520364A (en) * | 2013-09-05 | 2014-01-22 | 上海其易融生物技术有限公司 | Compound medicinal composition of cordyceps mycelia and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145740A (en) * | 1995-09-22 | 1997-03-26 | 贤英越 | Longan paste |
| CN101104006A (en) * | 2007-08-13 | 2008-01-16 | 叶天任 | Method for preparing Chinese caterpillar fungus extracting concentrated liquid and application thereof |
-
2012
- 2012-05-08 CN CN201210138729.6A patent/CN102670715B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145740A (en) * | 1995-09-22 | 1997-03-26 | 贤英越 | Longan paste |
| CN101104006A (en) * | 2007-08-13 | 2008-01-16 | 叶天任 | Method for preparing Chinese caterpillar fungus extracting concentrated liquid and application thereof |
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| CN102670715A (en) | 2012-09-19 |
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Denomination of invention: Cordyceps sinensis mycelium oral liquid Effective date of registration: 20230111 Granted publication date: 20140226 Pledgee: Agricultural Bank of China Limited by Share Ltd. Shunchang branch Pledgor: FUJIAN RUNXING BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2023350000013 |
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