CN102657828B - 一种治疗慢性心衰的药物组合物 - Google Patents
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Abstract
本发明涉及一种治疗慢性心衰的药物组合物，它是由下列原料药制成的药剂：三七、甘草、麦冬、葶苈子、苏叶、干姜、泽泻、黄芩。本发明所述的药物组合物的组方合理，疗效明确，可用于有效地治疗慢性心衰。
Description
技术领域
本发明涉及医药领域，具体地说，涉及一种治疗慢性心衰的药物组合物。
背景技术
慢性心衰是一个病史上以特异症状(呼吸困难和疲乏)和物理检查时以体征(液体储留)为特征的临床综合症。心衰多与左心功能异常有关：可表现为心腔大小和排空功能正常的舒张功能不全为主，但是充盈功能受损；也可表现为心腔明显扩大和室壁运动减弱的收缩功能不全为主，但充盈功能正常。许多患者同时存在收缩功能异常和舒张功能异常，而射血分数可以正常或异常。导致心衰的原因包括心脏本身疾患，同时与周围血管功能、肺动力学改变、植物神经功能和肾脏处理钠的功能有关。所以慢性心衰患者药物治疗血液动力学改善，可不会或者完全没有改善临床症状。
发明内容
本发明的目的是提供一种治疗慢性心衰的药物组合物。
为了实现本发明的目的，本发明提供一种治疗慢性心衰的药物组合物，它是由下列原料药按重量份计制成的药剂：
三七1～10份 甘草1～5份 麦冬1～5份 葶苈子1～10份
苏叶1～10份 干姜1～5份 泽泻1～10份 黄芩1～10份。
优选地，它是由下列原料药按重量份计制成的药剂：
三七5份 甘草3份 麦冬4份 葶苈子5份
苏叶6份 干姜5份 泽泻5份 黄芩10份。
本发明所述的药物组合物可与药学上可接受的载体制成各种剂型，比如片剂、胶囊剂、软胶囊、丸剂、颗粒剂、口服液或汤剂等。可采用本领域熟知的制剂技术手段来完成本发明药物组合物的制备。
所述的药学上可接受的载体为本领域熟知，为用于制备上述制剂的常用赋形剂或辅料。常用的赋形剂或辅料包括(但不限于)填充剂、润滑剂、分散剂、润湿剂、粘合剂、抗氧剂等等，例如，糖浆、阿拉伯胶、山梨醇、乳糖、糊精、淀粉、碳酸钙、滑石粉、聚乙二醇、羧甲基淀粉钠、硬脂酸镁等等。
本发明的药物组合物的组方合理，疗效明确，可有效地治疗慢性心衰。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
实施例1本发明药物组合物口服液的制备
称取三七500克、甘草300克、麦冬400克、葶苈子500克、苏叶600克、干姜500克、泽泻500克、黄芩1000克。加入9倍原料药重量的水，70℃加热2小时，滤过，滤液减压浓缩至2000ml，高速离心，微孔滤膜过滤，灌封到100个瓶中，灭菌即得。
实验例
一般资料
选择慢性心衰患者260例，纳入标准：(1)符合西医慢性心力衰竭的诊断标准；(2)符合中医心悸诊断标准，辨证基本病机为气阴两虚者；(3)年龄在40～70岁之间。病例排除标准：(1)不属于纳人标准的其它类型心律失常；(2)近期参加其它临床试验的患者。其中男性120例，女性140例，年龄最小45岁，最大69岁，平均年龄为53.2±7.6岁，病程为0.4～6.3年，平均3.7±1.8年。疾病类型：冠心病病人120例，高心病病人80例，风心病病人40例，心肌病病人20例。
治疗方案
口服实施例1中所述的口服液，一日两次，每次一瓶。连续治疗2个月。
疗效评定标准
显效：心悸症状消失，动态心电图明显改善；有效：心悸症状大部分消失，动态心电图有所改善；无效：心悸症状和动态心电图无变化或加重。
治疗结果：
经过一个疗程的治疗，发现全部患者均符合显效的标准。
Claims (2)
1.一种治疗慢性心衰的药物组合物，其特征在于，它是由下列原料药按重量份计制成的药剂：
三七 1～10份 甘草 1～5份 麦冬 1～5份 葶苈子 1～10份
苏叶 1～10份 干姜 1～5份 泽泻 1～10份 黄芩 1～10份。
2.根据权利要求1所述的治疗慢性心衰的药物组合物，其特征在于，它是由下列原料药按重量份计制成的药剂：
三七 5份 甘草 3份 麦冬 4份 葶苈子 5份
苏叶 6份 干姜 5份 泽泻 5份 黄芩 10份。
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| CN105213774A (zh) * | 2015-11-08 | 2016-01-06 | 长沙佰顺生物科技有限公司 | 一种治疗慢性心功能衰竭的药物组合物 |
| CN105213775A (zh) * | 2015-11-08 | 2016-01-06 | 长沙佰顺生物科技有限公司 | 一种治疗心脏疾病的药物组合物 |
| CN105194296A (zh) * | 2015-11-08 | 2015-12-30 | 长沙佰顺生物科技有限公司 | 一种治疗心脏疾病的药物组合物 |
| CN113559223B (zh) * | 2021-09-15 | 2022-04-15 | 王新东 | 一种治疗慢性心力衰竭的中药复方组合物及其制备方法 |
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| US20040058943A1 (en) * | 2001-02-09 | 2004-03-25 | Akira Fujimori | Medicinal composition for treatment of chronic cardiac failure |
| CN1186071C (zh) * | 2002-10-24 | 2005-01-26 | 河北以岭医药研究院有限公司 | 一种治疗慢性心衰的药物组合物及制备方法 |
| KR101002490B1 (ko) * | 2007-06-09 | 2010-12-17 | 동아제약주식회사 | 유데나필을 유효성분으로 함유하는 만성 심부전증 치료용약학적 조성물 |
| CN101085200B (zh) * | 2007-06-12 | 2010-05-19 | 王清海 | 一种治疗心力衰竭的中药组合物及其制备方法 |
| CN101199812B (zh) * | 2007-12-18 | 2010-10-27 | 山东步长制药有限公司 | 一种治疗心功能衰竭的中药颗粒剂的检测方法 |
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