CN102657643A - Composite organic acid-calcium effervescent tablet and preparation method thereof - Google Patents
Composite organic acid-calcium effervescent tablet and preparation method thereof Download PDFInfo
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- CN102657643A CN102657643A CN2012101001286A CN201210100128A CN102657643A CN 102657643 A CN102657643 A CN 102657643A CN 2012101001286 A CN2012101001286 A CN 2012101001286A CN 201210100128 A CN201210100128 A CN 201210100128A CN 102657643 A CN102657643 A CN 102657643A
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Abstract
The invention discloses a composite organic acid-calcium effervescent tablet and a preparation method thereof. The effervescent tablet comprises the following components, by mass, 30-60 parts of lactic acid-calcium gluconate, 1-4 parts of vitamin C, 0.01-2 parts of natural carotenoids, 20-30 parts of an effervescent agent acid source, 10-25 parts of an effervescent agent carbon dioxide source, 5-10 parts of an adhesive, 0.5-5 parts of a sweetener, 0.1-0.8 parts of an essence, and 1-10 parts of a lubricant. The effervescent tablet is prepared from main raw materials of the lactic acid-calcium gluconate, the vitamin C and the lactic acid-calcium gluconate, wherein the vitamin C which can reduces the pH value of the intestinal tract makes an acidic environment be formed in the small intestine, so the dissolving of indissolvable calcium salts is improved, thereby the calcium absorption rate is improved; and results of experiments show that the natural carotenoids have a promotion effect on the absorption of calcium. The effervescent tablet, which is a solid functional beverage which is rich in multiple healthcare effects and can be instantly drunk through instantly brewing, has the advantages of fast dissolving-out speed, good dissolvability, high in-vivo absorption rate, safe application, use convenience, and suitableness for people of all ages.
Description
Technical field
The present invention relates to a kind of calcium product and preparation method thereof, a kind of more precisely lactic acid-calcium gluconate is main
Compound organicAcid calcium effervescence tablet and preparation method thereof.
Background technology
Calcium is that human body is kept one of necessary element of orthobiosis, has the important physical biochemical function.1 ~ 2% of the about percentage of liveweight of calcium is the maximum mineral of reserves in the body, is the main constituent of skeleton and tooth, lacks enough calcium and brings adverse influence to health.Lack calcium like children's and cause rickets easily, growth promoter is slow, immunity degradation; Adult's calcium deficiency causes osteoporosis easily, and bone fragility increases, the easy fracture; Women's hypocalcia of gestation and age of sucking can have influence on fetus, baby's growth.Calcium also can be regulated muscle contraction in addition, and it is neural to calm, and lacks calcium and causes impatience easily; Advanced age, person's hypocalcia caused diseases due to habit disturbances such as senile dementia, hypertension, arteriosclerosis, diabetes easily.
Human calcium's source mainly is to obtain through food.As eat of rich calcareous milk product, small fish, beans etc., just must eat a large amount of such food but want to obtain day competent calcium; For modern times food life, the food of intensive processing is very many, and the mineral composition in the raw material is significantly reduced; It is irregular etc. that the quickening of the modern life and work rhythm, operating pressure reach living and diet greatly, causes nutrient to lack; Many factors make human body be absorbed in the shortage of calcium.
The material that replenishes as the human calcium is broadly divided into inorganic type and organic type calcium material.The inorganic type calcium material has: calcium carbonate, calcium oxide, calcium hydroxide, shell calcium, eggshell calcium etc., and these material solubility are all smaller; The calcium chloride dissolubility is big but bitterness is big.The organic type calcium material has: calcium citrate, calcium gluconate, calcium lactate etc., and their each dissolubility of comfortable 20 ℃ are respectively 0.1g/100ml, 3.5g/100ml, 5.0g/100ml, and dissolubility is less than normal.The modest Chinese patent of Zhang Zhen (CN101057867A, 2007.10.24), with Concha Ostreae, flower Concha Meretricis Seu Cyclinae, Ovum crusta Gallus domesticus and citric acid reactions is processed calcium citrate, its dissolubility is low; The Chinese patent of Yuan Jingcheng, Yuan Qun (CN1086378C 2002.6.19) prepares citric acid-calcium malate with citric acid, malic acid and calcium carbonate reaction, and its dissolubility is still lower, and the dissolubility under 20 ℃ is 0.5g ~ 1.1g/100ml.
The absorption of calcium is relevant with the size of the calcium content of organic calcium, dissolubility, and calcium content is big, dissolubility helps absorption of human body greatly.
Summary of the invention:
The object of the present invention is to provide that a kind of dissolubility is good, the body internal absorption factor is high and is rich in composite organic acid calcium effervescence tablet of multiple health-care effect and preparation method thereof.
A kind of composite organic acid calcium effervescence tablet provided by the invention according to the mass fraction, comprises following each component:
Calcium lactate gluconate 30~60,
Vitamin C 1~4,
Natural carotenoid 0.01~2,
Effervescent acid source 20~30,
Effervescent carbon dioxide source 10~25,
Binding agent 5~10,
Sweeting agent 0.5~5,
Essence 0.1~0.8,
Lubricant 1~10.
Described effervescent acid source is one or more in citric acid, malic acid, fumaric acid or the tartaric acid; The effervescent carbon dioxide source is one or both in sodium bicarbonate or the sodium carbonate.
Described binding agent is polyvinylpyrrolidone (PVP); Sweeting agent is stevioside, protein sugar, saccharin sodium or sucrose; Essence is orange flavor; Lubricant is polyethylene glycol 6000 or Macrogol 4000.
The present invention provides a kind of method for preparing of composite organic acid calcium effervescence tablet simultaneously, may further comprise the steps:
(1) calcium lactate gluconate was pulverized 100 mesh sieves;
(2) get effervescent carbon dioxide source and calcium lactate gluconate powder, essence, sweeting agent mixing and stirring after, add the binding agent mix homogeneously and granulate, cross 16 mesh sieves, wet grain is 50 ℃ of dryings, 20 mesh sieve granulate;
(3) stir with calcium lactate gluconate powder, essence, sweeting agent after vitamin C, natural carotenoid, effervescent acid source are crossed 40 mesh sieves, add the binding agent mix homogeneously then and granulate, cross 16 mesh sieves, wet grain is 50 ℃ of dryings, 20 mesh sieve granulate;
(4) the granule adding mix lubricant that step (2), (3) is made is even;
(5) compression molding;
(6) dry 2h under 60 ℃ of conditions, antibacterial then, packing get product.
Said calcium lactate gluconate is to be raw material with the Ovum crusta Gallus domesticus, after 850 ℃~1100 ℃ calcinings, obtains calcium oxide, carries out neutralization reaction with lactic acid and gluconic acid again and makes.
Beneficial effect of the present invention: the dissolubility of (1) calcium lactate gluconate is more a lot of greatly than the dissolubility of single calcium gluconate, calcium lactate; Calcium gluconate is that 3.5g/100ml, calcium lactate are 5.0g/100ml at 20 ℃ of following dissolubility at 20 ℃ of following dissolubility, and the dissolubility of calcium lactate gluconate is up to 20.0g/100ml.Dissolubility is big, helps absorption of human body.(2) vitamin C makes small intestinal form tart environment through reducing the intestinal pH value, promotes the dissolving of slightly solubility calcium salt, thereby improves calcareous absorbance; Vitamin C is participated in the multiple important biosynthetic process of albumen as the cofactor of enzyme, comprises the synthetic of collagen protein, to form the important substrate of cartilage, sclerotin, enamel and blood vessel epithelium; Vitamin C have build up resistance, preventing cold, Cress, whiten, function such as antioxidation, detoxifcation.(3) natural carotenoid absorbs than the carotenoid in the dietary fiber as enriching substance more easily, and it has the important physical function: potential Cytoplasm antioxidant prevents the detrimental effect of free radical; Improve body immunity, resist the invasion and attack of antibacterial and virus, anti-chromosomal aberration, anti-cancer; As provitamin A, and vitamin A plays an important role to the maturation and the integrity of bone, is the ripe essential composition with differentiation of osteocyte, and participates in bone development and the integrity of keeping epithelial tissue, the normal development of promotion skeleton.Find that through a large amount of experiments natural carotenoid has facilitation to the absorption of calcium.
(4) the used calcium lactate gluconate of the present invention is to be raw material with the industrial waste Ovum crusta Gallus domesticus, turns waste into wealth, and reduces environmental pollution.
Further specify beneficial effect of the present invention through mouse experiment below:
Process 13 effervescent tablet that restrains by table 1 quality share proportioning, 148mgCa/piece adds the liquid that water is processed 150mL then, and is for use.
Get 5 age in week 40 of Wistar mices, male, body weight 95 ~ 105g is divided into 5 groups at random; Every group 8, fasting 24h before the administration gives different calcium liquid to its mouse oral respectively by 10mL/kg body weight dosage; Respectively before throwing is given (0.0h), throw 0.5h after giving, 1.0h, 2.0h, 3.0h, 4.0h from the carotid artery 1.0mL that takes a blood sample, leave standstill, centrifugal; Separation of serum, it is to be measured to be stored in refrigerator (4 ℃), and calcium determinating reagent box (MXB method) is adopted in method for measuring.All analysis of experimental data adopts variance analysis and X 2 test.
Table 2 is experimental conditions of each experiment crowd, and table 3 is situations of change that each experimental group changes calcium in the blood in time.
Table 1
Prescription | 1 | 2 | 3 | 4 |
Calcium lactate gluconate | 40 | 40 | 40 | 40 |
Vitamin C | ? | 1 | ? | 1 |
Natural carotenoid | ? | ? | 1 | 1 |
Malic acid | 20 | 20 | 20 | 20 |
Sodium carbonate | 15 | 15 | 15 | 15 |
Polyvinylpyrrolidone | 5 | 5 | 5 | 5 |
Stevioside | 3.5 | 3.5 | 3.5 | 3.5 |
Orange flavor | 0.5 | 0.5 | 0.5 | 0.5 |
Polyethylene glycol 6000 | 3 | 3 | 3 | 3 |
Table 2
The experiment crowd | Drop into material | Throw liquid measure (mL/kg) | Mus number (only) |
1 | Calcium gluconate | 10 | 8 |
2 | Prescription 1 | 10 | 8 |
3 | Prescription 2 | 10 | 8 |
4 | Prescription 3 | 10 | 8 |
5 | Prescription 4 | 10 | 8 |
Table 3
Do not find dead mouse and abnormal phenomena during the mouse experiment.Experimental result shows, oral administration with calcic liquid after each group of 1 ~ 2 hour apparently higher than throwing and 0 hour time; Prescription 1 is that the assimilation effect of calcium lactate gluconate is superior to single calcium gluconate; Prescription 2, prescription 3, prescription 4 throw calcium concentration in the blood with the crowd after 1 ~ 2 hour, all be higher than prescription 1 throw with crowd's blood in calcium concentration, 4 amplitudes that increase of wherein filling a prescription are maximum, are superior to filling a prescription 2, the assimilation effect of prescription 3.Experiment shows, is the synthetic composite organic acid calcium of primary raw material effervescent with calcium lactate gluconate, vitamin C, natural carotenoid, and the calcium absorption performance significantly improves.
Product of the present invention not only can be used for calcium replenishing, carries out the adjusting of immunologic function, can also give full play to characteristics separately, being rich in nutrition health care.In addition; Product of the present invention is to be the effervescent sheet type that primary raw material is processed with calcium lactate gluconate, vitamin C, natural carotenoid; Be a kind of solid functional drinks of instant-drink, dissolution rate is fast, dissolubility good, body internal absorption factor height, application safety, easy to use, be easy to carry, all-ages.
Produce according to prescription provided by the present invention and method for preparing, can process the effervescent tablet of 3g/ sheet, the quality index of resulting composite organic acid calcium effervescence tablet is following:
The organoleptic indicator: these article are tablet, and outward appearance is bright and clean, and disintegrate is rapid, and are soluble in water, produce great amount of bubbles, and taste is sour-sweet tasty and refreshing.
Physical and chemical index: moisture≤5%, disintegration time≤60s, calcium content>=100mg/piece, Vc>=30mg/piece, carotenoid>=0.30mg/piece, As<0.5mg/>kg, Pb<0.1mg/>kg.
Sanitary index: total number of bacteria (cfu/g)≤3000, coliform (cfu/100g)≤90, pathogenic bacterium (pathogenic entero becteria) do not detect.
The specific embodiment:
A kind of composite organic acid calcium effervescence tablet provided by the invention according to the mass fraction, comprises following each component:
Calcium lactate gluconate 30~60,
Vitamin C 1~4,
Natural carotenoid 0.01~2,
Effervescent acid source 20~30,
Effervescent carbon dioxide source 10~25,
Binding agent 5~10,
Sweeting agent 0.5~5,
Essence 0.1~0.8,
Lubricant 1~10.
Described effervescent acid source is one or more in citric acid, malic acid, fumaric acid or the tartaric acid; The effervescent carbon dioxide source is one or both in sodium bicarbonate or the sodium carbonate.
Described binding agent is polyvinylpyrrolidone (PVP); Sweeting agent is stevioside, protein sugar, saccharin sodium or sucrose; Essence is orange flavor; Lubricant is polyethylene glycol 6000 or Macrogol 4000.
The present invention provides a kind of method for preparing of composite organic acid calcium effervescence tablet, may further comprise the steps:
(1) calcium lactate gluconate was pulverized 100 mesh sieves;
(2) get effervescent carbon dioxide source and calcium lactate gluconate powder, essence, sweeting agent mixing and stirring after, add the binding agent mix homogeneously and granulate, cross 16 mesh sieves, wet grain is 50 ℃ of dryings, 20 mesh sieve granulate;
(3) stir with calcium lactate gluconate powder, essence, sweeting agent after vitamin C, natural carotenoid, effervescent acid source are crossed 40 mesh sieves, add the binding agent mix homogeneously then and granulate, cross 16 mesh sieves, wet grain is 50 ℃ of dryings, 20 mesh sieve granulate;
(4) the granule adding mix lubricant that step (2), (3) is made is even;
(5) compression molding;
(6) dry 2h under 60 ℃ of conditions, antibacterial then, packing get product.
Said calcium lactate gluconate is to be raw material with the Ovum crusta Gallus domesticus, after 850 ℃~1100 ℃ calcinings, obtains calcium oxide, carries out neutralization reaction with lactic acid and gluconic acid again and makes.
Embodiment 1
Raw material | The quality share |
Calcium lactate gluconate | 30 |
Vitamin C | 1 |
Natural carotenoid | 0.01 |
Citric acid | 20 |
Sodium carbonate | 10 |
Polyvinylpyrrolidone | 5 |
Stevioside | 2.0 |
Orange flavor | 0.1 |
Polyethylene glycol 6000 | 1 |
Method for preparing:
(1) is raw material with the Ovum crusta Gallus domesticus, cleans up, carry out neutralization reaction with lactic acid and gluconic acid again and make calcium lactate gluconate, pulverized behind 100 mesh sieves subsequent use after 850 ℃~1100 ℃ calcinings obtain calcium oxide;
(2) get the sodium carbonate of formula ratio; Putting into mixer with the stevioside of the orange flavor of the calcium lactate gluconate powder of 1/2 formula ratio, 1/2 formula ratio, 1/2 formula ratio stirs; The polyvinylpyrrolidone mix homogeneously that adds 1/2 formula ratio then, with mass concentration 95% ethanol be that wetting agent is granulated, cross 16 mesh sieves; Wet grain is dry under 50 ℃, 20 mesh sieve granulate;
(3) vitamin C, natural carotenoid, the citric acid of formula ratio are crossed 40 mesh sieve mixings; The stevioside that adds orange flavor, 1/2 formula ratio of calcium lactate gluconate powder, 1/2 formula ratio of 1/2 formula ratio is put into mixer and is stirred; The polyvinylpyrrolidone mix homogeneously that adds 1/2 formula ratio then, with mass concentration 95% ethanol be that wetting agent is granulated, cross 16 mesh sieves; Wet grain is dry under 50 ℃, 20 mesh sieve granulate;
(4) get two kinds of granules of step (2), (3), add the lubricant polyethylene glycol 6000 mix homogeneously of formula ratio;
(5) compression molding;
(6) dry 2h under 60 ℃ of conditions, antibacterial then, packing get product.
Embodiment 2
Raw material | The quality share |
Calcium lactate gluconate | 40 |
Vitamin C | 2 |
Natural carotenoid | 0.5 |
Fumaric acid | 25 |
Sodium bicarbonate | 15 |
Polyvinylpyrrolidone (PVP) | 8 |
Saccharin sodium | 1.0 |
Orange flavor | 0.5 |
Macrogol 4000 | 5 |
Method for preparing is with embodiment 1.
Embodiment 3
Raw material | The quality share |
Calcium lactate gluconate | 50 |
Vitamin C | 3 |
Natural carotenoid | 1.0 |
Tartaric acid | 25 |
Sodium bicarbonate | 15 |
Polyvinylpyrrolidone (PVP) | 10 |
Sucrose | 5.0 |
Orange flavor | 0.6 |
Polyethylene glycol 6000 | 8 |
Method for preparing is with embodiment 1.
Embodiment 4
Raw material | The quality share |
Calcium lactate gluconate | 60 |
Vitamin C | 4 |
Natural carotenoid | 2.0 |
Malic acid | 30 |
Sodium carbonate | 20 |
Polyvinylpyrrolidone (PVP) | 10 |
Protein sugar | 2.5 |
Orange flavor | 0.8 |
Polyethylene glycol 6000 | 10 |
Method for preparing is with embodiment 1.
Embodiment 5
Raw material | The quality share |
Calcium lactate gluconate | 45 |
Vitamin C | 3.0 |
Natural carotenoid | 1.5 |
Citric acid | 20 |
Sodium carbonate: sodium bicarbonate (1:1) | 15 |
Polyvinylpyrrolidone (PVP) | 8 |
Protein sugar | 2.5 |
Orange flavor | 0.5 |
Polyethylene glycol 6000 | 5 |
Method for preparing is with embodiment 1.
Embodiment 6
Raw material | The quality share |
Calcium lactate gluconate | 40 |
Vitamin C | 2 |
Natural carotenoid | 2.0 |
Citric acid: malic acid (1:1) | 25 |
Sodium bicarbonate | 15 |
Polyvinylpyrrolidone (PVP) | 5 |
Stevioside | 3.5 |
Orange flavor | 0.5 |
Polyethylene glycol 6000 | 5 |
Method for preparing is with embodiment 1.
Claims (5)
1. a composite organic acid calcium effervescence tablet is characterized in that, according to the mass fraction, comprises following each component:
Calcium lactate gluconate 30~60,
Vitamin C 1~4,
Natural carotenoid 0.01~2,
Effervescent acid source 20~30,
Effervescent carbon dioxide source 10~25,
Binding agent 5~10,
Sweeting agent 0.5~5,
Essence 0.1~0.8,
Lubricant 1~10.
2. a kind of composite organic acid calcium effervescence tablet according to claim 1 is characterized in that, described effervescent acid source is one or more in citric acid, malic acid, fumaric acid or the tartaric acid; The effervescent carbon dioxide source is one or both in sodium bicarbonate or the sodium carbonate.
3. a kind of composite organic acid calcium effervescence tablet according to claim 1 is characterized in that described binding agent is a polyvinylpyrrolidone; Sweeting agent is stevioside, protein sugar, saccharin sodium or sucrose; Essence is orange flavor; Lubricant is polyethylene glycol 6000 or Macrogol 4000.
4. the method for preparing of the said a kind of composite organic acid calcium effervescence tablet of claim 1 is characterized in that, may further comprise the steps:
(1) calcium lactate gluconate was pulverized 100 mesh sieves;
(2) get effervescent carbon dioxide source and calcium lactate gluconate powder, essence, sweeting agent mixing and stirring after, add the binding agent mix homogeneously and granulate, cross 16 mesh sieves, wet grain is 50 ℃ of dryings, 20 mesh sieve granulate;
(3) stir with calcium lactate gluconate powder, essence, sweeting agent after vitamin C, natural carotenoid, effervescent acid source are crossed 40 mesh sieves, add the binding agent mix homogeneously then and granulate, cross 16 mesh sieves, wet grain is 50 ℃ of dryings, 20 mesh sieve granulate;
(4) the granule adding mix lubricant that step (2), (3) is made is even;
(5) compression molding;
(6) dry 2h under 60 ℃ of conditions, antibacterial then, packing get product.
5. according to the method for preparing of the said a kind of composite organic acid calcium effervescence tablet of claim 4; It is characterized in that; Said calcium lactate gluconate is to be raw material with the Ovum crusta Gallus domesticus, after 850 ℃~1100 ℃ calcinings, obtains calcium oxide, carries out neutralization reaction with lactic acid and gluconic acid again and makes.
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Cited By (2)
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CN102960743A (en) * | 2012-12-18 | 2013-03-13 | 中国药科大学 | Prescription of ready-to-eat functional drink, and preparation method and application thereof |
CN104116725A (en) * | 2014-07-03 | 2014-10-29 | 河南科技大学 | Method of preparing composite organic acid chelated calcium effervescent tablet by adopting egg shell as raw material |
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US20040254095A1 (en) * | 2002-09-11 | 2004-12-16 | Martin Kenneth A. | Supplement for treating musculoskeletal disorders |
US20040253227A1 (en) * | 2002-09-11 | 2004-12-16 | Martin Kenneth A. | Perioperative multivitamin protein beverage and additive for use in preparing an individual for fast surgical recovery |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102960743A (en) * | 2012-12-18 | 2013-03-13 | 中国药科大学 | Prescription of ready-to-eat functional drink, and preparation method and application thereof |
CN104116725A (en) * | 2014-07-03 | 2014-10-29 | 河南科技大学 | Method of preparing composite organic acid chelated calcium effervescent tablet by adopting egg shell as raw material |
CN104116725B (en) * | 2014-07-03 | 2016-04-20 | 河南科技大学 | A kind of take Ovum crusta Gallus domesticus as the method that composite organic acid chelating calcium effervescence tablet prepared by raw material |
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