CN102614283B - Medicament for promoting postoperative gastrointestinal function recovery and application of medicament - Google Patents
Medicament for promoting postoperative gastrointestinal function recovery and application of medicament Download PDFInfo
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- CN102614283B CN102614283B CN2012100982881A CN201210098288A CN102614283B CN 102614283 B CN102614283 B CN 102614283B CN 2012100982881 A CN2012100982881 A CN 2012100982881A CN 201210098288 A CN201210098288 A CN 201210098288A CN 102614283 B CN102614283 B CN 102614283B
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Abstract
The invention provides a medicament for promoting postoperative gastrointestinal function recovery. The medicament is prepared from the following Chinese herbal medicines in part by weight: 5 to 15 parts of dried orange peel, 5 to 15 parts of costus root, 5 to 15 parts of officinal magnolia bark, 5 to 15 parts of tuckahoe, 5 to 15 parts of root of red-rooted salvia, 5 to 15 parts of rhubarb, 5 to 15 parts of Chinese angelica, 5 to 15 parts of green tangerine peel, 5 to 15 parts of ginger processed pinellia tuber, and 3 to 5.5 parts of senna leaf. The invention also provides application of the medicament in preparation of medicaments for promoting postoperative gastrointestinal function recovery. Compared with the prior art, the medicament has the advantages that the raw material components are reduced, and the treatment effect is equivalent, so that the cost is reduced, the economical burden of patients is lightened, and the medicament is easy and convenient to prepare; the medicament effectively treats the root causes of weak postoperative gastrointestinal functions, and has a remarkable curative effect; and the medicament is prepared from pure Chinese medicaments, so the medicament does not have toxic or side effect and is easily accepted by the patients.
Description
Technical field
The present invention relates to a kind of medicine and application thereof that promotes gastrointestinal function recovery, specifically, is to take Chinese patent medicine prepared as raw material by Chinese herbal medicine.
Background technology
Malignant tumor of ovary accounts for 24%～56% of women's common cancer, accounts for the 3rd in female reproductive tract cancer.Operation is the Main Means for the treatment of ovarian cancer.The ovarian cancer operation is owing to will doing the other lymph node dissection of pelvic cavity and ventral aorta, operation wound has been not limited to pelvic cavity but must stimulation have been arranged to abdominal cavity and intestinal tube through the operation of abdomen, gastrointestinal tract unavoidably is interfered and even damages, add the temporary transient inhibition of anaesthetic, postoperative appearance one property crossed gastrointestinal peristalsis disappears and the intestinal tube paralysis occurs, and the morning and evening of gastrointestinal function recovery is directly connected to the rehabilitation of patient with operation.Therefore, adopt Drug therapy, to alleviate patient's postoperative abdominal distention symptom, it is very necessary promoting gastrointestinal function to recover early.
Generally believe at present, abdominal operation operation, anesthesia and patient's primary disease, the medicine for the treatment of, postoperative water electrolysis acid base imbalance, postoperative pain, malnutrition, positive position etc. all can cause the nerve of intestinal wall endogenous locomotor activity to suppress, thereby cause the generation of the slow and enteroparalysis of restoration of gastrointestinal function.Traditional Chinese medical science viewpoint thinks, abdominal postoperative is because mistake department falls in gastrointestinal smoother, and stomachache, swollen, the card marquis such as close, vomit appear in the patient, and operation causes patient's consumption and hinders vigour, and the deficiency of vital energy, anemia syndrome of blood stasis marquis appear in loss Tianjin blood, thereby have increased the weight of the enteroparalysis degree.Theory of Chinese medical science also thinks, after abdominal surgery because of wound, lose blood, anaesthetize, QI-blood circulation is unable, the gastrointestinal function dereliction of duty, clear QI failing to ascend, turbid QI failing to descend, hinder in middle Jiao, internal organs gas is difficult logical.
Chinese periodical " Jiangsu medicine ", the 36th the 20th phase of volume of October in 2010, " observation of curative effect of Liqi Decoction associating acupuncture to the rear restoration of gastrointestinal function of ovarian cancer operation " published, adopt following Therapeutic Method: salviamiltiorrhizabung, Radix Angelicae Sinensis, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Poria, Pericarpium Citri Reticulatae Viride, living army, each 10g of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Folium Sennae 6g decocts with water extracting juice 300ml, 100ml/ time, 3 times/d, postoperative 24h starts to close stomach tube 2h by Injection by stomach duct folder, stops after gastrointestinal decompression to withdraw the previous remark clothes, takes altogether 5 doses; 2 times/d of acupuncture point selection tsu san li, 5d, obtained good curative effect altogether.But the raw material type of this medicine is various, unavoidably be subject to the wide rare restriction in raw material source, and because some Chinese crude drug is expensive, can bring heavy financial burden to the patient, thereby be not suitable for promoting the use of, be necessary to be simplified on this basis, provide a kind of flavour of a drug number few, promote the effective medicine of malignant tumor of ovary gastrointestinal function recovery, but about this class medicine, have not been reported at present.
Summary of the invention
The objective of the invention is for deficiency of the prior art, a kind of medicine that promotes gastrointestinal function recovery is provided.
One purpose more of the present invention is that a kind of purposes of said medicine is provided.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of medicine that promotes gastrointestinal function recovery, it is mainly to be made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 5-15 part, Radix Aucklandiae 5-15 part, Cortex Magnoliae Officinalis 5-15 part, Poria 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Radix Et Rhizoma Rhei 5-15 part.
If described drug main is made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 8-12 part, Radix Aucklandiae 8-12 part, Cortex Magnoliae Officinalis 8-12 part, Poria 8-12 part, Radix Salviae Miltiorrhizae 8-12 part, Radix Et Rhizoma Rhei 8-12 part.
If described drug main is made by the crude drug of following weight portion: 10 parts of Pericarpium Citri Reticulataes, 10 parts of the Radix Aucklandiae, 10 parts of Cortex Magnoliae Officinalis, 10 parts, Poria, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Et Rhizoma Rhei.
Described medicine also comprises the crude drug of following weight portion: Radix Angelicae Sinensis 5-15 part, Pericarpium Citri Reticulatae Viride 5-15 part.
Described medicine also comprises the crude drug of following weight portion: Radix Angelicae Sinensis 8-12 part, Pericarpium Citri Reticulatae Viride 8-12 part.
Described medicine also comprises the crude drug of following weight portion: 10 parts of Radix Angelicae Sinensis, 10 parts, Pericarpium Citri Reticulatae Viride.
Described medicine also comprises the crude drug of following weight portion: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5-15 part, Folium Sennae 3-5.5 part.
Described medicine also comprises the crude drug of following weight portion: 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts of Folium Sennae.
The medicament of described medicine is capsule, granule, tablet, oral liquid, mixture or syrup.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is:
The application of medicine as above in the medicine of preparation promotion gastrointestinal function recovery.
The invention has the advantages that:
1, medicine material component of the present invention compared with prior art reduces to some extent, but therapeutic effect and prior art are suitable, thereby has reduced cost, has alleviated patient's financial burden, makes the preparation of medicine also easier simultaneously;
2, the etiology and pathogenesis of medicine of the present invention a little less than for gastrointestinal function recovery after operation, go deep into that it is basic, evident in efficacy;
3, medicine of the present invention is made by pure Chinese medicine, has no side effect, and is easy to be accepted by the patient.
The specific embodiment
Below the specific embodiment provided by the invention is elaborated.
Embodiment 1 promotes the preparation () of the medicine one of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 15 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 2 promotes the preparation (two) of the medicine one of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 5 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 3 promotes the preparation (three) of the medicine one of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 5 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 15 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 4 promotes the preparation (four) of the medicine one of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 5 promotes the preparation (five) of the medicine one of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 6 promotes the preparation (six) of the medicine one of gastrointestinal function recovery
8 parts of Pericarpium Citri Reticulataes, 12 parts of the Radix Aucklandiae, 8 parts of Cortex Magnoliae Officinalis, 8 parts, Poria, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 7 promotes the preparation (seven) of the medicine one of gastrointestinal function recovery
12 parts of Pericarpium Citri Reticulataes, 8 parts of the Radix Aucklandiae, 12 parts of Cortex Magnoliae Officinalis, 12 parts, Poria, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 8 promotes the preparation (eight) of the medicine one of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 8 parts of the Radix Aucklandiae, 12 parts of Cortex Magnoliae Officinalis, 8 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 9 promotes the preparation (nine) of the medicine one of gastrointestinal function recovery
Old 5 parts, 5 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 10 promotes the preparation (ten) of the medicine one of gastrointestinal function recovery
10 parts of Pericarpium Citri Reticulataes, 10 parts of the Radix Aucklandiae, 10 parts of Cortex Magnoliae Officinalis, 10 parts, Poria, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Et Rhizoma Rhei, conventional method decocts.
Embodiment 11 promotes the preparation () of the medicine two of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 15 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Angelicae Sinensis, 15 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 12 promotes the preparation (two) of the medicine two of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 5 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Angelicae Sinensis, 5 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 13 promotes the preparation (three) of the medicine two of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 5 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 15 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Angelicae Sinensis, 15 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 14 promotes the preparation (four) of the medicine two of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Angelicae Sinensis, 5 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 15 promotes the preparation (five) of the medicine two of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Angelicae Sinensis, 15 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 16 promotes the preparation (six) of the medicine two of gastrointestinal function recovery
8 parts of Pericarpium Citri Reticulataes, 12 parts of the Radix Aucklandiae, 8 parts of Cortex Magnoliae Officinalis, 8 parts, Poria, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Angelicae Sinensis, 12 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 17 promotes the preparation (seven) of the medicine two of gastrointestinal function recovery
12 parts of Pericarpium Citri Reticulataes, 8 parts of the Radix Aucklandiae, 12 parts of Cortex Magnoliae Officinalis, 12 parts, Poria, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Et Rhizoma Rhei, 12 parts of Radix Angelicae Sinensis, 8 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 18 promotes the preparation (eight) of the medicine two of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 8 parts of the Radix Aucklandiae, 12 parts of Cortex Magnoliae Officinalis, 8 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 12 parts of Radix Angelicae Sinensis, 5 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 19 promotes the preparation (nine) of the medicine two of gastrointestinal function recovery
Old 5 parts, 5 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Angelicae Sinensis, 8 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 20 promotes the preparation (ten) of the medicine two of gastrointestinal function recovery
10 parts of Pericarpium Citri Reticulataes, 10 parts of the Radix Aucklandiae, 10 parts of Cortex Magnoliae Officinalis, 10 parts, Poria, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Angelicae Sinensis, 10 parts, Pericarpium Citri Reticulatae Viride, conventional method decocts.
Embodiment 21 promotes the preparation () of the medicine three of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 15 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Angelicae Sinensis, 15 parts, Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5.5 parts of Folium Sennae, conventional method decocts.
Embodiment 22 promotes the preparation (two) of the medicine three of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 5 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Angelicae Sinensis, 5 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Folium Sennae, conventional method decocts.
Embodiment 23 promotes the preparation (three) of the medicine three of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 5 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 15 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Angelicae Sinensis, 15 parts, Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Folium Sennae, conventional method decocts.
Embodiment 24 promotes the preparation (four) of the medicine three of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Angelicae Sinensis, 5 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5.5 parts of Folium Sennae, conventional method decocts.
Embodiment 25 promotes the preparation (five) of the medicine three of gastrointestinal function recovery
5 parts of Pericarpium Citri Reticulataes, 15 parts of the Radix Aucklandiae, 15 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Angelicae Sinensis, 15 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5.5 parts of Folium Sennae, conventional method decocts.
Embodiment 26 promotes the preparation (six) of the medicine three of gastrointestinal function recovery
8 parts of Pericarpium Citri Reticulataes, 12 parts of the Radix Aucklandiae, 8 parts of Cortex Magnoliae Officinalis, 8 parts, Poria, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Angelicae Sinensis, 12 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5.5 parts of Folium Sennae, conventional method decocts.
Embodiment 27 promotes the preparation (seven) of the medicine three of gastrointestinal function recovery
12 parts of Pericarpium Citri Reticulataes, 8 parts of the Radix Aucklandiae, 12 parts of Cortex Magnoliae Officinalis, 12 parts, Poria, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Et Rhizoma Rhei, 12 parts of Radix Angelicae Sinensis, 8 parts, Pericarpium Citri Reticulatae Viride, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Folium Sennae, conventional method decocts.
Embodiment 28 promotes the preparation (eight) of the medicine three of gastrointestinal function recovery
15 parts of Pericarpium Citri Reticulataes, 8 parts of the Radix Aucklandiae, 12 parts of Cortex Magnoliae Officinalis, 8 parts, Poria, 5 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Et Rhizoma Rhei, 12 parts of Radix Angelicae Sinensis, 5 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Folium Sennae, conventional method decocts.
Embodiment 29 promotes the preparation (nine) of the medicine three of gastrointestinal function recovery
Old 5 parts, 5 parts of the Radix Aucklandiae, 5 parts of Cortex Magnoliae Officinalis, 5 parts, Poria, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Angelicae Sinensis, 8 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5.5 parts of Folium Sennae, conventional method decocts.
Embodiment 30 promotes the preparation (ten) of the medicine three of gastrointestinal function recovery
10 parts of Pericarpium Citri Reticulataes, 10 parts of the Radix Aucklandiae, 10 parts of Cortex Magnoliae Officinalis, 10 parts, Poria, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Angelicae Sinensis, 10 parts, Pericarpium Citri Reticulatae Viride, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts of Folium Sennae, conventional method decocts.
It should be noted that, it is the manufacture method of Chinese medicine decoction routine that the described conventional method of embodiment 1-30 decocts, and is about to described crude drug and decocts with water into decoction.
Embodiment 31 promotes the preparation of the medicinal tablet/capsule of gastrointestinal function recovery
Get the arbitrary described medicine of embodiment 1-30, add 9-11 times of water gaging, decoct 2-3.5 hour, leach medicine juice.Add again 9 times of water gagings, decoct 2.5 hours, leach medicine juice, merge the secondary decocting liquid, standing, the leaching supernatant, concentrated, let cool, add 3 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; Add pharmaceutical aids, vacuum drying, pulverize and granulate, and is pressed into tablet or fills encapsulated.
Embodiment 32 promotes the preparation of the drug particles of gastrointestinal function recovery
Get the arbitrary described medicine of embodiment 1-30, add 8-10 times of water gaging, decoct 3 hours, leach medicine juice.Add again 10 times of water gagings, decoct 2.5 hours, leach medicine juice, merge the secondary decocting liquid, standing, the leaching supernatant, concentrated, let cool, add 2 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, granulate, drying, granulate, obtain the 20g granule, packing 10g/ bag.
The preparation of the drug mixture/oral liquid of embodiment 33 promotion gastrointestinal function recovery/syrup
Get the arbitrary described medicine of embodiment 1-30, add 8-11 times of water gaging, decoct 3 hours, leach medicine juice.Add again 8 times of water gagings, decoct 3 hours, leach medicine juice, merge the secondary decocting liquid, standing, the leaching supernatant, concentrated, let cool, add 3.5 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, make mixture, oral liquid or syrup.
The observation of curative effect of embodiment 34 medicine of the present invention to the ovarian cancer post operation restoration of gastrointestinal function
One, data and method
1. physical data
1～Decembers in 2009 are accepted inpatient 240 examples of ovarian cancer operation, age 31-80 year, the median age 55.62 years old.Wherein, first operation 202 examples, second operation 38 examples, anesthesia method is epidural anesthesia, postoperative row patient-controlled analgesia (PCA).Postoperatively be divided into immediately following each group: matched group, acupuncture group, documents medicine group, medicine one add that acupuncture group, medicine two add the acupuncture group, medicine three adds the acupuncture group, every group of 40 examples, and each group has comparability aspect the basic documents such as age, stadium.
2. Therapeutic Method
(1) matched group: press the nursing of ovarian cancer post operation nursing routine, postoperative conventional semireclining position, fasting, gastrointestinal decompression, intravenous applications antibiotic, fluid infusion maintain water, electrolyte and acid-base balance and intravenous nutrition, postoperative early ambulant; (2) acupuncture group: give acupuncture in the conventional therapy nursing of matched group, the acupuncture point selection tsu san li, 2 times/d, be total to 5d; (3) documents medicine group: disclosed medication combined acupuncture give documents in the conventional therapy nursing of matched group in, be respectively 10 parts of Chinese medicine Pericarpium Citri Reticulatae, the Radix Aucklandiae, Cortex Magnoliae Officinalis, Poria, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae Viride, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 6 parts of Folium Sennae, decoct with water to concentration as containing crude drug amount 0.25g/mL, extracting juice 300ml, 100ml/ time, 3 times/d, postoperative 24h starts to close stomach tube 2h by Injection by stomach duct folder, stop after gastrointestinal decompression to withdraw the previous remark clothes, take altogether 5 doses, the acupuncture point selection tsu san li, 2 times/d, be total to 5d; (4) medicine one adds the acupuncture group: give the medication combined acupuncture of embodiment 10 preparations in the conventional therapy nursing of matched group, the medicine of embodiment 10 decocts with water to concentration as containing crude drug amount 0.25g/mL, extracting juice 300ml, 100ml/ time, 3 times/d, postoperative 24h starts to close stomach tube 2h by Injection by stomach duct folder, stop after gastrointestinal decompression to withdraw the previous remark clothes, take altogether 5 doses, the acupuncture point selection tsu san li, 2 times/d, be total to 5d; (5) medicine two adds the acupuncture group: give the medication combined acupuncture of embodiment 20 preparations in the conventional therapy nursing of matched group, the medicine of embodiment 20 decocts with water to concentration as containing crude drug amount 0.25g/mL, extracting juice 300ml, 100ml/ time, 3 times/d, postoperative 24h starts to close stomach tube 2h by Injection by stomach duct folder, stop after gastrointestinal decompression to withdraw the previous remark clothes, take altogether 5 doses, the acupuncture point selection tsu san li, 2 times/d, be total to 5d; (6) medicine three adds the acupuncture group: give the medication combined acupuncture of embodiment 30 preparations in the conventional therapy nursing of matched group, the medicine of embodiment 30 decocts with water to concentration as containing crude drug amount 0.25g/mL, extracting juice 300ml, 100ml/ time, 3 times/d, postoperative 24h starts to close stomach tube 2h by Injection by stomach duct folder, stop after gastrointestinal decompression to withdraw the previous remark clothes, take altogether 5 doses, the acupuncture point selection tsu san li, 2 times/d, be total to 5d.
3. curative effect determinate standard
List of references: money state. the impact [J] of purging FU-organs soup on the abdominal postoperative gastrointestinal function. practical Chinese medicine magazine, 2007,10(10): 618.Concrete criterion is as follows:
Produce effects: without abdominal distention, borborygmus occurs, passage of gas by anus in 12h; Effectively: without obvious abdominal distention, borborygmus is normal, passage of gas by anus in 12-36h; Improve: slight abdominal distention, borborygmus is normal, passage of gas by anus in 36-72h; Invalid: obvious abdominal distention is arranged, a little less than borborygmus, the not aerofluxus of the above anus of 72h.
4. statistical procedures
Enumeration data means with percentage rate, adopts χ
2Check, there is statistical significance P<0.05 for difference.
Two, result
Each organizes curative effect and difference is added up in Table 1.As can be seen from the table, acupuncture group, documents medicine group, medicine one add acupuncture group, medicine two and add acupuncture group, medicine three and add the acupuncture group and compare with matched group, and total effective rate is significantly increased, and difference has statistical significance; Medicine one adds acupuncture group, medicine two and adds acupuncture group, medicine three and add acupuncture group and acupuncture group relatively, and total effective rate is significantly increased, and difference has statistical significance, illustrates that medicine of the present invention can significantly promote the ovarian cancer post operation restoration of gastrointestinal function; Medicine one adds acupuncture group, medicine two and adds acupuncture group, medicine three and add the acupuncture group and compare with documents medicine group, and the difference not statistically significant, illustrate and adopt the less medicine of the present invention of flavour of a drug number can obtain good therapeutic effect equally.
Table 1 is respectively organized curative effect relatively [example (%)]
| Group | Number of cases | Produce effects | Effectively | Improve | Invalid | Total effective rate |
| Matched group | 40 | 2（5.0） | 7（17.5） | 21（52.5） | 10（25.0） | 75% |
| The acupuncture group | 40 | 3（7.5） | 8（20.0） | 22（55.0） | 7（17.5） | 82.5% # |
| Documents medicine group | 40 | 6（15.0） | 15（37.5） | 16（40.0） | 3（7.5） | 92.5% * |
| Medicine one adds the acupuncture group | 40 | 6（15.0） | 14（35.0） | 17（42.5） | 3（7.5） | 92.5% * |
| Medicine two adds the acupuncture group | 40 | 7（17.5） | 14（35.0） | 17（42.5） | 2（5.0） | 95.0% * |
| Medicine three adds the acupuncture group | 40 | 8（20.0） | 13（32.5） | 16（40.0） | 3（7.5） | 92.5% * |
Annotate: #, * all mean that difference has statistical significance, P<0.05.
In sum, medicine of the present invention has reduced the flavour of a drug number, has reduced cost, but to the recovery of gastrointestinal function after ovarian cancer operation successful still, more economical and practical, simple, be conducive to the recovery of gastrointestinal function recovery after operation, can alleviate the patient suffering, promote patient's early recovery.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (7)
1. a medicine that promotes gastrointestinal function recovery, is characterized in that, it is to be made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 5-15 part, Radix Aucklandiae 5-15 part, Cortex Magnoliae Officinalis 5-15 part, Poria 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Radix Et Rhizoma Rhei 5-15 part.
2. medicine according to claim 1, is characterized in that, it is to be made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 8-12 part, Radix Aucklandiae 8-12 part, Cortex Magnoliae Officinalis 8-12 part, Poria 8-12 part, Radix Salviae Miltiorrhizae 8-12 part, Radix Et Rhizoma Rhei 8-12 part.
3. medicine according to claim 1, is characterized in that, it is to be made by the crude drug of following weight portion: 10 parts of Pericarpium Citri Reticulataes, 10 parts of the Radix Aucklandiae, 10 parts of Cortex Magnoliae Officinalis, 10 parts, Poria, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Et Rhizoma Rhei.
4. a medicine that promotes gastrointestinal function recovery, it is characterized in that, it is to be made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 5-15 part, Radix Aucklandiae 5-15 part, Cortex Magnoliae Officinalis 5-15 part, Poria 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Radix Et Rhizoma Rhei 5-15 part, Radix Angelicae Sinensis 5-15 part, Pericarpium Citri Reticulatae Viride 5-15 part.
5. medicine according to claim 4, it is characterized in that, it is to be made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 5-15 part, Radix Aucklandiae 5-15 part, Cortex Magnoliae Officinalis 5-15 part, Poria 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Radix Et Rhizoma Rhei 5-15 part, Radix Angelicae Sinensis 8-12 part, Pericarpium Citri Reticulatae Viride 8-12 part.
6. medicine according to claim 5, is characterized in that, it is to be made by the crude drug of following weight portion: Pericarpium Citri Reticulatae 5-15 part, Radix Aucklandiae 5-15 part, Cortex Magnoliae Officinalis 5-15 part, Poria 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Radix Et Rhizoma Rhei 5-15 part, 10 parts of Radix Angelicae Sinensis, 10 parts, Pericarpium Citri Reticulatae Viride.
7. the application of medicine as claimed in claim 1 in the medicine of preparation promotion gastrointestinal function recovery.
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| CN102961732B (en) * | 2012-11-22 | 2016-04-27 | 青岛绿曼生物工程有限公司 | The composition and method of making the same for the treatment of rabbit enteritis |
| CN103656013B (en) * | 2013-12-19 | 2015-10-21 | 滨州医学院附属医院 | A kind of Chinese medicine for the treatment of gastrointestinal function decline after abdominal operation and preparation method thereof |
| CN105213680A (en) * | 2014-06-04 | 2016-01-06 | 邵阳市中医医院 | One treats paralytic ileus, promotes Chinese powder medicine of abdominal post-operation restoration of gastrointestinal function and preparation method thereof |
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| CN101773649A (en) * | 2010-04-09 | 2010-07-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating acute abdomen and preparation method thereof |
| CN102091152A (en) * | 2009-12-15 | 2011-06-15 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal composition with stomach-invigorating and digestion-promoting function and preparation method thereof |
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| KR101128646B1 (en) * | 2009-11-18 | 2012-03-26 | 최재완 | Preparation of Poria cocos liquor |
| KR20110125295A (en) * | 2010-05-13 | 2011-11-21 | 조남철 | Health assistance food used the euphorbia humifusa wild by main raw material and the manufacturing method therof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102091152A (en) * | 2009-12-15 | 2011-06-15 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal composition with stomach-invigorating and digestion-promoting function and preparation method thereof |
| CN101773649A (en) * | 2010-04-09 | 2010-07-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating acute abdomen and preparation method thereof |
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| 南京铁道医学院附属医院外科.扶正理气汤在腹部外科手术后的应用观察.《中医杂志》.1975,(第09期), |
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