CN102631490A - Traditional Chinese medicine composition capable of improving immunity and resisting fatigue - Google Patents
Traditional Chinese medicine composition capable of improving immunity and resisting fatigue Download PDFInfo
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- CN102631490A CN102631490A CN2012101219341A CN201210121934A CN102631490A CN 102631490 A CN102631490 A CN 102631490A CN 2012101219341 A CN2012101219341 A CN 2012101219341A CN 201210121934 A CN201210121934 A CN 201210121934A CN 102631490 A CN102631490 A CN 102631490A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a health care product composition capable of improving the human body immunity and resisting fatigue. The composition comprises the active ingredients such as ginseng, crocus sativus and herba epimedii. The composition has the functions of enhancing the organism immunity, resisting fatigue, calming the nerves and building bodies and has obvious curative effect and mild effects.
Description
Technical field
The present invention relates to a kind of collaborative Chinese medicine composition that improves body immunity, resisting fatigue and tranquillizing and allaying excitement that has.
Technical background
Along with socioeconomic continuous development; The raising day by day of people's living standard; People increase the degree of keeping a grip on of health gradually; Live in now all be that we receive many outside threats easily at everyone health, comprise air pollution, environmental pollution, operating pressure, economic pressures, bacterial virus, improper diet or the like.Moreover, because the variation of city work, rhythm of life is easy to make the people to produce confirmed fatigue, i.e. sub-health state, the factor of all these unfavorable health can make us usually that spirit can not be concentrated, hypomnesis, often indolent and listless, old and feeble ahead of time.Therefore improve autoimmunity, the ability that strengthens the various unfavorable health factors of antagonism is most important.
The present health product that are used for enhancing human body immunity power on the market are of a great variety, but action effect is uneven.
Summary of the invention
The technical problem that the present invention will solve is: the purpose of this invention is to provide a kind of enhancing human body immunity power, resisting fatigue and the quelling Chinese medicine composition of calming the nerves.Through being main Chinese crude drug with Radix Ginseng, Stigma Croci and Herba Epimedii, through mutual synergistic function, in the hope of disease resistance enhancemen, enhance immunity effect, alleviating physical fatigue and the quelling engineering of calming the nerves.
For solving the problems of the technologies described above; The present invention provides a kind of collaborative body immunity, antifatigue Halth-care composition of improving that have; It is characterized in that described compositions comprises that active component is a kind of to have Synergistic and improve human body immunity of organisms, resisting fatigue and have the quelling of calming the nerves Halth-care composition, is characterized in that described compositions comprises Radix Ginseng, Stigma Croci and Herba Epimedii.In the active component by weight: Radix Ginseng is 1-75 part, and Stigma Croci is 2-65 part, Herba Epimedii 3-65 part.Preferably: Radix Ginseng is 4-50 part, and Stigma Croci is 4-45 part, Herba Epimedii 6-40 part.
Related Radix Ginseng is meant the general name of a kind of herbaceos perennial of the Umbellales Araliaceae Radix Ginseng Panax of family among the present invention, comprises Radix Ginseng Rubra, Radix Ginseng, Radix Panacis Quinquefolii (Radix Panacis Quinquefolii), Radix Glehniae, Radix Codonopsis and Radix Pseudostellariae etc.Radix Ginseng among the present invention comprises through processing refinement back Radix Ginseng extract, the various forms in grinding descendant's pure extract powder or Radix Ginseng growth course.
Involved in the present invention to Stigma Croci (claiming Stigma Croci, Stigma Croci again), be the perennial flowers of a kind of Liliales Iridaceae crocus.Stigma Croci among the present invention comprises crocein powder after grinding, obtains Stigma Croci extracts or croceous other processing forms through various processes.
The Herba Epimedii that arrives involved in the present invention can be Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, pubescence Herba Epimedii, or the dried leaves of Herba Epimedii.Herba Epimedii among the present invention is hidden the Herba Epimedii powder that comprises after grinding, the icariin that passes through refinement, icariin I, Herba Epimedii A etc.
The definition of " collaborative improve " is appreciated that to after several kinds of medical materials combinations among the present invention, the raising of its drug effect during with respect to independent the use; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
In the component of the present invention, Herba Epimedii mainly act as the enhancing human body immunity function, and blood flow increasing increases coronary flow and anti-hypoxia, calmness, anticonvulsant effect.The Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.The effect of dispersing stagnation and relieving accumulation of pathogens, pain relieving, resisting fatigue and resolving stagnation for tranquilization is equalled, mainly played to Stigma Croci sweet in the mouth property.
The inventor finds that through test compositions of the present invention has outside the body immunity of raising, the antifatigue effect, has stable effect of reposing simultaneously.These single agent are that single agent is incomparable to the beneficial effect of human body effect after through a certain proportion of compositions.
Compositions of the present invention can directly be pulverized or through the active component of the refining compositions as treatment of the extraction of the conventional extractive technique in this area such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation.Said active component can be processed various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient composition, as is how granular tablet, granule, capsule, or oral liquid etc.According to the use needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The method for preparing of oral liquid, can but not only be confined to following a kind of, after active component is mixed; Decoction liquor is filtered in decocte with water, obtains solution; The gained solution concentration is obtained extractum, then gained extractum be dissolved in 5-10 times of weight of extractum weight concentration in the ethanol water according to weight meter 95%, mix; Quantitatively packing obtains oral liquid formulations.
The method for preparing of tablet is that the active component mixture is sieved, and behind the auxiliary agent pulverizing commonly used with preparing tablet, abundant mix homogeneously, crosses the 40-80 eye mesh screen, through tabletting the direct machine of dry powder is pressed into tablet.
The preparation technology of capsule preparations can for, the active component mixture is sieved, pulverizing with preparation tablet auxiliary agent commonly used, fully behind the mix homogeneously, crossing the 40-80 eye mesh screen, through granulating, drying is irritated capsule after the operations such as granulate, polishing, packing gets product.
The invention has the beneficial effects as follows:
Pharmaceutical composition of the present invention has benefiting QI for strengthening the superficies, the effect of human body immunity improving power, and medicine of the present invention is not warm not dry; Effect with invigorating spleen and reinforcing stomach, kidney invigorating and YANG supporting, wet dissipation eliminating impediment, enhancing immunity, resisting fatigue, antiviral, strengthening body; Evident in efficacy, action temperature with, have no side effect.This production of medicine technology is simple, be easy to take, evident in efficacy, be a kind of ideal raising human immunity, antifatigue medicine.
Detailed description of the preferred embodiments
Following examples have been explained various aspects of the present invention.They only in order to explanation, not delimit the scope of the invention.
Embodiment 1: contain the preparation that the people participates in the capsule of Stigma Croci, icariin
Radix Ginseng 70 grams, Stigma Croci 15 grams, icariin 25 grams
Above-mentioned Chinese medicine was soaked 40 minutes, and it is important that the water surface is higher than raw material, adds water inventory and be 8 times of total dose, the little fire in back that the boils attitude of boiling; Keep liquid level and be higher than raw material Chinese medicine height, decocted 2 hours, cross leaching filtrating, add 6 times water of total dose again; The back little fire attitude of boiling of boiling is kept liquid level and is higher than raw material Chinese medicine height, decocts 2 hours, filters twice filtrating of merging; Through concentrating under reduced pressure (pressure 0.06MPa, 65 ℃ of temperature) to dried cream, pulverize; Through 300 mesh sieves, add the magnesium stearate of gross weight 2%, incapsulate and get final product.
Embodiment 2: contain the preparation that the people participates in the tablet of Stigma Croci, Herba Epimedii
Radix Ginseng 18 grams, Stigma Croci 85 grams, icariin 35 grams
Above-mentioned Chinese crude drug is dried and crushed into coarse powder, with the ethanol of 50-60% be solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out behind the ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, mixing is granulated, and is pressed into tablet.
Embodiment 3: contain the preparation that the people participates in the capsule of Stigma Croci, Herba Epimedii
Radix Ginseng 18 grams, Stigma Croci 22 grams, icariin 90 grams
Above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing is packed into firmly softgel shell, makes Chinese medicine composition of the present invention.
Embodiment 4: contain the preparation that the people participates in the oral liquid of Stigma Croci, Herba Epimedii
Radix Ginseng is 75 grams, and Stigma Croci is 65 grams, Herba Epimedii 65 grams
After the said components mixing, decoction liquor is filtered in decocte with water; Obtain solution, the gained solution concentration obtained extractum, then gained extractum be dissolved in 5-10 times of weight of extractum weight concentration in the ethanol water according to weight meter 95%; Mix, quantitatively packing obtains oral liquid formulations.
Embodiment 5: contain the preparation that the people participates in the capsule of Stigma Croci, Herba Epimedii
Radix Ginseng 4 grams, Stigma Croci 4 grams, icariin 6 grams
Above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing is packed into firmly softgel shell, makes Chinese medicine composition of the present invention.
Test Example 1: the present invention is to improving the clinical efficacy of immune function of human body
The child: immunologic hypofunction, easy catching a cold, average every month more than twice, or suffer from twice above patient of pneumonia in 1 year.
Elderly patients: suffer from multiple chronic disease, be diagnosed as the patient of syndrome of deficiency of lung qi.
2, the method for administration and the course of treatment:
The oral embodiment of the invention 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5; Contrast: Radix Ginseng; Stigma Croci; Herba Epimedii; Radix Ginseng+Stigma Croci (1: 1); Stigma Croci+icariin (1: 1); Radix Ginseng+Herba Epimedii (1: 1)
Adult: each 3 examples, every day 3 times.
Child below 6 years old: each 1, every day 2-3 time.
Child more than 6 years old: each 2, each 2-3 time.
Above patient was a course of treatment with one month all, and it treats 1-3 the course of treatment.
3, observational technique:
Carry out blood, urine, just routine test and the heart, pulmonary function test, and observe: heating, aversion to cold, sniffle, pharyngeal symptom and whole body situation and the temperature of having a medical check-up, pharyngeal tonsil, the picture of the tongue pulse condition, therapeutic evaluation is carried out in variations such as fingerprint respectively.
4, therapeutic evaluation
Table one prescription of the present invention improves the clinical observation of immune function of human body
| Compositions | The example number | Obviously improve | Improve | Invalid | Total improvement rate % |
| Embodiment 1 | 120 | 88 | 16 | 16 | 86.7 |
| Embodiment 2 | 105 | 82 | 10 | 13 | 87.6 |
| Embodiment 3 | 121 | 92 | 15 | 14 | 88.4 |
| Embodiment 4 | 118 | 91 | 12 | 15 | 87.3 |
| Embodiment 5 | 125 | 94 | 15 | 16 | 87.2 |
| Radix Ginseng | 45 | 2 | 22 | 21 | 53.3 |
| Stigma Croci | 52 | 4 | 23 | 25 | 51.9 |
| Herba Epimedii | 41 | 6 | 17 | 18 | 56.1 |
| Radix Ginseng+Stigma Croci | 55 | 16 | 24 | 15 | 72.7 |
| Stigma Croci+icariin | 64 | 19 | 25 | 20 | 68.7 |
| Radix Ginseng+Herba Epimedii | 71 | 21 | 26 | 24 | 66.2 |
Drug side effect of the present invention: period in a medicine small number of patients xerostomia, outside the dry stool, all there is not any untoward reaction, drug withdrawal or decrement, mouthfeel, dry stool transference cure.
Test example 2: the present invention is to improving and promote the mice sleep test
Preparation of the present invention (embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5) is to its acute toxicity, three mutagenesis and improve sleep and detect; Draw following result: four preparations are to other SPF level Kunming mouse per os toxicity of both sexes; Once irritate the stomach amount and reach 10.0g/kg.bw, animal does not all see obvious poisoning symptom, no animal dead in the week; Press the acute toxicity grading criteria regulation, this animal subject belongs to nontoxic level.The result is all negative for three project mutagenicity tests (PCEMNR micronucleus test, mouse sperm deformity test, Salmonella reversion test); The feeding trial result showed in 30 days: this tried thing by 0.28,0.70,1.40g/kg.bw dosage (be equivalent to respectively recommend crowd's daily intaking amount 0.014g/kg.bw 20,50,100 times) all do not have obvious influence to the clinical examination of wistar rat, hematology, biochemical, organ weights and indexs such as coefficient and histopathology, do not find that animal subject has tangible toxic action;
Adopt SPF level kunming mice, tried thing continuously and improved sleep effect result of the test in 20 days and show: 1) this is tried the basic, normal, high dose groups of thing and is obviously prolonged the inductive mouse sleep time of threshold dose pentobarbital sodium, and difference has significance; 2) middle and high dose groups can obviously improve sub-threshold dose penta than the inductive mice sleep incidence rate of appropriate sodium, and difference has significance; 3) middle and high dose groups can obviously shorten the inductive mice sleep of barbital sodium incubation period, and difference has significance; Above result shows: this is tried thing and pentobarbital sodium, barbital sodium have collaborative sleep effect.Explain that compositions of the present invention has remarkable facilitation to the sleep of mice.
Test example 3: the present invention is to the influence test of mouse anti-reflecting fatigue
Preparation of the present invention (embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5) is to mouse anti-reflecting fatigue influence test.90 of mices are divided into six groups at random, press the gastric infusion of dosage shown in the table 2, and every day 1 time, continuous 10 days, normal control group and model group gave the equal-volume distilled water, and volume is 20ml/kg.And in first day on-test.After the last administration 1 hour, animal is put into 15 ± 1 ℃ swimming groove, observe mice and put into water and be sink to the water-bed unable again time of floating for continuing swimming time.The result sees that table 2. is visible by table 2 result, and compositions of the present invention can obviously prolong mice low temperature and continue swimming time.
Table 2. preparation of the present invention is to the influence of mice swimming time
Result of the test shows, but preparation significant prolongation mice low temperature of the present invention continues swimming time.
Claims (8)
1. one kind has the collaborative Halth-care composition that improves human body immunity of organisms, resisting fatigue and calm the nerves and calm and act on, and it is characterized in that being made up of the raw material that comprises following weight parts: Radix Ginseng is 1-75 part, and Stigma Croci is 2-65 part, Herba Epimedii 3-65 part.
2. according to the compositions of claim 1, it is characterized in that in total active component, by weight: Radix Ginseng is 4-50 part, and Stigma Croci is 4-45 part, Herba Epimedii 6-40 part.
3. according to the compositions of claim 1, it is characterized in that in total active component, by weight: Radix Ginseng is 3-25 part, and Stigma Croci is 2-20 part, Herba Epimedii 3-20 part.
4. according to the compositions of claim 1, it is characterized in that Herba Epimedii is an icariin.
5. according to the compositions of claim 1, it is characterized in that described compositions is the preparation of peroral dosage form.
6. according to the compositions of claim 1-5, it is characterized in that described compositions improves the application in the immunity health medicine in preparation.
7. according to the compositions of claim 1-5, it is characterized in that the application of described compositions in preparation anti-fatigue health-caring medicine.
8. according to the compositions of claim 1-5, it is characterized in that described compositions has the application in the calm health medicine of calming the nerves in preparation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070961A (en) * | 2013-02-04 | 2013-05-01 | 山西振东家庭健康护理用品有限公司 | Chinese medicinal anti-bacteria health care foot-massage solution and preparation method thereof |
| CN104224885A (en) * | 2014-09-11 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for relieving physical fatigue |
-
2012
- 2012-04-24 CN CN201210121934.1A patent/CN102631490B/en active Active
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| 李娌等: "淫羊藿苷药理作用研究进展", 《中国中药杂志》 * |
| 王海颖: "中药与免疫的研究概况", 《中医研究》 * |
| 高顺生: "现代中医药方剂在抗运动性疲劳中的应用", 《中国临床康复》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070961A (en) * | 2013-02-04 | 2013-05-01 | 山西振东家庭健康护理用品有限公司 | Chinese medicinal anti-bacteria health care foot-massage solution and preparation method thereof |
| CN103070961B (en) * | 2013-02-04 | 2014-12-17 | 山西振东家庭健康护理用品有限公司 | Chinese medicinal anti-bacteria health care foot-massage solution and preparation method thereof |
| CN104224885A (en) * | 2014-09-11 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for relieving physical fatigue |
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| CN102631490B (en) | 2013-08-14 |
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