CN102665417A - 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法 - Google Patents

用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法 Download PDF

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CN102665417A
CN102665417A CN2010800589745A CN201080058974A CN102665417A CN 102665417 A CN102665417 A CN 102665417A CN 2010800589745 A CN2010800589745 A CN 2010800589745A CN 201080058974 A CN201080058974 A CN 201080058974A CN 102665417 A CN102665417 A CN 102665417A
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optionally substituted
cycloalkyl
membered ring
substituted
compound
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P·J·康那
C·W·林斯利
C·R·霍普金斯
C·M·尼斯温德
R·D·高格廖蒂
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Vanderbilt University
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Vanderbilt University
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CN2010800589745A 2009-10-22 2010-10-22 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法 Pending CN102665417A (zh)

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Application Number Priority Date Filing Date Title
US25406209P 2009-10-22 2009-10-22
US61/254,062 2009-10-22
US29272510P 2010-01-06 2010-01-06
US61/292,725 2010-01-06
PCT/US2010/053825 WO2011050305A1 (en) 2009-10-22 2010-10-22 Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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CN102665417A true CN102665417A (zh) 2012-09-12

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CN2010800589726A Pending CN102665411A (zh) 2009-10-22 2010-10-22 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法

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US (2) US9180192B2 (https=)
EP (2) EP2490537A4 (https=)
JP (2) JP2013508412A (https=)
KR (2) KR20120129869A (https=)
CN (2) CN102665417A (https=)
AU (2) AU2010310518A1 (https=)
BR (2) BR112012009576A2 (https=)
CA (2) CA2779298A1 (https=)
IL (2) IL219296A0 (https=)
MX (2) MX2012004774A (https=)
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SG173465A1 (en) 2009-01-28 2011-09-29 Univ Vanderbilt Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
JP6161537B2 (ja) 2010-04-07 2017-07-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物及び使用の方法
AR088061A1 (es) 2011-09-27 2014-05-07 Hoffmann La Roche Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso
EP2853532B1 (en) 2013-09-28 2020-12-09 Instytut Farmakologii Polskiej Akademii Nauk 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
US10221172B2 (en) 2015-01-13 2019-03-05 Vanderbilt University Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10227343B2 (en) 2015-01-30 2019-03-12 Vanderbilt University Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
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