CN103520364A - Compound medicinal composition of cordyceps mycelia and preparation method thereof - Google Patents
Compound medicinal composition of cordyceps mycelia and preparation method thereof Download PDFInfo
- Publication number
- CN103520364A CN103520364A CN201310398836.7A CN201310398836A CN103520364A CN 103520364 A CN103520364 A CN 103520364A CN 201310398836 A CN201310398836 A CN 201310398836A CN 103520364 A CN103520364 A CN 103520364A
- Authority
- CN
- China
- Prior art keywords
- cordyceps mycelium
- medicament composition
- cordyceps
- compound medicament
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to the technical field of medicines, and in particular relates to a compound medicinal composition of cordyceps mycelia and a preparation method thereof. The compound medicinal composition of cordyceps mycelia comprises the following main medicinal components in parts by weight: 40-50 parts of cordyceps mycelia, 25-35 parts of longan pulp, 12-18 parts of barbary wolfberry fruit and 8-12 parts of lotus seeds. According to the compound medicinal composition of cordyceps mycelia, a variety of auxiliary medicinal materials are introduced to assist and improve the effect of the cordyceps mycelia, so that the compound medicinal composition has a variety of functions of adjusting human immune system, improving human immunity, resisting aging, tumor and fatigue and the like, and the effect of the compound medicinal composition is equivalent to that of natural cordyceps.
Description
Technical field
The present invention relates to medical technical field, particularly relate to compound medicament composition of a kind of Cordyceps mycelium and preparation method thereof.
Background technology
Hepialus armorieanus Oberthur larva is infected by Cordyceps (Cordyceps sinensis), after death corpse, tissue and mycelia are formed hard [Dan, keep in the winter time that worm shape is constant reaches the several months long (winter worm) in cold drying soil, until summer, warm and humidly from sclerotium, grow clava (ascostome) and basset (summer grass) when suitable, have another name called cordyceps sinensis, be called again Cordyceps sinensis, be called for short Cordyceps.It is the traditional rare medicinal herbs of China.Real Cordyceps is wild, and it mainly originates in province and municipal severe cold areas and the snow-capped mountains and marshlands such as Qinghai, Tibet, Xinjiang, Sichuan, Yunnan, Gansu, Guizhou.Famous strengthening by means of tonics medicine, conventional meat boiled dinner, the effect that has tonify deficiency to be healthy and strong.Be applicable to treat spitting of blood due to insufficiency of lung-QI and deficiency of both the lung and kidney, pulmonary tuberculosis etc. or sputum mixed with blood, cough.Breathe hard, night sweat etc., impotence due to deficiency of the kidney, waist knee joint ache etc. is also had to good curative effect, the person's that is also oldaged physically weak excellent tonic product.
Due to exhaustive exploitation, worm grass resources is exhaustion day by day in recent years, and people attempt cultivating Cordyceps mycelium and do substituting of natural cs, have obtained approval.System adopts and from natural cordyceps, isolates cordyceps species, and the fermentation of artificial culture liquid is made.Had now in a large number the reports about Cordyceps mycelium and natural cs active ingredient, its difference be mainly polyoses content than the high 1-2 of Cordyceps doubly, natural cordyceps general polysaccharides content is at 2-3%, Cordyceps mycelium polyoses content 6-9%.Although but its content of drug effect components of Cordyceps mycelium is low unlike natural cs, some active component is even higher than natural cs, but its therapeutic effect but has certain gap with natural cs all the time, this is also why its market price of natural cs is high all the time, and the resource main cause of exhaustion day by day.
It is primary raw material that the Cordyceps mycelium that liquid submerged fermentation cultivates is take in the present invention, consider that Cordyceps mycelium and natural cordyceps distinguish to some extent according to this feature, compatibility has the medicinal and edible Chinese medicine of strengthening by means of tonics effect and safety, assist to improve the curative effect of Cordyceps mycelium, make it to reach the efficacy effect of natural cordyceps.Formula used in the present invention comprises Arillus Longan, Fructus Lycii and Semen Nelumbinis.Wherein, Arillus Longan has invigorating the heart and spleen, the effect of nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.Arillus Longan is the aril of sapindaceous plant Arillus Longan, has another name called Fructus Alpiniae Oxyphyllae, sweet spleen, Arillus Longan.Arillus Longan is the official drug of the Pharmacopoeia of the People's Republic of China, desirable tonic.The traditional Chinese medical science is thought, Arillus Longan sweet in the mouth, warm in nature.Enter the heart, spleen channel.There is invigorating the heart and spleen, nourish blood allay excitement, the effect such as invigorating the spleen to arrest diarrhea, inducing diuresis to remove edema.Be applicable to the diseases such as body void, blood deficiency and yellow complexion, insufficiency of vital energy and blood, neurasthenia, severe palpitation, forgetful insomnia after being ill.As far back as Han dynasty period, Arillus Longan is just as medicinal.Li Shizhen (1518-1593 A.D.) is said: " the large benefit of Arillus Longan ", " food be take Fructus Litchi as expensive, and money benefit Arillus Longan is good." " daily book on Chinese herbal medicine ": " Fructus Alpiniae Oxyphyllae mind calming." " must join book on Chinese herbal medicine " think: " strengthening the spleen stomach, preserves painstaking effort to Arillus Longan, and moistening five ZANG-organs, controls palpitation with a distress feeling." " Quanzhou book on Chinese herbal medicine " think: Arillus Longan " tonifying YANG QI invigorating, tonifying the spleen and stomach." " medicineization justice ") say: " Arillus Longan, large nourishing YIN blood, after losing blood in all top, enters the same Semen Nelumbinis of GUIPI TANG, Semen Euryales with tonifying spleen-yin, make the prosperous system blood of spleen return through.As state of mind overstrain, heart channel insufficiency of blood, helps the Radix Rehmanniae, Radix Ophiopogonis to nourish the blood of the heart with this.Muscles and bones overwork again, liver is hollow, with this, helps Radix Rehmanniae Preparata, Radix Angelicae Sinensis, and liver nourishing is enriched blood." so far, Arillus Longan remains the important drugs of blood-enriching tranquillizing simply.According to modern study; Arillus Longan is eaten raw; taste is sweet tasty and refreshing; and nutritive value is very high; be rich in Hi CHO, protein, several amino acids and vitamin B, C, calcium, phosphorus, ferrum, tartaric acid, gland fat purine etc.; wherein, especially with many containing Citrin amount, for middle-aged and elderly people, there is the effect of protecting blood vessel, preventing sclerosis of blood vessels and fragility.When research Arillus Longan, find that it contains a kind of active component and has antidotal effect abroad.In Zhe Yu China pharmacy monograph Shennong's Herbal the earliest, the Arillus Longan of saying has not old the saying of making light of one's life by commiting suicide to match.So someone thinks that Arillus Longan is the antisenility cistanche food with better exploitation potential quality.Osaka, Japan Academy of Traditional Chinese Medicine once carried out anticancer test to more than 800 kinds of Natural Foods, medicine, found that the infusion of Arillus Longan has more than ninety percent suppression ratio to cervical cancer cell.The contained sugar amount of Arillus Longan is very high, is the monosaccharide of absorption easy to digest, can be directly absorbed by the body, therefore weak anemia is worn with age, and weakness due to chronic disease, often eating a little Arillus Longans is to have very much benefiting action; Women puerperal, Arillus Longan is also that food mended in important tune.Because of iron content and vitamin B2 very abundant, can alleviate uterine contraction and the sagging sense of palace body., anemia weak for women puerperal, body void etc., available Arillus Longan adds Radix Angelicae Sinensis, Fructus Lycii, several stewed chickens of Fructus Jujubae (enucleation).Can promoting blood flow to regulate menstruation, promote antisecosis.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum.Its sweet in the mouth, the flat effect with the liver and the kidney tonifying of property, say in Compendium of Material Medica and " take for a long time hard muscles and bones, make light of one's life by commiting suicide not old, cold-resistant summer-heat." traditional Chinese medical science conventional it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission.Modern pharmacology studies confirm that Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, has slow down aging, the effect of anti-fatty liver, adjusting blood fat and the aspect such as blood glucose, promotion hemopoietic function, and is applied to clinical.Lycium barbarum polysaccharide in Fructus Lycii is its important active ingredient, in Fructus Lycii, the content of polysaccharide is different and different with the place of production, wherein the polyoses content in lycium barbarum is different and different with the place of production, wherein the polyoses content in lycium barbarum is the highest, reach 8.2%, there is the Lycium barbarum polysaccharides (LBP) of immunological enhancement containing trace element and aminoacid, by six kinds of monosaccharide Ara, Clc, Gal, Man, Xyl and Rha, formed.In recent years; the Traditional Chinese Medicine experts of China according to modern clinic test principle in traditional Chinese medicine theory about Fructus Lycii safeguard and improve immune system, antioxidation, improve vision, the narration of the aspect such as liver function protecting, blood sugar lowering, blood pressure lowering is studied, and verified the pharmacological function of Fructus Lycii.
Semen Nelumbinis have to clear away heart-fire is amusing, spleen reinforcing antidiarrheal, and tranquilizing by nourishing the heart improving eyesight, invigorating middle warmer are reposed, and stomach is mended in spleen invigorating, antidiarrheal controlling nocturnal emission with astringent drugs, kidney tonifying relieving leukorrhea by astringents, the effect of nourishing vigour.Cure mainly vexed insomnia, insufficiency of the spleen chronic diarrhea, diarrhea with loose stool, chronic dysentery, pain in the lumbar region, man's seminal emission, married woman's leucorrhea with red and white discharge.Also can prevention of preterm birth, miscarriage, anemia of pregnant woman's soreness of waist.The nutritive value of Semen Nelumbinis is higher, contain rich in protein, fat and carbohydrate, calcium in Semen Nelumbinis, phosphorus and potassium content are very abundant, except forming the composition of skeleton and tooth, promote in addition blood coagulation, make some enzyme activation, maintain nerve conductivity, calm neural, maintain the retractility of muscle and the effects such as the rhythm and pace of moving things of heart beating.Abundant phosphorus or the key component of Nuclear extract, help body to carry out protein, fat, carbohydate metabolism, and maintain acid-base balance, and the formation of sperm is also played an important role.Semen Nelumbinis have the effect of tranquilizing by nourishing the heart.Middle-aged and elderly people particularly brain worker is often edible, can brain-strengthening, and memory reinforcing, increases work efficiency and can prevent the generation of alzheimer disease.Plumula Nelumbinis taste is extremely bitter, but has significant cardiotonic, can expand peripheral blood vessel, reduces blood pressure.Plumula Nelumbinis well goes the effect of heart-fire in addition, and treatment aphtha of the mouth and tongue, helps sleep.The effect that the useful heart the kidney invigorating of Semen Nelumbinis, invigorating the spleen to arrest diarrhea, controlling nocturnal emission with astringent drugs are calmed the nerves.
Summary of the invention
The shortcoming of prior art, the object of the present invention is to provide compound medicament composition of a kind of Cordyceps mycelium and its production and use in view of the above, for solving the problems of the prior art.
The present invention is exactly that to take the Cordyceps mycelium that liquid submerged fermentation cultivates be primary raw material, consider that Cordyceps mycelium and natural cordyceps distinguish to some extent according to this feature, compatibility has the medicinal and edible Chinese medicine of strengthening by means of tonics effect and safety, assist to improve the curative effect of Cordyceps mycelium, make it to reach the efficacy effect of natural cordyceps.
For achieving the above object and other relevant objects, the invention provides a kind of compound medicament composition of Cordyceps mycelium, its main pharmacodynamics composition by weight, comprises following component:
Cordyceps mycelium (peacilomyce hepiahi) 40-50 part;
Arillus Longan 25-35 part;
Fructus Lycii 12-18 part;
Semen Nelumbinis 8-12 part.
Described Arillus Longan is the dry fruit of Arillus Longan (Arillus Longan, Dimocarpus longgana Lour.).
Described Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum (Lycium barbarum L.).
Described Semen Nelumbinis are the dry mature seed of nymphaeaceae plant lotus (Nelumbo nucifera Gaertn.).
Second aspect present invention provides a kind of extract of compound medicament composition of Cordyceps mycelium, by the compound medicament composition extraction acquisition of described Cordyceps mycelium.
Third aspect present invention provides the preparation method of extract of the compound medicament composition of described Cordyceps mycelium, comprises the steps:
1), by after medicinal material drying, carry out coarse pulverization; By proportioning, weigh each component medical material powder, and mixing of materials is even;
2) step 1 gained mixed material is dropped into extraction pot, extracting in water, gained material carries out solid-liquid separation;
3) step 2 gained liquid phase reduced vacuum is concentrated, spraying is drying to obtain the extract of the compound medicament composition of described Cordyceps mycelium.
Preferably, in described step 1, coarse pulverization gained granule is 10-20 order granule.
Preferably, in described step 1, after mixing of materials is even, also utilize superfine technique further to pulverize.
Preferred, the particle diameter of further pulverizing gained material is 10-50 micron.
Preferably, in described step 2, the concrete steps of extracting in water are: first add 11.5-12.5 doubly to measure process water, be heated to 75-85 degree Celsius, and insulated and stirred 0.5-1.5 hour, centrifugalize, obtains filtrate 1 and residue; The residue obtained 9.5-10.5 that adds again doubly measures process water, is heated to 75-85 degree Celsius, and insulated and stirred is extracted 0.5-1.5 hour, and centrifugalize, obtains filtrate 2; Merge filtrate twice.
The water that adds of described process water doubly measures that all to take the quality of step 1 gained compound be benchmark.
Preferably, in described step 3, in described reduced vacuum concentration process, material is concentrated to proportion 1-1.1.
Fourth aspect present invention provides a kind of granular preparation of compound medicament composition of Cordyceps mycelium, by the extract of the compound medicament composition of described Cordyceps mycelium, is prepared.
Fifth aspect present invention provides the preparation method of granular preparation of the compound medicament composition of described Cordyceps mycelium, comprises the steps:
1) in the extract of the compound medicament composition of described Cordyceps mycelium, add ethanol to carry out granule manufacture as wetting agent;
2) step 1 gained material is carried out to particle drying, dry after granulate again.
Preferably, the mass ratio of described extract and ethanol is 1:0.03-0.1, the food stage ethanol that described ethanol is 80-95wt%.
Preferably, described step 1 granulate gained granule is 20-30 order granule.
Preferably, described step 2 granulate gained granule is 20-30 order granule.
Sixth aspect present invention provides the compound medicament composition of described Cordyceps mycelium in the purposes of preparing balance the body immune system medicine, antitumor drug or anti-fatigue medicament field.
The compound medicament composition of Cordyceps mycelium provided by the present invention, by introducing multiple auxiliary medical material, assist a ruler in governing a country the action and efficacy that improves Cordyceps mycelium, make it there is balance the body immune system, improve the multiple effects such as body immunity, defying age, antitumor, resisting fatigue (adjusting immunity and resisting fatigue effect are especially outstanding), make its effect and natural cs suitable.In addition, compound medicament composition provided by the present invention, containing any food additive, utilize the sugary height of Arillus Longan, Fructus Lycii sweet in the mouth, Semen Nelumbinis to go the sweet feature such as greasy simultaneously, regulate the taste of granule, replace the use of food additive, mouthfeel is more held easy for patients to accept.
The specific embodiment
Below, by specific instantiation explanation embodiments of the present invention, those skilled in the art can understand other advantages of the present invention and effect easily by the disclosed content of this description.The present invention can also be implemented or be applied by the other different specific embodiment, and the every details in this description also can be based on different viewpoints and application, carries out various modifications or change not deviating under spirit of the present invention.
Compatibility of the present invention meets Chinese medicine " monarch " principle, and following each Chinese medicine that the present invention adopts is made compatibility mutually, can bring into play its collaborative effect of curing the disease, and has drug effect and be interweaved, mutually promote and coordinate usefulness between each composition of raw material of Chinese medicine used.
Crude drug of the present invention (or medical material) all can obtain from common pharmacy or the purchase of Chinese crude drug sales company, and its specification meets national medical standard or meets the pertinent regulations such as Chinese Pharmacopoeia.The medical material adopting unless otherwise indicated, is tcm and herbal slice, and this tcm and herbal slice can be also to obtain by processing.
Alleged " patient " of the present invention refers to suffer from people, wild animal and the domestic animal of disease.Wild animal is without domestication's animal under naturalness.Domestic animal is the animal of the artificial breeding for food source is provided, as monkey, ape, Canis familiaris L., Mus, hamster, pig, rabbit, horse, milch cow, Babalus bubalis L., bull, sheep and goat etc." patient " that diagnose preferably selects mammal, especially people.
Criterion of therapeutical effect of the present invention is with reference to relevant criterion of therapeutical effect in " disease of tcm judgement criterion of therapeutical effect ".Recovery from illness: clinical symptoms all disappears, and lab testing is normal.Take a turn for the better: clinical symptom relief, lab testing improves or be normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
Compositions of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, or the dosage form that can further be prepared into through common process through extracting the final extracting solution of said composition gained, comprises capsule, tablet, granule, powder, oral liquid, soft capsule, pill, mixture, syrup, gel and sustained-release preparation etc.For above-mentioned dosage form can be realized, need when these dosage forms of preparation, add pharmaceutically acceptable adjuvant, as filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc.
Preparation technology of the present invention uses " specification requirement of new Chinese medicine Study on Preparation " in principle, and the main effective ingredient that uses modern new agent technology to extract medicine is used as medicine, and adds some pharmaceutically acceptable adjuvant or carriers.
Embodiment 1
The preparation of the granule of the compound medicament composition of Cordyceps mycelium:
1) prescription dispensing: select standard compliant medical material, be dried and reach requirement respectively, carry out coarse pulverization to 15 orders.Press recipe quantity and weigh Cordyceps mycelium, Arillus Longan, Fructus Lycii and four kinds of medical material powder of Semen Nelumbinis, mix homogeneously.
Formula is specially by weight: 45 parts of Cordyceps myceliums; 30 parts of Arillus Longans; 15 parts of Fructus Lycii; 10 parts, Semen Nelumbinis.
2) superfine grinding: utilize superfine technique to be crushed to 30 microns.
3) extract separation: drop into extraction pot, add 12 times of amount process waters, be heated to 80 degree, insulated and stirred 1 hour, centrifugalize, obtains filtrate 1, and residue adds 10 times of amount process waters, is heated to 80 degree, insulated and stirred is extracted 1 hour, and centrifugalize, obtains filtrate 2, merges filtrate twice.
4) concentrate drying: reduced vacuum is concentrated to proportion 1.05, spraying is dry obtains Chinese caterpillar fungus compound extract, and yield is about 42%, the qualified transformation of ownership agent of packing inspection workshop.
5) granule manufacture: at Chinese caterpillar fungus compound extract, add 6% food stage ethanol (purity 95wt%) as wetting agent, manufacture 20-30 order;
6) particle drying, granulate is to 20-30 order again;
7) packing inspection: utilize Small bag packaging machine to be packaged into the aluminium foil pouch of 5g.
Embodiment 2:
The drug effect of the compound medicament composition of Cordyceps mycelium to fatigue alleviating:
A. tested group: the compound medicament composition granule of the Cordyceps mycelium that embodiment 1 is prepared.
B. reference group: directly use step described in embodiment 1 to extract respectively in Cordyceps mycelium, Arillus Longan, Fructus Lycii and Semen Nelumbinis (identical with embodiment 1 consumption), obtain Cordyceps mycelium granule, Arillus Longan granule, Fructus Lycii granule and Semen Nelumbinis granule.
C. instructions of taking: every day twice, the each 5g of granule of the compound medicament composition of Cordyceps mycelium, warm boiled water.Each consumption of all the other reference group extracts is: Cordyceps mycelium reference group 2.3g, Arillus Longan reference group 1.5g, Fructus Lycii reference group 0.8g, Semen Nelumbinis reference group 0.5g.
D. experimental subject: chronic fatigue syndrome 35 examples of selecting to meet U.S. CDC (CDC) in 1994 the CFS diagnostic criteria of formulating, according to table of random number, patient is divided into 5 groups, tested group and each 10 examples of Cordyceps mycelium reference group, all the other organize 5 examples.
Fatigue scale-14 (Fatigue Scale-14, FS-14): Fatigue scale-14 is comprised of 14 entries, react from different perspectives respectively tired weight, ask experimenter to read over after each entry, according to the most applicable my situation select "Yes" or " no '.Except the 10th, 13,14 entries, for oppositely scoring, are answered "Yes" and are designated as 0 minute, answer "No" and are designated as 1 minute; Other 11 entries are all that forward is scored, and answer "Yes" and are designated as 1 minute, answer "No" and be designated as 0 minute, and calculate each group score value, organize score value by the patient of described group score value obtains after average.
Table 1 is respectively organized variation and the comparison of Fatigue scale-14 score value
| Group | Number of cases | Before treatment | After treatment |
| Cordyceps mycelium reference group | 10 | 9.9 | 7.2 |
| Arillus Longan reference group | 5 | 9.7 | 8.0 |
| Fructus Lycii reference group | 5 | 9.8 | 9.5 |
| Semen Nelumbinis reference group | 5 | 9.7 | 9.1 |
| Tested group | 10 | 9.8 | 3.8 |
From table 1, the compound medicament composition of Cordyceps mycelium has obviously improved Cordyceps mycelium to regulating the effect of human immune system and resisting fatigue.
Embodiment 3
The preparation of the granule of the compound medicament composition of Cordyceps mycelium:
1) prescription dispensing: select standard compliant medical material, be dried and reach requirement respectively, carry out coarse pulverization to 20 orders.Press recipe quantity and weigh Cordyceps mycelium, Arillus Longan, Fructus Lycii and four kinds of medical material powder of Semen Nelumbinis, mix homogeneously.
Formula is specially by weight: 40 parts of Cordyceps myceliums; 35 parts of Arillus Longans; 12 parts of Fructus Lycii; 12 parts, Semen Nelumbinis.
2) superfine grinding: utilize superfine technique to be crushed to 50 microns.
3) extract separation: drop into extraction pot, add 12.5 times of amount process waters, be heated to 75 degree, insulated and stirred 1.5 hours, centrifugalize, obtains filtrate 1, and residue adds 10.5 times of amount process waters, is heated to 75 degree, insulated and stirred is extracted 1.5 hours, and centrifugalize, obtains filtrate 2, merges filtrate twice.
4) concentrate drying: reduced vacuum is concentrated to proportion 1.1, spraying is dry obtains Chinese caterpillar fungus compound extract, and yield is about 43%, the qualified transformation of ownership agent of packing inspection workshop.
5) granule manufacture: at Chinese caterpillar fungus compound extract, add 10% food stage ethanol (purity 80wt%) as wetting agent, manufacture 20-30 order;
6) particle drying, granulate is to 20-30 order again;
Packing inspection: utilize Small bag packaging machine to be packaged into the aluminium foil pouch of 5g.
Gained granule carries out the efficacy testing of fatigue alleviating, approaches with embodiment 1 gained granule effect, has obviously improved Cordyceps mycelium to regulating the effect of human immune system and resisting fatigue.
Embodiment 4
The preparation of the granule of the compound medicament composition of Cordyceps mycelium:
1) prescription dispensing: select standard compliant medical material, be dried and reach requirement respectively, carry out coarse pulverization to 10 orders.Press recipe quantity and weigh Cordyceps mycelium, Arillus Longan, Fructus Lycii and four kinds of medical material powder of Semen Nelumbinis, mix homogeneously.
Formula is specially by weight: 50 parts of Cordyceps myceliums; 25 parts of Arillus Longans; 18 parts of Fructus Lycii; 8 parts, Semen Nelumbinis.
2) superfine grinding: utilize superfine technique to be crushed to 10 microns.
3) extract separation: drop into extraction pot, add 11.5 times of amount process waters, be heated to 85 degree, insulated and stirred 0.5 hour, centrifugalize, obtains filtrate 1, and residue adds 9.5 times of amount process waters, is heated to 85 degree, insulated and stirred is extracted 0.5 hour, and centrifugalize, obtains filtrate 2, merges filtrate twice.
4) concentrate drying: reduced vacuum is concentrated to proportion 1, spraying is dry obtains Chinese caterpillar fungus compound extract, and yield is about 40.5%, the qualified transformation of ownership agent of packing inspection workshop.
5) granule manufacture: at Chinese caterpillar fungus compound extract, add 3% food stage ethanol (purity 95wt%) as wetting agent, manufacture 20-30 order;
6) particle drying, granulate is to 20-30 order again;
Packing inspection: utilize Small bag packaging machine to be packaged into the aluminium foil pouch of 5g.
Gained granule carries out the efficacy testing of fatigue alleviating, approaches with embodiment 1 gained granule effect, has obviously improved Cordyceps mycelium to regulating the effect of human immune system and resisting fatigue.
In sum, the present invention has effectively overcome various shortcoming of the prior art and tool high industrial utilization.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all can, under spirit of the present invention and category, modify or change above-described embodiment.Therefore, such as in affiliated technical field, have and conventionally know that the knowledgeable, not departing from all equivalence modifications that complete under disclosed spirit and technological thought or changing, must be contained by claim of the present invention.
Claims (8)
1. a compound medicament composition for Cordyceps mycelium, its main pharmacodynamics composition by weight, comprises following component:
Cordyceps mycelium 40-50 part;
Arillus Longan 25-35 part;
Fructus Lycii 12-18 part;
Semen Nelumbinis 8-12 part.
2. an extract for the compound medicament composition of Cordyceps mycelium, is extracted and is obtained by the compound medicament composition of Cordyceps mycelium described in claim 1.
3. the preparation method of the extract of the compound medicament composition of Cordyceps mycelium as claimed in claim 2, comprises the steps:
1), by after medicinal material drying, carry out coarse pulverization; By proportioning, weigh each component medical material powder, and mixing of materials is even;
2) step 1 gained mixed material is dropped into extraction pot, extracting in water, gained material carries out solid-liquid separation;
3) step 2 gained liquid phase reduced vacuum is concentrated, spraying is drying to obtain the extract of the compound medicament composition of described Cordyceps mycelium.
4. the preparation method of the extract of the compound medicament composition of Cordyceps mycelium as claimed in claim 3, it is characterized in that, in described step 1, coarse pulverization gained granule is 10-20 order granule, after mixing of materials is even, also utilize superfine technique further to pulverize, the particle diameter of pulverizing gained material is 10-50 micron.
5. the preparation method of the extract of the compound medicament composition of Cordyceps mycelium as claimed in claim 3, it is characterized in that, in described step 2, the concrete steps of extracting in water are: first add 11.5-12.5 doubly to measure process water, be heated to 75-85 degree Celsius, insulated and stirred 0.5-1.5 hour, centrifugalize, obtains filtrate 1 and residue; The residue obtained 9.5-10.5 that adds again doubly measures process water, is heated to 75-85 degree Celsius, and insulated and stirred is extracted 0.5-1.5 hour, and centrifugalize, obtains filtrate 2; Merge filtrate twice.
6. the preparation method of the extract of the compound medicament composition of Cordyceps mycelium as claimed in claim 3, is characterized in that, in described step 3, in described reduced vacuum concentration process, material is concentrated to proportion 1-1.1.
7. a granular preparation for the compound medicament composition of Cordyceps mycelium, is prepared by the compound medicament composition of Cordyceps mycelium claimed in claim 1.
8. the compound medicament composition of Cordyceps mycelium as claimed in claim 1 is being prepared the purposes in balance the body immune system medicine, antitumor drug or anti-fatigue medicament field.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310398836.7A CN103520364A (en) | 2013-09-05 | 2013-09-05 | Compound medicinal composition of cordyceps mycelia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310398836.7A CN103520364A (en) | 2013-09-05 | 2013-09-05 | Compound medicinal composition of cordyceps mycelia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103520364A true CN103520364A (en) | 2014-01-22 |
Family
ID=49922951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310398836.7A Pending CN103520364A (en) | 2013-09-05 | 2013-09-05 | Compound medicinal composition of cordyceps mycelia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103520364A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077178A (en) * | 2007-06-22 | 2007-11-28 | 卢昶年 | Nutritive health-care food and its making method |
| CN102670715A (en) * | 2012-05-08 | 2012-09-19 | 福建润兴生物科技有限公司 | Cordyceps sinensis mycelium oral liquid |
-
2013
- 2013-09-05 CN CN201310398836.7A patent/CN103520364A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077178A (en) * | 2007-06-22 | 2007-11-28 | 卢昶年 | Nutritive health-care food and its making method |
| CN102670715A (en) * | 2012-05-08 | 2012-09-19 | 福建润兴生物科技有限公司 | Cordyceps sinensis mycelium oral liquid |
Non-Patent Citations (1)
| Title |
|---|
| 夏勇等: "冬虫夏草保健茶的毒性研究", 《癌变畸变突变》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102613555B (en) | Maca powder and ginseng composition and preparation method thereof | |
| CN102178840B (en) | Chinese medicinal preparation for relieving body fluid deficiency for people with yin-deficiency physique, preparation method thereof and application thereof | |
| CN104095231A (en) | Health-care product containing mair conditioning unita, dendrobium and American ginseng and preparation method thereof | |
| CN105852084A (en) | Functional food composition capable of reducing weight and reducing blood lipid and preparation method of functional food composition | |
| CN103555530A (en) | Lily healthcare medicinal liquor | |
| CN102266062A (en) | Evening primrose black sesame paste for women and preparation method thereof | |
| CN101884783B (en) | Wheat bran polypeptide-containing anti-fatigue traditional Chinese medicine and preparation method thereof | |
| CN101711840B (en) | Medicine-food dual-purpose composition suitable for cancerous patients and preparation method thereof | |
| CN103585479A (en) | Blood-replenishing pill and blood-replenishing capsule for treating iron-deficiency anemia | |
| CN108143974A (en) | Relieving alcoholism and protecting liver ball | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| KR101622104B1 (en) | COMPOSITION FOR PREVENTING, TREATING OR IMPROVING SKIN DISEASE, COMPRISING EXTRACT OF Cassia obtussifolia L. AND EXTRACT OF Hovenia ducis | |
| CN105707880A (en) | Health-care food and preparation method thereof | |
| CN108902945A (en) | A kind of colla corii asini cake and preparation method thereof that man eats | |
| CN103520302A (en) | Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof | |
| CN104055115B (en) | A kind of health products containing agate coffee, the stem of noble dendrobium and Panax Japonicus Var. Major and preparation method thereof | |
| CN106578813A (en) | Formula and making method of spina date seed-containing solid beverage | |
| CN102613628B (en) | Original ecological coconut germanium juice and producing method thereof | |
| CN1267141C (en) | Method for preparing compound medicinal capsule and powder for nourishing yin | |
| CN105231247A (en) | Fruit and vegetable multivitamin effervescent tablet and preparation method thereof | |
| CN101313975B (en) | Anti-neurasthenic medicine liqueur | |
| CN103520364A (en) | Compound medicinal composition of cordyceps mycelia and preparation method thereof | |
| CN104187264B (en) | A kind of alimentation composition that improves body immunity and preparation method thereof | |
| CN106728392B (en) | Traditional Chinese medicine for treating liver-stagnation and spleen-deficiency type impotence and preparation method thereof | |
| CN105497519A (en) | Preparation method for radix ginseng rubra-colla corii asini cell-wall breaking superfine powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140122 |