CN102655872B - Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 - Google Patents

Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 Download PDF

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Publication number
CN102655872B
CN102655872B CN201080045618.XA CN201080045618A CN102655872B CN 102655872 B CN102655872 B CN 102655872B CN 201080045618 A CN201080045618 A CN 201080045618A CN 102655872 B CN102655872 B CN 102655872B
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glu
actriib
leu
gdf trap
gly
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Chinese (zh)
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CN102655872A (zh
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J.西拉
R.S.皮尔萨尔
R.库马
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Priority claimed from PCT/US2009/004659 external-priority patent/WO2010019261A1/en
Priority to CN202110421547.9A priority Critical patent/CN113171442B/zh
Priority to CN201510979490.9A priority patent/CN105535938B/zh
Priority to CN201510979350.1A priority patent/CN105561295B/zh
Priority to CN202110879546.9A priority patent/CN113577291A/zh
Priority to CN201510979291.8A priority patent/CN105412908B/zh
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Priority to CN202110417494.3A priority patent/CN113082194B/zh
Publication of CN102655872A publication Critical patent/CN102655872A/zh
Publication of CN102655872B publication Critical patent/CN102655872B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201080045618.XA 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 Active CN102655872B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201510979490.9A CN105535938B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979350.1A CN105561295B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110879546.9A CN113577291A (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979291.8A CN105412908B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110421547.9A CN113171442B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110417494.3A CN113082194B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
PCT/US2009/004659 WO2010019261A1 (en) 2008-08-14 2009-08-13 Use of gdf traps to increase red blood cell levels
US12/583,177 US8058229B2 (en) 2008-08-14 2009-08-13 Method of increasing red blood cell levels or treating anemia in a patient
US12/583177 2009-08-13
USPCT/US2009/004659 2009-08-13
US12/583,177 2009-08-13
US30590110P 2010-02-18 2010-02-18
US61/305,901 2010-02-18
US61/305901 2010-02-18
PCT/US2010/045509 WO2011020045A1 (en) 2009-08-13 2010-08-13 Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels

Related Child Applications (6)

Application Number Title Priority Date Filing Date
CN202110417494.3A Division CN113082194B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979350.1A Division CN105561295B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979490.9A Division CN105535938B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110421547.9A Division CN113171442B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110879546.9A Division CN113577291A (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979291.8A Division CN105412908B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平

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CN102655872A CN102655872A (zh) 2012-09-05
CN102655872B true CN102655872B (zh) 2016-01-20

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CN201080045618.XA Active CN102655872B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110879546.9A Pending CN113577291A (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979291.8A Active CN105412908B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110421547.9A Active CN113171442B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979350.1A Active CN105561295B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110417494.3A Active CN113082194B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979490.9A Active CN105535938B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平

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CN202110879546.9A Pending CN113577291A (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979291.8A Active CN105412908B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110421547.9A Active CN113171442B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979350.1A Active CN105561295B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN202110417494.3A Active CN113082194B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平
CN201510979490.9A Active CN105535938B (zh) 2009-08-13 2010-08-13 Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平

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EP (3) EP3838919A1 (enExample)
JP (4) JP5909446B2 (enExample)
KR (5) KR20180085825A (enExample)
CN (7) CN102655872B (enExample)
AU (1) AU2010282361B2 (enExample)
BR (2) BR122020019169B1 (enExample)
CA (1) CA2770822C (enExample)
ES (2) ES2844123T3 (enExample)
IL (6) IL287990B (enExample)
MX (2) MX2012001916A (enExample)
NZ (3) NZ598348A (enExample)
RU (2) RU2592670C2 (enExample)
WO (1) WO2011020045A1 (enExample)

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