CN102656271A - 人体内产生对hiv的广泛t细胞应答 - Google Patents

人体内产生对hiv的广泛t细胞应答 Download PDF

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CN102656271A
CN102656271A CN2010800415531A CN201080041553A CN102656271A CN 102656271 A CN102656271 A CN 102656271A CN 2010800415531 A CN2010800415531 A CN 2010800415531A CN 201080041553 A CN201080041553 A CN 201080041553A CN 102656271 A CN102656271 A CN 102656271A
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hiv
mva
nef
gag
recombinant
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Chinese (zh)
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保罗·查普林
理查德·尼古拉斯
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Bavarian Nordic AS
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Bavarian Nordic Research Institute AS
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24171—Demonstrated in vivo effect
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800415531A 2009-10-08 2010-10-06 人体内产生对hiv的广泛t细胞应答 Pending CN102656271A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24964409P 2009-10-08 2009-10-08
US61/249,644 2009-10-08
EP10001264 2010-02-08
EP10001264.0 2010-02-08
PCT/EP2010/006114 WO2011042180A1 (en) 2009-10-08 2010-10-06 Generation of a broad t-cell response in humans against hiv

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CN102656271A true CN102656271A (zh) 2012-09-05

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US (1) US20120135032A1 (enExample)
EP (1) EP2486138A1 (enExample)
JP (1) JP2013507107A (enExample)
KR (1) KR20120093941A (enExample)
CN (1) CN102656271A (enExample)
AU (1) AU2010305030A1 (enExample)
CA (1) CA2767924A1 (enExample)
EA (1) EA201270108A1 (enExample)
MX (1) MX2012002531A (enExample)
SG (1) SG178909A1 (enExample)
WO (1) WO2011042180A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
AU2014231229A1 (en) * 2013-03-15 2015-09-17 Bavarian Nordic A/S Single high dose of MVA induces a protective immune response in neonates and infants
MA40783A (fr) 2014-10-03 2017-08-08 Los Alamos Nat Security Llc Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
WO2017139065A1 (en) 2016-02-08 2017-08-17 American Gene Technologies International Inc. Hiv vaccination and immunotherapy
EP3481418A4 (en) 2016-07-08 2020-03-11 American Gene Technologies International Inc. PRE-IMMUNIZATION AND IMMUNOTHERAPY OF HIV
US20220249653A1 (en) * 2019-06-27 2022-08-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions and methods for detecting hiv latency, treating hiv infection, and reversing hiv latency
AU2020384323A1 (en) 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines
FR3160186A1 (fr) 2024-03-13 2025-09-19 Odimma Therapeutics Vecteur non-viral pour transcription augmentee

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1434831A (zh) * 1999-12-23 2003-08-06 医疗研究局 对hiv免疫应答的改进或与其相关的改进
WO2003097675A1 (en) * 2002-05-16 2003-11-27 Bavarian Nordic A/S Fusion protein of hiv regulatory/accessory proteins
CN1636013A (zh) * 2000-07-14 2005-07-06 宾夕法尼亚州立大学托管会 可编码hiv辅助蛋白的dna疫苗
US20060188961A1 (en) * 2002-05-16 2006-08-24 Paul Howley Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of modified vaccinia virus ankara

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787901A (fr) 1971-09-11 1972-12-18 Freistaat Bayern Represente Pa Vaccin antivariolique
UA76731C2 (uk) * 2000-11-23 2006-09-15 Баваріан Нордік А/С Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації
DE60205388T2 (de) 2001-12-10 2006-03-30 Bavarian Nordic A/S Poxvirus-enthaltende zusammensetzungen und verfahren zu ihrer herstellung
DK1506301T3 (da) 2002-05-16 2014-07-21 Bavarian Nordic As Rekombinant poxvirus, der udtrykker homologe gener, der er indsat i poxvirusgenomet
US20060029619A1 (en) 2002-05-16 2006-02-09 Paul Howley Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter
JP5122983B2 (ja) 2005-02-24 2013-01-16 メディカル リサーチ カウンシル Ｈｉｖｃｏｎ：ｈｉｖ免疫原及びその使用
ES2281252B1 (es) 2005-07-27 2009-02-16 Consejo Superior De Investigaciones Cientificas Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida.
JP2010522761A (ja) 2007-03-26 2010-07-08 インターナショナル エイズ バクシーン イニシアティブ 改変ｍｖａウイルスｈｉｖ−１ベクターを用いて免疫応答を誘発する方法
US8268327B2 (en) * 2007-04-27 2012-09-18 Bavarian Nordic A/S Immediate protection against pathogens via MVA
WO2009056535A2 (en) * 2007-10-29 2009-05-07 Genimmune N.V. Methods and kits for inducing a ctl response using a prime boost regimen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1434831A (zh) * 1999-12-23 2003-08-06 医疗研究局 对hiv免疫应答的改进或与其相关的改进
CN1636013A (zh) * 2000-07-14 2005-07-06 宾夕法尼亚州立大学托管会 可编码hiv辅助蛋白的dna疫苗
WO2003097675A1 (en) * 2002-05-16 2003-11-27 Bavarian Nordic A/S Fusion protein of hiv regulatory/accessory proteins
US20060188961A1 (en) * 2002-05-16 2006-08-24 Paul Howley Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of modified vaccinia virus ankara

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FRANK J. PIACENTI, ET AL.: "An Update and Review of Antiretroviral Therapy", 《PHARMACOTHERAPY》, vol. 26, no. 8, 31 December 2006 (2006-12-31), pages 1111 - 1133, XP009098604 *

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WO2011042180A1 (en) 2011-04-14
SG178909A1 (en) 2012-04-27
KR20120093941A (ko) 2012-08-23
MX2012002531A (es) 2012-04-11
US20120135032A1 (en) 2012-05-31
CA2767924A1 (en) 2011-04-14
EA201270108A1 (ru) 2012-08-30
JP2013507107A (ja) 2013-03-04
AU2010305030A1 (en) 2012-05-10
EP2486138A1 (en) 2012-08-15

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